Materials
·
2015
·Vol. 8
·期 7
·4249-4257
·
IF 2.651
Cheng Song,Ruofan Du,Yongmei Zheng
Inspired by the high adhesiveness of the electrospun fiber, we propose a method to fabricate multi-scale heterogeneous hump-on-string fiber via the adsorption of nanoparticles, the NPCTi which is the hydrolysate of titanium tetrachloride (TiCl4) and the nanoparticles containing Al (NPCAl) which is produced by the hydrolysis of Trimethylaluminium (TMA, Al(CH3)3). The water collection efficiency of the fibers can be easily controlled via changing not only the size of the beads but also the ratio of the Ti and Al. In addition, we introduce a computational fluid dynamics (CFD) simulation to show the pressure distribution of on the surface of the fibers, which gives another explanation regarding the high water collection efficiency.Keywords:wet-induced assembly;heterogeneous;hump-on-string fiber
研究领域:
材料科学
·
仿生学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PNAS Nexus
·
2024
·Vol. 3
·期 12
·
IF 2.2
Ma Zhongjie,Jiang Miao,Song Yaohao,Sun Aile,Yi Shengzhu,Zhou Chao,Huang Xiang,Huang Mingjun,Aya Satoshi,Wei Qi-Huo
Ferroelectric nematic (NF) liquid crystals present a compelling platform for exploring topological defects in polar fields, while their structural properties can be significantly altered by ionic doping. In this study, we demonstrate that doping the ferroelectric nematic material RM734 with cationic polymers enables the formation of polymeric micelles that connect pairs of half-integer topological defects. Polarizing optical microscopy reveals that these string defects exhibit butterfly textures, featured with a 2D polarization field divided by Néel-type kink walls into domains exhibiting either uniform polarization or negative splay and bend deformations. Through analysis of electrophoretic motion and direct measurements of polarization divergences, we show that the string micelles are positively charged, and their side regions exhibit positive bound charges. To elucidate these observations, we propose a charge double-layer model for the string defects: the positively charged cationic polymer chains and densely packed RM734 molecules form a Stern charge layer, while small anionic ions and positive bound charges constitute the charge diffusion layer. Notably, our experiments indicate that only cationic polymer doping effectively induces the formation of these unique string defects. These findings enhance our understanding of ionic doping effects and provide valuable insights for engineering polar topologies in liquid crystal systems.
研究领域:
材料科学
·
物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Chenjing Gao,Hongrui Wang,Zaixin Hu,Mingxing Wu
In this study, a novel carbon bead string (CBS) is synthesized through a simple method, which is subsequently introduced into the dye-sensitized solar cells (DSCs) as a cathode catalyst. The resultant CBS cathode displays decent electro-catalytic activities for the traditional iodide redox couple (I 3 − /I − ). More importantly, CBS cathode presents distinct superiorities when applied in an organic sulfide redox couple (T 2 /T − ). T 2 /T − electrolyte-based DSCs with CBS cathode has resulted in a high power conversion efficiency (PCE) of 5.83%, which is much higher than that of Pt cathode-based counterpart (3.71%), demonstrating 57.1% of PCE improvement.
研究领域:
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 11
·2727-2735
·
IF 6.331
Qiu Huang,Fukun He,Jiafei Yu,Jing Zhang,Xiangyun Du,Qing Li,Gefei Wang,Ziyi Yu,Su Chen
The preparation of dual-release pharmaceutical microfibers provides an ideal material for new biomedical applications. We describe a microfluidic spinning method for engineering heterotypic bead-on-string fibers with the ability to carry dual cargos and to deliver on demand. The core of our technology is to combine microfluidic spinning with biomaterial preparation, in which hydrophobic and hydrophilic cargos can be integrated into a bead-on-string microfiber structure. We demonstrate the loading of bovine serum albumin (BSA) in the sodium alginate phase and ibuprofen in the polylactic acid (PLA) phase, respectively. The heterotypic bead-on-string fibers are biocompatible and show hemostatic ability in vivo. These heterotypic bead-on-string fibers are then woven as a skin scaffold and shown to promote wound healing by loading antibacterial and anti-inflammatory cargos.
