Oxidative Medicine and Cellular Longevity
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2022
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IF 7.31
Lidan Xiong,Hailun He,Jie Tang,Qi Yang,Li Li
The vermilion of the human lip, covered by a skinny epithelium with little melanin, is quite susceptible to damage from ultraviolet (UV) radiation exposure. However, commercial sunscreen filters and indelible dyes used in lipsticks can cause health hazards after percutaneous absorption or accidentally oral administration. Inspired by plant pigmentation as natural filters to protect themselves against overexposure to UV, safer bio-based sunscreens of cellulose enveloped with anthocyanin (AN) were developed using bionic design. Cellulose nanocrystals (CNC), derived from acid hydrolysis of cellulose, reinforced enhancement of UV absorption and shielding properties of AN. This innovation addresses the issue that naturally sourced UV filter application to sunscreen does not achieve a desired sun protection factor (SPF) value because of the low specific extinction value (E1,1). We also stated that the diverse formula of anthocyanin sunscreen lipsticks with CNC exhibited 10 times more SPF value than AN alone. Furthermore, they possess competitive benefits such as pleasing texture, superior adhesion, impermeable, nonphototoxicity, ease of application, and removal. This work provides a promising proof-of-concept for studying the features of natural sunscreens in the design of simple, safe, efficient, and green sunscreens.
研究领域:
材料科学
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化妆品科学
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生物技术
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纳米技术
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药学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Zheng Zhang,Yang Wang,Ting Li,Junjie Wu,Jing Huang,Jie Jiang,Mingqing Chen,Weifu Dong
Sun protection has gradually become an indispensable living habit of human beings, and sunscreens are needed under various circumstances. Considering the disadvantages and abuse of traditional sunscreen additives which are proved to have some potential threats to human body and natural environment, it is an urgent need to develop new sunscreens with both safety and high efficiency for the evolution of the industry. Therefore, as a complement to the shortcomings, polydopamine (PDA) was hybridized with zinc oxide (ZnO) by a simple sol-gel method. The obtained novel sunscreen agent had high ultraviolet (UV) resistance efficiency, as the SPF (∼77.2) and PA (PA+++) value at only 10 wt% addition could meet the daily sunscreen requirements. Besides, the permeation of ZnO and Zn 2+ could be almost completely avoided through the epidermis layer of skin, due to the increase of mussel-inspired adhesive force. Furthermore, the free radical scavenging rate could reach 88.1% at low concentration, and it was proved to have no cytotoxicity. Overall, the ZnO-PDA has a good application prospect in high-efficiency and safe sunscreen, and it can be an impetus for the development of novel cosmetics.
研究领域:
材料科学
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化妆品科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
BIORESOURCE TECHNOLOGY
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2023
·
IF 11.4
Ying Xu,Cheng-Ye Ma,Shao-Chao Sun,Chen Zhang,Jia-Long Wen,Tong-Qi Yuan
In this study, light-colored lignin was extracted from bamboo shoot shells (BSS) using a hydrated deep eutectic solvent (DES) pretreatment. The hydrated DES used in pretreatment consist of formic acid, benzyl triethylammonium chloride (BTEAC) and water. The pretreatment using a hydrated DES containing 30% water (H30) demonstrate efficient delignification (82.9%). Additionally, the hydrated DES protected the β- O -4 linkage from excessive cleavage and recondensation as well as keep the light-colored of lignin. Moreover, the hydrated DES extracted lignin exhibits superior antioxidant performance and tyrosinase inhibitory capacity compared to the control. Notably, incorporating 5% lignin of H30-extracted lignin into a commercial suncream led to a remarkable enhancement of the SPF value, elevating from 14.8 to 32.6. In summary, the proposed hydrated DES pretreatment method offers significant benefits for extracting light-colored lignin, thereby promoting the multifunctional application of lignin in cosmetics.
研究领域:
化学工程
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材料科学
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化妆品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2024
·
IF 2.7
Shide Li,Hongsheng Luo,Ronghua Qiu,Kaibin Huang,Ziying Chen,Xiangjun Fu
In order to improve the aqueous solubility and enhance stability of resveratrol (RES), an inclusion complex (RES-ECH-βCD) of RES with epichlorohydrin-modified β-cyclodextrin (ECH-βCD) was prepared using freeze-drying. The effects of RES-ECH-βCD on the solubility and stability of RES were investigated. Phase solubility studies indicated that ECH-βCD significantly enhanced the solubility of RES compared to β-cyclodextrin (β-CD). Thermal stability tests showed that the inclusion complex exhibited superior thermal stability compared to free RES. Furthermore, the application of RES-ECH-βCD in sunscreen formulations was validated. The formulation exhibited sun protection properties, with RES-ECH-βCD working synergistically with α-glucosyl rutin (Rutin-G) to significantly enhance both SPF and PFA. These findings suggest that RES-ECH-βCD not only improves the solubility and stability of RES but also has promising potential for use in cosmetic and sunscreen products.
