SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Long Wu,Wenmin Yin,Xuecai Tan,Pan Wang,Fan Ding,Huan Zhang,Biru Wang,Weiyun Zhang,Heyou Han
It is attractive but remains challenging to develop nanomaterials-based methods to realize the colorimetric detection of ultratrace biological analytes. In this work, an HAuCl 4 -H 2 O 2 system was developed for the visual detection of intracellular hydrogen peroxide (H 2 O 2 ) based on the Au-Pt/SiO 2 sensing platform. Owing to their excellent intrinsic peroxidase-like activity, Au-Pt/SiO 2 nanospheres were introduced to catalyze the decomposition of H 2 O 2 and then directly reduce HAuCl 4 into gold nanoparticles (Au NPs) for the naked-eye detection. The produced Au NPs behaved color variations from light purple to wine red as H 2 O 2 concentration increased. Under the optimal conditions, this strategy showed excellent sensitivity for H 2 O 2 with a detection limit of 0.1 nM by naked-eye readout and 0.1 pM by UV–vis spectrometer (S/N = 3), as well as acceptable selectivity for H 2 O 2 , which could meet the demand for the detection of H 2 O 2 in biological systems. The method was further validated by the determination of H 2 O 2 in HeLa cells with low cellular cytotoxicity. Thus, this strategy would provide simple and sensitive detection of H 2 O 2 in biological systems, revealing the potential application in clinical, biological and environmental researches.
研究领域:
生物分析化学
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纳米生物学
·
医学检测
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2021
·
IF 4.833
Zhihuan Zhao,Pengfei Yang,Xiao Zhang,ShashaYang,Jianying Lin,Jimin Fan,Bing Zhang
MoS 2 /C@SiO 2 spheres were successfully synthesized by a one-step hydrothermal method using silica as the template, sodium molybdate as the Mo source and glucose as the carbon precursor. In this paper, the antitumor ability of MoS 2 /C@SiO 2 and C@SiO 2 nanospheres was evaluated through the photothermal effect induced by near infrared (NIR) spectroscopy and the drug loading and release behaviors of the model drug doxorubicin (DOX). The photothermal conversion efficiency (η) of MoS 2 /C@SiO 2 of 42.5% was 1.2 times that of C@SiO 2 (34.7%), which indicated its significant photothermal effect. The drug loading of MoS 2 /C@SiO 2 of 46.5% was much higher than that of C@SiO 2 (12.4%); it was 3.75 times that of C@SiO 2 . The cumulative drug release of MoS 2 /C@SiO 2 and C@SiO 2 under a simulated acidic tumor environment and NIR irradiation was 58.9% and 27.29%, respectively. Moreover, the cell viability assays verified that MoS 2 /C@SiO 2 -DOX had excellent antitumor ability under the co-stimulation of endogenous (pH) and exogenous (NIR) compared with C@SiO 2 -DOX. The experimental results showed that the survival rate of cancer cells in MoS 2 /C@SiO 2 -DOX under coordinated treatment was only 19.4%, while that of C@SiO 2 -DOX was 24.6%.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2017
·
IF 2.986
Xiaolin Liu,Yongxin Tao,Huihui Mao,Yong Kong,Jian Shen,Linhong Deng,Linsong Yang
Near-infrared (NIR) light has great potential in biomedical applications due to its advantages of deep penetration depth and low photodamage to biological tissues. In this paper, we constructed a novel core-shell structured drug nanocarrier, Fe 3 O 4 @Au@SiO 2 , for the controlled delivery of etoposide (VP16), a chemotherapeutic drug for cancer patients. The novel core-shell structured drug delivery platform is composed of a mesoporous silica shell and a magnetic Fe 3 O 4 core using Au nanoparticles (AuNPs) as the interlayer, which is characterized by atomic force microscopy (AFM), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, N 2 adsorption/desorption isotherms and the magnetic measurements with vibrating-sample magnetometer (VSM). The synergistic effects of AuNPs, mesoporous silica and Fe 3 O 4 make the core-shell structured nanocomposites an excellent candidate for targeted and NIR light irradiation-controlled drug delivery. For the proposed nanocarrier of VP16, the mesopores in silica can enhance the encapsulation capacity of the nanocarrier and the AuNPs can effectively convert the NIR light into heat to speed up the drug deliver; meanwhile, the incorporation of Fe 3 O 4 with high magnetization to the drug delivery platform realize drug targeting under an applied external magnetic field.
