CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Yee-Shin Chang,Cheng-Xin You,Tai-Chen Kuo
In this study, SrY₂O₄:Dy³⁺ phosphors were synthesized using the solid-state reaction method and evaluated after heat treatment at 1300 °C for 5 h. XRD analysis confirmed the orthorhombic structure of SrY₂O₄ with residual Y₂O₃ present. The addition of Dy³⁺ ions caused lattice expansion, impacting grain size and crystallinity. SEM images showed that the phosphor particles had irregular shapes with minimal size variation, although they tended to agglomerate due to high-temperature heat treatment. Optical analysis revealed significant absorption and emission peaks, with a strong excitation band in the 200–306 nm range and prominent sharp peaks in the 306–480 nm range, particularly at a 0.5 mol% doping concentration. Emission spectra indicated the highest intensity at 0.5 mol% Dy³⁺ concentration, with intensity decreasing due to concentration quenching at higher levels. Thermal stability tests showed peak emission intensity at 70 °C, with stability maintained up to 190 °C before notable thermal quenching. Chromaticity coordinates remained within the warm white region at both temperatures. This study provides detailed insights into the effects of Dy³⁺ doping on the structural, optical, and thermal properties of SrY₂O₄ phosphors. Compared to previous studies on rare-earth-doped SrY₂O₄ phosphors, this work is the first to systematically explore the substitution of Y³⁺ ions with Dy³⁺ ions until full replacement. The study not only confirmed that the highest emission intensity occurs at 0.5 mol% Dy³⁺ concentration, but also demonstrated that Dy³⁺-doped SrY₂O₄ phosphors exhibit excellent thermal stability, with emission stability maintained below 150 °C. These findings expand the potential applications of Dy³⁺-doped SrY₂O₄ phosphors, particularly in high-temperature environments and solid-state lighting.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF CELLULAR PHYSIOLOGY
·
2018
·Vol. 234
·期 7
·11440-11450
·
IF 3.923
Zheng-Yu Liu,Hong-Wei Pan,Yan Cao,Jiao Zheng,Yu Zhang,Yi Tang,Jin He,Yong-Jun Hu,Chang-Lu Wang,Qiong-Chao Zou,Qing-Hua Fu,Le Zhang,Jian-Qiang Peng,Jing Ling,Ning Peng,Jing-Jing Rong,Zhao-Fen Zheng
microRNAs (miRs) are essential in the development of heart failure. The aim of this study is to investigate the effect of microRNA-330 (miR-330) on left ventricular remodeling via the TGF-β1/Smad3 signaling pathway by targeting the sex-determining region Y (SRY) in mice with myocardial ischemia–reperfusion injury (MIRI). Differentially expressed gene (DEG) in myocardial ischemia–reperfusion (IR) was screened out and the miR that targeted the DEG was also predicted and verified. A model of MIRI was established to detect the expression of miR-330, SRY, transforming growth factor-β (TGF-β1), and Sekelsky mothers against dpp3 (Smad3). To further investigate the role of miR-330 in MIRI with the involvement of SRY and TGF-β1/Smad3 signaling pathway, the modeled mice were treated with different mimic, inhibitor, or small interfering RNA (siRNA) to observe the changes of the related gene expression, as well as the myocardial infarction size and volume of myocardial collagen. SRY was screened out and verified as a target gene of miR-330. The MIRI mice showed enlarged myocardial infarction size, increased volume of myocardial collagen, increased expression of miR-330, TGF-β1 and Smad3, while decreased the expression of SRY. The MIRI mice treated with miR-330 inhibitor showed decreased myocardial infarction size, the volume of myocardial collagen, and expression of TGF-β1 and Smad3 but promoted expression of SRY. Our findings demonstrated that downregulated miR-330 could suppress left ventricular remodeling to inhibit the activation of the TGF-β1/Smad3 signaling pathway via negatively targeting of SRY in mice with MIRI. This can be a potential target in the strategy to attenuate patient suffering.
研究领域:
心脏病学
·
分子生物学
·
遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
·
2021
·
IF 4.294
Shuwen Tan,Yi Zhou,Haiquan Zhao,Jinhua Wu,Hui Yu,Yin Yang,Yalan Yang,Huabin Zhao,Hua Li
XX sex reversal, also called XX disorders of sex development (XX-DSD), is a condition affecting the development of the gonads or genitalia, and is relatively common in pigs. However, its genetic etiology and transcriptional regulation mechanism in the hypothalamic-pituitary-gonadal axis (HPGA) remain mostly unknown. XX-DSD ( SRY -negative) pigs and normal sows were selected by external genitalia observation. The hypothalamus, which is the integrated center of the HPGA was sampled for whole-transcriptome RNA-seq. The role of DEmiRNA was validated by its overexpression and knockdown in vitro. A total of 1,258 lncRNAs, 1,086 mRNAs, and 61 microRNAs differentially expressed in XX-DSD pigs compared with normal female pigs. Genes in the hormone biosynthesis and secretion pathway significantly up-regulated, and the up-regulation of GNRH1 , KISS1 and AVP may associate with the abnormal secretion of GnRH. We also predicted the lncRNA-miRNA-mRNA co-expression triplets and constructed three competing endogenous RNA (ceRNA) potentially associated with XX-DSD. Functional enrichment studies suggested that TCONS_00340886 , TCONS_00000204 and miR-181a related to GnRH secretion. Further, miR-181a inhibitor up-regulated GNRH1 , PAK6 , and CAMK4 in the GT1-7 cells. Conversely, transfection of miR-181a mimics obtained the opposite trends. The expression levels of FSHR , LHR , ESR1 and ESR2 were significantly higher in XX-DSD gondas than those in normal sows. Taken together, we proposed that the balance of endocrine had broken in XX-DSD pigs. The current study is the first to examine the transcriptomic profile in the hypothalamus of XX-DSD pigs. It provides new insight into coding and non-coding RNAs that may be associated with DSD in pigs.
研究领域:
遗传学
·
分子生物学
·
动物科学
·
内分泌学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Dongliang Liu,Wanqing Chen,Chuan Zhou,Meijuan Fei,Fengli Liang,Yuxing Gu,Meigui Xu,Ran Ran,Wei Zhou
For solid oxide fuel cells, it is an effective strategy to enhance the oxygen reduction reaction activity of cathode through introducing active nanoparticles on electrode surface. In this study, we developed a novel cathode SrY 0.05 W 0.05 Co 0.9 O 3-δ and optimizing strategy of CO 2 -induced surface in-situ reconfiguration. The nanoscale SrCO 3 particles and the oxide nanoparticles could be produced after the treating atmosphere was switched from CO 2 to air. Both SrCO 3 nanoparticles and nano-oxides are beneficial to the oxygen reduction reaction kinetics of surface process and the area specific resistance of symmetric cell with SrY 0.05 W 0.05 Co 0.9 O 3-δ electrode decreased from 0.085 to 0.054 Ω cm 2 at 600 ℃. Although the nano-sized SrCO 3 was degraded in air over time, the oxide nanoparticles held a stable state for a long time and the resistance finally stabilized at ∼0.068 Ω cm 2 . However, for classic cathode Ba 0.5 Sr 0.5 Co 0.8 Fe 0.2 O 3−δ , it possesses a strong interaction with CO 2 so that the produced large-sized BaCO 3 failed to transform into nanoparticles and totally decompose. Therefore, designing the suitable cathode and tailoring the interaction between CO 2 and electrode materials are significant to realize the CO 2 -induced surface in-situ reconfiguration.
研究领域:
材料科学
·
电化学
·
能源材料
·
催化
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）