COLLOIDS AND SURFACES B-BIOINTERFACES
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2017
·
IF 3.887
Fuqiang Guo,Jiajia Shang,Hai Zhao,Kangrong Lai,Yang Li,Zhongxiong Fan,Zhenqing Hou,Guanghao Su
As one of nanomedicine delivery systems (NDSs), drug nanocrystals exhibited an excellent anticancer effect. Recently, differences of internalization mechanisms and subcellular localization of both drug nanocrystals and small molecular free drug have drawn much attention. In this paper, paclitaxel (PTX) as a model anticancer drug was directly labeled with 4-chloro-7-nitro-1, 2, 3-benzoxadiazole (NBD-Cl) (a drug-fluorophore conjugate Ma et al. (2016) and Wang et al. (2016) [1,2] (PTX-NBD)). PTX-NBD was synthesized by nucleophilic substitution reaction of PTX with NBD-Cl in high yield and characterized by fluorescence, XRD, ESI–MS, and FT-IR analysis. Subsequently, the cube-shaped PTX-NBD nanocrystals were prepared with an antisolvent method followed by surface functionalization of SPC and MPEG-DSPE. The obtained specific shaped [email protected] NCs had a hydrodynamic particle size of ∼50 nm, excellent colloidal stability, and a high drug-loading content of ∼64%. Moreover, in comparison with free PTX-NBD and the sphere-shaped PTX-NBD nanocrystals with surface functionalization of SPC and MPEG-DSPE ( [email protected] NSs), [email protected] NCs remarkably reduced burst release and improved cellular uptake efficiency and in vitro cancer cell killing ability. In a word, the work highlights the potential of theranostic prodrug nanocrystals based on the drug-fluorophore conjugates for cell imaging and chemotherapy.
研究领域:
药学
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纳米技术
·
癌症研究
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Yanan Wei,Bingfeng Wang,Xinfang Cui,Yaseen Muhammad,Yanjuan Zhang,Zuqiang Huang,Xuesheng Li,Zhenxia Zhao,Zhongxing Zhao
MIL(Fe)/Fe-doped nanospongy porous biocarbon (Fe-SPC) composite was fabricated from MIL-100(Fe) via in situ growth on a unique Fe-doped nanospongy porous biocarbon (Fe-SPC) and was used as Fenton-like catalyst for advanced degradation of thiamethoxam (THIA). Fe was loaded on silkworm excrement and calcined to Fe-SPC with nanospongy and high sp2 C structure. The in situ growth strategy embedded the Fe-SPC into MIL-100(Fe) crystals and formed conductive heterojunctions with an intensified interface by Fe-bridging effect, which was confirmed by negative shift of Fe3+ binding energy in X-ray photoelectron spectroscopy. MIL(Fe)/Fe-SPC composites exhibited high degree of crystallinity and surface area (Brunauer–Emmett–Teller: 1730 m2/g). Liquid chromatography–mass spectrometry and density functional theory simulations demonstrated that THIA was converted to a relatively stable compound (C4H5N2SCl), which could be captured by MIL-100(Fe) with strong chemical bonding energy (Fe–N, −587 kJ/mol), followed by a significant geometric distortion, resulting in a thorough degradation. Efficient charge separation and synergistic chemisorption-catalysis strategy resulted in the high catalytic activity of MIL(Fe)/Fe-SPC. The composite catalyst concurrently exhibited high mineralization ratio with 95.4% total organic carbon removal (at 25 °C and 180 min) and good recycling ability under wider neutral/alkaline conditions. Endorsing to these intriguing properties, MIL(Fe)/Fe-SPC can be deemed an efficient contender for removal of hard-degradable pesticides and other environmental pollutants in practical applications.
