FUEL PROCESSING TECHNOLOGY
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2021
·
IF 7.033
Hong Li,Jiajun Guo,Yuhao Zhang,Liang Zhao,Jinsen Gao,Chunming Xu,Haitao Pang,Pengfei Hao
The separation of aromatics from fluid catalytic cracking (FCC) diesel is of great significance for environmental protection. The extraction ability of 1-methyl-2-pyrrolidinone (NMP), sulfolane (SUL), and 4-formylmorpholine (NFM) were studied by the liquid-liquid equilibrium (LLE) experimental, and the corresponding LLE data of NMP/SUL/NFM + 1-methylnaphthalene + dodecane systems were obtained. The calculated distribution coefficients and separation factors showed that the solubility of 1-methylnaphthalene was the highest in NMP and the selectivity of SUL to 1-methylnaphthalene was the strongest. The effects of solvent structures were investigated by a combination of experiments and quantum chemical calculations . The 1-methylnaphthalene is more soluble in solvents with planar molecular structure because the steric hindrance between the two molecules is smaller, and the group with more electronegative has higher selectivity for 1-methylnaphthalene. Moreover, the reduced density gradient (RDG) and atoms in molecules (AIM) analyzed found that the main extraction mechanism of the three solvents was van der Waals (VDW) and weak hydrogen bond , in which VDW was dominant. Finally, the binary interaction parameters of NRTL and UNIQUAC models were obtained, which make up for the blank in Aspen simulation for the separation of FCC diesel by organic solvents.
研究领域:
环境科学
·
化学工程
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DOI
高影响因子
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2023
·Vol. 107
·期 18
·5813-5827
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IF 5
Wu Tong,Guo Sheng-Zhi,Zhu Hai-Zhen,Yan Lei,Liu Zhi-Pei,Li De-Feng,Jiang Cheng-Ying,Corvini Philippe François-Xavier,Shen Xi-Hui,Liu Shuang-Jiang
Abstract Sulfonamide antibiotics (SAs) are serious pollutants to ecosystems and environments. Previous studies showed that microbial degradation of SAs such as sulfamethoxazole (SMX) proceeds via a sad -encoded oxidative pathway, while the sulfonamide-resistant dihydropteroate synthase gene, sul , is responsible for SA resistance. However, the co-occurrence of sad and sul genes, as well as how the sul gene affects SMX degradation, was not explored. In this study, two SMX-degrading bacterial strains, SD-1 and SD-2, were cultivated from an SMX-degrading enrichment. Both strains were Paenarthrobacter species and were phylogenetically identical; however, they showed different SMX degradation activities. Specifically, strain SD-1 utilized SMX as the sole carbon and energy source for growth and was a highly efficient SMX degrader, while SD-2 did could not use SMX as a sole carbon or energy source and showed limited SMX degradation when an additional carbon source was supplied. Genome annotation, growth, enzymatic activity tests, and metabolite detection revealed that strains SD-1 and SD-2 shared a sad -encoded oxidative pathway for SMX degradation and a pathway of protocatechuate degradation. A new sulfonamide-resistant dihydropteroate synthase gene, sul918 , was identified in strain SD-1, but not in SD-2. Moreover, the lack of sul918 resulted in low SMX degradation activity in strain SD-2. Genome data mining revealed the co-occurrence of sad and sul genes in efficient SMX-degrading Paenarthrobacter strains. We propose that the co-occurrence of sulfonamide-resistant dihydropteroate synthase and sad genes is crucial for efficient SMX biodegradation. Key points
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Two sulfamethoxazole-degrading strains with distinct degrading activity, Paenarthrobacter sp. SD-1 and Paenarthrobacter sp. SD-2, were isolated and identified.
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Strains SD-1 and SD-2 shared a sad-encoded oxidative pathway for SMX degradation.
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A new plasmid-borne SMX resistance gene (sul918) of strain SD-1 plays a crucial role in SMX degradation efficiency.