研究领域:
生物医学工程
·
药学
·
组织工程
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Xin Lu,Yingdong Chen,Wentao Yan,Kaizhen Wang,Yong Zhou,CongJie Gao
Polytetrafluoroethylene (PTFE) membranes with three-dimensional interconnected porous networks are usually used as air filters. However, they are easily contaminated by oily aerosols in air filtration, resulting in a decrease in filtration efficiency. Herein, a strategy for the preparation of amphiphobic PTFE membranes with a ring-on-string-like micro/nano structure for air purification was proposed. First, the PTFE fibers were locked by OTS polysiloxane rings to form an OTS layer with ring-on-string-like structure by spraying octadecyltrichlorosilane (OTS) solution on the membrane surface. Subsequently, fluorinated silica (F–SiO 2 ) nanoparticles were sprayed to build the micro/nano structure and the surface with low surface energy. The prepared amphiphobic membrane had high liquid repellency to water (～153°), diiodomethane (～136°) and hexadecane (～124°). Moreover, the membrane amphiphobicity exhibited a high stability, which can be ascribed to the OTS layer. The layer has a special ring-on-string-like structure and can act as an anchor to fix the nanoparticles on the membrane surface because of the strong interaction between OTS and the nanoparticles. The filtration test results showed that the amphiphobic membrane developed possessed high removal efficiency for 0.1, 0.16 and 0.2 μm particles (˃ 99.9670%). As for the anti-oil fouling ability, the amphiphobic membrane maintained a pressure drop below 3 kPa in the smoke filtration within 10 min, meaning that the membrane developed had a high anti-oil fouling ability. The developed amphiphobic PTFE membrane in this work has a promising prospect in air purification in oil environments.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER INTERNATIONAL
·
2021
·Vol. 70
·期 9
·1396-1403
·
IF 2.99
Tingxiao Li,Yifan Huang,Lei Wang,Binjie Xin
A bead-on-string structure with special beads at the microscale level could act as an effective carrier for solid drug particles as well as giving a continuous and sustained release profile. Tetracycline hydrochloride (TCH), used as solid model drug particles, was ground to obtain nanoscale and well-distributed size. Electrospun poly[lactic- co -(glycolic acid)] (PLGA) bead-on-string nanofibers loaded with TCH of different particle sizes were fabricated for controlled drug delivery. The morphology of TCH particles and bead-on-string nanofibers were observed using a particle sizer and scanning electron microscopy. The effects of drug particle size on the release behaviors of nanofibers were further investigated and analyzed using UV–visible spectrophotometry. In vitro release results suggested that bead-on-string nanofibers encapsulating ground TCH particles had higher total drug release quantity compared with unground particle-loaded nanofibers. Coating of the surface of PLGA/TCH nanofibers was investigated for controlled-release effects and the release mechanism to understand the drug–polymer carrier interaction. The results indicated that coating on both sides of nanofibrous membranes could effectively decrease the initial burst release. Bead-on-string nanofibers proved to be promising mats for drug delivery applications. © 2021 Society of Industrial Chemistry.
