Materials
·
2023
·Vol. 16
·期 6
·2362
·
IF 3.4
Kuntong Song,Yi Li,Ruiqi Zhang,Nan Wang,Junhong Liu,Wenxia Hou,Qing Zhou,Xingmei Lu
Compared with conventional pyrolysis, steam-assisted pyrolysis of polyethylene terephthalate (PET) can effectively eliminate char and upgrade terephthalic acid (TPA). However, during steam-assisted pyrolysis of PET, the degree of cracking still varies greatly, and while some of the product is excessively cracked to gas, the other part is still insufficiently cracked. In addition, these two types of products seriously affect the yield and purity of TPA. To further enhance the TPA, an attempt was made to reduce these impurities simultaneously by synergistic catalysis among the different components of the metal–acid catalyst. Through a series of experiments, Pt@Hzsm-5 was screened as the optimal catalyst. In the catalytic steam-assisted pyrolysis of PET, the optimum reaction temperature decreased to 400 °C, the calculated yield of TPA increased to 98.23 wt%, and the purity increased to 92.2%. The Pt@Hzsm-5 could be recycled three times with no significant decrease in the obtained yield of TPA. The catalytic mechanism of the Pt@Hzsm-5 was investigated through the analysis of the products and isotope tracing experiments. The Pt catalyzed the hydrogen transfer reaction between the water molecules and PET molecules, which inhibited the excessive cracking of TPA by improving the hydrogen transfer efficiency, reduced the generation of gaseous products, and improved the calculated yield of TPA. In contrast, the Hzsm-5 catalyzed the reaction of monovinyl ester cracking to TPA, effectively reducing the impurities in the solid product, increasing the olefin yield, and improving the purity of TPA. This discovery not only clarifies the synergistic catalytic effect of the Pt@Hzsm-5 in the steam-assisted pyrolysis of the PET reaction but also lays the foundation for further screening of other inexpensive metal–acid catalysts. This is of great significance to realize the industrial application of TPA preparation by PET pyrolysis.Keywords:PET;metal–acid catalyst;steam-assisted pyrolysis;TPA
研究领域:
化学工程
·
催化材料
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DOI
PubMed
高影响因子
Science Advances
·
2024
·Vol. 10
·期 5
·
IF 11.7
Ben Wang,Qinglong Wang,Kai Fung Chan,Zhipeng Ning,Qianqian Wang,Fengtong Ji,Haojin Yang,Shuai Jiang,Zifeng Zhang,Bonaventure Yiu Ming Ip,Ho Ko,Jacqueline Pui Wah Chung,Ming Qiu,Jianguo Han,Philip Wai Yan Chiu,Joseph Jao Yiu Sung,Shiwei Du,Thomas Wai Hong Leung,Simon Chun Ho Yu,Li Zhang
Micro/nanorobots provide a promising approach for intravascular therapy with high precision. However, blood vessel is a highly complex system, and performing interventional therapy in those submillimeter segments remains challenging. While micro/nanorobots can enter submillimeter segments, they may still comprise nonbiodegradable parts, posing a considerable challenge for post-use removal. Here, we developed a retrievable magnetic colloidal microswarm, composed of tPA-anchored Fe3O4@mSiO2 nanorobots (tPA-nbots), to archive tPA-mediated thrombolysis under balloon catheter-assisted magnetic actuation with x-ray fluoroscopy imaging system (CMAFIS). By deploying tPA-nbot transcatheter to the vicinity of the thrombus, the tPA-nbot microswarms were magnetically actuated to the blood clot at the submillimeter vessels with high precision. After thrombolysis, the tPA-nbots can be retrieved via the CMAFIS, as demonstrated in ex vivo organ of human placenta and in vivo carotid artery of rabbit. The proposed colloidal microswarm provides a promising robotic tool with high spatial precision for enhanced thrombolysis with low side effects.
