JOURNAL OF SURFACTANTS AND DETERGENTS
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2025
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IF 1.8
Bochuan Lin,Jing Wang,Jiansheng Zha,Kuan Chang
Solubilization of oil-soluble substances in aqueous solution is essential in daily chemistry. Commonly used synthetic solubilizers are environmentally harmful and have limited applications. In this study, sophorolipid, a biosurfactant, was purified through an efficient, simple, and solubilization-compatible method, yielding an aqueous acidic sophorolipid (acid-SL) with high purity of 96 wt%. The bola structure of acid-SL conferred reversible pH-responsive micelle behavior and therefore a distinctive solubilization effect on polar small molecules under neutral pH environment. Based on this, the synergistic solubilization effect of acid-SL in combination with rhamnolipid (RL) was confirmed, with the optimal compound ratio being acid-SL/RL = 0.95:0.05. The compound system significantly improved the solubilization ability under acidic conditions and had superior solubilization capacity for oil-soluble substances such as essential oils, fragrances, and preservatives compared to commonly used solubilizers like Polysorbate 20 and Polyoxyethylene 40.
研究领域:
应用化学
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环境科学
·
生物学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2017
·
IF 6.065
Mingming Sun,Mao Ye,Wentao Jiao,Yanfang Feng,Pingfeng Yu,Manqiang Liu,Jiaguo Jiao,Xiaojia He,Kuan Liu,Yuanchao Zhao,Jun Wu,Xin Jiang,Feng Hu
The emerging mixed contamination of antibiotics and microplastics in greenhouse soil has made the control of antibiotic resistant gene (ARG) transmission a novel challenge. In this work, surfactant sophorolipid was applied to enhance the dissipation of tetracycline (TC) and tet genes in the presence of microplastics in greenhouse soil. During 49 days of incubation, soil bacteria and phages were both found to be the crucial reservoirs of ARGs. Meanwhile, microplastic’s presence significantly inhibited the dissipation of TC and ARGs in the soil. However, sophorolipid application was proved to outweigh the negative impact caused by microplastic existence, and lead to the highest dissipation of soil TC and ARGs. Significant positive correlation was detected between the dissipation rate of water-soluble and exchangeable TC content and bacteria/phage co-mediated ARG levels. This also held true between the two fractions of soil TC and the ratio of ARG level in the bacteria to that in the phages (B ARGs /P ARGs ). The opposite impacts of microplastic presence and sophorolipid amendment on the TC/ARG dissipation found in this work provides new information for understanding ARG transmission between bacteria and phages in the mixed contaminated greenhouse soil.
研究领域:
环境科学
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微生物学
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DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2024
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IF 2.8
Xin-Xi Ding,Cheng Jiang,Mingguang Li,Xianghong Li,Dan-Dan Shao
Background Strengthening the recycling and utilization of resources is deeply significant in achieving carbon neutrality. The nanofiltration membranes possess separation ability within the nanoscale by utilizing special pore size ranges and surface charge properties, showing great application prospects in resource recycling. The commercial nanofiltration membranes are mainly prepared by interfacial polymerization with fast reaction speed and easy scaling-up advantages. However, the obtained polyamide nanofiltration membranes possess dense selective layers with low permeance and separation efficiency to the molecules. Herein, the biodegradable surfactant sophorolipid was added to the aqueous solution to improve the performance of the polyamide nanofiltration membranes. Results Compared with the traditional nanofiltration membranes, the permeance of the sophorolipid-modified nanofiltration membrane was improved from 3 to 18 L·m −2 ·h −1 ·bar −1 . The modified membrane showed high rejection of the dyes with large molecular structures and low rejection of those with small molecular structures. Conclusion The modified membrane may separate the mixed dye solution of congo red (molecular weight 696.66 g/mol) and indigo carmine (molecular weight 407.98 g/mol) and the mixed congo red/NaCl solution precisely. Besides, the modified membrane showed good anti-fouling properties in the long-term stability test. This study may offer research significance for the resource treatment of printing and dyeing wastewater. © 2024 Society of Chemical Industry (SCI).
