DALTON TRANSACTIONS
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2024
·Vol. 53
·期 44
·17989-18002
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IF 3.5
Jie Zhang,Langping Dong,Feng Wang,Jingshan Hou,Yongzheng Fang
Cyan-emitting phosphors are urgently needed to address the “cyan gap” in artificial full-spectrum lighting. In this research, a series of Sr(2−y)BayY4La4(SiO4)6O2:xEu2+ (0.005 ≤ x ≤ 0.08, 0.0 ≤ y ≤ 2.0) phosphors with tunable luminescence was synthesized. Through cation regulation, the luminescence color of Sr(2−y)BayY4La4(SiO4)6O2:xEu2+ can be adjusted from yellow to cyan. Crystal structure analysis revealed that Eu2+ ions simultaneously occupy [Sr1/Ba1Y1La1] and [Sr2/Ba2Y2La2] sites, resulting in multiple luminescence centers and a broadened emission spectrum. With increasing Ba2+ ion concentration, the PLE spectrum was red-shifted from 337 nm to 372 nm, and the excitation intensity in the violet region was significantly enhanced, making it more compatible with violet LED chips. Meanwhile, the PL spectrum was blue-shifted from 543 nm to 496 nm with increasing Ba2+ concentration, accompanied by an increase of about 10 times in the excitation and emission intensity. The optimized Ba2Y4La4(SiO4)6O2:0.02Eu2+ phosphor can be excited by violet light and emits bright cyan light effectively, which can be used to fill the “cyan gap”. Eventually, a series of white LED devices was manufactured by combining the as-prepared luminescence-tunable phosphors with commercial phosphors. Among them, the 410 nm violet LED chip-based WLED(Ba2) device comprising Ba2Y4La4(SiO4)6O2:0.02Eu2+ exhibited the best electroluminescence performance, increasing the color rendering index from 82.0 to 98.6, verifying the compensation effect of the Ba2Y4La4(SiO4)6O2:Eu2+ phosphor on cyan light.
研究领域:
材料科学
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光电子学
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固态照明
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无机化学
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发光材料
✓ 已验证
DOI
高影响因子
Biomaterials Advances
·
2022
·
IF 0
Liqiu Hu,Yongmei Ge,Zhe Cao,Ye Tian,QiLi Sun,Zhen Li,Jing Ma,Yutong Wu,Ning Wang,Bin Tang
Polyetheretherketone (PEEK) is a potential bone repair material because of its stable chemical and good mechanical properties. However, the biological inertness of PEEK limits its clinical application. Sr 2+ has multi biological functions, including promoting bone formation and blood vessel regeneration and inhibiting inflammation. In this paper, PEEK was modified with Sr 2+ with the purpose to construct PEEK bone graft material with triple functions of osteogenesis, angiogenesis, and anti-inflammatory. The results showed that Sr-modified PEEK could stably release Sr 2+ for a long time in the PBS solution, and indeed could promote the proliferation and differentiation of osteoblasts, promote angiogenesis, and inhibit inflammation. Therefore, it is believed that this multifunctional PEEK with Sr 2+ should show great promise for clinical applications in bone repair.
研究领域:
生物医学工程
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材料科学
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组织工程
✓ 已验证
产品关联
DOI
PubMed
Advanced Science
·
2024
·
IF 14.3
Jin Liu,Yilin Shi,Yajun Zhao,Yue Liu,Xiaoru Yang,Kai Li,Weiwei Zhao,Jianmin Han,Jianhua Li,Shaohua Ge
Surface modification is an important approach to improve osseointegration of the endosseous implants, however it is still desirable to develop a facile yet efficient coating strategy. Herein, a metal–phenolic network (MPN) is proposed as a multifunctional nanocoating on titanium (Ti) implants for enhanced osseointegration through early immunomodulation. With tannic acid (TA) and Sr 2+ self-assembled on Ti substrates, the MPN coatings provided a bioactive interface, which can facilitate the initial adhesion and recruitment of bone marrow mesenchymal stem cells (BMSCs) and polarize macrophage toward M2 phenotype. Furthermore, the TA-Sr coatings accelerated the osteogenic differentiation of BMSCs. In vivo evaluations further confirmed the enhanced osseointegration of TA-Sr modified implants via generating a favorable osteoimmune microenvironment. In general, these results suggest that TA-Sr MPN nanocoating is a promising strategy for achieving better and faster osseointegration of bone implants, which can be easily utilized in future clinical applications.
