Communications Biology
·
2023
·Vol. 6
·期 1
·1-14
·
IF 5.9
Tang Ziyi,Jiang Wuqiao,Li Shuangli,Huang Xue,Yang Yi,Chen Xiaorong,Qiu Jingyi,Xiao Chuyu,Xie Ying,Zhang Xu,Li Jianguo,Verma Chandra Shekhar,He Yun,Yang Aimin
Antimicrobial peptides are promising alternatives to conventional antibiotics. Herein, we report a class of “tadpole-like” peptides consisting of an amphipathic α-helical head and an aromatic tail. A structure-activity relationship (SAR) study of “tadpole-like” temporin-SHf and its analogs revealed that increasing the number of aromatic residues in the tail, introducing Arg to the α-helical head and rearranging the peptide topology dramatically increased antimicrobial activity. Through progressive structural optimization, we obtained two peptides, HT2 and RI-HT2, which exhibited potent antimicrobial activity, no hemolytic activity and cytotoxicity, and no propensity to induce resistance. NMR and molecular dynamics simulations revealed that both peptides indeed adopted “tadpole-like” conformations. Fluorescence experiments and electron microscopy confirmed the membrane targeting mechanisms of the peptides. Our studies not only lead to the discovery of a series of ultrashort peptides with potent broad-spectrum antimicrobial activities, but also provide a new strategy for rational design of novel “tadpole-like” antimicrobial peptides.
研究领域:
生物化学
·
分子生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Biaowen Wei,Jun Feng,Caidi Chen,Shixi Zhong,Shijun Liao,Yigang Yu,Xiuhua Li
A series of tadpole-type ionic ionomers PPO-DMODAs with long alkyl side chains designed for electrodialysis (ED) desalination were synthesized successfully from dimethyloctadecylamine (DMODA) and brominated poly (2,6-dimethyl-1,4-phenylene oxide) (BPPO). The series of AEMs display stably low water uptakes ranging from 6.2% to 15.1% and high dimensional stabilities with swelling rations of 1.9%–4.8% at temperatures of 25 °C–60 °C. The nano-phase separated tadpole-type ionic structures ensure that the PPO-DMODAs membranes show excellent permselectivities with values above 94.6% and outstanding ED performances in the mostly reported desalination system of NaCl aqueous solutions. Especially, PPO-DMODA-3 surpasses commercial membrane TWEDA1 in ED competitions and ED-stability matches with current efficiency (η) of 88.7%, salt flux (J) of 80.61 mg m −2 s −1 , energy consumption (EC) of per kg of NaCl of 2.56 kWh kg −1 and η retentions of the repeated runs higher than 97% of that of the origin run. Moreover, PPO-DMODA-3 membrane obtained from the ethanol solution exhibits stable aggregate structure and ED performances comparable to those of the PPO-DMODA-3 membranes cast with NMP and TCE solutions. Good solubility of PPO-DMODAs in ethanol offers an environmentally friendly green method to fabricate ED AEMs. In consideration of the advantages of low cost, simple synthesis process and green membrane casting technology, PPO-DMODA-3 membrane has a strong potential for ED-desalination application.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 12
·2877-2884
·
IF 6.331
Yanping Cao,Shengjie Liu,Zhaoqiang Wu,Hong Chen
Linear poly(N-hydroxyethylacrylamide) (PHEAA) is regarded as one of the most promising antifouling materials because of its excellent antifouling properties and good hemocompatibility. However, the antifouling performance of topological PHEAAs remains largely unknown. Herein, the preparation of antifouling surfaces based on a tadpole-shaped PHEAA coating is reported for the first time, and how the tadpole-shaped PHEAA architecture affects antifouling performance is investigated. It is shown that the tadpole-shaped PHEAA-modified surfaces exhibit better antifouling performance than linear copolymer precursor-modified surfaces with identical molar masses and chemical compositions. This may be primarily attributed to the presence of cyclic PHEAA head chain segments in the tadpole-shaped PHEAA copolymer, and the absence of interchain entanglements can facilitate the formation of smoother and densely packed grafts, which result in better antifouling properties.