研究领域:
环境科学
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材料科学
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DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 17
·11782-11793
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IF 3.9
Xiaoxiao Gu,Lixian Xu,Haoyang Yuan,Cailing Li,Juan Zhao,Shuang Li,Dinghua Yu
Anti-bacterial photodynamic therapy is the most promising treatment protocol for bacterial infection, but low accumulation of photosensitizers has seriously hindered their development in clinical application. Here, with inherent outstanding affinity to bacterial cell envelope, sophorolipid produced from Candida bombicola has been conjugated to toluidine blue (SL-TB) through amidation reaction. The structure of SL-TB conjugates was identified by 1H-NMR, FT-IR and ESI-HRMS. The interfacial assembly and photophysical properties of SL-TB conjugates have been disclosed through surface tension, micro-polarity, electronic and fluorescence spectra. After light irradiation, the log10 (reduced CFU) of free toluidine blue to P. aeruginosa and S. aureus were 4.5 and 7.9, respectively. In contrast, SL-TB conjugates showed a higher bactericidal activity, with a reduction of 6.3 and 9.7 log10 units of CFU against P. aeruginosa and S. aureus, respectively. The fluorescence quantitative results showed that SL-TB could accumulate 2850 nmol/1011 cells and 4360 nmol/1011 cells by P. aeruginosa and S. aureus, which was much higher than the accumulation of 462 nmol/1011 cells and 827 nmol/1011 cells of free toluidine blue. Through the cooperation of triple factors, including sophorose affinity to bacterial cells, hydrophobic association with plasma membrane, and electrostatic attraction, higher SL-TB accumulation was acquired, which has enhanced antibacterial photodynamic efficiencies.
研究领域:
微生物学
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药理学
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DOI
PubMed
高影响因子
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2021
·Vol. 105
·期 5
·2033-2042
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IF 4.813
Wang Xiao,Xu Na,Li Qinglin,Chen Shengqi,Cheng Hui,Yang Mo,Jiang Ting,Chu Jun,Ma Xiaojing,Yin Dengke
Liver cancer, one of the most common types of cancer in the world, is the second leading cause of death for cancer patients. For liver cancer, there is an urgent need for an effective treatment with no or less toxic side effects. Lactonic sophorolipids (LSL), as a potential anticancer drug, has attracted wide attention of pharmaceutical researchers with its good biological activities. The effects of LSL and cell death inhibitors were measured by MTT test on HepG2 cells. Meanwhile, the morphology of the cells was observed under a microscope. The apoptosis rate was detected by flow cytometry, and the expression levels of enzyme activity of Caspase-3 and Caspase-9 were measured by detection kits. Meanwhile, mRNA levels of Apaf-1 , Caspase-3 , Bax , and Bcl-2 were measured by quantitative real-time RT-PCR; protein levels of Caspase-3, Cleaved Caspase-3, Bax, and Bcl-2 were measured by western blot. LSL can inhibit the proliferation of cells, and it is possible to induce apoptosis in cells. The HepG2 cells with LSL co-culture exhibited typical apoptotic morphology, and the expression levels of enzyme activity of Caspase-3 and Caspase-9 increased ( P < 0.05). We also found that LSL increases cell apoptosis rate and regulates the expression of genes and proteins associated with apoptosis through the Caspase-3 pathway. These results indicate that LSL may be one of the potential drug candidates to inhibit the proliferation and induce apoptosis in HepG2 cells.
Key points
• LSL, which is of good biological activities such as anti-bacterium, virus elimination, and inflammatory response elimination, has been firstly used to intervene in vitro to investigate its effect on HepG2 cell proliferation. • LSL can inhibit the proliferation of cells, and it is possible to induce apoptosis in HepG2 cells through the Caspase-3 pathway. • The mechanism of LSL action on HepG2 cell proliferation was firstly also discussed, which provides a certain experimental reference for the clinical treatment of liver cancer. Graphical abstract
研究领域:
肿瘤学
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药理学
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细胞生物学
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Tingting Zhang,Hao He,Qing Xu,Jiasheng Lv,Chaoyi Wu,Yefei Zhou,Zhenjiong Wang
Lactonic sophorolipid (LSL) exhibits numerous surfactant activities, such as emulsification , wetting action, dispersion effect, and oil-washing activities. Nevertheless, LSLs have poor water solubility, which restrains their application in the petroleum industry . In this research, a new compound, lactonic sophorolipid cyclodextrin metal-organic framework (LSL-CD-MOFs), was obtained by loading LSL into γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs). The LSL-CD-MOFs were characterized by N 2 adsorption analysis, X-ray powder diffraction analysis, Fourier transform infrared spectroscopy , and thermogravimetric analysis . Loading LSL into γ-CD-MOFs significantly increased the apparent water solubility of LSL. However, the critical micelle concentration of LSL-CD-MOFs was similar to that of LSL. Furthermore, LSL-CD-MOFs effectively reduced the viscosities and improved the emulsification indices of oil–water mixtures. Oil-washing tests, which were conducted using oil sands, revealed that the LSL-CD-MOFs yielded an oil-washing efficiency of 85.82 % ± 2.04 %. Overall, γ-CD-MOFs are promising carriers for LSL, and LSL-CD-MOFs are a potential, low-cost, new, green surfactant for enhanced oil recovery.
