Phytochemistry Letters
·
2019
·
IF 1.338
Yanhui Wang,Xueli Cao,Boyu Qin,Ying Wang,Lan Xiang,Jianhua Qi
Four new tirucallane-type saponins (i.e., sapinmusaponin S–V, which include one new structure and three new stereoisomers) and a known compound sapinmusaponin G were isolated from the flowers of Sapindus mukorossi . All of them could significantly induce neurite outgrowth of PC12 cells. The structures of active compounds were determined using spectroscopic data and chemical derivatization. Specific inhibitor experiments and Western blot analysis of sapinmusaponin S, which is the most active compound, were performed. Results indicated that the insulin-like growth factor 1 receptor/phosphoinositide 3-kinase/extracellular regulated protein kinase signaling pathway is involved in this action.
研究领域:
药理学
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植物化学
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神经科学
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
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2025
·
IF 2.5
Parvez Ahmad,Sangeeta Devi Khangembam,Anil Kumar Gangwar,Vipin Kumar Yadav,Prafull Kumar Singh,Yogendra Singh,Ravi Prakash Goyal,Surendra Pratap Chakraverty,Rajesh Kumar Verma
Biological scaffolds prepared after decellularization are used for the restoration of damaged tissues. A number of chemicals are used for bioscaffold preparation, and some of them damage their composition and architecture. Herein, we investigated the Sapindus mukorossi fruit pericarp extract (SPE) (5%) for decellularization of the caprine dermis. The dermal samples were processed in 5% SPE over magnetic stirrer for 96h at room temperature. The decellularization efficiency of SPE was analyzed by histological examination, DAPI staining, scanning electron microscopy (SEM), quantification of DNA hydroxyproline and hemocompatibility determination. Further, these acellular caprine dermal scaffolds were transplanted on full thickness skin wounds of group III New Zealand white rabbits. The wounds were left open in group I (Sham) and reconstructed by autograft in group II (n = 6 in each group). Continuous agitation of native caprine dermal tissues in 5% SPE for 96 hours leads to complete decellularization without affecting the extracellular matrix architecture. Microscopic observation of decellularized samples did not show any nuclei. DNA quantity was reduced (p < .05) in decellularized samples and scaffolds were found to be hemocompatible. Complete healing was observed on day 28 in groups II and III. No significant difference was noted in IgG in all the groups. Quantitative assessment of MDA showed a significant increase in groups I and II. Our results suggested that the 5% SPE solution effectively decellularized the native caprine dermis and the scaffolds were well tolerated by the animals.
研究领域:
组织工程
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再生医学
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生物材料学
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DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2019
·
IF 4.191
Zaizhi Liu,Mengling Gui,Tongtong Xu,Le Zhang,Lingtao Kong,Li Qin,Zhengrong Zou
An aqueous enzymatic-ultrasonication extraction (AEUE) technique involving sequential treatment with enzyme mixtures (neutral protease/cellulase/pectinase) followed by ultrasonication was proposed for the extraction of oil from Sapindus mukorossi seed kernels. Statistical optimization was successfully applied to determine the optimal AEUE conditions. Three parameters, including enzyme amount, ultrasonic time and power, were screened from eight parameters using the Plackett–Burman design and further optimized by the Box–Behnken design for the attainment of a high yield of S. mukorossi seed kernels oil. The optimal AEUE conditions with a yield of 82.67% ± 2.21%, relative to the Soxhlet method, were obtained as follows: incubation time of 8 h, amount of 4%, pH of 7, incubation temperature of 60 °C, shaking speed of 600 rpm, water solid ratio of 16 mL/g, ultrasonic time of 56 min, and ultrasonic power of 240 W. The S. mukorossi seed kernels oil acquired using AEUE exhibited a lower acid value and a higher iodine value than that acquired by the Soxhlet method. Meanwhile, all the oils showed similar fatty acid profiles according to GC–MS analysis, regardless of the extraction method, indicating that AEUE is capable of S. mukorossi seed kernels oil extraction. In summary, the results from this study indicate that the developed AEUE is an efficient process for the separation of nonedible oil of for use in biodiesel production.
