TALANTA
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2024
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IF 5.6
Al-Fakih Ali Mohammed,Chaohong Feng,Ting Jiang,Wei Xu
Miniaturized mass spectrometers, with their increasing portability and performance enhancements, play a crucial role in selectively analyzing target compounds within complex mixtures, particularly in situ environments. As part of our ongoing efforts to enhance the analytical capabilities of the custom-built "brick" mass spectrometer, this study compared and optimized methods for ion isolation using Stored Waveform Inverse Fourier Transform (SWIFT) and Grid-SWIFT waveforms. The efficacy of the SWIFT and Grid-SWIFT waveforms in selective ion isolation was investigated, and through optimization of both waveforms, improved ion isolation efficiency, and peak resolution were demonstrated by adjusting waveform duration and amplitude. The results conclusively showed that Grid-SWIFT outperforms traditional SWIFT waveforms in enhancing the isolation of target ions. Additionally, a novel simulation-based approach was developed to simulate the behavior of ion trajectories under the SWIFT and Grid-SWIFT waveforms within LIT to provide a theoretical basis for better performance of the Grid-SWIFT waveforms. Results show that longer waveform durations help reduce energy leakage, providing higher isolation efficiency. Grid-SWIFT waveforms exhibited significantly less energy leakage compared to SWIFT waveforms. Consequently, using Grid-SWIFT as isolation waveforms improved the mass spectra' intensity and resolution.
研究领域:
分析化学
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质谱技术
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仪器科学与技术
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Zuqiang Xu,Ting Jiang,Qian Xu,Yanbing Zhai,Dayu Li,Wei Xu
Besides portability and increasingly improved performances, the ability of screening target analyte from complex compounds is a crucial function of miniature mass spectrometers, especially for in situ analysis. Selected reaction monitoring (SRM) and multiple reaction monitoring (MRM) operation modes are the most widely used mass spectrometry operation methods for target analyte quantitation. As a continuous effort to improve the analytical performances of the “brick” mass spectrometer, built in-house, pseudo-SRM and pseudo-MRM modes were realized on the linear ion trap mass analyzer in the device. A broadband excitation waveform in both time and frequency domains, namely, the Grid-SWIFT waveform, was constructed and compared with the conventional SWIFT waveform. By isolating target ions during the ion introduction period using the Grid-SWIFT waveform, target ions could be efficiently accumulated inside the ion trap without experiencing space charge effects and interferences from nontarget ions in the samples. As a result, not only the detection sensitivity of the target analyte could be increased, but also the quantitation accuracy over a relatively wide concentration range could be improved.
研究领域:
分析化学
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质谱分析
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仪器科学与技术
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Ang Li,Jian Sun,Haoqiang Yan,Dayu Li,Wei Xu
In miniature ion trap mass spectrometry, achieving a balance between isolation resolution and efficiency is a formidable challenge. The presence of absorption curves causes target ions to inadvertently absorb energy from AC signal components near their resonant frequencies. To mitigate this issue, SAM–SFM waveforms introduce a parameter known as the decreasing factor. Unlike SWIFT waveforms, SAM–SFM’s spectral profile intentionally departs from a rectangular window, adopting an arch-shaped excitation window to minimize the impact on target ions and improve ion isolation efficiency. SAM–SFM waveforms have the advantage of low computational complexity, enabling real-time computation using an embedded FPGA technology. Regardless of any parameter changes, the FPGA can consistently guarantee waveform output within 1 μs. This not only enhances throughput but also eliminates the need for a PC in miniature mass spectrometry devices. The performance of SAM–SFM has been validated on an improved “Brick” miniature ion trap mass spectrometer. Comparative experiments with SWIFT waveforms confirm the lossless unit-mass isolation capabilities of SAM–SFM. This waveform has the capability to simultaneously isolate multiple target ions, even allowing for the lossless isolation of ions with lower abundance within isotopic clusters, albeit at the cost of requiring extended isolation durations.