研究领域:
微生物学
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环境科学
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分子生物学
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DOI
PubMed
高影响因子
Applied Biological Chemistry
·
2024
·Vol. 67
·期 1
·1-11
·
IF 2.3
Yu Ziqing,He Wen,Shi Weiwu
All chronic renal disorders eventually lead to renal interstitial fibrosis (RIF). Chronic inflammation and pro-fibrotic substances are familiar companions of the fibrotic process. The Sulforaphane (Sul) molecule is particularly useful in protecting the liver from oxidative damage. To investigate the Sul effects on fibrosis markers and inflammatory proteins in the kidney of NRK52E cell line and rats and clarify the mechanism of TGF-β/Smad signaling pathway in a rat model of RIF were developed in the present study. Sul (50, 100, and 200 ng/ml) remarkably reduced the gene expressions of tumor necrosis factor (TNF-α), interleukin-6 (IL-6), interleukin (IL)-1β, collagen 3 (COL3A1), collagen 1 (COL1A1), and α-smooth muscle actin (α-SMA) in fibrotic NRK52E cells compared with those in cells inspired by transforming growth factor-α (TGF-α). Histopathological investigations showed that Sul administration retained renal tissue structure and decreased kidney tissue fibrosis in rats subjected to unilateral ureteral blockage (UUO). The expression level of TNF-α, IL-6, IL-1β, COL3A1, COL1A1, and α-SMA in the rats’ kidneys exposed to UUO was also suppressed by the treatment of Sul. In the present study, western blot analysis showed that Sul upregulated the expressions of fibrotic NRK52E cells Smad7 and rat model UUO groups while simultaneously decreasing the stimulation of Smad2/3 and the expressions of cyclooxygenase-2, NF-κB, Smad4, activator protein-1, and high-mobility group protein B1. Ultimately, Sul’s ability to inhibit the TGF-β/Smad pathway and the development of inflammation factors may mitigate RIF.
研究领域:
医学
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药理学
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分子生物学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Can Cheng,Jianjun Li,Jinyan Cao,Jiaxiu Guo,Wanglai Cen
The absorption properties of N-(2-hydroxyethyl) morpholine (HEM), morpholine (MP) and N-(2-aminoethyl) morpholine (AEM) for SO 2 were studied using sulfolane (SUL) as solvent in this work. Among these solvent combinations, HEM/SUL shows the best cyclic absorption performance, and the capacity of HEM-SUL-40 (40 wt% of HEM and 60 wt% of SUL) to absorb 8580 mg/m 3 SO 2 (the remainder is N 2 ) is 192.18 mg/g at 293.15 K. The absorption capacity of the second cycle is 97.5% of the first absorption cycle, which is higher than 70% of the Cansolv amine solution in a commercial application with similar experimental conditions. However, MP/SUL is difficult to desorb at high temperature, and the absorption capacity of AEM/SUL is much lower than HEM/SUL and MP/SUL. According to the FTIR , 1 H NMR and 13 C NMR, all three cyclic amines have charge transfer effects with SO 2 . The structure of HEM/SUL can be recovered after heating, but MP cannot be recovered. Δ r G m ° in the reaction against HEM with SO 2 increases significantly with increasing temperature. The Δ r G m ° of HEM-SO 2 and MP-SO 2 at 353.15 K is −12.56 kJ/mol and −16.29 kJ/mol, respectively, which further explains the easy desorption of HEM-SO 2 and the difficult desorption of MP-SO 2 at high temperature.
研究领域:
化学工程
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环境科学
·
物理化学
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DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2014
·Vol. 22
·期 6
·4587-4596
·
IF 2.757
Li Jianan,Cheng Weixiao,Xu Like,Strong P. J.,Chen Hong
In this study, we determined the abundance of 8 antibiotics (3 tetracyclines, 4 sulfonamides, and 1 trimethoprim), 12 antibiotic-resistant genes (10 tet , 2 sul ), 4 antibiotic-resistant bacteria (tetracycline, sulfamethoxazole, and combined resistance), and class 1 integron integrase gene ( intI 1) in the effluent of residential areas, hospitals, and municipal wastewater treatment plant (WWTP) systems. The concentrations of total/individual targets (antibiotics, genes, and bacteria) varied remarkably among different samples, but the hospital samples generally had a lower abundance than the residential area samples. The WWTP demonstrated removal efficiencies of 50.8 % tetracyclines, 66.8 % sulfonamides, 0.5 logs to 2.5 logs tet genes, and less than 1 log of sul and intI 1 genes, as well as 0.5 log to 1 log removal for target bacteria. Except for the total tetracycline concentration and the proportion of tetracycline-resistant bacteria ( R
2 = 0.330, P < 0.05), there was no significant correlation between antibiotics and the corresponding resistant bacteria ( P > 0.05). In contrast, various relationships were identified between antibiotics and antibiotic resistance genes ( P < 0.05). Tet (A) and tet (B) displayed noticeable relationships with both tetracycline and combined antibiotic-resistant bacteria ( P < 0.01).
研究领域:
环境科学
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微生物学
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公共卫生
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）