研究领域:
化学工程
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食品科学
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生物技术
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DOI
高影响因子
Colloid and Interface Science Communications
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2023
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IF 4.5
Aiping Hui,Fangzhi Duan,Yongfeng Zhu,Hao Yang,Aiqin Wang
The cinnamaldehyde has the enormous potential in the antibacterial fields, but the inherent volatility is the major weaknesses in practical application. Herein, a novel strategy of which to encapsulate cinnamaldehyde into Pickering emulsion was adopted. The Pickering emulsion was stabilized with particles of Sapindus mukorossi modified palygorskite ( Sm -Pal), and exhibited good pH and ionic strength resistance and storage stability, even in high salt environments. More importantly, the Pickering emulsion stabilized possessed enhanced antibacterial activities, the reduction (%) of Pickering emulsion toward Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureus ) and drug resistance bacteria-extended spectra of β -lactamases producing Escherichia coli (ESBL) and methicillin-resistant Staphylococcus aureus (MRSA) were 69.8%, 99.6%, 100% and 99.8%, respectively. This strategy could inspire novel designs for functional Pickering emulsions with efficient protective effect.
研究领域:
材料科学
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微生物学
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药物化学
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产品关联
DOI
高影响因子
Results in Chemistry
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2021
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IF 0
Liu Yang,Hong Zheng,Lian Liu,Wenjie Wu,Shuya Wang
Biomass carbon materials have been widely used as electrode materials for super-capacitors (SC) due to their economic, environmental, and sustainable characteristics. In this work, we proposed that the Sapindus Mukorossi Peel (SMP) was used as a precursor to prepare a Sapindus Mukorossi Peel-based activated carbon material (SMPC) through carbonization and KOH activation. The morphology and structure of SMPC were characterized by various test methods. Cyclic voltammetry (CV), galvanostatic charge–discharge (GCD) and electrochemical impedance spectroscopy (EIS) were used to characterize its electrochemical performance. The results show that SMPC has suitable pore size distribution, a large number of heteroatom functional groups and excellent electrical conductivity. In addition, the amount of activator also has an important influence on the performance of SMPC. When the mass ratio of carbon material to KOH is 1:3, the prepared sample SMPC-3 has the largest specific surface area (SSA) was 1254.5 m 2 /g. Moreover, SMPC-3 also has excellent electrochemical properties, high specific capacitance (at 1 A/g, the specific capacitance can reach 314.5F/g), good cycle stability (at 5 A/g, cyclic charge and discharge 5000 times, the specific capacitance is only lost by 4.2%.), superior rate performance (when the current density is increased from 0.5 A/g to 10 A/g, the specific capacitance retention rate is 80.4%). Assembling SMPC-3 // SMPC-3 into a symmetrical SC shows higher energy density (at 0.1 A/g, the energy density is 6.68 Wh/Kg) and power density (at 5 A/g, the power density is 3250 W/Kg).
研究领域:
材料科学
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能源存储
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生物质利用
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产品关联
DOI
CURRENT ISSUES IN MOLECULAR BIOLOGY
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2025
·Vol. 47
·期 5
·316
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IF 3
Zibing Zhao,Aohuan Zhang,Liya Song,Congfen He,Huaming He
Background:Sapindus mukorossiGaertn is a deciduous tree with saponins as the main active ingredients and has been utilized in medicine and cosmetic industries. Currently, the investigations ofS. mukorossimainly focus on the pericarp and seed kernel parts, while other parts are yet to be studied and developed. This study aimed to investigate the anti-acne potential ofS. mukorossiflower water extract (SMFW) by in vitro experiments.Methods and Results:The DPPH, ABTS, superoxide anion radical scavenging assay, and FRAP assay revealed the strong antioxidant activities of SMFW. The antibacterial activity of SMFW againstCutibacterium acneshas been evaluated with an inhibition diameter of 14.08 ± 0.63 mm. Furthermore, SMFW significantly inhibited the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-β) in lipopolysaccharide (LPS)-stimulated THP-1 macrophages. Transcriptome analysis showed that SMFW treatment reversed 448 LPS-upregulated DEGs and 349 LPS-downregulated DEGs, and KEGG enrichment analysis indicated that SMFW might exert its anti-inflammatory effect via NOD-like receptor and JAK-STAT signaling pathways.Conclusions:SMFW exhibited antioxidant, antibacterial, and anti-inflammatory properties in in vitro experiments. RNA-seq analysis indicated that SMFW may alleviate inflammation by regulating the NOD-like receptor and JAK-STAT signaling pathways. In summary, SMFW has shown potential for anti-acne efficacy and can be used as a natural raw material in cosmetics.