研究领域:
石油工程
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材料科学
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化学工程
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环境科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
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IF 8.2
Qiang Zhang,Yu Miao,Haibin Zhao,Yi Liu,Zhiqiang Wu,Junjie Zhu,Yuan Fang,Baoye Ma,Lidong Chen,Qian Chen,Yang Yang
Acute lung injury (ALI), characterized by dysregulated inflammation, remains a life-threatening condition with high clinical morbidity and mortality. Aerosol inhalation offers a promising route for targeted pneumonia therapy; however, its efficacy is significantly limited by poor drug penetration through the airway mucus barrier. To address this challenge, we developed an innovative surfactant-based delivery system utilizing ring-opened sophorolipids (acidic sophorolipids, aSL), which endowed them with both surfactant properties and amphiphilicity, thereby achieving dual functionalities: (1) facilitating enhanced cellular endocytosis and prolonged pulmonary retention and (2) serving as a versatile platform for hydrophobic drug encapsulation. All-trans retinoic acid (ATRA), as a representative hydrophobic drug, was assembled into sophorolipids, forming aSL@ATRA, which effectively mitigated lung tissue damage by downregulating inflammatory cell infiltration (including macrophages, neutrophils, and monocytes) and key proinflammatory cytokine secretion, while preserving the alveolar–capillary barrier integrity. Moreover, aSL@ATRA exhibited a favorable safety profile, with nearly no observable adverse effects in ALI-bearing mice. These findings position aSL@ATRA as a breakthrough noninvasive inhalation platform, offering substantial therapeutic potential not only for ALI but also for other refractory respiratory diseases.
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产品关联
DOI
PubMed
高影响因子
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
·
2026
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IF 2.8
Wang Yaya,Di Zhiting,Akimbekov Nuraly S.,Liu Xiangrong,Tastambek Kuanysh,He Shihua,Zhou Anning,Bao Yuan
Anaerobic digestion (AD) represents a promising approach for enhancing coal resource utilization and advancing sustainable development within the coal industry. This study investigates the role of sophorolipid biosurfactants in enhancing methane production during coal AD. Sophorolipid supplementation significantly increased methane yield by reshaping the microbial community, enriching key bacteria ( Proteiniphilum , Petrimonas ) and methanogens ( Methanobacterium , Methanosarcina ). Metagenomic analysis revealed concurrent upregulation of glycolytic genes and critical pathways for pyruvate-to-acetate conversion ( aceE , PDH , ALDH ) and CO₂ reduction ( fdh , fdo ), driving methanogenesis through both acetoclastic and hydrogenotrophic pathways. Mechanistically, sophorolipid enhanced microbial membrane permeability and upregulated the TolC gene of the bacterial type I secretion system, facilitating extracellular enzyme release and coal depolymerization. These biological effects were complemented by physicochemical changes, including reduced liquid surface tension and increased ζ-potential, which improved microbe–enzyme–coal interactions. Fourier transform infrared spectroscopy and gas chromatography–mass spectrometry confirmed the degradation of aromatic and aliphatic hydrocarbons. Collectively, sophorolipid biosurfactants enhance coal biodegradation efficiency through synergistic microbial, genetic, and interfacial mechanisms, offering a promising strategy for cleaner coal conversion.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Xiaoxiao Gu,Dongmei Li,Haoyang Yuan,Cailing Li,Dinghua Yu,Guowei Wang,Shuang Li
Baicalin is a flavonoid compound extracted from the Scutellaria baicalensis plant. It possesses strong free radical scavenging ability and has a wide range of medical applications in antibacterial, anti-inflammatory, and anti-tumor fields. However, its limited solubility in water restricts its application. In this study, we prepared SL-DMEA by the amidation of acidic sophorolipids and N, N-dimethylethanolamine, while SL-TMEAI was synthesized via the quaternization of SL-DMEA with iodomethane. The structures of SL-DMEA and SL-TMEAI were confirmed by 1 H NMR, FT-IR, and Mass spectra. Surface tension and micelle microenvironment indicated that SL-DMEA and SL-TMEAI exhibit superior surface activity. Furthermore, the solubility of baicalin in aqueous solutions containing SL-DMEA and SL-TMEAI was approximately 70 mg/L and 75 mg/L, while it was only 18 mg/L in SL-COOH solution, which were significantly higher than the solubility in pure water (4 mg/L). Similarly, SL-DMEA and SL-TMEAI can enhance the antioxidant activity of baicalin. Specifically, in the SL-TMEAI aqueous solution, the free radical scavenging rate of baicalin was increased by 10 %–20 %. Density functional theory calculations revealed that SL-DMEA and SL-TMEAI formed stable hydrogen bonds with baicalin molecules, which can increase the solubility of baicalin in water and expose the groups that react with free radicals in the solution, thereby enhancing the antioxidant activity. These results demonstrated that SL-DMEA and SL-TMEAI could significantly enhance the solubility and antioxidating of baicalin in water through a hydrotropy mechanism.