研究领域:
材料科学
·
表面化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Comparative Biochemistry and Physiology D-Genomics & Proteomics
·
2021
·
IF 2.674
Liming Chang,Bin Wang,Meihua Zhang,Jiongyu Liu,Tian Zhao,Wei Zhu,Jianping Jiang
Corticosterone (CORT)-mediated adaptive plasticity improves animal fitness in stressful environments. Although it brings ecological benefits, the cost potentially constrains its expression and evolution. Revealing the factors affecting plasticity costs is of great ecological and evolutionary significance. Evidence indicates that both CORT and background colour can induce metabolic changes in animals, which in turn determine phenotypic plasticity . However, whether and/or how CORT and background colour jointly act on plastic responses has not been studied. Here, this question has been investigated in amphibian tadpoles ( Microhyla fissipes ) exposed to CORT at different background colours (white or black) using integrated morphological, histological, and transcriptomic analyses. The results showed that CORT exposure increased relative tail length, immune function, and metabolic maintenance (i.e., transcription of substrate catabolism and oxidative phosphorylation) at the expense of reduction in growth rate and skin melanin level. The black background also increased relative tail length and metabolic maintenance (i.e., transcription of oxidative phosphorylation) at the cost of reduction in growth rate, but increased skin melanin level. The expression of critical pigmentation genes indicated that black background activated a distinct and opposite pigmentation regulating route to CORT. Although there was no interactive effect of background colour and CORT on phenotypic and metabolic variations, their additive effects further impact the trade-off between somatic growth, metabolic maintenance, and pigmentation in terms of resource allocation. In conclusion, the individual and additive effects of background colour and CORT exposure on tadpole plasticity were revealed. These results likely provide new insights into the environmental adaptation of animals.
研究领域:
生态学
·
进化生物学
·
生理学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Ming You,Fangzhi Mou,Ke Wang,Jianguo Guan
In analogy to eukaryotic cells that move by beating the flagella, magnetically powered micro/nanorobots with flexible filaments are capable of eluding the limitation of the scallop theorem to generate net displacement in a three-dimensional space, but they are limited by complicated fabrication and low speed. Here, we demonstrate a tadpole-like flexible microswimmer with a head and tail that are both magnetic by developing a magnetically assisted in situ polymerization method. The flexible microswimmer consists of a magnetic-bead head fixed to a nanochain bundle of magnetic nanoparticles (tail), and the tail length and stiffness can be adjusted simply by changing the duration and strength of the applied magnetic field during fabrication, respectively. For the microswimmer under an oscillating magnetic field, the magnetic head generates an undulatory motion, which can be further increased by the flexible magnetic tail. The magnetically induced undulation of the head and tail generates a traveling wave propagating through its flexible tail, resulting in efficient tadpole-like propulsion of the microswimmer. The flexible microswimmer runs at a maximum motion speed when the tail length is ∼5 times the diameter of the magnetic head, corresponding to ∼half the wavelength of the undulatory motion. The flexible microswimmers reported here are promising for active sensing and drug delivery, as the tails can be designed with various responsive hydrogels, and the results are expected to advance flexible micro/nanorobots.
研究领域:
生物医学工程
·
纳米技术
·
机器人学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2016
·Vol. 27
·期 10
·1376-1382
·
IF 1.823
Naipu He,Yue Wang,Zhenwu Lu
The temperature-responsive poly (N, N-diethylacrylamide) (pDEAAm) with narrower molecular weight distribution was prepared by the atom transfer radical polymerization and characterized by 1 HNMR and gel permeation chromatography. The temperature-responsive “tadpole-shaped” BSA–pDEAAm hybrids were fabricated via a free Cys-34 residue of bovine serum albumin (BSA) site specifically binding to the end group disulfide bonds of pDEAAm and characterized by native-polyacrylamide gel electrophoresis (Native-PAGE) and matrix-assisted laser desorption/ionization time of flight mass spectrometry. Their temperature-responsive behaviors were measured by ultraviolet-visible spectra (UV-Vis). The lower critical solution temperature (LCST) of the pDEAAm was identified as 28°C, and the LCST of BSA–pDEAAm hybrids was identified as 31°C. The morphologies of BSA–pDEAAm hybrids self-assembled in the aqueous solutions with two different temperatures at 25 °C and 40°C were investigated by transmission electron microscopy. Below the LCST of BSA–pDEAAm hybrids, the separate spherical nanoparticles were observed. In contrast, bundles and clusters were observed above the LCST of BSA–pDEAAm hybrids. The results suggested that the self-assembly morphology of BSA–pDEAAm hybrids depended upon the pDEAAm block in BSA–pDEAAm hybrids, and the morphology transitions were effected by the LCST of BSA–pDEAAm hybrids. It would be expected to be used in biomedicine and materials science. Copyright © 2016 John Wiley & Sons, Ltd.