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2018
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IF 3.849
Shujie Ma,Leilei Fu,Siqi He,Xiaopeng Lu,Yuanyong Wu,Zhiqing Ma,Xing Zhang
The evaluation of herbicidal activity and the isolation of plant allelopathic substances can lead to the discovery of new herbicide. This study has confirmed that the ethanol extract of S. mukorossi leaves was inhibitory to growth of Avena fatua L. and Amaranthus retroflexus L. both in petri dish experiment and pot culture assay, with the fresh weight inhibition varied between 47.60% and 62.05% at a concentration of 40 g/L of the leaf extract, being comparable to that of a commercialized natural product herbicide pelargonic acid at a concentration of 4 g/L. Five herbicidal compounds, oleanolic acid (1) , lupeol (2) , d-pinitol (3) , hexadecanoic acid (4) and octadecanoic acid (5) were isolated from the most active fraction, petroleum ether extract. D-pinitol (3) showed the highest growth inhibitory activity against both the shoot and root of A. fatua , with the half maximal inhibitory concentration (IC 50 ) values of 53.61 and 56.43 μg/mL, respectively. Furthermore, oleanolic acid (1) and d-pinitol (3) also inhibited the growth of A. retroflexus with the IC 50 value of 56.05 and 61.89 μg/mL against shoot growth, and 58.07 and 66.70 μg/mL against root growth, respectively. Thus, oleanolic acid (1) and d-pinitol (3) are the main phytotoxin constituents of S. mukorossi , and these compounds have the potential for further development as a botanical herbicide.
研究领域:
植物生理学
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化感作用
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天然产物化学
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杂草科学
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农药学
✓ 已验证
DOI
高影响因子
Frontiers in Microbiology
·
2024
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IF 4
Xu Chong,Pan Danyang,Zhang Dexiang,Lin Lin,Chen Yiti,Liang Shuangcheng,He Jingyu
Introduction: Microorganisms as a component of scalp ecosystem play a vital role in human scalp health. Soapberry pericarp is employed in improving scalp health, and its content of active ingredients could be enhanced resulted in fermentation. This study aims to investigate the effect of the fermentation filtrate from soapberry pericarp on the diversity of scalp microorganisms.Methods: The components in fermentation filtrate from soapberry pericarp were analyzed by HPLC-Q-Orbitrap HRMS, and 16S and ITS sequences of 198 samples from three different used stages (Day 0, Day 7, Day 28) were sequenced using the Illumina Novaseq platform. Microbial diversity was assessed using alpha diversity (Chao1 and Shannon indexes) and beta diversity (weighted unifrac and unweighted unifrac). Principal coordinate analysis (PCoA) and linear discriminant analysis (LDA) effect size analysis (LEfSe) were used to visualize microbial variation among different stages.Results: There were 22 components were identified in the fermentation filtrate from soapberry pericarp by HPLC-Q-Orbitrap HRMS. The alpha-diversity and beta-diversity analyses showed that scalp microbial diversity and composition were influenced by the fermentation filtrate of soapberry pericarp. Based on functional analysis, this study found an enrichment of healthy scalp-related bacterial pathways, such as amino acid, nucleoside, and nucleotide biosynthesis, while a decrease in fungal pathogenesis pathways, specifically saprotroph and symbiotroph pathways, was observed.Discussion: The study described about the complex community dynamics of human scalp microorganisms during the stages of using the fermentation filtrate from soapberry pericarp. This result will help rationally utilize the fermentation filtrate from soapberry pericarp to keep or improve human scalp health.
研究领域:
微生物学
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药学
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生物技术
·
皮肤科
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）