研究领域:
医学工程
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生物材料
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介入治疗
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xin Hai,Zhiyong Guo,Xin Lin,Xuwei Chen,Jianhua Wang
A fluorescent probe TPA@GQDs is fabricated by the conjugation of terephthalic acid (TPA) on the surface of graphene quantum dots (GQDs). The TPA@GQDs probe not only has favorable dispersibility but also exhibits excellent fluorescence stability over a wide pH range and high ionic strength and favorable antiphotobleaching ability. The great fluorescence enhancement of TPA@GQDs induced by the reaction between TPA and hydroxyl radicals makes the TPA@GQDs a powerful probe for the sensitive assay of hydroxyl radicals, giving rise to a low detection limit down to 12 nmol L–1. Meanwhile, the obtained fluorescent TPA@GQDs probe shows low cytotoxicity and favorable biocompatibility. Its potential in bioimaging is demonstrated by the quantitative fluorescent imaging of hydroxyl radicals in living HeLa cells under different circumstances, which enables the opportunities to study hydroxyl radicals dynamics in living cells.
研究领域:
生物化学
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细胞生物学
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分析化学
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Pengfei Xie,Xiao Rong,Xuelian Qin,Min Li,Yan Zuo,Bingjie Liu,Sujiao Cao,Jie Yang,Li Qiu
Ultrasound (US) becomes an appealing modality for stimulating or amplifying immune responses during cancer therapy, which is also termed sono-immunotherapy. However, the clinical prospect has not been fully realized due to the scarcity of efficient sonosensitizers. Herein, for the first time a novel Os-doped Au-tri(pyridin-4-yl) amine coordination structure (Os@Au-TPA)-based sonosensitizer is originally designed and synthesized for sono-immunotherapy of breast-metastasized tumors. Impressively, Os@Au-TPA shows much higher US-mediated 1 O 2 -producing activity than Au-TPA as well as the other traditional sonosensitizers, for example, ≈41.6 folds to ce6, 19.5 times to Protoporphyrin IX (PpIX), 12.0 to Indocyanine Green (ICG), and 11.1 to Iron phthalocyanine (Pc(Fe)). The Os@Au-TPA can not only generate abundant ROS upon US irradiation to implement sonodynamic therapy (SDT), stimulating cell apoptosis and further immunogenic cell death, but can also generate O 2 to alleviate hypoxia to promote the polarization of M2 to M1 macrophages to enhance tumor immunogenicity. As a result, when combined with PD-L1 antibody, it remodels the immunosuppressive tumor microenvironment, achieves concurrent sonodynamic-triggered immune activation, and eradicates both the original and distant-metastasized tumors efficiently. This work not only provides a new strategy to construct potent sonosensitizers from pyridine-metal coordination structures but also proves that sonosensitizers with high performance are crucial in boosting cancer sono-immunotherapy.
研究领域:
肿瘤学
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生物医学工程
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免疫学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Jinshan Chen,Qiao Zeng,Shuangyou Bao,Fei Wang,Chi Wang,Kai Li,Yi Mei
Designing efficient and selective photocatalysts for CO 2 conversion under mild and practical conditions remains a significant challenge. This study aims to establish a sustainable strategy for constructing MOF-derived TiO 2 @TPA hybrids that enable efficient charge separation and selective CO 2 -to-CO conversion under low CO 2 concentrations without sacrificial agents. To achieve this, a TiO 2 @TPA hybrid material was synthesized via in-situ hydrothermal transformation of MIL-125(Ti) in water at 100 °C, without the use of organic solvents or high-temperature calcination. The resulting composite integrates TiO 2 nanocrystals with polymeric terephthalic acid (TPA) through Ti–O–C bonds, forming a stable interface that promotes ligand-to-metal charge transfer (LMCT). This interfacial structure enhances visible-light absorption and facilitates efficient charge separation. When applied to photocatalytic CO 2 reduction under low CO 2 concentrations (∼10 %), the TiO 2 @TPA hybrid achieved highly selective CO generation without the need for sacrificial agents or photosensitizers. In situ infrared spectroscopy and surface photovoltage analysis revealed the formation and stabilization of *COOH intermediates, elucidating the enhanced reaction pathway. This study demonstrates a scalable strategy for constructing MOF-derived hybrid photocatalysts and provides insights into interfacial design for selective CO 2 separation and conversion.
