SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
·
IF 4.098
Zichen Yang,Chaoqun Ma,Jiao Gu,Yamin Wu,Chun Zhu,Lei Li,Hui Gao,Wenzhi Yin,Zirui Wang,Ye Zhang,Yunpeng Shang,Chengwei Wang,Guoqing Chen
Benzoic acid, which has a pivotal role in food additive, is prohibited to add as a preservative in dairy products. China, Brazil, and other countries have proposed standard methods to detect the addition of benzoic acid in food. Surface-enhanced Raman scattering (SERS) is an upcoming spectral detection technique, which has been widely used in the field of material analysis with the advantages of non-invasive, fast detection speed and complex environment with little interference. To detect the illegal use of benzoic acid in dairy industry, we developed Ag-COF (covalent-organic framework) material as SERS substrate to detect benzoic acid in liquid milk. The great enhancement ability of Ag-COF substrate is controlled by the addition of acetic acid and complex interplay between COF material and benzoic acid. This detection method has high sensitivity and reliability that allows us to achieve limit of detection (LOD) of 0.13 μg/mL in milk and 0.00372 μg/mL in water by applying this method. In experiment on recovery rate of real samples, the detection time is less than 15 minutes and the relative standard deviation (RSD) ranged from 2.82% to 5.69%. Therefore, this method has practical significance of the detection of benzoic acid in dairy products.
研究领域:
食品科学
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分析化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
·
IF 9.965
Aodi Zhang,Yusai Zhou,Feng Xue,Xudong Peng,Hongyu Chen,Hong Wang
The surface enhanced Raman scattering (SERS) reporters are rather limited, and the Raman peaks still overlap in varying degrees, making SERS multiplex coding a critical bottleneck in the exploration of SERS nanotechnology. Herein, we design a general strategy to expand the SERS probe scope to 26 probes of six types, which can be further expanded within a limited range, with stable performance and structure. By constructing (Au-aggregate)@Ag@silica and (Au-aggregate)@silica nanocomposites, we develop optimal enhancement strategies for each Raman molecules. Mixed signal-ligand SERS probes improve the complexity of Raman spectra and expand the coding capacity. By integrating the strategies, SERS inks are produced and applied in anti-counterfeiting. With these improvements, this work breaks the constrains of probe selection, bringing SERS one step closer to the sensor or anti-counterfeiting application.
研究领域:
纳米技术
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材料科学
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分析化学
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光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2020
·
IF 8.758
Yusai Zhou,Gui Zhao,Jingming Bian,Xiaoli Tian,Xuejun Cheng,Hong Wang,Hongyu Chen
Forged signature threatens the authenticity of personal identity. Here, an effective SERS anti-counterfeiting system is designed for personal signatures. Mixed ligands improve the complexity of Raman spectra and expand the coding capacity. Fourteen distinct combinations are created from mere five ligands, and great expansion is possible with modest expansion of the ligand library. On the other hand, the (Au-aggregate)@Ag@PSPAA nanostructure significantly increases the surface-enhanced Raman scattering (SERS) intensity and stability so that excellent performance is achieved in SERS detection. By integrating these strategies, SERS inks are produced and applied in signature anti-counterfeiting. The resulting spectra are converted to barcodes that are readily detected through a smart phone APP. With these improvements, this work brings SERS one step closer toward practical applications in signature anti-counterfeiting.
研究领域:
材料科学
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光谱学
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化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL SCIENCES
·
2021
·Vol. 37
·期 2
·315-320
·
IF 2.081
Siqingaowa HAN,Chen ZHANG,Zhijie CHEN,Xuanyu SHA,Wuliji HASI
This paper describes a method based on surface enhanced Raman spectroscopy (SERS) technology for rapid detection of dezocine in urine and serum. Firstly, an Ag colloid substrate was prepared and characterized. Then the Raman characteristic peaks of dezocine were assigned from both theoretical and experimental aspects. Finally, the Raman peak at 661 cm−1 was selected as its characteristic peak to perform SERS detection on dezocine in urine and serum, and the detection limits of dezocine in urine and serum were determined. The relationships between the characteristic peak intensity and the concentration of dezocine in urine and serum were fitted and the recovery rates were calculated. This rapid, accurate and non-destructive method establishes a good foundation for rapid on-site detection of dezocine in biological samples.
