MOLECULES
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2024
·Vol. 29
·期 17
·4238
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IF 4.2
Zhuoyi Ren,Jiangfen Sheng,Qibin Yuan,Yizhen Su,Linhua Zhu,Chunyan Dai,Honglei Zhao
The combustion of fuel with high sulfur concentrations produces a large number of sulfur oxides (SOx), which have a range of negative effects on human health and life. The preparation of catalysts with excellent performance in the oxidative desulfurization (ODS) process is highly effective for reducing SOxproduction. In this paper, cross-linked polyvinylimidazole (VE) was successfully created using a simple ontology aggregation method, after which a catalyst of polyvinylimidazolyl heteropolyacid clusters (VE-HPA) was prepared by adding heteropolyacid clusters. Polyvinylimidazolyl-phosphotungstic acid (VE-HPW) showed an outstanding desulfurization performance, and the desulfurization efficiency reached 99.68% in 60 min at 50 °C with H2O2as an oxidant. Additionally, the catalyst exhibited recyclability nine consecutive times and remained stable, with a removal rate of 98.60%. The reaction mechanism was eventually proposed with the assistance of the free radical capture experiment and GC-MS analysis.
研究领域:
化学工程
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环境科学
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产品关联
DOI
PubMed
高影响因子
EcoMat
·
2023
·Vol. 6
·期 2
·e12434
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IF 14.6
Syed Comail Abbas,Zifeng Hua,Qidu Deng,Md Sohel Ahommed,Jiajia Guo,Hai Huang,Xiaojuan Ma,Shilin Cao,Yonghao Ni
Natural polymers-based carbon electrodes have gained significant research attention for next-generation portable supercapacitors. Herein, present an environmentally benign and novel approach for the synthesis of N/S-O x carbon material derived from natural polymers on gram scale. By capitalizing the synergistic effect of sulfonated lignin and amino-containing chitosan, this methodology produces a straightforward, low-budget, and scalable process. The incorporation of sulfonate motifs from lignin contributes to the formation of C-SO x moieties and multi-porous architecture with a high surface area. Simultaneously, amino groups in chitosan induce nitrogen doping, enhancing conductivity, and wettability. The resulting N/SO x carbon material exhibits a micro/meso-porous architecture, facilitating electrolyte diffusion, and demonstrating improved rate capability and pseudocapacitance via Faradaic redox reactions. The N/SO x carbon material showcases notable capacitance (392 F g −1 at 1 Ag −1 ) as compared with the reported carbon materials form biomass and outstanding cyclic stability (94.8% retention after 5000 cycles). By optimizing various chitosan mass ratios, the most effective N/SO x carbon material SNACM = S/N-doped activated carbon material (SNACM-2) was produced using a lignin: chitosan sample ratio of 1:2 for symmetric supercapacitors. Furthermore, the quasi-solid-state symmetric supercapacitors based on SNACM-2 exhibit an excellent specific capacitance of 142 F g −1 at 1 A g −1 , coupled with outstanding flexibility. The SNACM-2 demonstrates a high-energy density of 9.8 W h kg −1 at a power density of 0.5 kW kg −1 . This study presents a successful strategy for transforming low-valued, eco-friendly natural polymers into renewable, high-performance carbon materials for supercapacitors.
研究领域:
材料科学
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能源存储
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环境科学
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DOI
高影响因子
Environmental Progress & Sustainable Energy
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2018
·Vol. 37
·期 6
·2026-2033
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IF 1.326
Ke Wang,Ji Sun,Pengfei Zhao
The development of novel Li 4 SiO 4 -based sorbents is hampered by a lack of understanding of the mechanisms governing CO 2 adsorption on the Li 4 SiO 4 surface. In this work, the adsorption of CO 2 and flue gas components (such as H 2 O and SO X (SO 2 and SO 3 )) on a simulated Li 4 SiO 4 surface was investigated using ab initio-based energetic calculations. The Li 4 SiO 4 surface was modeled by a cluster of lithium silicate, in which the atoms were unsaturated to simulate the active sites. Furthermore, Fourier transform infrared (FTIR) spectra were also analyzed. The calculated results showed that three possible configurations were determined: CO 2 weakly sorbed on the oxygen sites of Li 4 SiO 4 through physisorption; a carbonate species appeared, which was characterized by chemisorption; and a linear cluster of Li + -O = C=O formed, having the largest sorption energy. These three possible pathways were likewise in accordance with the FTIR results. Moreover, a pre-chemisorption of water on Li 4 SiO 4 resulted in promoted CO 2 capture, while the presence of competitive SO X sorption on the same active sites as CO 2 sorption showed an inhibition effect. The results clarify the complex adsorption mechanisms on the Li 4 SiO 4 surface. © 2018 American Institute of Chemical Engineers Environ Prog, 37: 1901–1907, 2018
研究领域:
化学工程
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环境科学
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产品关联
DOI
高影响因子
ACS ES&T Engineering
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2024
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IF 7.4
Yong Li,Bohan Chen,Xiaolei Zhang,Zhizhan Luo,Mengen Lei,Tao Song,Youcheng Wei,Ji Li,Zhiyun Long,Jun Ma