研究领域:
生物化学
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药物化学
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材料科学
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产品关联
DOI
高影响因子
Scientific Reports
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2023
·Vol. 13
·期 1
·1-13
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IF 4.6
Xu Rui-Qi,Ma Ling,Chen Timson,Zhang Wei-Xiong,Chang Kuan,Wang Jing
Biosurfactants are attracting much interest due to their potential application as therapeutic agents in the medical and cosmetic field. Previous studies have demonstrated that biosurfactant such as sophorolipid (SL) exhibits immunomodulatory effects. In this article, we found the potential of sophorolipid for inhibiting histamine-induced itch and preliminarily explored its molecular basis. First, behavioral tests indicated that SL can remit the histamine-induced scratching behaviors of mice. Second, SL can suppress the the calcium influx induced by histamine, HTMT and VUF8430 in HaCaT cells. RT-PCR analysis showed that the histamine-induced upregulation of mRNA levels of phospholipase Cγ1, 1,4,5-trisphosphate receptor (IP3R), and protein kinase Cα can be inhibted by SL, suggesting that SL may impede the PLC/IP3R signaling pathway activated by histamine. In further tests, the capsaicin-induced calcium influx can also be inhibited by SL. The immunofluorescence and molecular docking analysis indicated that SL acts as an inhibitor of transient receptor potential vanilloid-1 (TRPV1) activation to decrease calcium influx against stimuli. In summary, these results revealed that SL may inhibit histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity. This paper indicates that SL can be a useful treatment for histamine-dependent itch.
研究领域:
药理学
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皮肤病学
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分子生物学
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治疗学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
·
IF 3.412
Shengfeng Peng,Ziling Li,Liqiang Zou,Wei Liu,Chengmei Liu,David Julian McClements
There is great interest in developing colloidal delivery systems to enhance the water solubility and oral bioavailability of curcumin, which is a hydrophobic nutraceutical claimed to have several health benefits. In this study, a natural emulsifier was used to form sophorolipid-coated curcumin nanoparticles. The curcumin was loaded into sophorolipid micelles using a pH-driven mechanism based on the decrease in curcumin solubility at lower pH values. The sophorolipid-coated curcumin nanoparticles formed using this mechanism were relatively small (61 nm) and negatively charged (−41 mV). The nanoparticles also had a relatively high encapsulation efficiency (82%) and loading capacity (14%) for curcumin, which was present in an amorphous state. Both in vitro and in vivo studies showed that the curcumin nanoparticles had an appreciably higher bioavailability than that of free curcumin crystals (2.7–3.6-fold), which was mainly attributed to their higher bioaccessibility. These results may facilitate the development of natural colloidal systems that enhance the oral bioavailability and bioactivity of curcumin in food, dietary supplements, and pharmaceutical products.
研究领域:
食品科学
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药剂学
·
营养学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Long Zhou,Bin Zheng,Kai Zhang,Chengjie Xue,Zhanqiang Fang
Nanoscale zero-valent iron (nZVI) is regard as a promising reductant for halogenated organic compounds remediation, while it still suffers from low reactivity and poor electron selectivity toward monobrominated diphenyl ether. In this paper, the modified nZVI was successfully prepared via introducing sophorolipid during the synthesis of nZVI by a one-step method (SL-nZVI). The experimental results demonstrated that the degradation efficiency of SL-nZVI for BDE-3 could reach up to 99.96%, which was significantly higher than that of nZVI (59.60%). TEM and BET characterizations indicated that the modified nZVI possessed excellent dispersion properties and higher specific surface area, while the electrochemical tests results revealed that the sophorolipid modification reduced the charge transfer resistance of nZVI and favored the electron transfer . Besides, the introduced sophorolipid enhanced solubilization of hydrophobic organic contaminants via halogen bonding interaction also contributes to the increasement of BDE-3 degradation. More importantly, the experimental results also indicated that the utilization efficiency and electron selectivity of nZVI particles for the BDE-3 were significantly improved after sophorolipid modification (from 56.64% and 2.69% to 74.14% and 7.39%, respectively), and this could be owned to more accessible active sites, as well as the increased hydrophobicity of nZVI, which is not conducive to the adsorption of hydrophobic BDE-3 onto the nZVI surface, but reduces the occurrence of side reaction between nZVI and water. Those results demonstrate that the sophorolipid modification is an efficient strategy for nZVI in the remediation of hydrophobic BDE-3, and also highlight the promising prospects of sophorolipid in increasing the reactivity and electron selectivity of nZVI.
研究领域:
环境科学
·
化学工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）