研究领域:
光催化材料
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环境化学
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材料科学
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可持续化学
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二氧化碳转化
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产品关联
DOI
高影响因子
ACS Omega
·
2023
·
IF 4.1
Muhua Chen,Peng Chen,Zhen Ji,Min Yu,Jihuai Tan,Bo Fu,Xinbao Zhu
The hydrosilylation reaction driven by a homogeneous catalyst has been widely used in the industrial synthesis of functionalized silicone compounds. However, the homogeneous catalyst for hydrosilylation has the shortcomings of nonrecyclability, undesirable side reactions, and high cost. In this work, a highly efficient heterogeneous catalyst was prepared by loading Pt ions on MIL-88 modified with trimethoxy[3-(phenylamino)propyl]silane. In comparison with previous research studies, the resulting catalyst can exhibit high catalytic activity and excellent stability during the hydrosilylation reaction, which was attributed to the presence of a pyrrolic nitrogen structure between TPA-MIL-88 and the Pt ion. Besides them, 1.2%Pt/TPA-MIL-88 showed the highest catalytic activity and can be reused five times without significant deactivation. Importantly, 1.2%Pt/TPA-MIL-88 also achieved satisfactory results when it was used to catalyze the hydrosilylation reaction for other olefins, implying great potential for application in the silicone industry.
研究领域:
化学工程
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催化
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材料科学
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-17
·
IF 14.7
Lin Lin,Ba Zhaojing,Tian Hao,Qin Haoxiang,Chen Xi,Zhou Xin,Zhao Shanlan,Li Lang,Xue Fangchao,Li Hong,He Lang,Li Xiaochen,Du Jiahui,Zhou Zhenhua,Zeng Wen
There is no effective and noninvasive solution for thrombolysis because the mechanism by which certain thrombi become tissue plasminogen activator (tPA)-resistant remains obscure. Endovascular thrombectomy is the last option for these tPA-resistant thrombi, thus a new noninvasive strategy is urgently needed. Through an examination of thrombi retrieved from stroke patients, we found that neutrophil extracellular traps (NETs), ε-(γ-glutamyl) lysine isopeptide bonds and fibrin scaffolds jointly comprise the key chain in tPA resistance. A theranostic platform is designed to combine sonodynamic and mechanical thrombolysis under the guidance of ultrasonic imaging. Breakdown of the key chain leads to a recanalization rate of more than 90% in male rat tPA-resistant occlusion model. Vascular reconstruction is observed one month after recanalization, during which there was no thrombosis recurrence. The system also demonstrates noninvasive theranostic capabilities in managing pigs’ long thrombi (>8 mm) and in revascularizing thrombosis-susceptible tissue-engineered vascular grafts, indicating its potential for clinical application. Overall, this noninvasive theranostic platform provides a new strategy for treating tPA-resistant thrombi.
研究领域:
生物医学工程
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诊疗学
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心血管医学
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神经学
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医学成像
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产品关联
DOI
PubMed
高影响因子
CHEMISTRY & BIODIVERSITY
·
2025
·
IF 2.5
Zebin Huang,Wanying Zhang,Qi Shu,Xiao-Chun Guo,Xi Zheng,YuJing Lu
Inflammation is an important predisposing factor for many chronic diseases. The dietary flavonoid silibinin has excellent anti-inflammatory properties in cells, but its low bioavailability in the blood compromises its therapeutic potential. This study aims to investigate the potential of dibenzoylmethane (DBM) to synergistically enhance the anti-inflammatory benefits of silibinin (SB). The synergistic effects of DBM and SB in combination were evaluated in LPS-induced RAW264.7 cells and TPA-induced mice. In addition, a network pharmacology approach and molecular docking were used to explore the key targets and signaling pathways of DBM and SB in combination. The results showed that DBM and SB synergistically inhibited the production of NO, ROS, IL-1β, and TNF-α in a 1:1 concentration ratio. These two compounds may exert their synergistic effects by modulating the NF-κB and HIF-1 signaling pathways, among others. Molecular docking revealed that both compounds exhibited high binding affinities to iNOS and COX-2. Compared with single compound use, the two compounds in combination significantly reduced ear edema and inflammatory cell infiltration, and inhibited the protein expression of iNOS and COX-2 in TPA-induced mice. This research provides a rationale for the combination of DBM and SB as an effective anti-inflammatory agent.
