GENE
·
2015
·
IF 2.138
Ping Chen,Jiying Wang,Haiyin Li,Yan Li,Peng Chen,Tian Li,Xi Chen,Junjie Xiao,Liang Zhang
In insects, pigment patterns are formed by melanin, ommochromes, and pteridines. Here, the effects of pteridine synthesis on melanin formation were studied using 4th instar larvae of a wild-type silkworm strain, dazao ( Bombyx mori ), with normal color and markings. Results from injected larvae and in vitro integument culture indicated that decreased activity of guanosine triphosphate cyclohydrolase I (GTP-CH I, a rate-limiting enzyme for pteridine synthesis), lowers BH4 (6R- l -erythro-5,6,7,8-tetrahydrobiopterin, a production correlated with GTP-CH I activity) levels and eliminates markings and coloration. The conversion of phenylalanine and tyrosine to melanin was prevented when GTP-CH I was inhibited. When BH4 was added, phenylalanine was converted to tyrosine , and the tyrosine concentration increased. Tyrosine was then converted to melanin to create normal markings and coloration. Decreasing GTP-CH I activity did not affect L-DOPA (3,4- l -dihydroxyphenylalanine). GTP-CH I affected melanin synthesis by generating the BH4 used in two key reaction steps: (1) conversion of phenylalanine to tyrosine by PAH (phenylalanine hydroxylase) and (2) conversion of tyrosine to L-DOPA by TH (tyrosine hydroxylase). Expression profiles of BmGTPCH Ia , BmGTPCH Ib , BmTH , and BmPAH in the integument were consistent with the current findings.
研究领域:
昆虫学
·
生物化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 42
·18166-18176
·
IF 2.7
Jing Xiao,Linshan Peng,Ailan Ouyang,Xin Mo,Yiping Yao,Chunyan Wang,Chunpei Yan
A phosphonate-functionalized Zr@FMA material was prepared in this work as an adsorbent for the efficient recovery and enrichment of Th(IV) from aqueous solutions. The adsorbent, prepared by functionalizing Zr@FMA with alendronate sodium (ALS), a well-known active bisphosphonate, demonstrates good water stability and a large surface area, making it suitable for the separation and enrichment of Th(IV) in aqueous solutions. A comparison of the adsorption behavior of Th(IV) on Zr@FMA-ALS with the unfunctionalized Zr@FMA reveals that the introduction of phosphonate groups significantly enhances the maximum adsorption capacity and rate of Zr@FMA-ALS. The adsorption data aligns well with the Langmuir isotherm model, suggesting a uniform distribution of Th(IV) on the adsorbent surface in a monolayer coverage. Thermodynamic analysis indicates an endothermic and spontaneous adsorption process. Zr@FMA-ALS also shows excellent selectivity for Th(IV) over other metal ions in mixed solutions. Insights into the adsorption mechanism are provided through SEM, XPS, and FT-IR analyses, indicating that ALS molecules play a crucial role in capturing Th(IV) on the surface of Zr@FMA-ALS.
研究领域:
化学工程
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材料科学
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环境科学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Lijun Guo,Liangqiong Peng,Jiheng Li,Wenhua Zhang,Bi Shi
The simultaneous removal and selective separation of U(VI) and Th(IV) via adsorption remain challenging due to their strong mobility, reactivity, and similar chemical properties. Thus, a surface-functioned lignin nanoparticle (AL-PEI) was synthesized to adsorb U(VI)/Th(IV) in a unitary system via a pH-dependent process. In alkaline solution, AL-PEI exhibited excellent adsorption performance, and the maximum adsorption capacities for U(VI) and Th(IV) reached 392 and 396 mg/g, respectively. Discrepantly in acidic solution, the adsorption performance of AL-PEI for U(VI) could still reach a high capacity (332 mg/g), whereas highly limited adsorption capacity (less than 40 mg/g) for Th(IV) was obtained, and the separation factor of U(VI) from U(VI)-Th(IV) matrix significantly reached 6662 in 3 M of the HNO 3 medium. The simultaneously efficient adsorption in alkaline solution and highly selective separation performance in acidic solution of AL-PEI also showed excellent anti-ions interference capacities, high reusability, and strong stability. This study is the first to apply lignin fabricating radiation-resistant adsorbent material, and the adsorbent displays good performance for U(VI)/Th(IV) removal and selective separation via a novel pH-dependent process, which is important to the green and sustainable development of nuclear energy and environmental protection.
