ENERGY & FUELS
·
2022
·
IF 4.654
Bowen Sun,Ping Guo
Determination of condensate oil saturation in condensate gas reservoirs is the key parameter for estimating condensate oil blockage and gas well productivity. In PVT experiments, the constant volume depletion (CVD) method is usually adopted to obtain condensate oil saturation. However, in this method, the effect of porous media is not considered. This study applied a low field nuclear magnetic resonance (NMR) test instrument in which 1D T2 and 2D T1–T2 NMR techniques are carried out to investigate the condensate oil saturation of “condensate gas-saturated” core plugs in the depletion process of 29 to 5 MPa at 25 °C. It was observed here that the T1/T2 ratios of condensate oil and gas at the signal peak are approximately 20 and 60, respectively, and the condensate oil and gas could be distinguished by positions in 2D NMR T1–T2 maps. Additionally, a standard equation (the relationship between the signal intensity and the condensate oil saturation) with an excellent linear relationship was established for the calculation of the condensate oil saturation in core plugs. The results indicated that the condensate oil first appears in micropores, and the retrograde condensation phenomenon of the core mainly comes from the contribution of mesopores and macropores; furthermore, the maximum condensate oil saturation in the porous medium is 5.36% higher than that in the PVT cylinder, and the dew point pressure in the porous medium is 11.83% higher than that in the PVT cylinder. The T1–T2 NMR technique may become an efficient approach for assessing fluid distributions and saturations, simultaneously possessing potential applications for characterizing fluid occurrence states in the core.
研究领域:
石油工程
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地球物理
·
储层表征
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Qiao Wang,Yimin Gong,Jianing Li,Xin Zeng,Dan Luo,Yun Ling,Yaming Zhou,Zhenxia Chen
Metal-organic frameworks (MOFs) are crystalline porous materials with tunable structures, where metal ions or clusters serves as magnetic centers and organic ligands offer spatial separation. These characteristics, combined with their diverse topologies, make MOFs promising candidates for contrast agents (CAs) in magnetic resonance imaging (MRI). Herein we synthesized four MOFs based on the same triangular Fe3O clusters with different topologies: MIL-101(Fe) (mtn net), MIL-100(Fe) (moo net), MIL-59(Fe) (pcu net), and MIL-88B(Fe) (acs net). To clarify the relationship between topologies and T2 relaxivities, the MOFs were tailored into uniform, nanoscale spherical morphologies. Notably, the value of T2 relaxivity for MIL-88B(Fe) with acs topology is nearly three times of that for MIL-101(Fe) with mtn topology at 7.0 T. By comparing with the magnetic properties of Fe3O molecular clusters and Ga-doped MIL-88B(Fe), our analysis demonstrated the significant advantage of MOFs with fixed arrays, adjustable component and diverse topologies in enhancing magnetic relaxation. Cellular MRI experiments further revealed that MIL-88B(Fe) could differentiate between M1 and M2 macrophages, highlighting its potential for monitoring tumor progression. These findings offer valuable insights into how MOF topology can be strategically utilized to enhance T2 relaxivities for MRI applications.
研究领域:
材料科学
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医学影像
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生物医学工程
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DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 31
·18054-18061
·
IF 3.119
Jing Chen,Hui-Hui Xiang,Zu-Zhi Zhao,Yun-Kai Wu,Meng-Yu Fei,Meng-Meng Song
An ultra-sensitive T2-weighted MR imaging contrast agent was prepared based on Fe3O4 nanoparticles and Gd3+ ions (Fe3O4@Gd). Amino modified Fe3O4 nanoparticles were conjugated to diethylenetriamine pentaacetic acid, and finally coordinated with Gd3+ ions. The nanoparticles had a uniform morphology with a size of 100 nm and a Gd/Fe mass ratio of 1/110. The r2 (transverse relaxivity) of the Fe3O4 nanoparticles increased from 131.89 mM−1 s−1 to 202.06 mM−1 s−1 after coordination with Gd3+ ions. MR measurements showed that the aqueous dispersion of Fe3O4@Gd nanoparticles had an obvious concentration-dependent negative contrast enhancement. Hepatoma cells were selected to test the cytotoxicity and MR imaging effect. The application of Fe3O4@Gd nanoparticles as contrast agents was also exploited in vivo for T2-weighted MR imaging of rat livers. All the results showed the effectiveness of the nanoparticles in MR diagnosis.