Elemental sulfur autotrophic partial denitrification (S0-PDN) can supply nitrite for anaerobic ammonium oxidation without an organic carbon requirement. This study aimed to evaluate the impact of high salinity on S0-PDN and investigate the feasibility of an enhanced strategy involving the addition of glycine betaine (GB). The results showed that high salinity inhibited S0-PDN by over 60% as salinity increased from low (0 and 5 g/L) to high (10 and 15 g/L) levels, even though Thiobacillus (65.9%–84.0%) was always the dominant genus. The reason might be the suppression of high salinity on the bioactivity. Surprisingly, the addition of GB (1 mmol/L) effectively enhanced the performance of S0-PDN under high salinity conditions (10 g/L), resulting in a 5.1-fold increase in the NO3–-N conversion efficiency and a 3.1-fold increase in the effluent NO2–-N concentration. Metagenomics analysis revealed that high salinity did not alter the dominant microbial composition. GB facilitated the recovery of the nitrate conversion capacity of sulfur autotrophic denitrifying bacteria with the up-regulation of nitrate reductase genes (by 18.1%) and Sox genes (by 21.4%). However, GB also stimulated the growth of heterotrophic denitrifying bacteria. Part of the nitrite produced in S0-PDN was reduced through heterotrophic denitrification with GB as an electron donor. Overall, the addition of GB was demonstrated as an effective approach to mitigate the inhibitory effects of high salinity on S0-PDN, which offers valuable theoretical support for its application in high-salinity wastewater treatment.
研究领域:
环境工程
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微生物学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2022
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IF 14.224
Zhendong Yu,Suhang Xun,Meizan Jing,Haofeng Chen,Weiyu Song,Yanhong Chao,Mohammad Rahmani,Yuxiao Ding,Mingqing Hua,Jian Liu,Wenshuai Zhu
To prevent SO x emission and produce low-sulfur diesel oil, we develop a 3D assembly TiO 2 nanoflower catalyst with controllable oxygen vacancies for oxidative desulfurization (ODS) in diesel oil. The roles of oxygen vacancy (OV) and associated Ti 3+ in TiO 2 are fully discussed: the increased OV and Ti 3+ are beneficial for the promoted chemical adsorption of peroxy groups, from − 0.5 eV to − 1.26 eV; also facile to the reduction of the energy barriers of O-O and O-H bonds cleavage, respectively by 1.38 eV and 1.24 eV, thus greatly boosting the generation of hydroxyl radicals·OH and superoxide radicals·O 2 - . Besides, the ODS reaction undergoes two possible pathways, the mechanism and the kinetics are investigated. Above all, the 100% ODS rate can be obtained in only 30 min under optimal conditions, showing a promising perspective of oxygen vacancy engineering for converting hazardous sulfides into high-value chemicals.
研究领域:
材料科学
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催化
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环境化学
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能源工程
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DOI
高影响因子
Translational Lung Cancer Research
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2024
·Vol. 13
·期 10
·2698
·
IF 4
Ziying Zhao,Xiaoqing Feng,Huijuan Wu,Shuisheng Chen,Changsong Ma,Ziyun Guan,Luwen Lei,Kejing Tang,Xiao Chen,Yong Dong,Yubo Tang
Background Lung cancer is one of the most common malignant tumors worldwide. Despite advances in lung cancer treatment, patients still face challenges related to drug resistance and recurrence. Current methods for evaluating anti-cancer drug activity are insufficient, as they rely on two-dimensional (2D) cell culture and animal models. Therefore, the development of an in vitro drug evaluation model capable of predicting individual sensitivity to anti-cancer drugs would greatly enhance the success rate of drug treatments for lung cancer patients. The purpose of this research is to utilise conditional reprogramming technology to cultivate patient-derived lung cancer cells and to construct an in vitro 3D culture model using sodium alginate (SA) and gelatin. The aim is to study the biological characteristics of cells in the 3D culture model and to further investigate the sensitivity of anti-cancer drugs based on the alginate-gelatin 3D culture model. This approach provides new means and insights for personalized precision anti-cancer therapy and the development of new anti-cancer drugs. Methods Conditional reprogramming technology was used to generate conditionally reprogrammed lung adenocarcinoma cells (CRLCs). Alginate-gelatin hydrogel micro-beads were created to explore their potential use in the assessment of anti-cancer drugs. Cell proliferation was also examined using the MTS assay method. Live/dead staining was performed to estimate cell distribution and viability using calcein acetoxymethyl ester/propidium iodide (calcein-AM/PI) double staining. Protein expression was assessed by Western blot. Results The cells grown in the three-dimensional (3D) culture were in a state of continuous proliferation, and there was an obvious phenomenon of cell mass growth. The drug sensitivity assay results demonstrated that compared with the 2D-grown cells, the CRLCs grown in the alginate-gelatin hydrogel micro-beads exhibited more resistance to anti-cancer drugs. The results also showed that the 3D-cultured CRLCs showed greater protein expression levels of stem cell hallmarks, such as Nanog Homeobox (NANOG), SRY-Box Transcription Factor 2 (SOX-2), and aldehyde dehydrogenase 1 family member A1 (ALDH1A1), than the 2D-grown cells. Conclusions These findings suggest that the 3D hydrogel cell culture models more closely mimicked the in vivo biological and clinical behavior of cells, and demonstrated higher innate resistance to anti-cancer drugs than the 2D cell culture models, and thus could serve as valuable tools for diagnosis, drug screening, and personalized medicine.