研究领域:
环境科学
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材料科学
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化学工程
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DOI
PubMed
高影响因子
CHEMOSPHERE
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2022
·
IF 8.943
Haiying Gao,Hui Yu,Jun Yu,Tianhui Xu,Yiming Feng,Yan Wang,Jun Qian,Chaoqun Tan
An origin Fenton-like system was discussed for the abatement of refractory contaminants. Sodium percarbonate (SPC) was utilized as the source of H 2 O 2 and crystal boron ( C -boron) was applied to enhance the activation of H 2 O 2 . Under the conditions of 0.50 mM Fe 3+ , 0.34 mM SPC, and heterogeneous catalysis using 100 mg L −1 C -boron, four target pollutants, at the initial concentrations of 20 μM, could be efficiently degraded by the Fenton-like system, with a degradation rate within 20 min up to 81.1% (aspirin, ASA), 92.8% (nitrobenzene, NB), 94.7% (flunixin meglumine, FMME), and 94.3% (benzoic acid, BA) respectively and total organic carbon removal up to 25.0%. The increase of Fe 2+ concentration indicated that the conversion of Fe 2+ /Fe 3+ was remarkably promoted by C -boron. Degradation reactions at acidic pH were comparatively fast, with pH-dependent k obs of 9.9 × 10 −2 min −1 (ASA), 1.5 × 10 −1 min −1 (NB), 1.7 × 10 −1 min −1 (FMME), and 1.9 × 10 −1 min −1 (BA), whereas those at neutral and alkaline pH were slower. Furthermore, reactive oxygen species including · OH, 1 O 2 , and O 2 · − were identified by in-situ electron paramagnetic resonance tests. The contribution ratios of · OH turned out to be about 71.3–86.7% for the decomposition of four contaminants. The elimination of natural organic matter and the performance of material recycling highlighted the potential for its application in water treatment . The inhibition rate of Chlorella pyrenoidosa reached 211.9% in the C -boron/Fe 3+ /SPC system. The relatively high algae toxicity limited its application scope, which requires additional research to resolve.
研究领域:
环境科学
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水处理
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化学工程
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污染物降解
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DOI
PubMed
高影响因子
Materials Express
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2023
·Vol. 13
·期 8
·1339-1345
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IF 0.7
Liao Wanrong,Fang Wang,Xu Juan
Lung cancer is a common malignancy of the respiratory system with a high morbidity and mortality. We intended to identify the apoptosis-promoting role of tripterine in lung cancer. Lung cancer SPC-A-1 cells were exposed to low, moderate, and high dosage of tripterine (2, 5 and 10 μmol/L)
with the model group not being intervened. After treatment, the role of tripterine in SPC-A-1 cell apoptosis was observed. In addition, lung cancer cells were transfected with TNF-α mimic (pc-TNF-α group) and TNF-α inhibitor (si-TNF-α group).
Tripterine +pc-TNF-α group was set up to determine the interaction between tripterine and TNF-α. The cell survival rate, TNF-α and Caspase-3 expression levels then were detected by MTT and flow cytometry. Tripteryglide treatment dose-dependently decreased
lung cancer cell viability and induced cell apoptosis, resulting in an increase of TNF-α expression. However, when TNF-α expression was inhibited upon transfection, SPC-A-1 cell apoptosis was suppressed. TNF-α mimics activated apoptosis and up-regulated
Caspase-3 expression. Combination of tripteryglide and TNF-α mimics more significantly elevated apoptotic rate of lung cancer cells when elevating the content of Caspase-3. SPC-A-1 cells are highly sensitive to TNF-α and TNF-α significantly increases
the activity and expression of Caspase-3. Tripteryglide can up-regulate TNF-α expression to facilitate lung cancer cell apoptosis and increase Caspase-3 expression.