研究领域:
医学影像学
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纳米医学
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生物材料学
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产品关联
DOI
PubMed
高影响因子
Science China-Materials
·
2024
·Vol. 67
·期 12
·4101-4110
·
IF 6.8
Luo Meng,Guo Jiajing,Zhu Yi,Deng Jiali,Lu Hongwei,Li Lei,Wang Zhongling
Acidity-activatable magnetic resonance imaging (MRI) nanoprobes offer great potential for in vivo cancer imaging by targeting the acidic tumor microenvironment (TME). However, their effectiveness is limited by the delayed response at tumor sites and uncontrollable background noise, compromising imaging accuracy and reliability. Herein, an acidic TME-responsive nanoprobe, SPIO@ZIF-8@Gd (SZG), with dually activatable T 1 and T 2 MR signals is shown for acidity-selective contrast enhancement in a rapid response manner. It shows decreased T 1 and T 2 contrast intensity in normal physiological conditions. Once targeting acidic TME, the zeolitic imidazolate framework-8 (ZIF-8) layer undergoes instantaneous decomposition, releasing Gd 3+ ( T 1 -weighted), and exposing the inner SPIO ( T 2 -weighted) core, thereby sequentially recovering the signals. Compared to previously reported T 1 - T 2 nanoprobes, SZG demonstrates noticeable “dual activation” after just 30 min and reaches its peak 4 h after acid incubation. Additionally, it shows an excellent “acidity correlation” between relaxation times and pH values. When the SZG nanoprobe is used combined with “dual-contrast enhanced subtraction (DESI)”, the contrast difference between diseased and normal tissue can be increased by 10 times, which is significantly higher than traditional single-mode T 1 / T 2 contrast agents. Collectively, these findings demonstrate a rapid imaging strategy of dual-activation MR imaging of the acidic TME and simultaneous background suppression, thus paving the way for precise tumor malignancy differentiation, early tumor detection, and accurate tumor grading.
研究领域:
医学影像学
·
生物材料学
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Yan Jia,Jinyan Liu,Shenghan Zhou,Xiaohui Ren
The depletion of fossil fuel reserves and their environmental impact have driven the adoption of ethanol-gasoline blends (EGBs) as an alternative fuel, with the aim of reducing gasoline consumption and greenhouse gas emissions. However, the introduction of water and pollutant ions during bioethanol production, transportation, and usage has the potential to lead to corrosion in pipelines and storage equipment. This study investigates the corrosion behaviour of T2 copper in EGBs containing a simulated liquid (SL) and evaluates the corrosion inhibition mechanism of Turkish red oil (TRO) as an eco-friendly inhibitor. Surface observation, electrochemical techniques, and surface analysis (SEM, AFM, XPS) were employed to assess corrosion behaviour. The results obtained from this study indicate that an increase in SL concentration results in an intensification of corrosion, as evidenced by a decrease in charge transfer resistance ( R ct ) and an increase in corrosion current density ( I corr ). The addition of TRO has been shown to significantly inhibit corrosion, with optimal efficiency exceeding 90 % at 500 ppm, resulting in a smooth copper surface. Furthermore, XPS analysis has confirmed the adsorption of TRO molecules on T2 copper, while theoretical analysis has revealed that TRO's electron-donating and electron-accepting groups facilitate parallel adsorption, thereby enhancing corrosion inhibition. This study provides experimental and theoretical insights into the corrosion inhibition of green organics in EGBs, supporting their wider application in sustainable energy systems.