研究领域:
环境科学
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核工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
MUSCLE & NERVE
·
2025
·Vol. 71
·期 3
·474-486
·
IF 3.1
Zhuajin Bi,Qing Zhang,Huajie Gao,Huizhen Ge,Jiayang Zhan,Mengge Yang,Bitao Bu
Introduction/Aims Tofacitinib, a first-generation Janus kinase (JAK) 1/3 inhibitor, is commonly used for treating ulcerative colitis and rheumatoid arthritis. However, its role in myasthenia gravis (MG) remains unclear. This study aimed to evaluate the immunomodulatory effects of tofacitinib on experimental autoimmune myasthenia gravis (EAMG) and peripheral blood mononuclear cells (PBMCs) from patients with MG. Methods Flow cytometry, enzyme-linked immunosorbent assay (ELISA), quantitative reverse transcription polymerase chain reaction (qRT-PCR), and Western blot were used to evaluate the effects of tofacitinib on T helper (Th) cell profiles, humoral immune responses, and the JAK-signal transducer and activator of transcription (STAT) pathway proteins. Results In vivo, tofacitinib significantly ameliorated EAMG severity in rats, reducing the proportions of Th1, Th17 and memory B cells, and anti-acetylcholine receptor (AChR) antibodies levels, while increasing the proportions of regulatory T (Treg) cells. In vitro, tofacitinib administration resulted in a significant decrease in the proportions of Th1 and IgG-secreting B cell, and a significant upregulation of Treg cells in mononuclear cells (MNCs) from EAMG rats, which was consistent with findings in PBMCs from MG patients. Further analysis revealed that tofacitinib inhibited CD4 + T cell differentiation into Th1 by decreasing phosphorylated STAT1 levels, while promoting Treg differentiation via increased phosphorylated STAT5 levels in MNCs from EAMG rats. Discussion Tofacitinib modulates Th cell profiles and humoral immune responses by targeting the JAK–STAT pathway, suggesting its potential as a therapeutic candidate for MG. Further clinical studies are warranted to evaluate the efficacy and safety of tofacitinib in MG patients.
研究领域:
免疫学
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药理学
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神经病学
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产品关联
DOI
PubMed
高影响因子
Royal Society Open Science
·
2022
·Vol. 9
·期 8
·
IF 3.653
Lin Li,Ting Yu,Zhenghua Qian,Xiaoling Wu,Hui He,Guoan Ye,Yanbo Qiao
Two new metal-organic frameworks (MOFs) (Th/ Ce -TCPE) based on 1,2,4,5-tetrakis(4-carboxyphenyl)ethylene were obtained using a straightforward reaction under moderate conditions. Th and Ce formed the central units of this MOF in the mononuclear and in the unusual trinuclear cluster configurations, respectively. The resulting MOFs were analysed by fluorescence spectroscopy to understand their luminescence. The obtained data revealed that benzene's electron cloud density and torsion angle on the ligand were affected by the acetic acid molecule and Th(IV), which caused Th-TCPE to irradiate stronger blue emission, but Ce-TCPE showed no fluorescence due to the self-quenching. Such a unique luminescence property could be used for fluorescence or radiopharmaceutical sensing.
研究领域:
化学
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材料科学
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无机化学
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分析化学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Lei-Tao Sha,Qiang Wu,Yi-Fan Zhang,Wei-Jia Wang,Fei Wu,Qing-Gang Huang,Ze-Yi Yan
The hydrophobic deep eutectic solvents (HDES) with low viscosity, density and environmental friendliness have been prepared and characterized based on trioctylphosphine oxide (TOPO) and N,N -dihexyl succinamic acid (DHSCA), which were used as both extractant and organic phase for highly efficient removal of radioactive elements of U(VI) and Th(IV) from rare earth (RE) leaching solution. The extraction efficiency of U(VI) and Th(IV) exceeded 99 % by a single stage extraction. Benefiting from the blocking effect of hydrogen bonding on P = O and the good affinity of DHSCA and TOPO for actinides, the present HDES exhibited the excellent extraction selectivity for U(VI) and Th(IV) over Fe(III), Al(III), Mg(II), Ca(II) and RE(III). Even after seven extraction-stripping cycles, the prepared HDES could still effectively remove radioactive U(VI) and Th(IV) from RE leaching solution. The co-extracted U(VI) and Th(IV) was further separated and enriched by two successive stripping steps. Using the slope analysis, 31 P NMR and FT-IR spectra, the stoichiometry of extracted species and the extraction mechanism of HDES to Th(IV) and U(VI) were evaluated. Due to the superior extraction efficiency, excellent environmental compatibility and sustainability, the present approach offers a practical alternative for removal of radioactive elements from rare earth minerals.