研究领域:
高分子化学
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Jiancong Pan,Manru Liu,Biaowen Wei,Shijun Liao,Xiuhua Li
Three kinds of long-side-chain-modified tadpole-type anion exchange membranes (AEMs) named QPEK-DMODAs with microphase separated structures designed for electrodialysis (ED) acid recovery were fabricated from N,N-dimethyloctadecylamine (DMODA) as quaternization agent and poly(arylene ether ketone) (PEK) as skeleton, which is the copolymer of 2,2′,6,6′-tetramethyl biphenol (TMBP) and 4,4′-difluorobenzophenone (DFBP). QPEK-DMODAs were characterized systematically including basic structures and properties, ED recovery performance of H 2 SO 4 solutions without or with metal impurities, and corrosive acid stability. The well-defined microphase separation structure of QPEK-DMODA-3 is formed by the suitable distribution of tadpole ionic groups at the highest IEC of 2.09 mmol g −1 . The aggregate structure offers the membrane competent mechanical stability, ion conductivity and permselectivity, as well as low energy consumption and water transport ratio at the ED process. QPEK-DMODA-3 exhibits higher current efficiency (54.58 %) and recovery H + concentration (1.74 M) than those of QPEK-DMODA-1, QPEK-DMODA-2 and commercial AMX with comparable energy consumption to that of AMX under the ED conditions of Fe 2+ absence. Moreover, the Fe 2+ removal rate (88.74 %) and ion selectivity (S = 57.32) of QPEK-DMODA-3 are remarkably higher than those of AMX (67.10 % and 17.32) without the scarce of recovery efficiencies in the ED recovery tests of 0.50 M H 2 SO 4 solution containing 0.10 M of Fe 2+ . The combination of the comparable tolerance to strong acid to that of AMX and the confirmed good ED recovery performances declares a strong potential of tadpole-type QPEK-DMODA-3 in waste acid recovery by electrodialysis.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Yumeng Gao,Wentao Wang,Mohsen Mohammadniaei,Ming Zhang,Jian Shen,Ninglin Zhou
Bacterial infection has become a global health issue. The misuse of antibiotics has been resulting in increased drug resistance and bioaccumulation. Therefore, developing a highly safe antibacterial agent, with high antibacterial performance is demanding. Inspired by the natural motors performing automated tasks in complicated living environments, we demonstrate tadpole-like nanoparticles (TNPs) with several functions, including high photothermal conversion efficiency, peroxidase-like catalytic activity, glutathione peroxidase-like activity, and catalase-like activity. TNPs produce hydroxyl radical (•OH) at an extremely low concentration of hydrogen peroxide of 0.006%, which can damage bacterial cell membranes, proteins, and DNA. Moreover, the glutathione peroxidase-like activity disrupts the anti-oxidative mechanism of bacteria and improves the permeability of the cell membranes, consequently enhancing the killing effect of ROS. In addition, TNPs possess tadpole-like asymmetry to overcome Brownian motion, demonstrating strong directional motion propelled by O 2 . The in vivo experiments indicate that TNPs could also shorten the inflammatory period and promote angiogenesis, making them a very promising antibacterial agent.
研究领域:
纳米技术
·
生物医学工程
·
材料科学
·
微生物学
·
治疗学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2021
·
IF 4.43
Hualong Zhang,Wen Xu,Zhigang Wu,Chao Liu,Chunyan Hong
In this study, an efficient strategy was presented to prepare monocyclic polymers via combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and light-induced cycloaddition reaction, and tadpole-shaped copolymer was further synthesized via ring-opening polymerization (ROP) using cyclic polystyrene (C-PS) as macroinitiator. A series of well-defined α, ω-hetero bifunctional homopolymers with furan-protected maleimide and o-methylbenzaldehyde terminals, including polystyrene (PS), poly ( N, N -dimethylacrylamide) (PDMA) and poly ( N -isopropylacrylamide) (PNIPAAm) were prepared via RAFT polymerization. After deprotection, highly active maleimide group at the end of linear polymer coupled intramolecularly with photoenol structure (photoisomer of o-methylbenzaldehyde) via Diels-Alder cycloaddition reaction under 365 nm UV irradiation in dilute solution, leading to the formation of cyclic polymer. The monocyclic polymers were characterized with 1 H NMR, UV–Vis spectroscopy, gel permeation chromatography (GPC) and MALDI-TOF MS. Furthermore, the C-PS containing hydroxyl group was used as macroinitiator to prepare tadpole-shaped copolymer CPS- b -PCL via the ROP of ε-caprolactone.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2026
·
IF 15.5
Fu Zhao,Qin Yuanbo,Qi Feng,Di Chunyang,Zhao Zengqiong,Li Yutong,Wang Jinbin,Chen Jing,Song Hongjia,Zhong Xiangli
Damping materials play a crucial role in mitigating vibrations and minimizing noise pollution across both military and civilian sectors. However, they often encounter the challenge of damping failure under extreme or variable temperature environments due to the narrow glass transition region. Herein, we proposed an innovative strategy by introducing natural phenol (D-α-tocopherol) into the disulfide-based polyurethane elastomer (PUE), which exhibited ultra-wide effective damping temperature range (–53 ~ 118 ℃), large Tan δ area (77 K) and excellent self-healing properties compared with reported PUE composites. Interestingly, D-α-Tocopherol possesses molecular structure resembling tadpoles with abdominal suckers and flexible tails, which facilitated the formation of intermolecular hydrogen bonds and dangling chains in the PUE. The intermolecular hydrogen bond promoted the phase separation of the soft and hard segments in PUE, thus forming ultra-wide glass transition regions. Meanwhile, the dangling chain effectively increased the free volume between the PUE chains, facilitating the movement of the PUE chain and further accelerating the breaking and recombination of hydrogen and disulfide bonds. The introduction of D-α-Tocopherol increased the energy-loss pathways and significantly enhanced the damping performance of the PUE composites from low to high temperature. This work provides a novel strategy for designing high-performance damping materials.