研究领域:
肿瘤学
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药理学
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细胞生物学
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DOI
高影响因子
CHEMOSPHERE
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2018
·
IF 4.427
Chaoqun Tan,Qinglong Xu,Haochen Zhang,Zheming Liu,Shuxin Ren,He Li
A high-efficient, eco-friendly and applicable oxidant of percarbonate (SPC, Na 2 CO 3 ·1.5H 2 O 2 ) is applied as oxidant in ozonation (O 3 ) process. In this work, coumarin (COU) decomposition by O 3 and O 3 /SPC was proposed in terms of diverse parameters, including ozone concentration, SPC dosage and pH, with regard to the pseudo-first-order kinetic model. About 96.5% of 25 mg L −1 COU was removed by 209.3 mg L −1 SPC and 2.08 mg L −1 O 3 within 30 min, whereas 49.8% of COU was exhausted in O 3 system alone. High ozone concentration and pH could enhance COU removal, and overdose SPC has an inhibition effect as CO 3 2− could react with ·OH. Furtherly, the generation of hydroxyl radicals ( OH) via a chain reaction in O 3 was ascertained based on indirect alcohols quenching tests and direct electron spin resonance (ESR) spin-trapping tests, though high initial SPC concentration led to no trapping of OH by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) in O 3 /SPC. According to the concentration of dissolved ozone and prior study, a fast reaction kinetic model was estimated firstly for O 3 /SPC system and well fitted with different condition. The hydroxylated intermediates of 7-hydroxylcoumarin and 6,7-hydroxylcoumarin were recognized and the degradation pathways were proposed. The findings of the study can broaden the research direction of SPC and provide a new application information for SPC in environmental pollution control .
研究领域:
环境科学
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化学工程
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DOI
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
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2019
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IF 3.197
Xiuxia Wang,Liping Huang,Yiwei Zhang,Fanling Meng,Maria Donoso,Roy Haskell,Liang Luo
The binary-lipid system of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) can hydrate to gels on contacting with aqueous mediums, which has emerged as a versatile and promising delivery matrix for extended drug release applications. In the present work, we have characterized the gelation process of this SPC/GDO lyotropic gel (SGLG) system by rheology and evaluated the drug release profiles from the SGLG formulations with different SPC/GDO mass ratios. Our study has demonstrated that simply adjusting the SPC/GDO mass ratio can tune the lipid gelation behavior and modulate the drug release profiles. More importantly, the drug release from the SGLG formulations follows a two-compartment (fast and slow release compartments) release kinetics that has not been reported before. We posit that the fast release compartment corresponds to the passive diffusion of the drug during the early stage of the gel formation. After the boundary gel phase generation, the drug release is then dominated by the slow diffusion process from SGLG. The pharmacokinetic studies in rats match well with the in vitro studies, suggesting that the binary-lipid formulation is an excellent candidate for on-demand sustained drug delivery system.
研究领域:
药剂学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Liangyu Zhao,Yang-Guo Zhao,Chunji Jin,Dexiang Yang,Yanan Zhang,Mupindu Progress
Tetracycline (TC) was widely used and frequently detected in various water bodies, where the presence of TC posed a significant threat to the health of aquatic organisms. Furthermore, antibiotics were hardly degraded by biological treatment. Thus, in order to enhance the removal of TC, we proposed the use of a novel ultraviolet/sodium percarbonate (UV/SPC) advanced oxidation process and initiated an in-depth study. The study investigated the influence of oxidant dosage, initial pH, UV intensity, and TC concentration on the removal of TC. The results demonstrated that the UV/SPC system efficiently removed TC, with removal efficiency increasing as the SPC concentration increased. Within the pH range of 3–11, TC degradation exhibited minimal variation, indicating the UV/SPC system's strong adaptability to pH variations. The research on the impact of the water matrix on TC removal revealed that HCO 3 − had an inhibitory effect on TC degradation, while NO 3 − promoted TC degradation. Additionally, the presence of free radical species (·OH, ·CO 3 − , ·O 2 − ) were detected and rate constants for the secondary reactions ( k ·OH,TC = 6.3 × 10 9 L mol −1 ·s −1 , k ·CO3-,TC = 3.4 × 10 8 L mol −1 ·s −1 ) were calculated, indicating that ·OH exhibited a stronger oxidative performance compared to ·CO 3 − . This study did not only present a novel strategy via UV/SPC to remove TC but also uncovered the unique role of ·CO 3 − for contaminant removal.
