SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Yangzheng Huang,Shao-Lu Li,Zhenxing Fu,Genghao Gong,Yunxia Hu
As an emerging membrane separation technology, organic solvent nanofiltration (OSN) has shown great application potential in the field of pharmaceutical and chemical industries referring to organic media. Herein, we prepared a novel microporous thin-film composite (TFC) OSN membrane with superior perm-selective performances, which was fabricated by applying 4,4′,4″-trihydroxytriphenylmethane (Tris-Phenol) to react with trimesoyl chloride (TMC) by interfacial polymerization (IP) technique. The rigid, non-planar and multifunctional nature of Tris-Phenol endowed the polyarylate nanofilm with enhanced microporosity. Of note, the prepared composite membrane showed good selectivity to small organic solutes with molecular weight cut-off (MWCO) as low as ∼295 Da, meanwhile had medium methanol permeance up to 5.86 LMH/bar, by the help of surfactant dodecyl trimethyl ammonium chloridea (DTAC) during the IP reaction. The experiments showed that the Tris-Phenol membrane exhibited extraordinary long-term operation stability. In addition, the Tris-Phenol membrane could achieve separation of solutes with similar molecular weights but different charges. This research well illustrated the novel IP monomer design strategy to fabricate new TFC OSN membrane with high perm-selectivity.
研究领域:
材料科学
·
化学工程
·
分离技术
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Chen Wang,Yeyong Li,Lingjun Zeng,Chongli Shi,Yi Peng,Hui Li,Haibo Chen,Jun Yu,Jin Zhang,Biao Cheng,Ruolin Pan,Xiaoli Wang,Minghui Xiang,Yuan Huang,Yongdi Liu
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) has received concerns due to its frequent detection in environmental media and biological samples. Our previous study has indicated TDCPP reduced the lifespan of Caenorhabditis elegans ( C. elegans ) by triggering an unconventional insulin/insulin-like growth factor signaling (IIS) pathway. This study continued to investigate the possible deleterious effects of TDCPP relating to longevity regulation signal pathways and biological processes. Specifically, this study uniquely performed small RNA transcriptome sequencing (RNA-seq), focusing on the underlying mechanisms of TDCPP-reduced the longevity of C. elegans in-depth in microRNAs (miRNAs) . Based on Small RNA-seq results and transcript levels of mRNA involved in the unconventional IIS pathway, a small interaction network of miRNAs-mRNAs following TDCPP exposure in C. elegans was preliminarily established. Among them, up-regulated miR-48 and miR-84 ( let-7 family members) silence the mRNA of daf-16 (the crucial member of the FoxO family and pivotal regulator in longevity) via post-transcription and translation dampening abilities, further inhibit its downstream target metallothionein-1 ( mtl-1 ), and ultimately contributed to the reduction of nematode longevity and locomotion behaviors. Meanwhile, the high binding affinities of TDCPP with miRNAs cel-miR-48–5p and cel-miR-84–5p strongly support their participation in the regulation of nematode mobility and longevity. These findings provide a comprehensive analysis of TDCPP-reduced longevity from the perspective of miRNAs.
研究领域:
毒理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Crystals
·
2024
·Vol. 14
·期 12
·1104
·
IF 2.4
Xian-Rui Zhang,Bao-Lin Wu,Jing-Jing Han,Jin-Qing Li
Naproxen (NAP) is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the arylpropionic acid class. Classified as a Biopharmaceutical Classification System (BCS) class II drug, NAP exhibits low water solubility, thus resulting in restricted oral bioavailability. This study aimed to evaluate the effectiveness of pharmaceutical salts in enhancing the solubility and oral bioavailability of NAP. Two novel NAP salts, specifically naproxen-ethylenediamine (NAP-EDA) and naproxen-trometamol (NAP-TRIS), were synthesized using a 2:1 and 1:1 stoichiometric ratio, respectively. The NAP-EDA and NAP-TRIS powders were thoroughly characterized using single-crystal X-ray diffraction (SXRD), powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC), providing a comprehensive understanding of their structural and thermal properties. Additionally, the solubilities and dissolution rates of NAP-EDA and NAP-TRIS salts were assessed in water and a pH 6.86 phosphate buffer. Notably, the solubility of NAP-TRIS salt increased markedly, by 397.5-fold in water and 6.2-fold at pH 6.86. Furthermore, in vivo pharmacokinetic studies in rats revealed that NAP-TRIS salt displayed faster absorption and higher peak blood concentrations compared to NAP. These results indicate that the NAP-TRIS salt effectively enhanced the solubility and oral bioavailability of naproxen. In conclusion, this study underscores the potential of pharmaceutical salts, particularly NAP-TRIS, in improving the solubility and oral bioavailability of drugs with low aqueous solubility, presenting a promising avenue for advancing drug delivery and therapeutic outcomes.
