JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Yi Hao,Xingyan Wang,Kaili Wang,Sijie Zhang,Long Zhang,Wenhao Liu,Xueyi Liu,Ruixia Gao,Sicen Wang,Jingang An
The rise of drug-resistant bacteria, including multidrug-resistant (MDR) strains, has exposed the limitations of current antibiotic treatments. Chemodynamic therapy (CDT) has emerged as a promising approach due to its ability to generate reactive oxygen species (ROS) through Fenton or Fenton-like reactions in infection microenvironments (IMEs). However, the short lifespan, limited diffusion range of ·OH, and restricted variety of ROS reduce the effect of CDT. This study developed amine porphyrins (TAPP)-functionalized Fe 3 O 4 nanoparticles (Fe 3 O 4 @TAPP NPs) as a multifunctional antibacterial platform. The TAPP layer can not only trap bacteria through electrostatic attraction in acidic environments but also increase the localized heat upon near-infrared (660 nm) excitation, reducing the effective action distance and boosting the production rate of ·OH. Notably, TAPP was covalently bonded to Fe 3 O 4 nanoparticles via its amine groups and the carboxylic groups on Fe 3 O 4 , preventing TAPP self-aggregation under physiological conditions, and preserving the PDT effect. Therefore, the TAPP layer on Fe 3 O 4 nanoparticles performs three functions, resolving the three limitations simultaneously to enhance CDT in a triple-action strategy. The developed Fe 3 O 4 @TAPP NPs exhibit improved antibacterial efficiency both in vitro and in vivo . Overall, this study provides an innovative strategy to construct an antibacterial nanoplatform for synergistically enhanced CDT antibacterial treatment, exhibiting great potential for future biomedical applications.
研究领域:
生物医学工程
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纳米医学
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感染与免疫
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
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IF 9.5
Yanqing Wei,Yize Zhao,Yue Liu,Na Luo,Zunchang Gao,Pu Hou,Yang Liu,Yanhua Zhang,Pengfei Huo
Nanochannel ionic diodes require extremely complex and expensive fabrication processes. Polyelectrolyte ionic diodes attracted widespread attention among ionic rectification systems due to their simplicity of development and the ability to break the size limits of the nanochannel. However, enhancement of their rectification ratio is still in the exploratory stage. In this study, chitosan (CS) hydrogels and sodium polyacrylate (PAAs) hydrogels were prepared as the substrates for the heterostructured ionic diodes. 5,10,15,20-Tetrakis(4-aminophenyl)-21H,23H-porphyrin (TAPP) was selected to regulate the rectification ratio of ionic diodes. By adding 0.05 wt % TAPP to the CS hydrogel, the rectification ratio of the ionic diode can be increased to 10, which is 4 times larger than that of the undoped ionic diode. In contrast, the rectification ratio of the ionic diodes with TAPP added in the PAAs hydrogel decreases to 2. In addition, the ionic diode composed of the TAPP-doped CS hydrogel and PAAs hydrogel has the characteristics of a high open-circuit voltage. The open-circuit voltage of the 10 mm × 10 mm × 4 mm heterojunction hydrogel reached 370 mV. The ionic diodes can be used as a self-powered power supply device.
研究领域:
材料科学
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电化学
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纳米技术
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能源存储
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2021
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IF 6.988
Jing Li,Junhua Li,Yuji Pu,Sai Li,Wenxia Gao,Bin He
In this study, we reported a nanocomplex (PAF) of PEGylated polygalacturonic acid, 5,10,15,20-tetrakis (4-aminophenyl) porphyrin (TAPP), and Fe3+ for photodynamic therapy (PDT)-enhanced ferroptosis in cancer treatment. PAF exhibited a size of 135 nm and a TAPP and Fe3+ loading content of 6.99 and 0.77%, respectively. The singlet oxygen (1O2) generation capacity of TAPP can be activated and significantly enhanced at acidic pH (4.5–5.0). Besides, the enhanced near-infrared absorption of TAPP at acidic pH enabled a further increase in 1O2 generation capability by a near-infrared laser (760 nm). The polysaccharide-based polymer carrier offers excellent biocompatibility, and PAF displayed a proliferative effect in both normal (L929) and cancer (B16) cells. However, upon light irradiation, PAF exhibited high toxicity to B16 melanoma cells by intracellular reactive oxygen species elevation, glutathione depletion, and lipid peroxidation. PAF displayed a much better anticancer effect than the nanocomplex containing Fe3+ or TAPP alone, indicating the PDT-enhanced ferroptosis in PAF. This study suggested that PDT-enhanced ferroptosis could be a facile and robust strategy of nanotherapeutics with high potency, tumor selectivity, and excellent biocompatibility.
研究领域:
纳米医学
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癌症治疗
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2022
·Vol. 14
·期 27
·9702-9714
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IF 8.307
Haijiao Wang,Jun Tao,Chaoli Xu,Ying Tian,Guangming Lu,Bin Yang,Zhaogang Teng
Nanoparticle flexibility is an important parameter in determining cell uptake and tumor accumulation, thus modulating therapeutic efficiency in cancer treatment. Herein, we successfully prepared CuS-embedded human serum albumin hollow nanocapsules (denoted CuS/HSA) by a hard-core-assisted layer-by-layer coating approach. This approach afforded CuS/HSA hollow nanocapsules with controllable shell thickness, tunable flexibility, uniform size (272.9 nm), a large hollow cavity, peroxidase-like activity, excellent photothermal conversion ability, and a high tetra-(4-aminophenyl) porphyrin (TAPP) loading capacity (27.3 wt%). The peroxidase-like activity of the CuS nanoparticles enabled them to overcome tumor hypoxia and augment the sonodynamic therapeutic (SDT) effects and photothermal conversion ability for photothermal therapy (PTT). In vitro experiments showed that the CuS/HSA-TAPP hollow nanocapsules efficiently induced cancer cell apoptosis under US irradiation and cancer cell ablation under laser irradiation, thus facilitating synergistic SDT and PTT. Importantly, the flexibility of the CuS/HSA hollow nanocapsules resulted in significantly enhanced cellular internalization and a longer mean residence time (131.3 h) than their solid counterparts (21.0 h). In a breast tumor model, the flexible CuS/HSA hollow nanocapsules exhibited high tumor accumulation of up to 27.1%. In vivo experiments demonstrated that the flexible CuS/HSA-TAPP hollow nanocapsules effectively eliminated breast tumors via the synergistic effect of SDT and PTT.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）