研究领域:
环境科学
·
水处理工程
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 16
·15733-15742
·
IF 2.8
Fu Xiaori,Dionysiou Dionysios D.,Brusseau Mark L.,Zaman Waqas Qamar,Zang Xueke,Lu Shuguang,Qiu Zhaofu,Sui Qian
This study presents a performance comparison of Fe(II)-catalyzed sodium percarbonate (SPC), Fe(II)-EDDS-catalyzed SPC, and of the innovative hydroxylamine hydrochloride (HA)-Fe(II)-EDDS-catalyzed SPC for the degradation of trichloroethylene (TCE) in water. TCE degradation was greater in the Fe(II)-EDDS-catalyzed SPC system compared to the Fe(II)-catalyzed SPC system, indicating the effectiveness of adding EDDS as an enhancement factor for the removal of TCE. Moreover, TCE degradation was faster in the HA-Fe(II)-EDDS-catalyzed SPC system compared to the Fe(II)-EDDS-catalyzed SPC system, illustrating that HA can play a synergistic role in TCE degradation. Analysis of iron distribution in the three systems demonstrated that EDDS addition maintained iron in soluble form, and that the generation of soluble ferrous from ferric iron was expedited with addition of HA. Studies using nitrobenzene and carbon tetrachloride probes provided insights on the generation of hydroxyl radical (HO • ) and superoxide anion radical (O 2 •− ) in the three systems. A gradual increasing contribution of O 2 •− to TCE removal in Fe(II)-catalyzed SPC, Fe(II)-EDDS-catalyzed SPC, and HA-Fe(II)-EDDS-catalyzed SPC systems was verified through free-radical scavenger tests. Finally, monitoring of Cl − concentrations manifested the complete dechlorination of TCE. A possible mechanism of TCE degradation involving two pathways of HO • oxidation and O 2 •− reaction was proposed.
研究领域:
环境科学
·
化学工程
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DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
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2019
·
IF 2.29
Kai Kang,Xiaodong Liang,Georgios M. Kontogeorgis,Xiaopo Wang
In this work, the experimental measurements for liquid densities of n -decane and m -xylene binary mixtures were performed over the entire composition range with a high-pressure vibrating-tube densimeter. The range of temperatures for the present measurements was from 293.15 K to 363.15 K and the pressures were up to 60 MPa. The combined expanded uncertainty of the density measurements is estimated to be 0.001 ρ with 0.95 confidence. Experimental density values were correlated by the modified Tammann-Tait equation. The simplified Perturbed Associating Fluid Theory (sPC-SAFT) and Cubic Plus Associated (CPA) equations of state (EoS) were applied to predict the densities of n -decane and m -xylene and their mixtures. Reasonably results were observed between the experimental data and calculated results for the two equations, and the deviation is less than 0.48% and 0.89% with sPC-SAFT and CPA EoS, respectively. In addition, excess molar volumes were determined from the experimental density data as well as from sPC-SAFT and CPA models. The effects of pressure and temperature on the excess molar volume were also discussed.
研究领域:
化学工程
·
热力学
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流体相行为
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高压物理化学
·
状态方程建模
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2025
·
IF 0
Wu Guizhi,Duan Xuebin,Xu Hongqing,Han Chunyu,Liu Jing,Yan Boyin,Li Jincheng,Wang Jianming,Wang Songxue
The UV/SPC process was employed for the removal of rhodamine B (RhB), and the influences of reaction parameters and natural water components on the degradation of RhB were systematically studied. The results demonstrate that RhB can be efficiently eliminated in the UV/SPC system compared to using UV photolysis or SPC oxidation alone, with •OH and CO 3 •− being the main radicals to degrade RhB. The degradation efficiency of RhB was enhanced with increasing SPC concentration but decreased with increasing initial RhB concentration. Moreover, the degradation efficiency of RhB decreased with the increasing initial pH. When pH increased from 3 to 11, the degradation efficiency of RhB declined from nearly 100 to 81.93% within 20 min. Natural organic matter (NOM) and anions (Cl − and HCO 3 − ) exhibited an inhibitory effect on the degradation of RhB in the UV/SPC system, and the inhibitory effect was aggravated with the increase of NOM and anion concentrations. Consequently, there was a decrease in the degradation efficiency of RhB in the UV/SPC system in real water compared to pure water. The byproducts generated during the degradation of RhB were attributed to hydroxylation, N -deethylation, and C-O bond cleavage. Some intermediate products from RhB degradation still pose relatively high environmental risks, while most have low environmental hazards.