研究领域:
药学
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药物递送系统
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生物药剂学
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DOI
高影响因子
ANALYST
·
2018
·Vol. 143
·期 16
·3821-3828
·
IF 3.864
Chuanxia Chen,Qun Yuan,Pengjuan Ni,Yuanyuan Jiang,Zhenlu Zhao,Yizhong Lu
Alkaline phosphatase (ALP) is a significant biomarker for diagnostics. Simple, selective and sensitive detection of ALP activity is thus of critical importance. In this study, an artful fluorescence assay for ALP is proposed based on adenosine triphosphate (ATP) hydrolysis-triggered disassociation and fluorescence quenching of cerium coordination polymer nanoparticles (CPNs). ATP, a recognized natural substrate of phosphatase, can serve as a superb “antenna” to sensitize the luminescence of Ce3+ with the aid of tris(hydroxymethyl) aminomethane (Tris), forming Ce3+–ATP–Tris CPNs. In the presence of ALP, ATP will be catalytically converted into adenosine and inorganic orthophosphate, however neither of them can sensitize Ce3+ in alkaline media. As a result, the obtained CPNs are disassociated, inducing the quenching of the fluorescence. On this basis, a straightforward fluorescence assay for ALP activity is rationally developed. The fluorescence quenching efficiency shows a linear relationship for ALP within the activity range from 0.1 to 10 mU mL−1 with a detection limit of 0.09 mU mL−1 under the optimal experimental conditions. Moreover, this facile yet effective fluorescence method featured simplicity, cost-effectiveness, high sensitivity and high selectivity and can be successfully utilized for the quantitative detection of ALP in human serum samples.
研究领域:
生物化学
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医学诊断
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纳米技术
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产品关联
DOI
PubMed
高影响因子
CHROMATOGRAPHIA
·
2014
·Vol. 78
·期 1
·119-123
·
IF 1.37
Yang Xiujuan,Liu Cui,Chen Zuanguang
A novel and rapid method was developed for the determination of uric acid in human urine by capillary electrophoresis with an improved electromagnetic induction detector. Electrophoretic parameters affecting the separation efficiency, such as buffer composition, buffer pH, buffer concentration, and electroosmotic flow modifier, were systematically investigated. An electrolyte solution consisting of 8.5 mmol L −1 tris(hydroxymethyl)aminomethane (Tris), 1.5 mmol L −1 citric acid, and 0.2 mmol L −1 cetyltrimethylammonium bromide, pH 8.0, was found to be suitable for sample determination. Uric acid was separated and detected within 2.3 min, with a linear response range from 5 to 400 µg mL −1 and a correlation coefficient of 0.9998. Intraday and interday precision were 1.6 and 2.5 % ( n = 6), respectively. The recoveries were between 98.3 and 100.5 %. This simple, effective, and stable method is a good alternative to existing methods for uric acid determination. Also, the improved electromagnetic induction detector holds great promise in clinical analysis.
研究领域:
分析化学
·
临床分析
·
电泳技术
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DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2016
·
IF 0.62
Zheng-Bai Zhao,Hai-Jiao Xie,Yan-Li Li,Yong Jiang
In this article, the multicomponent hydrogel was prepared by the copolymerization of the hydrophobic silicon-containing monomer tris(trimethylsiloxy)-3-methacryloxypropyl-sliane (TRIS) with the hydrophilic monomers 2-hydroxyethyl methacrylate (HEMA) and N-vinyl pyrrolidone (NVP). The ethanol extraction experiments as well as the FTIR, DSC results showed that the copolymerization was effective. The silicone hydrogel that had hydrophilic and hydrophobic phases could be loaded with hydrophilic drug (FITC) and hydrophobic drug (Nile Red) simultaneously. The drug release properties of the hydrogel were studied by taking advantage of its innate stimuli-responsiveness to solvent and pH. The release behaviors of hydrophilic and hydrophobic drugs were found to be solvent dependent. And the release behavior of hydrophilic drug was also pH sensitive. With the characteristics above, the silicone hydrogels can be good candidates for specified materials and may have broad applications in responsiveness, drug release, contact lens, etc.