研究领域:
分析化学
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质谱技术
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仪器科学与技术
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Anhui Yu,Zhiguang Guo
Droplet manipulation on functional surfaces is an urgent problem to be solved. Fast and precise droplet manipulation plays an important role in many applications, such as microreactors and microfluidics. Although numerous techniques have been developed to manipulate droplets by injecting external stimuli, it remains a challenge to achieve high-precision, high-sensitivity, and fast droplet manipulation on smart, slippery response surfaces. Here, we report an intelligent slippery photopyroelectric response near-infrared-induced MXene-barium titanate/polyimide (SFMBPI) membrane. By using local near-infrared radiation (NIR), we can precisely control the droplet transport on the SFMBPI membrane, and SFMBPI uses electrospinning technology to better lock the dimethylsilicone oil, reducing the loss during the control process. Moreover, due to the presence of the pyroelectric layer, double external stimuli can be achieved. The thermal stimulation of the photothermal layer and the charge action of the pyroelectric layer make the manipulation of droplets on the SFMBPI surface more efficient and faster. Moreover, the experiment of negative gravity transport at an inclination angle of 6° demonstrates that the existence of the pyroelectric layer results in a greater driving force on the droplets, which can be more widely used. In addition, by inducing the direction of the NIR, programmable droplet transport and droplet merging can be achieved. Also, the SFMBPI membrane can be used for underwater bubble manipulation. This precise manipulation of droplets on the surface of SFMBPI membranes can be widely used in other fields, such as microfluidics.
研究领域:
材料科学
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微流控技术
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表面科学
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DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
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2025
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IF 11.5
Wei Liu,Juan Zhang,Yanfang Wang,Yaqin He,Yuanwu Wang,Xiangqian Wei,Yuejun Yao,Jianchang Xu,Wentao Zhang,Tao Sheng,Haibin Dai,Jinqiang Wang,Zhen Gu
Long-acting glucose-responsive insulin is anticipated to reduce the frequency of injections via replacing both rapid-acting and long-acting insulin. Sequential rapid glucose-responsive insulin release and instant absorption are essential to the swift onset of action. Herein, we have developed injectable long-acting glucose-responsive insulin formulations (GRIF) prepared from glucosamine-modified insulin aspart (ASP-G n ) and phenylboronic acid-modified poly- ʟ -lysine (PLL-FPBA). The complex can form stable GRIF reservoir subcutaneously after injection. Upon food intake, the elevated blood glucose (BG) triggers the release of monomolecular insulin aspart (or ASP-G n ), which can be absorbed immediately to downregulate BG back to the normal range. Among the diverse formulations investigated, GRIF prepared from two-glucosamine-modified insulin aspart and twice weight of PLL-FPBA facilitates the best in vitro glucose-responsive insulin release performance. In type 1 diabetic mouse and minipig models, GRIF exhibit notably swift onset of action and achieve superior BG control. In addition, GRIF reveal no discernible signs of associated toxicity in the studied animals.
研究领域:
药剂学
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生物医学工程
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糖尿病研究
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DOI
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高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 192
·期 1
·1-11
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IF 5.3
Chen Xueke,Huang Tongfu,Wang Xin,Wu Chunyan,Yi Fei,Wan Ziqiang,Zou Bao,Xiong Wei,Liao Fusheng,Fan Hao,Yin Zhaojiang
The ultrahigh-sensitive detection of H 2 S is reported using a novel dual-ligand metal–organic framework (MOF) electrochemiluminescence (ECL) sensor. By combining tetrakis(4-carboxyphenyl) porphyrin (TCPP) and 1,3,6,8-tetrakis(4-carboxyphenyl) pyrene (TBAPy) as ligands and employing zirconium as the metal source, a spindle-shaped Zr-PyTCPPMOF was successfully designed and synthesized. Notably, the multiple nitrogen structures of porphyrin provided abundant binding sites for sulfur (S), further enhancing the ECL signal of Zr-PyTCPPMOF. The sensor shows a good linear relationship in the 0.01–100 μM range, with a detection limit reaching 1.18 nM (S/N = 3). When analyzing actual serum samples, the recovery was between 96.6 and 106.2%. Ultimately, the dual-ligand ECL platform based on Zr-PyTCPPMOF achieved trace detection of H 2 S, which is expected to provide reliable technical support for early environmental monitoring and disease diagnosis. Graphical abstract
研究领域:
分析化学
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环境科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
International Journal of Distributed Sensor Networks
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2015
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IF 0.665
Daniel Granlund,Christer Åhlund,Patrik Holmlund
Technological advances within the area of wireless sensor technology allow WSNs to be used in a increasing number of measurement scenarios. As new application areas are emerging, such as infrastructure monitoring and smart cities, the need for sensor mobility handling requires efficient and secure authentication protocols. This paper presents EAP-Swift, a novel EAP based authentication protocol with a focus on lightweight processing and faster response. It supports end-to-end session encryption key generation and mutual authentication. By utilizing lightweight hashing algorithms, the challenge-response authentication mechanism uses only two round trips to the AAA server for the complete authentication procedure leading to the reduction of latency by 33% compared to the baseline protocols. Further, using extensive experimentation, we validate that the authentication time can be kept below 250 ms and the power consumption can be kept below 15 mJ. Furthermore, we show that a battery lifetime of more than four years can be achieved when running the system on a regular button cell battery. Finally, the protocol was verified in terms of security using the AVISPA tool.
