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Dendritic porous SnO2/SiO2@polymer nanospheres for pH-controlled styptic drug release

Na Cao,Xin Xie,Yu Zhang,Yanbao Zhao,Liuqin Cao,Lei Sun

Dendritic porous tin oxide/silica (DTS) nanospheres (NSs) were prepared by emulsion-condensation route. DTS NSs have an average diameter of 80   nm and possess accessible center-radial large pore channels, which endow them high surface area, less drug diffusion resistance and more mass transport. SnO 2 quantum dots (QDs) embedded in silica skeleton can be used to track the drug release behavior. DTS NSs were coated by chitosan/polymethacrylic acid and polymer shell would make them achieve great loading capacity and pH-sensitive release for aminomethylbenzoic acid (AMBA).