研究领域:
材料科学
·
药学
·
生物医学工程
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产品关联
DOI
高影响因子
Journal of Cleaner Production
·
2022
·
IF 11.072
Meng Chen,Hu Yang,Zhen-liang Xu,Chong Cheng
Separation of single or mixed dyes in saline solutions can recover valuable chemicals from dye-containing wastewater. Application of ultrafiltration (UF) in this area is limited by the performance of traditional UF membranes and remains a challenge to achieve high efficacy. Herein, three uncharged polyacrylonitrile-tris(hydroxymethyl)aminomethane (PAN-Tris) UF membranes were adopted for anionic dye separation in saline solutions. These membranes were prepared via in situ modification and characterized by XPS, 1 H NMR spectroscopy, contact angle, permeation , mechanical properties, etc. Congo red (CR), methyl blue (MB), and methyl orange (MO) were chosen as model dyes with different sizes and valences. The as-prepared PAN-Tris membranes possessed mean pore sizes ranging from 8.14 to 10.98 nm, but with strong negative zeta potential ranging from −12 to −43 mV at pH 7. Thus, they rejected above 98% CR (with large molecular size) and MB (with high valence), and fractionated the mixtures of CR or MB with MO (with monovalence) in water solutions. The maximum flux of a dye solution reached about 85 L⋅m −2 ⋅h −1 at 1 bar. Subsequently, the influences of operating pressure, dye concentration, pH value, salt type (NaCl, Na 2 SO 4 , MgCl 2 , or MgSO 4 ) and salt concentration (1000, 5000, or 10000 ppm) on the dye separation property of the membranes were investigated. The results showed that dye rejection behavior depends on the molecular size and valence of dye, as well as membrane property. Thereafter, the electric double layer (EDL) model and the static permeation analysis were combined to investigate the separation mechanism through the changes of the electrostatic effects and effective pore sizes of the membranes in saline solutions. Guided by the revealed mechanism, the MB/CR mixture was successfully separated by using a NaCl solution (≥5000 ppm) for the first time. Overall, this study not only demonstrates that novel UF membranes hold promise for highly effective treatments of dye-containing wastewater, and but also provides an insightful understanding of the dye rejection mechanism that can guide the rational design of UF membranes.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
TOXICOLOGY
·
2022
·
IF 4.571
Jielin Tang,Jiayi Li,Qinyu Zhou,Guzailinuer Kuerban,Jinyan Qin,Hongdan Zhang,Rongli Sun,Lihong Yin,Yuepu Pu,Juan Zhang
As a new type of flame retardant , Organic Phosphate Flame Retardant has been widely used worldwide. The purpose of our research is to determine the neurotoxicity of Tris (1,3-dichloroisopropyl) phosphate (TDCPP) to Caenorhabditis elegans and its mechanism. L1 larvae wild-type C. elegans were exposed to different concentrations of TDCPP, and the effects on motor behavior (head thrashes, body bends, pumping times, chemotaxis index), ROS levels, and p38MAPK signaling pathway-related gene expression levels were measured. Three transgenic nematode strains, BZ555, DA1240, and EG1285, were also used to study the effects of TDCPP on nematode dopamine neurons, glutamate neurons, and GABA neurons. The results showed that TDCPP can inhibit the head thrashes and body bends of the nematode, reduce dopamine production, increase the level of ROS in the body, and affect the expression of genes related to the p38MAPK signaling pathway. We next employed ROS production and motor behavior as toxicity assessment endpoints to determine the involvement of p38 MAPK signaling in the regulation of response to TDCPP. The results showed that the nematodes with low expression of pmk-1 were less sensitive to the TDCPP. It was suggested that TDCPP had neurotoxicity and regulated neurotoxicity to C. elegans by activating the p38-MAPK signaling pathway. The research in this article provides important information for revealing the environmental health risks of organophosphorus flame retardants and their toxic mechanism of action.