研究领域:
分析化学
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生物医学工程
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药物分析
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
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2016
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IF 7.476
Chunyuan Song,Boyue Yang,Yu Zhu,Yanjun Yang,Lianhui Wang
With years of outrageous mercury emissions, there is an urgent need to develop convenient and sensitive methods for detecting mercury ions in response to increasingly serious mercury pollution in water. In the present work, a portable, ultrasensitive SERS sensor is proposed and utilized for detecting trace mercury ions in water. The SERS sensor is prepared on an excellent sliver nanorods array SERS substrate by immobilizing T-component oligonucleotide probes labeled with dye on the 3′-end and –SH on the 5′-end. The SERS sensor responses to the specific chemical bonding between thymine and mercury ions, which causes the previous flexible single strand of oligonucleotide probe changing into rigid and upright double chain structure. Such change in the structure drives the dyes far away from the excellent SERS substrate and results in a SERS signal attenuation of the dye. Therefore, by monitoring the decay of SERS signal of the dye, mercury ions in water can be detected qualitatively and quantitatively. The experimental results indicate that the proposed optimal SERS sensor owns a linear response with wide detecting range from 1 pM to 1 μM, and a detection limit of 0.16 pM is obtained. In addition, the SERS sensor demonstrates good specificity for Hg 2+ , which can accurately identify trace mercury ions from a mixture of ten kinds of other ions. The SERS sensor has been further executed to analyze the trace mercury ions in tap water and lake water respectively, and good recovery rates are obtained for sensing both kinds of water. With its high selectivity and good portability, the ultrasensitive SERS sensor is expected to be a promising candidate for discriminating mercury ions in the fields of environmental monitoring and food safety.
研究领域:
环境科学
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分析化学
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材料科学
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
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2018
·
IF 5.123
Dan Li,Yadan Ma,Huazhen Duan,Fei Jiang,Wei Deng,Xingang Ren
A fluorescent and surface-enhanced Raman spectroscopy (SERS) dual-mode probe is developed for imaging of intracellular Zn 2+ based on N-(2-(bis(pyridine-2-ylmethyl)amino)ethyl)-2-mercaptoacetamide (MDPA) modified gold nanoparticles (MDPA-GNPs). Benefiting from the chelation-enhanced fluorescence (CHEF) between MDPA-GNPs and Zn 2+ , the fluorescent intensities of MDPA-GNPs are substantially enhanced with the increment of Zn 2+ concentrations, which can be clearly observed by the naked eye. Under physiological conditions, the probe exhibits a stable response for Zn 2+ from 1 μM to 120 μM, with a detection limit of 0.32 μM in aqueous solutions. The resultant MDPA-GNPs can be used for ultrasensitive SERS detection of Zn 2+ because of the strong inter-particle plasmonic coupling generated in the process of Zn 2+ -triggered MDPA-GNPs self-aggregation, with a low detection limit of 0.28 pM, which is eight order of magnitude lower than the United States Environmental Protection Agency (US EPA)-defined limit (76 μM) in drinkable water. More importantly, the proposed probe can be applied for efficient detection of intracellular Zn 2+ with excellent biocompatibility and cellular imaging capability. Therefore, a highly sensitive and selective nanosensor has been demonstrated for both reliable quantitative detection of Zn 2+ in aqueous solution and real-time imaging of intracellular Zn 2+ , suggesting its significant potential utility in bioanalysis and biomedical detection in the future.