研究领域:
药学
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化妆品化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
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IF 7.328
Nini Li,Xiaohong Ji,Bulei Wang,Yanglin Guo,Changhao Wang,Yashao Chen
Living organisms tend to evolve various naturally photoprotective mechanisms to avoid photodamage. Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin. However, the concerns of its dark color, skin penetration and photoprotective efficiency remain yet to be solved. Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDA h -GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDA h NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β -glycerophosphate ( β -GP) as a modulator. The CS-PDA h -GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β -GP content in the hydrogels. The CS-PDA h -GP-HA hydrogels also possess excellent resistance toward skin penetration. The photoprotective performances of CS-PDA h -GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV–Vis spectroscopy. Compared with the TiO 2 nanoparticles in CS-GP-HA hydrogel, the CS-PDA h -GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions. When protected by the CS-PDA h -GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group. These results suggest that the CS-PDA h -GP-HA hydrogels could efficiently shield the UV irradiation and protect the skin from photodamage. This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
研究领域:
材料科学
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生物医学工程
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纳米技术
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光生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POULTRY SCIENCE
·
2023
·
IF 4.4
Lili Zhang,Yutong Hou,Zhanbang Ma,Jinjin Xie,Jiahui Fan,Yaru Jiao,Fangfang Wang,Zongxi Han,Shengwang Liu,Deying Ma
ABSTRACT Vitamin A is a fat-soluble vitamin that is a crucial mediator of the immune system. In this study, we evaluated the effect of oral vitamin A supplementation on host immune responses to infectious bronchitis virus ( IBV ) infection in chickens. Forty 1-day-old specific pathogen-free ( SPF ) chickens were fed a basal diet and randomly divided into 2 groups ( n = 20 birds per group). Chickens in the experimental group were treated orally with vitamin A (dissolved in 0.1 mL soybean oil, at a dose of 8,000 IU per kg diet) daily. Birds in the control group were orally administered 0.1 mL soybean oil without vitamin A until 21 d of age. On d 21 after birth, all chickens were infected with 0.1 mL of 10 6.5 50% median embryo infectious dose of a pathogenic IBV strain (CK/CH/LDL/091022) by intraocular and intranasal routes. The results demonstrated that oral vitamin A supplementation did not affect the clinical course of disease and growth performance of SPF chickens. However, vitamin A supplementation increased the IBV-specific IgG serum levels and decreased the viral load in some tissues of IBV-infected chickens. In addition, the results demonstrated that vitamin A supplementation decreased the expression levels of most immune-related molecules in some tissues of IBV-infected chickens. Vitamin A supplementation decreased the mRNA expression levels of some avian β-defensins ( AvBD2, 3, 6, 7, 11 , and 13 ) and increased the expression levels of AvBD9 and AvBD12 in some tissues of IBV-infected chickens. Similarly, vitamin A supplementation decreased the mRNA expression levels of some cytokines (interferon-γ, interleukin-1β [ IL-1β ], and IL-6 ) and increased the mRNA expression levels of IL-2 in some tissues of IBV-infected chickens. Furthermore, vitamin A supplementation decreased the mRNA expression levels of myeloid differentiation primary response protein 88, nuclear factor-κB p65, toll-like receptor 3, toll-like receptor 7 , and CD4. In summary, the present study suggests that vitamin A supplementation enhances the immune function of SPF chickens against IBV infection by inhibiting viral replication, increasing the IBV-specific antibody titer, and suppressing the excessive inflammatory responses to IBV infection.
研究领域:
免疫学
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兽医学
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微生物学
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家禽科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Yue Cai,Yangyang Zhu,Haoguan Gui,Jiabao Fan,Junjie Nian,Cun Zhu,Yoojung Song,Sungbong Kye,Xiubo Zhao,Chao Yao
A high-energy ball milling strategy was developed to optimize nano titanium dioxide (nano-TiO2) through sodium lignosulfonate (SL)-mediated electrostatic surface modification. At 20 wt % nano-TiO2 and 5 wt % SL, the colloidal system achieved optimal stability with a sun protection factor (SPF) elevation from 15 to 17. Subsequent emulsion formulation with various aqueous phase to oil phase mass ratios (κ) yielded a Pickering emulsion at different pH values, demonstrating exceptional interfacial stabilization via nano-TiO2 and SL electrostatic assembly. The optimized TSL-4 emulsion (κ = 1:1, pH = 4) exhibited remarkable storage stability (keeping over 25 SPF value after 6 weeks of accelerated test) and thermal resilience (maintaining above 91% SPF retention through 10 freeze–thaw cycles.). Biological evaluations of TSL-4 (κ = 1:1) emulsion demonstrated no phototoxicity (irradiated vs nonirradiated viability difference < 2%), low cytotoxicity (90% HaCaT cell viability), and minimal cutaneous permeation (no nanoparticle accumulation in subcutaneous layers). The biomass-compound-modified nano-TiO2 system establishes a multifunctional sunscreen platform that synergistically integrates UV attenuation, colloidal stability, and biosafety.
研究领域:
纳米技术
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胶体科学
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化妆品科学
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材料工程
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）