Thermodynamic Modeling and Solubility Parameter of 2,6-Pyridinedicarboxylic Acid in Selected Solvents at Different Temperatures
Solubility of 2,6-pyridinedicarboxylic acid (PDCA) in methanol, ethanol, n-propanol, isopropanol, tetrahydrofuran (THF), 1,4-dioxane, acetic acid, formic acid, acetonitrile, ethyl acetate, toluene, and in binary mixed solvents (methanol + THF) was determined by a static analytical method at 0.1 MPa and various temperatures. The PDCA solubility parameters were obtained using Scatchard–Hildebrand theory. The solubility of PDCA in mixtures containing different ratios of methanol and THF demonstrated a maximum-solubility effect. The Apelblat and the Buchowski–Ksiazaczak (λh) equations, as well as Wilson, nonrandom two-liquid (NRTL), and universal quasi-chemical models, were applied to process and fit the experimental data. All models reproduced the experimental data satisfactorily. The NRTL model provided the best correlation results for these systems, with the root-mean-square deviation below 1.39%. This work provides solubility data, solubility parameters, and thermodynamic modeling data of PDCA, which are important for industrial production and crystallization of PDCA.
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