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Lingke Liu,Yaling Mao,Minjuan Gao,Xingyu Fan,Yueqin Li
Poly(N-isopropylacrylamide) (PNIPAM) composite hydrogels have emerged as prime candidates for soft hydrogel actuators. However, due to the strong dependence of their actuation behavior on structural features, challenges remain in terms of insufficient driving force, slow response speed, and limited deformation capacity. Herein, we fabricated a photothermal-responsive PNIPAM/SA/MXene hydrogel by incorporating Ti 3 C 2 T x MXene and sodium alginate (SA) into a PNIPAM matrix as the active layer. Through interfacial infiltration, this hydrogel was then integrated with a pH-responsive poly(acrylamide-co-acrylic acid) [P(AAM-co-AA)] hydrogel to create a bilayer actuator with the configuration PNIPAM/SA/MXene//P(AAM-co-AA). By controlling the environmental temperature and pH value, the actuator exhibits remarkable bidirectional actuation, including a broad bending range (+100° to −917°) and high initial velocity (4.5°/s over 103 s), enabling flower-shaped actuators to achieve fast programmable petal blooming/closing. By virtue of the photothermal effect of MXene and the thermoresponsive property of the PNIPAM scaffold, a 10-mm-long PNIPAM/SA/MXene strip can achieve a 180° rotation within 30 s under the control of near-infrared (NIR) light, thereby simulating the motion of a sailboat. Furthermore, the PNIPAM/SA/MXene strain sensor achieved a good sensitivity (GF = 2.54) over a wide strain ranging from 0 ∼ 400 %, and an ultra-fast response time (150 ms). Under near-infrared light irradiation, the PNIPAM/SA/MXene-based actuator realizes a self-sensing function to monitor its deformation state by correlating the response relationships between surface temperature, bending angle, and relative resistance changes. A specially designed self-sensing actuator is used to perceive Morse codes through real-time electrical signals and pattern variations. This work presents a scalable strategy for fabricating high-performance hydrogel actuators for bionic soft robotics and highlights its significant potential in multiplex motion perception.
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DOI
高影响因子
Nano-Micro Letters
·
2023
·Vol. 15
·期 1
·1-15
·
IF 26.6
Lu Xin,Xie Daibin,Zhu Kaihua,Wei Shouhao,Mo Ziwei,Du Chunyu,Liang Lirong,Chen Guangming,Liu Zhuoxin
The MXene-boosted rapid gelling expedites the assembly of flexible thermocell arrays, overcoming the typical constraint of complicated device fabrication processes.
The hydrogel electrolyte can sustain stable thermoelectrochemical performance under various challenging conditions, including large, repeated, and sustained deformations, and multiple cut-healing cycles.
The as-assembled thermocell array exhibits device-level self-healing capability and high adaptability to human body, efficiently harvesting low-grade heat for wearable applications.