研究领域:
生物材料学
·
药剂学
✓ 已验证
DOI
高影响因子
TRANSACTIONS OF TIANJIN UNIVERSITY
·
2018
·Vol. 24
·期 3
·272-281
·
IF 0
Xu Fengyun,Na Ping
Novel three-dimensional string and ball-like titanium dioxide/reduced graphene oxide, TiO 2 /rGO (STG) composites were prepared using a one-step hydrolysis process followed by a low-temperature hydrothermal treatment. The STG composites exhibited excellent photo-catalytic degradation performance for methylene blue owing to a good synergistic effect between TiO 2 and rGO. The STG composites with 1.0 wt% of rGO loading exhibited the highest removal rate of 86.0% for methylene blue and its reaction rate constant (5.27 × 10 −3 min −1 ) was much higher than those of pure string and ball-like TiO 2 (ST). In addition, the STG composites also showed an outstanding capability for the photo-catalysis degradation of other cationic dyes. In addition, a possible photo-catalytic degradation mechanism for the STG composite was postulated, in which \(^{ \bullet } {\text{O}}_{2}^{ - }\) and • OH were the main oxidizing groups. This work offers new insights into a better design and preparation of novel composite materials for the removal of organic dyes.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
DESALINATION
·
2022
·
IF 11.211
Simin Li,Liangzhong Li,Jiahao Zhong,Ruixue Ma,Xiaohang Xu,Huiguang Wu,Yang Yu
A novel Janus membrane was fabricated by constructing a thin hydrophobic layer with beads-on-string structure on the surface of superhydrophilic polyacrylonitrile (PAN) electrospun nanofiber (ENs) substrate through hybrid electrospinning and electrospraying techniques. The electrosprayed polystyrene/poly(dimethylsiloxane) (PS/PDMS) beads were interlinked by nanofibers and further anchored by 3-D network formed by electrospinning polyvinylidene fluoride-co-hexafluoropropylene (PH). Surface roughness and morphology of formed beads and relevant hydrophobic layers could be highly affected by weight ratios and concentrations of PS and PDMS. The hydrophobic layer (PH-7PS/7PDMS) prepared by electrospraying PS/PDMS (7 wt%/7 wt%) mixed solution showed the highest water contact angle (WCA) value of 148.5 o and the largest surface roughness of 812 nm. The optimized Janus membrane could exhibit a water flux of 27.7 L/m 2 h and a salt rejection efficiency close to 100 % at the temperature difference of 40 °C when 3.5 wt% sodium chloride (NaCl) was used as the feed solution. The addition of PDMS could endow the Janus membrane with better performance stability and anti-fouling ability due to the enhanced surface hydrophobicity and formation of unique multi-level roughness on the hydrophobic layer. The prepared Janus membrane could be used as a promising candidate for the direct contact membrane distillation (DCMD) process.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2024
·
IF 4.8
Feifan Liu,Yuanmei Bai,Xue Wu,Yan Wan,Shifang Luo,Linao Zhang,Tao Li,Hua Tang,Xianjin Tang,Rong Chen,Qinghua Chen,Yuhuan Xie,Peixin Guo
Ethnopharmacological relevance Allergic rhinitis (AR) stands as a non-infectious inflammatory condition affecting the nasal mucosa, marked by bouts of sneezing, nasal itching, and congestion. This ailment afflicts individuals across all age groups and poses challenges for effective treatment due to its chronic nature. Cangerzisan (CEZS), documented in the Jishengfang compendium, represents a traditional Chinese medicinal formula long utilized for AR management. Aim of the study : Investigating mechanism beneath therapeutic effect of CEZS in alleviating AR. Materials and methods The main active components in CEZS were determined by High Performance Liquid Chromatography (HPLC).The active constituents of CEZS and their corresponding targets were identified through an exhaustive screening process employing TCMSP database. To identify targets relevant to AR, GeneCards, OMIM, and DisGeNET databases were thoroughly applied. Protein-protein interaction (PPI) network was assembled utilizing STRING platform. Potential signaling pathways influenced by CEZS were delineated through GO and KEGG enrichment analyses. Subsequently, an AR model was induced by administering aluminum hydroxide (Al(OH)3) and ovalbumin (OVA) for affecting basal and local sensitization, respectively, facilitating experimental validation of the principal signaling pathways. Results There were 61 active constituents identified within CEZS, targeting a pool of 129 entities associated with AR treatment. Pathways analysis of KEGG revealed that CEZS potentially inhibits AR advancement via modulating TLR4 signaling pathway. Animal experiments demonstrated that CEZS effectively alleviated symptom scores in guinea pigs with AR. Moreover, it exhibited notable improvements in serum immune and inflammatory factors levels, as well as reduced inflammatory infiltration within nasal mucosa, including goblet and mast cells. CEZS was found to enhance GATA-3 expression while reducing T-bet expression, thereby modulating the TH1/TH2 immune balance. Additionally, CEZS downregulated HMGB1, TLR4, and p–NF–κB/NF-κB protein expressions within nasal mucosa of guinea pigs. Conclusions The therapeutic mechanism of CEZS against AR involves rectifying TH1/TH2 immune imbalance and upregulating inflammatory and immune factors through modulating key proteins expression within TLR4 pathway. This targeted regulation effectively impedes AR progression.
