Functionalized graphene oxide-modified poly(ε-caprolactone) composites ((graphene oxide)GO/PCL) were successfully synthesized by Steglich esterification for drug applications of controlled release. Lomefloxacin (LMF) was selected as a model drug to investigate its controlled release properties. The controlled release effect of the LMF-contained pills of the GO/PCL and polylactic acid blend was evaluated. In contrast to the pure PCL, GO/PCL could effectively adjust the time of drug release and release the drug at a constant rate, achieving the controlled release requirements. Furthermore, different additive amounts of graphene oxide have different effects on adjusting the time of controlled release, while the best result obtained under the ratio is 4% GO/PCL as carrier of drug. Thus, high-quality drug carrier materials are obtained which are more suitable for clinical use. Exploring the optimum addition of graphene oxide is very significant for the development of GO/PCL carrier material.
Poly(dimethylsiloxane)-block-methoxypolyethylene glycols (PDMS-b-mPEG) were synthesized by Steglich esterification. The high-permeable membrane (PSf/PDMS-b-mPEG) was prepared by using PDMS-b-mPEG as additives. The successful synthesis of PDMS-b-mPEG was confirmed by nuclear magnetic resonance. Field emission scanning electron microscopy images show that the distribution of finger-like macroporous and sponge-like macroporous can be modulated by controlling the ratio of the hydrophilic/hydrophobic components of additives. The distribution of additives and membrane wettability are validated with X-ray photoelectron spectroscopy and water contact angle test. The permeability of the blended membrane, especially for the membrane PSf/PDMS-b-mPEG1900 (M3), was remarkably improved. The water permeability of M3 (239.4 L/m2·h·bar) was 6.6 times that of the unblended membrane M0 (42.5 L/m2·h·bar). The findings of protein BSA filtration show that the flux recovery ratio of M3 is 89.2% at a BSA retention rate of about 80%, which demonstrates that the polysulfone membranes blended with PDMS-b-mPEG have excellent antifouling performance and extraordinary permeability.
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