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2021
·Vol. 42
·期 20
·2100354
·
IF 5.734
Haohui Huo,Zepeng Li,Tianyi Tan,Long Chen,Goran Ungar,Richard Hoogenboom,Qilu Zhang,Feng Liu
A general approach to asymmetrically localize nanoparticles (NPs) in larger polymeric nanostructures is demonstrated by coassembly of tadpole-like silver NPs (AgNPs) and amphiphilic block copolymers (BCPs). The tadpole-like AgNPs are prepared by template synthesis using a tailor-made A(BC) 20 star polymer, namely poly(ethylene glycol)[poly(acrylic acid)- block -polystyrene] 20 [PEG(PAA- b -PS) 20 ], as template resulting in AgNPs decorated with twenty short PS chains and one long PEG chain, named Ag@PEG(PS) 20 . The asymmetric distribution of these AgNPs in various polymeric nanostructures, e.g., spherical micelles, cylindrical micelles, vesicles, and sponge phase, is achieved via coassembly of the as-prepared Ag@PEG(PS) 20 and PEG- b -PS in solution driven by the anisotropic nature of the Ag@PEG(PS) 20 . This report not only provides a new strategy for the fabrication of tadpole-like NPs but also offers opportunity for off-center distributing NPs in hybrid assemblies, which may find applications in, e.g., sensing, catalysis, and diagnostics.
研究领域:
高分子化学
·
纳米材料科学
·
胶体与界面化学
·
生物医用材料
·
药物递送系统
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 40
·6529-6538
·
IF 5.342
Xiaoqiang Xue,Yangjing Chen,Kang Liang,Wenyan Huang,Hongjun Yang,Li Jiang,QiMin Jiang,Bibiao Jiang,Hongting Pu
The ring-forming behavior of polymers with an odd number of arms in highly dilute solutions has been studied using tri-arm polystyrene (PSt3) as a model through combining atom transfer radical polymerization (ATRP) and atom transfer radical coupling (ATRC) technologies. The star polymer, PSt3, with three arms and a central core was obtained by ATRP of styrene using a designed initiator with three active Br terminals and ester groups, followed by the Br terminal–Br terminal radical coupling of PSt3, which was implemented via intramolecular ATRC under high dilution conditions. A tadpole-shaped cyclic polymer (tadpole-PSt) was successfully prepared, proving that there no intermolecular side reactions that occur during the intramolecular ATRC of PSt3. Interestingly, the tadpole-PSt not only possesses a cyclic topology, but also contains a living chain, in contrast to other cyclic analogues that have been previously reported. Finally, the tadpole-PSt was used as a building block to construct a type of barbell polymer (barbell-PSt) by removing most of the solvent via vacuum distillation at the end of the intramolecular ATRC of PSt3. Size exclusion chromatography, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, 1H nuclear magnetic resonance spectroscopy and hydrolysis experiments proved that high-purity cyclic polymers (tadpole-PSt and barbell-PSt) were successfully prepared. The thermal properties of the cyclic and star polymers were analyzed using differential scanning calorimetry and thermogravimetric analysis. The results demonstrated that the formation of a cyclic topology makes a huge contribution to the increase in the glass transition temperature (Tg) and thermal stability of the polymer.
研究领域:
聚合物科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）