Tf2O-Promoted Intramolecular Schmidt Reaction of the ω-Azido Carboxylic Acids
A designed Tf2O-promoted intramolecular Schmidt reaction of 2-substituted ω-azido carboxylic acids was demonstrated. Tf2O was used as an activation reagent for the carboxylic acid, and ω-azido anhydride was in situ generated, releasing a molecular TfOH, which acted as an acid promoter for the Schmidt process. A series of 2-substituted pyrrolidines was produced and acetylated for better purification. The strategy was also efficient for conversion of a 4-substituted ω-azido carboxylic acid to the tricyclic lactam.
研究领域:
有机化学
·
合成化学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）