研究领域:
肿瘤学
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药理学
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生物技术
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
Journal of Orthopaedic Surgery and Research
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2022
·Vol. 17
·期 1
·1-10
·
IF 2.677
Bin-bin Zhang,Da-wa Zha Xi,Chao Li,Lan-tao Zhang,Tao Wu,Chuan Lu,Chao-zheng Liu,De-chun Li,Chang Feng,Shu-qing Wei,Zu-nan Dong,Xian-wei Pei,Zhang Zhi-xia,Ke-wen Li
Background Bone marrow mesenchymal stem cells have always been a heated research topic in bone tissue regeneration and repair because of their self-renewal and multi-differentiation potential. A large number of studies have been focused on finding the inducing factors that will promote the osteogenic differentiation of bone marrow mesenchymal stem cells. Previous studies have shown that macrophage exosomes or miRNA-26a-5p can make it work, but the function of this kind of substance on cell osteogenic differentiation has not been public.Methods M2 macrophages are obtained from IL-4 polarized bone marrow-derived macrophages. Exosomes were isolated from the supernatant of M2 macrophages and identified via transmission electron microscopy (TEM), western blotting, and DLS. Chondrogenic differentiation potential was detected by Alcian blue staining. Oil red O staining was used to detect the potential for lipogenic differentiation. And MTT would detect the proliferative capacity of cells. Western blot was performed to detect differential expression of osteogenic differentiation-related proteins.Results The results showed that M2 macrophage exosomes will promote bone differentiation and at the same time inhibit lipid differentiation. In addition, M2 macrophage-derived exosomes have the function of promoting the expression of SOX and Aggrecan suppressing the level of MMP13. The exosome inhibitor GW4689 suppresses miRNA-26a-5p in M2 macrophage exosomes, and the treated exosomes do not play an important role in promoting bone differentiation. Moreover, miRNA-26a-5p can enable to promote bone differentiation and inhibit lipid differentiation. miRNA-26a-5p can promote the expression of ALP (alkaline phosphatase), RUNX-2 (Runt-related transcription factor 2), OPN(osteopontin), and Col-2(collagen type II). Therefore, it is speculated that exosomal miRNA-26a-5p is indispensable in osteogenic differentiation.Conclusion sThe present study indicated that M2 macrophage exosomes carrying miRNA-26a-5p can induce osteogenic differentiation of bone marrow-derived stem cells to inhibit lipogenic differentiation, and miRNA-26a-5p will also promote the expression of osteogenic differentiation-related proteins ALP, RUNX-2, OPN, and Col-2.
研究领域:
干细胞生物学
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骨组织工程
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外泌体研究
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微小RNA功能
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Hui Wang,Zuhao Li,Jiaqi Liu,Haoran Chang,Jincheng Wang,Shanliang Song,Yue Zhao,Xin Zhao
The progression of osteoarthritis (OA) is dramatically accelerated by excessive reactive oxygen species (ROS)-induced apoptosis of chondrocytes and the inflammatory response of synovial macrophages. In this study, we developed an injectable hydrogel with a catalase-mimicking nanozyme activity as a therapeutic agent for OA. In vitro experiments confirmed that the HA and peroxide-mimetic nanoenzyme-enhanced hydrogel, containing ε-polylysine/Mn 1.8 Co 1.2 O 4 (ε-PLE/MnCoO) nanoparticles, continuously eliminated ROS and inflammatory cytokines while promoting the polarization of inflammatory macrophages (M1 phenotype) towards anti-inflammatory macrophages (M2 phenotype) in dysfunctional microenvironments. When used for intraarticular injections in OA models, the nanoenzyme-enhanced hydrogel effectively reduced oxidative stress by scavenging ROS and regulating the immune microenvironment. It resulted in a subsequent reduction in the expression of inflammatory factors, including MMP-13, TNF-α, IL-1β, and iNOS in both the synovium and joint fluid. Moreover, cartilage repair was enhanced by the promotion of COL-2 and SOX-9 expression in the cartilage tissue, whereas osteophyte formation in OA was reduced. This study introduced an innovative treatment strategy for the clinical management of OA, demonstrating its significant potential for application in treating OA.
研究领域:
生物医学工程
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骨科
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纳米技术
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）