研究领域:
材料科学
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化学工程
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能源研究
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产品关联
DOI
高影响因子
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
·
2021
·
IF 0.284
Hao Guo,Songjie Fan,Jianhua Liu,Yumei Wang
With co-precipitation method we successfully synthesized an aqueous dispersible, superparamagnetic manganese ferrite nanoparticles at relatively low temperature (190 °C). This material shows potential application as T 2 MRI contrast agent. Cost-effective and less toxic manganese (II) chloride (MnCl 2 ·4H 2 O) and iron (III) chloride hexahydrate (FeCl 3 ·6H 2 O) were used as precursors and 2-[2-(2-Hydroxyethoxy)ethoxy] ethanol (TEG) were utilized as solvent which served as stabilizer and provided a reduction system. The mean diameter of these nanoparticles is about 7 nm. Its saturation magnetization (Ms) and relaxivity value (r 2 ) are as high as 46 emu/g and 593.9 mM −1 s −1 respectively. In vitro cell study demonstrated pancreatic cancer cells could keep viable when the manganese ferrite nanoparticles concentration reached up to 50 μg/mL.
研究领域:
材料科学
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医学影像学
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2024
·
IF 10.7
Mingyue Ding,Leina Dou,Tong Bu,Zizhe Li,Yexuan Mao,Meng Dang,Xianqing Huang,Lianjun Song,Zhanhui Wang,Xiya Zhang
In this study, we incorporated nanometal surface energy transfer (NSET) in lateral flow immunoassay (LFIA) and explored the relationship between fluorescence quenching efficiency and detection sensitivity to improve sensitivity of NSET-LFIA system. We developed nine gold nanoparticles (GNPs) with absorption spectrum in the range of 520–605 nm as acceptors and quantum dot microspheres (QDMs) with emission spectrum of 530, 570, and 610 nm as donors. By analyzing the overlap integral area, fluorescence quenching efficiency, and detection sensitivity of 27 donor-acceptor pairs, we observed that the larger overlap integral area led to higher fluorescence quenching efficiency and detection sensitivity. A maximum fluorescence quenching efficiency of 91.0% was obtained from the combination of GNPs at 605 nm and QDMs at 610 nm, achieving the highest detection sensitivity. We developed NSET-LFIA for the detection of T2 toxin with a limit of detection of 0.04 ng/mL, which was 10-times higher than that obtained via conventional GNP-LFIA. NSET-LFIA represents a versatile, ultrasensitive and valuable screening tool for small molecules in real samples.
研究领域:
分析化学
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食品安全检测
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 27
·12905-12914
·
IF 6.97
Manman Xie,Shijia Liu,Christopher J. Butch,Shaowei Liu,Ziyang Wang,Jianquan Wang,Xudong Zhang,Shuming Nie,Qian Lu,Yiqing Wang
Superparamagnetic iron oxide nanoparticles (SPIONs) have a history of clinical use as contrast agents in T2 weighted MRI, though relatively low T2 relaxivity has caused them to fall out of favor as new faster MRI techniques have gained prominence. We demonstrate that SPIONs coated with a monolayer of succinylated heparin (Su-HP-SPIONs) exhibit over four-fold increased T2 relaxivity (460 mM−1 s−1) as compared to the clinically approved SPION-based contrast agent Feridex (98.3 mM−1 s−1) due to greatly increased water interaction from increased hydrophilicity and thinner coating as supported by our proposed parametric model. In vivo, the performance increase of the Su-HP-SPIONs in T2 MRI imaging of xenograft tumors is ten-fold that of our in-house synthesized Feridex analogue, due to better tumor localization from the smaller size imparted by the thinner coating. In addition to these significantly improved magnetic properties, the succinylated heparin coating also exhibits favorable synthetic reproducibility, solution stability, and biocompatibility. These findings demonstrate the untapped potential of SPIONs as possible high performance clinical T2 contrast agents.
研究领域:
医学影像学
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纳米医学
·
生物材料
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-12
·
IF 17.694
Lu Hongwei,Chen An,Zhang Xindan,Wei Zixiang,Cao Rong,Zhu Yi,Lu Jingxiong,Wang Zhongling,Tian Leilei
Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO 2 @MnO 2 , which shows decreased T 1 and T 2 contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO 2 ) layer decomposes into magnetically active Mn 2+ (T 1 -weighted), and the T 1 and T 2 signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T 1 and T 2 images can be accurately regulated by the silicon dioxide (SiO 2 ) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO 2 . Through the “dual-contrast enhanced subtraction” imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO 2 @MnO 2 is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation.