研究领域:
生物医学工程
·
药学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2018
·Vol. 22
·期 11
·3475-3484
·
IF 2.509
Wang Hang,Li Xiaojie,feng Xi,Liu Ya,Kang Weimin,Xu Xianlin,Zhuang Xupin,Cheng Bowen
A novel approach is proposed to prepare a proton-conductive nanochannel membrane based on polyvinylidene difluoride (PVDF) porous membrane with modified SiO 2 nanospheres. The hydrophilic PVDF porous membrane with a 450-nm inner pore size was chosen as the supporting structure. Pristine SiO 2 with a uniform particle size of 95–110 nm was synthesized and functionalized with –NH 2 and –COOH, respectively. Through-plane channels of porous membrane and arranged functional nanoparticles in pores could contribute to constituting efficient proton transfer channels. The characteristics such as morphology, thermal stability, water uptake, dimensional swelling, proton conductivity and methanol permeability as proton exchange membranes, of the SiO 2 nanospheres, and the composite membrane were investigated. The formation of ionic channels in membrane enhanced the water uptakes and proton conduction abilities of the composite membranes. PVDF/Nafion/SiO 2 –NH 2 exhibited superior proton conductivities (0.21 S cm −1 ) over other samples due to several proton sites and the acid–base pairs formed between –NH 2 and –SO 3 H. Furthermore, all the composite membranes exhibited improved methanol resistance compared with Nafion. Therefore, such a design based on porous membrane provided feasibility for high-performance proton exchange membrane in fuel cell applications.
研究领域:
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zhijia Liao,Ninghao Chu,Zhenyu Yuan,Yanbai Shen,Fanli Meng
This study successfully synthesized “silver ear-like” Co(OH)F using 15 nm SiO 2 spheres as seeds. Gas sensitivity of Co(OH)F with and without SiO 2 spheres to toluene was compared at different annealing temperatures. The results demonstrate that the Co(OH)F-Si-350 sensor exhibits optimal gas sensitivity to toluene, with a response of 35 (R g /R a ) to 100 ppm of toluene at 220℃, with response and recovery times of 50 s and 80 s, respectively. Notably, the sensor detected toluene concentrations as low as 50 ppb, indicating good sensitivity to low concentrations. These findings suggest that the structural transformation resulting from the introduction of SiO 2 nanospheres, forming ultra-thin nanosheet clusters (∼12 nm), provides abundant active sites, effectively promoting substance diffusion and adsorption/desorption processes. Additionally, the incorporation of fluorine enhances the Lewis acidity of the material, facilitating the formation of stable adsorption states for gas molecules on the surface. These results reveal the significant impact of the structural transformation caused by the introduction of SiO 2 nanospheres on gas sensitivity, providing a strong theoretical foundation for further optimizing gas sensor design.
研究领域:
材料科学
·
传感器技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS & DESIGN
·
2017
·
IF 4.364
Ran Zhang,Rongrong Xie,Deping Liu,Xiaolong Jia,Qing Cai,Xiaoping Yang
Porous silica fibers were fabricated aiming to broaden the applications of SiO 2 nanosphere materials. The fibers were built with SiO 2 nanospheres via electrospinning and calcinations . At first, SiO 2 nanospheres (synthesized by Stober method) were surface-modified using γ-aminopropyltriethoxysilane to obtain SiO 2 -NH 2 nanospheres, which dispersed homogeneously in the solvent. Then, polyacrylonitrile (PAN) and polymethylmethacrylate (PMMA) were introduced in different weight ratios into the suspension. Subsequently, PAN/PMMA/SiO 2 composites were electrospun , followed by preoxidization and calcination to transfer PAN into carbon form and to remove PMMA component. Thus, porous silica fibers were fabricated with SiO 2 nanospheres binding together during carbonization and porous structure was formed. The porosity, pore size and pore volume of porous silica fibers were controllable by adjusting the content of SiO 2 nanospheres and the weight ratio of PAN/PMMA. Accordingly, the drug adsorption and release performance of these porous silica fibers depended on their micro-structural features. The thus-obtained porous silica fibers displayed great potentials in applications such as drug carriers and adsorbents.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 27