研究领域:
药理学
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免疫学
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分子生物学
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炎症研究
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Xiaoqing Wang,Huiyi Chen,Jihui Zhang,Hong Zhou,Xiangying Meng,Na Wang,Yishan Fang,Bo Cui
The detection of Escherichia coli ( E. coli ) is of great significance for the environment and human health. Herein, a photoelectrochemical (PEC) detection strategy based on molecularly imprinted polymers (MIPs) was proposed for the sensitive detection of E. coli . 4,4′,4″-Trinitrotriphenylamine (TPA-NO 2 ) was prepared using a simple nitration reaction. Subsequently, MIP films were polymerized on the surface of TPA-NO 2 using 1,3-dihydrothieno[3,2- d ]pyrimidine-2,4-dione as the functional monomer with the dual functions of specific recognition and sensitization. The linear range was 10–10 8 CFU/mL and the limit of detection was 10 CFU/mL. It showed favorable recoveries in real sample tests of milk, orange juice and tomato. Additionally, the ability of functional monomers to bind excellently with E. coli was verified using molecular docking techniques. This research provided broader possibilities for constructing MIPs-PEC sensors and analyzing the interaction mechanism between E. coli and functional monomers.
研究领域:
分析化学
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生物技术
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环境科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Yang Yuan,Pei Yin,Tao Wang,Zengming Yang,Weidong Yin,Shaoxiong Zhang,Chunxuan Qi,Ma Hengchang
A variety of triphenylamine (TPA) are shown to undergo C–C bond formation using quinone-based chloranil/H + reagent as the metal free oxidative system to afford triphenylamine dimers very conveniently. Then, TPA dimers have been further converted to the emission color tunable compounds via simple chemical transformations. Importantly, we established the primary relationship between chemical structures with the optical behaviors from the aspect of emission (λ em ) wavelength, fluorescence life time (τ) and aggregation-induced-emission (AIE) property in this work. The further application of these compounds to cell imaging was fully demonstrated.
研究领域:
有机化学
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生物医学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2013
·Vol. 160
·期 3
·H173
·
IF 2.588
Bin Hu,Xiaojing Lv,Jingwei Sun,Mi Ouyang,Zhiyan Fu,Cheng Zhang
In this study, a novel material, Z-2, 3-bis(4-(thiophen-3-yl)-phenyl) –acrylonitrile (Z-TPA), was synthesized and characterized. Optical and electrochromic properties of its homopolymer and copolymer with 3, 4-Ethylenedioxythiophene (EDOT) were investigated in details. UV–vis absorption and fluorescence spectra showed that this material possessed the properties of aggregation-induced emission (AIE) due to the introduction of acrylonitrile, which could show sky-blue emitting at the aggregation state and almost no emitting at the solution state. Both its polymer and copolymer displayed better redox activity. Spectroelectrochemical analysis displayed that the copolymer film exhibited multicolor showing, with a claret red in the fully reduced form and a blue-green color in the fully oxidized. Spectrochronoamperometry data revealed that the copolymer films had fast switching time and high chromatic contrast as compared to the homopolymer P(Z-TPA). What's more, the copolymer film was used to construct a dual type polymer electrochromic device (ECDs) with PEDOT. The performance of ECDs were also investigated.
研究领域:
材料科学
·
光学
·
电化学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Sayed Mir Sayed,Xiang-Fei Li,Hao-Ran Jia,Samran Durrani,Fu-Gen Wu,Xiaolin Lu
Lipid droplets (LDs) are spherical dynamic subcellular organelles, and play crucial roles in a number of cellular functions, such as lipid metabolism, protein degradation, membrane formation, energy storage, and signal transduction. It is widely recognized that the dysfunction of LDs can lead to many diseases, and hence it is important to monitor the size, distribution, and movement of LDs in living cells. Herein, we report a dibenzothiopene core-based fluorescent probe named triphenylamine dibenzothiophene-S,S-dioxide (TPA-DBTD), which can exhibit aggregation-induced emission (AIE) characteristic and realize selective and wash-free imaging of LDs in live cells. Most importantly, this probe can efficaciously track the dynamic changes of LDs including lipophagy (an autophagic process that is responsible for the degradation of lipids) in live mammalian cells and stain LDs in fungi. Hence, we believe that TPA-DBTD with high photostability, good biocompatibility, AIE characteristic, and LD staining ability in diverse biological systems (mammalian cells and microorganisms) can find practical applications in the fields of biomedical science, cell biology, and diagnosis of LDs-associated diseases.
研究领域:
生物医学
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细胞生物学
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诊断学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）