研究领域:
生物分析
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生物医学
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化学传感
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2025
·
IF 6.7
Xiaoyu Tian,Jinwei Bao,Lei Song,Bo Zhang,Junsheng Yang,Liangbo Sun,Houchang Pei,Qiang Cao,Qianqian Lin
Noble-metal-free surface-enhanced Raman spectroscopy (SERS) substrates have the advantages, such as abundant resources, uniformity, good biocompatibility, and chemical stability, and they have sparked widespread attention in food safety assessment. However, the lack of controllable synthesis and fabrication method limits their performance in practical applications, especially in the production of high SERS activity substrates. In this study, we introduce a femtosecond laser direct writing technique to precisely manipulate and modify microstructures, successfully fabricating micro-rings of different sizes. Benefiting from the localized field enhancement effect of the optical microcavity, the Sb 2 S 3 micro ring exhibits significantly enhanced Raman signals compared to the unmodified Sb 2 S 3 thin film and the degree of signal enhancement is closely related to the size of the micro rings. Notably, the in-situ formed Sb nanoparticles during the micro ring fabrication process generate pronounced plasmonic effects. These plasmonic hot spots synergistically couple with the localized field enhancement of the optical microcavity, enabling secondary amplification of Raman signals. Furthermore, we used rhodamine 6G (R6G) and basic orange II as probe molecules, and the results indicate that the proposed Sb 2 S 3 micro-ring substrate exhibits excellent SERS performance. This study demonstrates the potential of using advanced laser technology to manufacture highly active noble-metal-free SERS substrates and highlights the importance of microstructure design in enhancing Raman signals, providing new insights for future applications in food safety detection and other fields.
研究领域:
光谱分析
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材料科学
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食品安全检测
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 59
·37443-37448
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IF 3.361
Huiting Wang,Hairan Zhang,Ling Zhang,Shibo Zhao,Yaxian Chen,Yu Wan,Qian Zhang,Lixin Xia
An ionic liquid (IL)-based liposome was utilized as a substrate to construct a SERS platform. The isotropy of the IL outer surface together with its ion-exchange property led to the array-like growth of Au nanoparticles (NPs), generating hot-spots and resulting in anionic probes being present on the hot-spot regions. The simultaneous strategy of enrichment and localization endowed the platform with ability to detect trace amounts of anionic probes.
研究领域:
分析化学
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纳米技术
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生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Huanhuan Sun,Hongyan Yu,Boyang Han,Junjie Ma,Rensheng Wang,Yanping Song
Pressure-induced surface-enhanced Raman spectroscopy (PI-SERS) is among the foremost achievements of high-pressure fields, benefiting from the advantage that pressure-modulated interactions between substrates and molecules overcome the weakness of individual substrates or molecules. However, the pressure corresponding to PI-SERS enhancement is currently still at a low-pressure stage within 8 GPa. Therefore, how to realize PI-SERS enhancement under higher or ultrahigh pressure remains a huge challenge. Here, we applied few-layer WS2 (FL-WS2) nanosheets as PI-SERS substrates and selected 4-mercaptobenzoic acid (4-MBA) molecules with a big energy gap as probes to explore PI-SERS enhancement in more depth. The experimental results indicate that the PI-SERS signals increase gradually as pressure increases and reaches a maximum at 18 GPa, which has set a pressure record for the PI-SERS field so far. Different from the C exciton resonance-induced SERS intensities at ambient conditions, the charge-transfer transition between FL-WS2 and 4-MBA is strengthened via the pressure-induced increase in the band gap of FL-WS2 and decrease in the highest-occupied molecular orbital–lowest unoccupied molecular orbital (HOMO–LUMO) energy gap of 4-MBA, thus enhancing PI-SERS signals accordingly. Therefore, this strategy will be beneficial for practical applications in the field of optoelectronics and for the design of other PI-SERS sensors for trace detection in complex and extreme environments.