·期 12
·13161-13170
·
IF 1.798
Qin Tianxiu,Zhang Shuxia,Chen Pei,Zhao Fengqi,Gao Hongxu,Chen Xinbing,An Zhongwei
TiO 2 nanocrystals are inserted in the pores of monodispersed mesoporous SiO 2 nanospheres with 20–35 nm diameter by a facile two-step method involving vacuum-rotary evaporation and subsequent calcination. Characterization by XRD, TEM, EDX, FT-IR and N 2 sorption techniques suggests that, the pores of the mesoporous SiO 2 nanosphere can effectively stabilize the anatase phase of TiO 2 nanocrystals with size about 6 nm even at high temperature of 750 °C. The photocatalytic activities of the samples with different TiO 2 loading amount were evaluated by the degradation of Rhodamine B dye in aqueous solution under UV-light irradiation. It is found that photocatalytic efficiencies of these materials are much better than commercial P25. Where the sample with TiO 2 loading of 43 % exhibits the highest photocatalytic efficiencies with complete degradation of Rhodamine B within 32 min, which is attributed to the balance between high surface area and suitable TiO 2 loading amount.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
ANALYST
·
2015
·Vol. 140
·期 19
·6684-6691
·
IF 4.107
Fengmin Qiao,Zhenzhen Wang,Ke Xu,Shiyun Ai
A facile process was developed for the synthesis of FeSe–Pt@SiO2 nanospheres based on the hydrothermal treatment of FeCl3·6H2O, selenium and NaBH4 in ethanolamine solvent, followed by reducing HPtCl4 with NaBH4 in the presence of FeSe particles to obtain FeSe coated with Pt NPs (FeSe–Pt), ending with a surfactant assembled sol–gel process to obtain FeSe–Pt@SiO2. The morphology and composition of FeSe–Pt@SiO2 were characterized by transmission electron microscopy, high resolution TEM, X-ray diffraction and Fourier transform infrared spectroscopy. Structural analyses revealed that FeSe–Pt@SiO2 nanospheres were of regular spherical shape with smooth surfaces due to the SiO2 shells, compared with FeSe particles with 150 nm lateral diameter. The prepared FeSe–Pt@SiO2 nanospheres possessed both intrinsic glucose oxidase (GOx-) and peroxidase-mimic activities, and we engineered an artificial enzymatic cascade system with high activity and stability based on this nanostructure. The good catalytic performance of the composites could be attributed to the synergy between the functions of FeSe particles and Pt NPs. Significantly, the FeSe–Pt@SiO2 nanospheres as robust nanoreactors can catalyze a self-organized cascade reaction, which includes oxidation of glucose by oxygen to yield gluconic acid and H2O2, and then oxidation of 3,3,5,5-tetramethylbenzidine (TMB) by H2O2 to produce a colour change. Colorimetric detection of H2O2 and glucose using the FeSe–Pt@SiO2 nanospheres was conducted with high detection sensitivities, 0.227 nM and 1.136 nM, respectively, demonstrating the feasibility of practical sensing applications. It is therefore believed that our findings in this study could open up the possibility of utilizing FeSe–Pt@SiO2 nanospheres as enzymatic mimics in diagnostic and biotechnology fields.
研究领域:
生物传感
·
纳米医学
·
酶学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2015
·
IF 3.512
Na Cao,Xin Xie,Yu Zhang,Yanbao Zhao,Liuqin Cao,Lei Sun
Dendritic porous tin oxide/silica (DTS) nanospheres (NSs) were prepared by emulsion-condensation route. DTS NSs have an average diameter of 80 nm and possess accessible center-radial large pore channels, which endow them high surface area, less drug diffusion resistance and more mass transport. SnO 2 quantum dots (QDs) embedded in silica skeleton can be used to track the drug release behavior. DTS NSs were coated by chitosan/polymethacrylic acid and polymer shell would make them achieve great loading capacity and pH-sensitive release for aminomethylbenzoic acid (AMBA).