研究领域:
民族药理学
·
药理学
·
免疫学
·
传统中药
·
生物信息学
·
实验验证
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Zhengquan Sun,Yanyun Ju,Yufeng Xiong,Lijie Dong
Particulate matter (PM) pollution poses a significant risk to public health, as it can carry pathogens such as bacteria and viruses into the body through the respiratory tract, leading to a variety of illnesses. Electrospun nanofibrous membranes (ENMs) exhibit substantial promise for air filtration applications. However, most nanofibrous membranes have a trade-off between filtration efficiency and pressure drop. The bead-on-string structured membranes are characterized by their ability to achieve a higher efficiency and lower pressure drop. Here, we prepared a bead-on-string-like structure of ENM with fluxible poly(p-phenylene terephthalamide) (f-PPTA) and silver nanoparticles (Ag NPs) on a polypropylene (PP) nonwoven fabric substrate. The two layers of membranes enable graded filtration and reduce the pressure drop. The f-PPTA plays a role in controlling both the diameter and roughness of nanofibrous membranes, and its grafted quaternary ammonium salts impart antimicrobial properties to the membrane. Ag NPs serve as a skeleton and form a bead-on-string-like structure with f-PPTA/PA6 nanofibers. In conclusion, this membrane achieves a 99.39% efficiency for PM0.3, a low-pressure drop of 21 Pa, and a quality factor (QF) value of 0.24 Pa–1 and exhibits antibacterial properties against both E. coli and S. aureus. This study indicates that the nanofiber structure can be transformed into a bead-on-string-like structure with low-pressure drop by reasonable matching of the size of nanoparticles and nanofibers, and the combined action of f-PPTA and Ag NPs can effectively improve the antibacterial effect of nanofiber membranes, which is of significant importance for the research on high-efficiency particulate air (HEPA) filter.
研究领域:
环境科学
·
材料科学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Qingxiu Liu,Jie Liu,Shufa Qin,Ying Pei,Xuejing Zheng,Keyong Tang
This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology. In detail, cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology were obtained by acid hydrolysis followed by intensive sonication. The D-H-Cel nanofibrils were prepared through oxidizing part of the non-esterified hydroxyl groups on the H-Cel into aldehyde groups. D-H-Cel were then mixed with gelatin and D-H-Cel/Gel composite hydrogels were produced. During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains. Since the cellulose nanofibrils were covalently bonded to gelatin, the stress could be efficiently transferred between the reinforcing agent and matrix, resulting in a composite hydrogel with drastically increased mechanical strength. The compressive strength of D-40H-Cel/Gel hydrogel reached 3.398 MPa. SEM images showed a highly porous three-dimensional structure in the hydrogel with regulated pore size. The crosslinking indices were measured with ninhydrin assay. The composite hydrogels could maintain their shape well in buffer solution . The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Biomolecules
·
2021
·Vol. 11
·期 5
·635
·
IF 4.879
Ding Li,Menglong Wang,Wen-Liang Song,Deng-Guang Yu,Sim Wan Annie Bligh
A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy.Keywords:side-by-side electrospinning;Janus structure;beads-on-a-string;immediate release;sustained release
研究领域:
药剂学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）