研究领域:
材料科学
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能源技术
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xia Zhang,Fuhao Dong,Mingming Yu,Xu Xu,He Liu,Haiqin Lu
The development of environmentally friendly waterborne polyurethane (WPU) elastomers can significantly reduce reliance on organic solvents, which is crucial for environmental protection. However, the manufacturing of WPU elastomers with high strength and self-healing properties has proven to be extremely challenging. Hence, a rapid self-healing supramolecular material featuring high strength was explored by synergistically combining flexible disulfide and urea bonds into water-borne polyurethane (WPU). Simultaneously, combining cellulose nanofibres (CNF) rich in hydroxyl groups with the WPU matrix not only enables a dynamic network composed of strong hydrogen bonds but also forms a strain-induced reversible network under the special nano-confinement effect. Surprisingly, the obtained nanocomposite films showed outstanding mechanical properties, with extremely high tensile strength (54.4 MPa), elongation at break (896.1 %), and toughness (255.6 MJ/m −3 (−|−)). After incorporating CNF, the nanocomposite elastomer exhibited the desired self-healing efficiency (92.7 %). Furthermore, the prepared nanocomposite elastomer emits blue fluorescence under 365 nm ultraviolet irradiation, which can be used for microcrack detection in equipment. In addition, we verified the broad application prospects of the nanocomposite elastomers in clothing anti-counterfeiting. Our study provides new insights into the development of luminescent materials with rapid self-healing abilities and high strength.
研究领域:
材料科学
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环境科学
·
化学工程
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产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Bingzhi Li,Kun Cheng,Pengyu Chen,Linpin Luo,Liang Zhang,Ting Du,Tong Zhang,Qingqing Li,Yiyue Ma,Jing Sun,Maojun Jin,Jianlong Wang,Yiping Chen
The acidophilic and heat-resistant characteristics of Alicyclobacillus acidoterrestris ( A. acidoterrestris ) pose significant challenges to fruit juice production. Traditional thermal removal methods are often ineffective against this resilient bacterium. To address this issue, we developed a novel adsorbent, magnetic carbonation carbon-lysozyme nanohybrid (MCL), composed of magnetic nanoparticles with a thin carbon shell and covalently grafted lysozyme. The outer lysozyme facilitates binding to the bacterial surface through two modes: electrostatic attraction and chemical interaction, acting as a vital engine for bacterial adhesion. The ultrathin carbon coating enhances dispersion, reduces magnetic loss, provides more adsorption sites for lysozyme grafting, and ensures stable function in acidic environments. Benefiting from the large surface area of MCL and the specific peptidoglycan recognition structure of lysozyme, MCL exhibits rapid adsorption kinetics and can completely remove 10 4 CFU/mL of A. acidoterrestris from juice within 20 min. The MCL demonstrates excellent capture performance, negligible cytotoxicity, and no significant impact on juice quality, offering a promising non-thermal strategy to improve juice safety.
研究领域:
食品科学
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微生物学
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纳米技术
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生物技术
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产品关联
DOI
PubMed
高影响因子
Particuology
·
2021
·
IF 3.067
Jinbo Ouyang,Xiaohong Xing,Jian Chen,Limin Zhou,Zhirong Liu,Jerry Y.Y. Heng
Swift cooling crystallization of vanillin was investigated in water, ethanol, isopropanol and ethyl acetate. Morphology and polymorph evolution of vanillin were discussed in terms of solvent, supersaturation ratio and silica template. PXRD, DSC, FTIR and microscope were used to identify polymorphs of vanillin. Results showed that the nucleated polymorphs of vanillin depended largely on the solvent, supersaturation ratio and silica template. Low supersaturation ratios favor the nucleation of stable form I in water, and high supersaturation ratio exceeds 7 generating 100% metastable form II. However, if the supersaturation ratio is too high ( S >8), liquid–liquid phase separation will occur, and no crystals could be obtained. In other solvents such as ethanol, isopropanol and ethyl acetate, only form I was obtained. However, it should be noted that the morphology of form I prepared in ethanol, isopropanol and ethyl acetate is distinct from that obtained in water, the former is flake-like and the latter is rod-like. The nucleation of vanillin from different solution was also studied with the presence of SiO 2 , SiO 2 –NH 2 and SiO 2 −COOH templates, which did not change the nucleated polymorph of vanillin, but changed the nucleation and growth rate of stable form I.
研究领域:
化学工程
·
材料科学
·
晶体学
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DOI
高影响因子
危险品化学品经营许可证（带存储）