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2023
·Vol. 13
·期 7
·1294
·
IF 5.3
Luwei Shi,Longxing Zhang,Yanping Yang,Haipeng Zhang,Ruijie Yao,Caoquan Yuan,Shaobo Cheng
Polyethylene oxide (PEO)-based composite polymer electrolytes (CPEs) containing in situ SiO2fillers are prepared using an electrostatic spinning method at room temperature. Through the in situ hydrolysis of tetraethyl silicate (TEOS), the generated SiO2nanospheres are uniformly dispersed in the PEO matrix to form a 3D ceramic network, which enhances the mechanical properties of the electrolyte as a reinforcing phase. The interaction between SiO2nanospheres and PEO chains results in chemical bonding with a decrease in the crystallinity of the PEO matrix, as well as the complexation strength of PEO chains with lithium ions during the hydrolysis process. Meanwhile, the addition of SiO2nanospheres can disturb the orderliness of PEO chain segments and further suppress the crystallization of the PEO matrix. Therefore, improved mechanical/electrochemical properties can be obtained in the as-spun electrolyte with the unique one-dimensional high-speed ion channels. The electrospun CPE with in situ SiO2(10 wt%, ca. 45 nm) has a higher ionic conductivity of 1.03 × 10−3S cm−1than that of the mechanical blending one. Meanwhile, the upper limit of the electrochemical stability window is up to 5.5 V versus Li+/Li, and a lithium-ion migration number can be of up to 0.282 at room temperature. In addition, in situ SiO2electrospun CPE achieves a tensile strength of 1.12 MPa, elongation at the break of 488.1%, and it has an excellent plasticity. All in all, it is expected that the electrospun CPE prepared in this study is a promising one for application in an all-solid-state lithium-ion battery (LIB) with a high energy density, long life cycle, and high safety.Keywords:all-solid-state lithium battery;solid-state polymer electrolyte;in situ SiO2nanospheres;electrostatic spinning;electrochemical properties
研究领域:
材料科学
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Hongding Zhang,Sifei Wu,Mengwei Sun,Jiaoyu Wang,Man Gao,Hai-Bo Wang,Linxia Fang
Glutathione (GSH)-switched fluorescent assays have appealed much attention due to rapid signal changes of fluorescent probes. However, exposure to exterior environment of fluorescent probe causes photobleaching and premature leakage, leading to low sensitivity and poor photostability. Herein, luminescent SiO 2 nanoparticles encapsulated with Ru(bpy) 3 2+ ( [email protected] 2 ) were designed and synthesized as fluorescent probe to construct a GSH-switched fluorescent assay. The encapsulation of Ru(bpy) 3 2+ in the SiO 2 nanoparticles could effectively prevent the leakage of Ru(bpy) 3 2+ molecules, improving the photostability of probe. The fluorescence of [email protected] 2 nanoparticles was quenched by coating MnO 2 nanoparticles on [email protected] 2 surface ( [email protected] 2 @MnO 2 nanocomposites) through an in situ growth approach, which reduced background of the assay. The MnO 2 nanoparticles not only further inhibited the leakage of Ru(bpy) 3 2+ molecules, but also could serve as a recognition unit of GSH. In the presence of GSH, the MnO 2 nanoparticles on the surface of [email protected] 2 nanoparticles were reduced to Mn 2+ , resulting the fluorescence recovery of [email protected] 2 nanoparticles. Thus, a signal-on fluorescent strategy was constructed for GSH detection. The assay displayed good analytical performance for GSH detection with a low detection limit of 16.2 nM due to excellent fluorescence quenching ability of MnO 2 nanoparticles and special role of [email protected] 2 nanoparticles to block probe leakage. The proposed assay was also applied to measure GSH levels in human serum samples. This work paves a new way to detect GSH with high sensitivity.
研究领域:
分析化学
·
纳米技术
·
生物传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 65
·52369-52381
·
IF 3.84
Zhanchao Liu,Zhaoyong Hu,Yan Liu,Minjia Meng,Liang Ni,Xiangguo Meng,Guoxing Zhong,Fangfang Liu,Yanmin Gao
Utilising a general protocol for making surface-imprinted core–shell microparticles via a RAFT-mediated approach, we developed a Cu(II) imprinted polymer with a novel magnetic nanosphere, γ-Fe2O3@meso-SiO2, as support. Attributed to the controlled/living polymerization mechanism of the RAFT polymerization process, the Cu(II) imprinted polymer prepared by RAFT polymerization (IIP-RAFT) presented a more well-defined morphology, more mono-dispersed properties, and much higher magnetic responsiveness, compared to the Cu(II) imprinted polymer prepared by traditional free-radical polymerization (IIP-TP). Moreover, in the static saturation binding experiments, a higher binding capacity of IIP-RAFT (210 mg g−1) than IIP-TP (145 mg g−1) was also found. Afterwards, a series of adsorption experiments were carried out to systematically evaluate the adsorption performance of the as-prepared IIP-RAFT. And the results showed that IIP-RAFT exhibited excellent selectivity, good reusability and desirable dynamic adsorption behavior, and could be an ideal candidate for SPE sorbents for the removal of Cu(II) in real wastewater.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）