研究领域:
医学影像
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癌症研究
·
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2016
·
IF 8.387
Qiuming Liu,Liwen Song,Shuai Chen,Jingyi Gao,Peiyu Zhao,Jianzhong Du
Improving the relaxivity of magnetic resonance imaging (MRI) contrast agents is an important challenge for cancer theranostics. Herein we report the design, synthesis, characterization, theoretical analysis and in vivo tests of a superparamagnetic polymersome as a new MRI contrast agent with extremely high T 2 relaxivity (611.6 mM −1 s −1 ). First, a noncytotoxic cancer-targeting polymersome is synthesized based on a biodegradable diblock copolymer , folic acid-poly( l -glutamic acid)- block -poly( ε -caprolactone) [FA-PGA- b -PCL]. Then, ultra-small superparamagnetic iron oxide nanoparticles (SPIONs) are in situ generated in the hydrophilic PGA coronas of polymersomes to afford magnetic polymersomes. The in vivo MRI assay revealed prominent negative contrast enhancement of magnetic polymersomes at a very low Fe dose of 0.011 mmol/kg. Moreover, this cancer-targeting magnetic polymersome can effectively encapsulate and deliver anticancer drug to inhibit the tumor growth, demonstrating promising theranostic applications in biomedicine .
研究领域:
生物医学工程
·
纳米医学
·
分子影像学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 32
·1802281
·
IF 13.325
Chen Bai,Zhengyang Jia,Lina Song,Wei Zhang,Yi Chen,Fengchao Zang,Ming Ma,Ning Gu,Yu Zhang
To achieve the accurate diagnosis of tumor with the magnetic resonance imaging (MRI), nanomaterials-based contrast agents are developed rapidly. Here, a tumor targeting nanoprobe of c(RGDyK) modified ultrasmall sized iron oxide is reported with high saturation magnetization and high T 1 -weighted imaging capability, attributed to a large number of paramagnetic centers on the surface of nanoprobes and rapid water proton exchange rate (inner sphere model), as well as strong superparamagnetism (outer sphere model). These nanoprobes could actively target and gradually accumulate at the tumor site with a time-dependent T 1 –T 2 contrast enhancement imaging effect. In in vivo MRI experiments, the nanoprobes exhibit the best T 1 contrast enhancement at 30 min after intravenous administration, followed by gradually vanishing and generating T 2 contrast enhancement with increasing time at tumor site. This is likely due to time-dependent nanoprobes aggregation in tumor, in good agreement with in vitro experiment where aggregated nanoprobes display larger r 2 / r 1 value (19.1) than that of the dispersed nanoprobes (2.8). This dynamic property is completely different from other T 1 -T 2 dual-modal nanoprobes which commonly exhibit the T 1 - and T 2 -weighted enhancement effect at the same time. To sum up, these c(RGDyK) modified ultrasmall Fe 3 O 4 nanoprobes have significant potential to improve the diagnostic accuracy and sensitivity in MRI.
研究领域:
生物医学工程
·
纳米医学
·
影像诊断学
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Jialei Han,Ziwei Duan,Changjiang Liu,Yadong Liu,Xinyu Zhao,Bo Wang,Shuaishuai Cao,Dalin Wu
19F magnetic resonance imaging (19F MRI) is gaining attention as an emerging diagnostic technology. Effective 19F MRI contrast agents (CAs) for in vivo applications require a long transverse (or spin–spin) relaxation time (T2), short longitudinal (or spin–lattice) relaxation time (T1), high fluorine content, and excellent biocompatibility. Here, we present a novel hyperbranched polymeric 19F MRI CA based on β-cyclodextrin and phosphorylcholine. The influence of the branching degree and fluorine content on T2 was thoroughly investigated. Results demonstrated a maximum fluorine content of 11.85% and a T2 of 612 ms. This hyperbranched polymeric 19F MRI CA exhibited both great biocompatibility against cells and organs of mice and high-performance imaging capabilities both in vitro and in vivo. The research provides positive insights into the synthesis strategies, topological design, and selection of fluorine tags for 19F MRI CAs.
研究领域:
医学影像学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）