研究领域:
环境科学
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化学工程
·
水处理技术
·
高级氧化技术
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产品关联
DOI
PubMed
WATER RESEARCH
·
2021
·
IF 11.236
Xiaoxiang Cheng,Jinchuan Lian,Zixiao Ren,Chengsi Hou,Yan Jin,Lijie Zhang,Xuewu Zhu,Congwei Luo,Daoji Wu,Heng Liang
To alleviate algal fouling in membrane water treatment processes, conventional technologies such as coagulation with poly aluminum chloride (PACl) has been widely adopted by many drinking water treatment plants. However, coagulation alone exhibited relatively weak removal effect for algal pollutants, and the coagulant residues due to the excess dosage also raised concerns. Thus, a novel process of coupling sodium percarbonate (SPC) oxidation and PACl coagulation was proposed, integrated with membrane filtration for algae-laden water treatment. The dosages of PACl and SPC were optimized, and the SPC dosing strategies were systematically compared. The changes in the characteristics of algal pollutants were investigated, and the results revealed that the resistance of algal foulants to aggregation was decreased, and the particle size of algal foulants became larger. With the synergism of coagulation and oxidation, the degradation of fluorescent organics was strengthened, and macromolecular biopolymers were decomposed into low molecular weight organics. The fouling control efficiency was further explored, and the results indicated that both irreversible and reversible fouling were effectively controlled, among which PACl/SPC (simultaneous treatment) performed best with the irreversible fouling reduced by 90.5%, while the efficiency of SPC-PACl (SPC followed by PACl) was relatively lower (57.3%). The fouling mechanism was altered by slowing the formation of cake filtration, and the reduction of algal cells played a more important role for the fouling alleviation. The interface properties of contaminated membranes ( i.e. , functional groups, images, and micromorphology) were characterized, and the efficiency of the proposed strategy was further verified. The proposed strategy exhibits great application values for improving membrane performance during algae-laden water treatment.
研究领域:
环境科学
·
水处理工程
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产品关联
DOI
PubMed
高影响因子
Water
·
2023
·Vol. 15
·期 21
·3838
·
IF 3.4
Siru Zhou,Chuanhan Chen,Ruohong Li
Sludge conditioning is a crucial step in sludge dewatering aimed at minimizing excessive sludge production. The Fenton process, which harnesses oxidative radicals to dismantle extracellular polymeric substances (EPS) and microorganisms, has been unequivocally proven to enhance sludge dewaterability. However, the widespread adoption of the Fenton process is hampered by its high costs and logistical challenges in transportation. In contrast, the Fe(II)-activated sodium percarbonate (Fe(II)/SPC) process has emerged as a promising technology for sludge conditioning due to its remarkable performance and safe operation. However, limited information is available regarding the optimization of Fe(II)/SPC for sludge conditioning and dewatering at full scale. This study conducted the sludge conditioning and dewatering process within a full-scale wastewater treatment plant, utilizing the response surface methodology (RSM) to optimize the Fe(II)/SPC process. Furthermore, this study investigated its impact on sludge structure and compared the economic benefits of the Fe(II)/SPC process with other full-scale conditioning processes. The results of bound water and LDH analysis revealed that the Fe(II)/SPC process not only degraded EPS but also disrupted microbial cells, thereby releasing intracellular water. Based on the RSM results, we successfully established a polynomial prediction model to determine the optimal capillary suction time (CST) and moisture content. The optimal parameters determined through RSM were an initial pH of 3.02, Fe(II) dosage of 0.05 g/g TSS, and SPC dosage of 0.07 g/g TSS. The validation test confirmed the accuracy of the prediction results, with the conditioned sludge exhibiting a CST of 31.6 s and a moisture content of 51.47%. Furthermore, when compared to the PFS and Fenton processes, the Fe(II)/SPC process demonstrated higher economic efficiency and safety, while maintaining good dewatering performance. Overall, the Fe(II)/SPC treatment shows promise as a prospective sludge dewatering and conditioning process.Keywords:sludge conditioning;sodium percarbonate;advanced oxidation process;sludge dewaterability
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高影响因子
危险品化学品经营许可证（带存储）