研究领域:
化学工程
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环境科学
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核化学
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材料科学
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DOI
高影响因子
ORGANIC ELECTRONICS
·
2023
·
IF 3.2
Di Zhao,Qiuhong Cui,Xingyu Zhang,Hongyu Ji,Xin Liu,Liang Qin,Yuanyuan Hu,Yanbing Hou,Yufeng Hu,Zhidong Lou,Feng Teng
Organic salt doping is an effective method to control the electrical properties of organic semiconductor materials, while its underlying mechanism remains to be studied. In this work, we report the improvement of organic field-effect transistor (OFET) performance by doping the D-A polymer semiconductor PTB7-Th with organic salts. The underlying mechanism of PTB7-Th's organic salt doping in OFETs has been explored to fill the existing research gap. The doping of organic salts can improve the hole mobility of the device and change the threshold voltage . In addition, at low doping ratios, the on-off ratio of the device is not sacrificed but remains unchanged. Finally, we have made a series of characterizations of the properties of doped polymers through absorption, EPR , and UPS , which provide specific guidelines for modifying D-A polymer devices.
研究领域:
材料科学
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电气工程
·
有机电子学
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DOI
高影响因子
Journal of Asthma and Allergy
·
2022
·
IF 3.027
Yang Sun,Tiancong Liu,Weiliang Bai
Purpose This work aimed to investigate the effects of MAF bZIP transcription factor B (MAFB) on the progression of allergic rhinitis (AR). Patients and Methods Nasal mucosa was isolated from AR patients and healthy individuals from Shengjing Hospital of China Medical University. The experimental procedures were approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University (2019PS341K) in accordance with the Declaration of Helsinki. Informed consents were signed by participants or a parent/legal guardian of the participants under 18 years old of age. Then, an AR mouse model with MAFB overexpression was established with 25 μg ovalbumin (OVA) sensitization on day 0, 7, 14, followed by an injection with 1×10 7 TU/mL lentivirus MAFB on day 19 and a nasal challenge with 500 μg OVA from day 21 to 27. Results The results revealed that MAFB was down-regulated in the nasal mucosa of AR patients. The up-regulation of MAFB protected the AR mice against the OVA-induced allergic symptoms (sneezing and nasal rubbing) by alleviating the OVA-induced epithelial thicknesses, goblet cell hyperplasia, and inflammation including the eosinophil and mast cell infiltration. Moreover, MAFB facilitated the T helper (Th) 1 response and inhibited the Th2 and Th17 responses by the down-regulation of T-box transcription factor 21 and the up-regulation of GATA binding protein-3 as well as retinoid-related orphan receptor-γt in the splenocytes of AR mice. MAFB was found to repress the differentiation of naive CD4 + T cells into Th2 cells. Subsequently, MAFB overexpression reversed the OVA-induced enhancement of epithelial permeability, downregulation of tight junctions, and upregulation of cadherin-26, indicating the protective role of MAFB on epithelial barrier integrity. Conclusion MAFB protected against OVA-induced AR via the alleviation of inflammation by restoring the Th1/Th2/Th17 imbalance and epithelial barrier dysfunction.
研究领域:
免疫学
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分子生物学
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转化医学
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产品关联
DOI
PubMed
高影响因子
Nature Synthesis
·
2025
·
IF 20
Sheng Weiming,Xie Fei,Rajeshkumar Thayalan,Zhao Yue,Jiang Yufei,Chen Wang,Ye Shengfa,Maron Laurent,Zhu Congqing
Theoretical studies predict that homoatomic metal–metal bonds of f -block actinide elements should be ubiquitous. Surprisingly, however, the isolation and characterization of compounds featuring an actinide–actinide bond has proven challenging and the field remains undeveloped. Here we report a well-defined thorium dimer featuring a Th–Th two-centre one-electron (2c-1e) σ bond and a 2c-1e π bond. This thorium dimer was synthesized by reducing a Th(IV) chloride complex with potassium metal in tetrahydrofuran. Magnetic measurements indicate that this thorium dimer features exceedingly strong antiferromagnetic coupling between the two formal Th(III) centres with a coupling constant J ≤ −1,200 cm −1 such that the Th–Th interaction has covalent bond character. Detailed computational investigations further support the existence of the Th–Th bond in this molecule. These results demonstrate that diactinide complexes with actinide–actinide bonds are accessible but require an appropriate ligand framework to stabilize low-valent actinide centres.