研究领域:
毒理学
·
环境健康
·
分子生物学
·
神经科学
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Ala’a Mhmoued Abdllh Alboull,Hao Jiang,Tasneem Omda Edrees Isaa,Zhiyong Dong,Tadele Eticha,Guobao Xu
Sugar alcohols are low-calorie sugar substitutes commonly used in sugar-free products. In this study, we report for the first time Ru(bpy)32+ electrochemiluminescence (ECL) of sugar alcohols. Ru(bpy)32+ ECL of sugar alcohols, including sorbitol, mannitol, isbitol (also called isomalt, isomaltitol, and palatinitol), maltitol, lactitol, xylitol, and erythritol, was investigated. The applicability of the Ru(bpy)32+ ECL system for sugar alcohol detection was demonstrated by using sorbitol as a representative analyte. The optimized system exhibited excellent analytical performance, with a wide linear detection range from 0.5 μM to 5 mM and a low detection limit of 0.026 μM (S/N = 3). In practical applications, the system demonstrated outstanding accuracy in detecting sorbitol in pharmaceutical samples, with recovery rates ranging from 97.75 to 104.00%. These findings establish the Ru(bpy)32+ ECL as an effective and sensitive method for the detection of sugar alcohols.
研究领域:
分析化学
·
电化学
·
食品科学
·
药物分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHEMISTRY COMMUNICATIONS
·
2025
·
IF 4.2
Xuanhe Liu,Baiqing Sun,Lehao Lin,Gaimei Zhang,Hui Li,Jiazi Shi,Min Wu,Dongdong Wang,Jiandong Lu,Kang Du,Xiaoli Song
The commercialization of supercapacitors hinges critically on developing low-cost electrode materials capable of simultaneously delivering high energy density and long-term stability. To address this challenge, we developed a dual‑nitrogen doping strategy using tris(hydroxymethyl)aminomethane (Tris) and urea to fabricate three-dimensional nitrogen-doped graphene (URNG) through a one-step hydrothermal process. Characterization of the material reveals that the optimized nitrogen conformation of URNG has a 2.07 % increase in pyrrole-N content compared to single nitrogen-source doped graphene (NG), a change that significantly enhances the charge storage capacity while maintaining structural integrity. Electrochemical measurements demonstrate that the assembled symmetric supercapacitor achieves a high energy density of 57.2 Wh·kg −1 at a power density of 670 W·kg −1 . The URNG electrodes deliver a specific capacitance of 194.2 F·g −1 at 0.5 A·g −1 (17.1 % higher than NG) while maintaining 87 % capacitance retention after 5000 cycles. The practical applicability of this material was successfully demonstrated by powering a 1.8 V LED device. This work not only provides a facile synthesis strategy but also offers fundamental insights into nitrogen configuration control for advanced energy storage systems.
研究领域:
材料科学
·
电化学
·
储能
·
纳米技术
·
化学合成
✓ 已验证
产品关联
DOI
高影响因子
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
·
2024
·
IF 0.3
Da-Chun Jiang,Hai-Yuan Zhu
C 9 H 9 Br 3 , monoclinic, P 2 1 (no. 4), a = 8.7420(4) Å, b = 4.4696(2) Å, c = 13.3526(6) Å, β = 97.785(2)°, V = 516.92(4) Å 3 , Z = 2, R
gt
( F ) = 0.0235, wR
ref
( F 2 ) = 0.0528, T = 150 K.
CCDC no.: 2332847
研究领域:
化学
·
晶体学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Jingyuan Wang,Ling Yang,Jiuren Xie,Yichong Wang,Ting-Jie Wang
Herein, efficient amino modification of silica (SiO2) nanoparticles using tris(hydroxymethyl)aminomethane (Tris) was performed via aqueous mixing, spray drying, and thermal treatment. The hydroxymethyl and amino groups of Tris reacted with the silanol groups on the SiO2 particle surface. Tris amination does not produce volatile organic compounds. Moreover, Tris does not condense itself and can be easily grafted in a single molecular layer on the particle surface. The grafting density of Tris reached 2.60 nm–2. Tris amination increases the reactivity of the particle surface and significantly enhances the grafting density of stearic acid on the SiO2 particles and the hydrophobicity of the particles.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）