研究领域:
生物材料
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组织工程
·
免疫学
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骨科
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Yujie Zhang,Chuanfeng An,Yang Zhang,Haoyue Zhang,Abdullah Faqeer Mohammad,Qiao Li,Weijian Liu,Fei Shao,Jiayi Sui,Changle Ren,Kai Sun,Fang Cheng,Jia Liu,Huanan Wang
Cell microenvironment is a collection of dynamic biochemical and biophysical cues which functions as the key factor in determining cell behavior. Encapsulating single cell into micrometer-scale hydrogels which mimics the cell microenvironment can be used for single cell analysis, cell therapies, and tissue engineering. Here, we developed a microfluidics-based platform to engineer the niche environment at single cell level using alginate microgels crosslinked by different metal ions to regulate stem cell behavior for bone regeneration. Specifically, we revealed that Ca 2+ in the engineered microenvironment promoted osteogenic differentiation of encapsulated stem cells and substantially accelerated the matrix mineralization compared to Sr 2+ in vitro . However, the superior osteoinductive capacity of Ca 2+ compared with Sr 2+ led to comparable bone healing in a rat bone defect model. This attributed to Sr 2+ in microgels to inhibit the osteoclast activity and bone resorption after implantation. In summary, the present study demonstrates metal ions as a critical factor in the environmental cues to affect cell behavior and influence the efficacy of stem cell-based therapy in tissue regeneration, and provides new insights to engineer an expecting microenvironment for regenerative medicine.
研究领域:
组织工程
·
干细胞生物学
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再生医学
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生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Yi Huang,Yu Qiang,Ruobing Yi,Shuai Wang,Shanshan Liang,Liang Chen
Graphene oxide (GO) membranes are considered ideal candidates for efficient water treatment due to their unique two-dimensional structure and excellent sieving properties. However, the swelling of graphene oxide in aqueous solutions makes it still challenging for practical application. Inspired by the spider web, in this work, we developed a “network-trapped engineering” strategy to stabilize the interlayer spacings of GO membranes, which are defined as GS-Sr membranes. The sodium alginate (SA) and Sr 2+ were successfully fixed as the “network” and “rivets” in-between the GO nanosheets, respectively. Benefiting from the design of the network structure, the GS-Sr membranes exhibited excellent interlayer spacing stability. Meanwhile, this evenly distributed network structure in the GO laminates can further optimize the stacking of nanosheets, forming more orderly 2D confined nanochannels. As a result, the membranes exhibited superior salt/dye sieving performance, with a separation factor up to 179.13 for Na 2 SO 4 /CR, while still maintaining an outstanding water permeance of 70.14 L m −2 h −1 bar −1 . Furthermore, the GS-Sr membrane demonstrated stable separation performance in the long-term test, and the mechanical stability has also been enhanced in the mechanical test. Overall, compared with traditional simple cross-linking strategies, this strategy offers a new insight into fine-construction of two-dimensional nanochannels.
研究领域:
材料科学
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环境工程
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Qing Wang,Ya Gao,Yanzheng Chen,Xuan Wang,Qingguo Pei,Taiyu Zhang,Changping Wang,Jinsong Pan
Bone implant-associated infections and inflammations, primarily caused by bacteria colonization, frequently result in unsuccessful procedures and pose significant health risks to patients. To mitigate these challenges, the development of engineered implants with spatiotemporal regulation capabilities, designed to inhibit bacterial survival and modulate immune responses in the early stage, while promoting bone defect healing in the late stage is proposed. The implants are functionalized with ε-poly-l-lysine-phenylboronic acid (PP) via dynamic boronic ester bonds, which facilitate its release through a reactive oxygen species (ROS) and pH-responsive strategy, thereby establishing an antibacterial microenvironment on and around the implants. Additionally, the dynamic metal coordination interaction facilitates the loading and sustained release of Sr 2+ under an acidic environment, providing immunomodulatory and osteogenic effects. The ROS/pH-responsive feature, coupled with the implant-bone tissue integration process, affords precise spatiotemporal regulation of the Ti-TA-Sr-PP implants. This strategy represents a promising approach for the preparation of advanced bone implants.
研究领域:
生物材料
·
组织工程
·
生物医学工程
·
骨科
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）