研究领域:
无机化学
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理论化学
·
配位化学
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DOI
高影响因子
Nano Research
·
2021
·Vol. 15
·期 2
·1472-1478
·
IF 8.897
Feng Han,Xiong Xiaohong,Gong Lele,Zhang Huiping,Xu Ying,Feng Xuefeng,Luo Feng
The reticular chemistry strategy presents a powerful molecule-design tool to tailor the physical and chemical properties of metal-organic framework (MOF). In this work, we for the first time investigated the effect of organic ligands on the radionuclide sequestration (TcO 4 − ) of thorium-organic framework. Through a coordination modulation technique, two novel isoreticular thorium-organic frameworks, namely Th-MOF-67 and Th-MOF-68, were obtained. Relative to the antetype MOF of Th-MOF-66 that shows extremely low uptake of ReO 4 − (a chemical surrogate of radioactive TcO 4 − ), the isoreticular MOFs of Th-MOF-67 and Th-MOF-68 enable ultrahigh uptake of ReO 4 − , giving an impressively 36.8-fold or 56-fold enhancement, respectively. The adsorption capacity of Th-MOF-68 is as high as 560 mg/g, exceeding most reported adsorbents for such use. The mechanism for such exceptional outstanding performance, as unveiled by both the single crystal X-ray diffraction and theoretical calculation, is due to coordination interaction for Th-MOF-67, when a tetrazolate ligand was used, or a combined effect from both coordination interaction and anion-exchange for Th-MOF-68, if using a triazolate ligand.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2012
·Vol. 295
·期 1
·167-177
·
IF 1.52
He F. F.,Wang H. Q.,Wang Y. Y.,F Wang X.,Zhang H. S.,Li H. L.,Tang J. H.
A new complex of N , N ′-bis(3-allyl salicylidene) o -phenylenediamine and thorium(IV) (Th(IV)) was synthesized and used as the functional monomer for a novel Th(IV) magnetic ion-imprinted polymer; this polymer was synthesized using a surface imprinting technique that included the modified magnetic Fe 3 O 4 particle and used tetraethyl orthosilicate, 3-Aminopropyltriethoxysilane and maleic anhydride in the process. The magnetic polymer was characterized using FT-IR, and powder- and single crystal-XRD. The behavior of Th(IV) was investigated using batch experiments. At pH 4.5, the uptake capacity of this adsorbent and that of the non-imprinted polymer was 42.54 and 14.10 mg g −1 , respectively, and the relative selectivity coefficient values of the synthesized adsorbent for Th(IV)/La(III), Th(IV)/Ce(III), Th(IV)/Nd(III), and Th(IV)/U(VI) were 82.2, 93.1, 21.0 and 62.4 times greater than that of the non-imprinted matrix, respectively. In addition, the Th(IV) adsorption process using Fe 3 O 4 @SiO 2 -IIP follows pseudo-second-order reaction kinetics and the Langmuir adsorption isotherm. The thermodynamic parameters also suggest that the adsorption of Th(IV) onto Fe 3 O 4 @SiO 2 -IIPs was a spontaneous and endothermic process.
研究领域:
材料科学
·
环境化学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Inorganics
·
2023
·Vol. 11
·期 11
·422
·
IF 2.9
Yunpeng Xia,Yi Shen,Yang-Rong Yao,Qingyu Meng,Ning Chen
A novel Non-Isolated-Pentagon-Rule (non-IPR) isomer of thorium-based endohedral mono-metallofullerenes (mono-EMFs), Th@C1(17418)-C76, was successfully synthesized and characterized using MALDI-TOF mass spectroscopy, single-crystal X-ray diffraction, UV-vis-NIR spectroscopy, and Raman spectroscopy. The molecular structure of this non-IPR isomer was determined unambiguously as Th@C1(17418)-C76using a single-crystal X-ray diffraction analysis. The crystallographic results further revealed that the optimal Th site resided at the intersection of two adjacent pentagons, similar to that of U@C1(17418)-C76. Additionally, the UV-vis-NIR spectra of Th@C1(17418)-C76exhibited distinct differences compared to the previously reported U@C1(17418)-C76, highlighting the distinctive electronic structure of actinium-based endohedral metallofullerenes (EMFs). The Raman spectrum of Th@C1(17418)-C76exhibited similarities to that previously reported for thorium-based EMFs, indicating the analogous strong metal–cage interactions of thorium-based EMFs.Keywords:endohedral metallofullerenes;mono-metallofullerenes;thorium;X-ray crystallography
研究领域:
化学
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材料科学
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纳米技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）