研究领域:
材料科学
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纳米技术
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光电子学
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光谱学
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产品关联
DOI
高影响因子
ANALYTICAL SCIENCES
·
2020
·Vol. 36
·期 9
·1025-1030
·
IF 2.049
Xiaoxuan LI,Lijun LI,Yuhan HE
Based on the reversible covalent binding between borates and glycoproteins, we proposed a scheme that can specifically recognize and detect immunoglobulin G (IgG). The application of magnetic materials to enrich SERS probes can provide an enhanced signal and repeatability. The results showed that the prepared sandwich-like complex displayed high sensitivity and excellent selectivity for IgG. The Raman peak intensity showed a good linear relationship in the concentration range of 1 mg/mL – 1 ng/mL. The linear equation was y = 657.93x + 2963.9, R2 = 0.996. Parallel testing of this sandwich-like complex proved to have excellent repeatability. This method provided a new possibility for clinical non-immunity and the quantitative detection of IgG.
研究领域:
分析化学
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生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2024
·
IF 2.9
Kaibo Yuan,Qinqin Qian,Miaomiao Wu,Bingxia Wang,Shuwen Zeng,Dong Chen,Muhammad Danang Birowosuto,Diing Shenp Ang,Chenjie Gu
Active control the surface-enhanced Raman scattering (SERS) enhancement shows great potential for realizing smart detection of different molecules. However, conventional methods usually involve time-consuming structural design or sophisticated fabrication process. Herein, we reported an electrically tunable field effect transistor (FET) comprised by WOx/MoOx hybrid as the SERS active layer. In the experiment, WOx/MoOx hybrid were first prepared by mixing different molar ratios of WOx and MoOx oxides. Then, R6G molecules was used as the Raman reporter, it showed that the intensity of the SERS signal observed on the most optimal hybrids (molar ratio = 1:3) could be promoted by two times as high as that observed on a single WOx or MoOx based substrate, which was ascribed to enhanced charge transfer efficiency by the constructed nano-heterojunction between the WOx and MoOx oxides. Thereafter, a back-gate FET was fabricated on a SiO2/Si substrate, and the most optimal WOx/MoOx hybrid was deposited as the gate channel as well as the SERS active layer. After that, a series of gate bias (from -15 V to 15 V) were implemented to actively tune the SERS performance of the FET. It evidenced that SERS EF can be further tuned from 2.39 × 107 (-15 V) to 6.55 × 107 (+10 V), which is ~7.4 / 4.1 times high than that observed on the pure WOx device (8.81 × 106) or pure MoOx (1.61 × 107) device, respectively. Finally, the mechanism behind the electrical tuning strategy was investigated. It revealed that a positive voltage would bend the conduction band down, which raised the electron density near the Fermi level. Consequently, it triggered the resonance charge transfer and significantly improved the SERS performance. On the contrary, a negative gate voltage attracted the holes to the Fermi level, which deferred the charge transfer process, and caused the degradation of the SERS enhancement.
研究领域:
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Qingling Nie,Peipei Xu,Jiajia Liu,Yanhanzhuo Wang,Qian Huang,Ruiyun You,Yunzhen Liu,Lizhi Li,Yudong Lu
To improve the sensitivity, accuracy and specificity of the assay, a two-dimensional silver substrate with EF=5.85×10 8 was first synthesized as a SERS substrate, on the surface of which DSP molecules were modified to form a DSP-antibody coupling through the activation of two N-hydroxy succinimide (NHS) esters to capture TNF-α. Subsequently, aptamerized silver-coated gold nanospheres (Au@TFMBA@Ag) were synthesized as Surface-Enhanced Raman Scattering (SERS) recognition probes. These probes were employed to create a sandwich structure for the quantitative detection of Tumor Necrosis Factor-alpha (TNF-α), utilizing the SERS signal intensity at 1374 cm −1 . Quantitative detection of TNF-α was successfully accomplished within the concentration range of 10 −4 to 10 −10 mg·mL −1 . Clinical serum samples were collected and subjected to testing. Significance analysis, conducted through the T-test (p < 0.0001), unequivocally showed the method's ability to differentiate between sera from normal individuals and those diagnosed with colon cancer.
研究领域:
生物医学
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癌症检测
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）