ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Weicai Liu,Hui Zong,Mengshu Li,Ziquan Zeng,Shijing Gong,Ke Yu,Ziqiang Zhu
A two-dimensional MXene (Ta4C3) was innovatively used herein to modulate the space group and electronic properties of vanadium oxides, and the MXene/metal–organic framework (MOF) derivative VO2(B)@Ta4C3 with 3D network cross-linking was prepared, which was then employed as a cathode to improve the performance of aqueous zinc ion batteries (ZIBs). A novel method combining HCl/LiF and hydrothermal treatments was used to etch Ta4AlC3 to obtain a large amount of accordion-like Ta4C3, and the V-MOF was then hydrothermally grown on the surface of the stripped Ta4C3 MXene. During the annealing process of V-MOF@Ta4C3, the addition of Ta4C3 MXene liberates the V-MOF from agglomerative stacking, allowing it to show additional active sites. More significantly, Ta4C3 prevents the V-MOF in the composite structure from converting into V2O5 of space group Pmmn but into VO2(B) of space group C2/m after annealing. A considerable advantage of VO2(B) for Zn2+ intercalation is provided by the negligible structural transformation during the intercalation process and the special tunnel transport channels, which have an enormous area (0.82 nm2 along the b axis). According to first-principles calculations, there is a strong interfacial interaction between VO2(B) and Ta4C3, which deliver remarkable electrochemical activity and kinetic performances for the storage of Zn2+. Therefore, the ZIBs prepared with the VO2(B)@Ta4C3 cathode material exhibit an ultra-high capacity of 437 mA h·g–1 at 0.1 A·g–1 while showing good cycle performance and dynamic performance. This study will offer a fresh approach and a reference for creating metal oxide/MXene composite structures.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Shuying He,Yuerong Lv,Jingnan Qiu,Shudan Cui,Zixian Gao,Liang Peng
Treating metabolic dysfunction-associated fatty liver disease (MAFLD) and reducing the occurrence of MAFLD-associated liver cancer remain challenging. Two-dimensional (2D) tantalum carbide (Ta4C3) MXene nanozymes (MXenzymes) exhibit antioxidant and anti-inflammatory activities and have thus attracted considerable attention in the fields of oncology and engineering. However, the potential mechanism of action and bioactive properties of Ta4C3 in MAFLD remain uncertain. In our study, Ta4C3 not only inhibited lipid accumulation and disrupted lipid metabolism in hepatocytes but also reduced cell death caused by fatty acids by decreasing intracellular reactive oxygen species (ROS) levels, which significantly promoted the polarization of M1 macrophages to M2 macrophages by alleviating oxidative stress and further suppressing inflammatory factor expression. In mice fed a methionine–choline-deficient (MCD) diet, Ta4C3 reduced lipid accumulation, the infiltration of inflammatory cells, and liver cell apoptosis by modulating the cellular microenvironment through its anti-inflammatory and antioxidant properties. Therefore, Ta4C3 can be used as a multifunctional bioactive material to alleviate hepatic steatosis and inflammation in individuals with MAFLD/metabolic dysfunction-associated steatohepatitis (MASH) because of its robust antioxidant and anti-inflammatory effects.
研究领域:
医学
·
生物材料学
·
肝脏病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
·
2025
·Vol. 15
·期 7
·426
·
IF 5.6
Kai Hua,Liang Li,Pei Liang
MXenes are a class of two-dimensional materials exhibiting excellent surface-enhanced Raman scattering (SERS) performance. Currently, the SERS studies of MXenes have been primarily focused on those with M2X and M3X2structural motifs. In order to expand the SERS sensing application based on MXenes, in this paper, a SERS sensor made of Ta4C3@AgNP nanocomposite material was fabricated by electrostatic self-assembly. Tests such as different concentrations of R6G probe molecules showed that the minimum detection limit of this SERS sensor was 10−8M, demonstrating excellent sensitivity. When different test areas are selected, the relative error of intensity under the same wave number is less than 10.7%, showing good repeatability and consistency. Furthermore, the Ta4C3@AgNP nanocomposite SERS sensor was used to detect the pesticide Ziram, and a quantitative model was established. Application detection indicates that this sensor has good sensitivity for the pesticide Ziram, and the minimum detection limit was 10−6M, which exceeded national standard requirements. The findings of this study have potential application value in the fields of food safety and environmental protection.
研究领域:
分析化学
·
材料科学
·
食品安全
·
环境监测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Fan Wu,Xiangxiao Meng,Zongxing Liu,Tiantian Lv,Long Yu,Jiarong Zhang,Ya’nan Zhao,Chang Zhao,Guangjian Xing
Flexible and long-term stable piezoresistive sensors still have room for improvement, in terms of sensitivity and cost reduction. Therefore, future research will focus on developing pressure-sensitive materials with improved performance and reduced cost. This study presents a stable suspension of Ta4C3 nanosheet using an etching and intercalation method. Subsequently, a Ta4C3 nanosheet/melamine sponge was created through a dipping-drying method and utilized as a flexible framework for wearable piezoresistive sensors. The sensors demonstrate exceptional pressure-sensing performance, including a high sensitivity (4.01 kPa–1) over a wide linear range of 0.018–12.06 kPa, a low hysteresis, a low detection limit (18.5 Pa), a short response time (35.4 ms), and a quick recovery time (27.88 ms), as well as long-term stability and durability. These sensors can be utilized for real-time monitoring of various physiological activities in the human body. Moreover, they hold potential applications in wirelessly detecting human movement and robot motion.
研究领域:
材料科学
·
生物医学工程
·
传感技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Faqing Shi,Limeng Liu,Yujin Wang,Guihong Geng
TaC 0.6 -Cu composites were fabricated by hot pressing of TaC, Ta and Cu powder mixtures. X-ray diffraction, scanning electron microscopy, transmission electron microscopy, scanning-transmission microscopy, X-ray energy-dispersive spectroscopy, and selected area electron diffraction were used to investigate formation process and growth behavior of the ζ-Ta 4 C 3-x lamellae. Cu addition did not change the reaction sequence of TaC + Ta → Ta 2 C + TaC y → ζ-Ta 4 C 3-x to form the targeted ζ-Ta 4 C 3-x phase, but enhanced growth of ζ-Ta 4 C 3-x lamellae by introducing a dissolution-reprecipitation mechanism due to presence of Cu liquid at high temperatures. ζ-Ta 4 C 3-x could directly nucleate and grow on h-Ta 2 C grain surface, meanwhile C immediately reacted with Ta solutes in Cu liquid after the C atoms diffusing along the {111} TaCy stacking faults out of parental γ-TaC y grains to initiate extension of ζ-Ta 4 C 3-x lamella outside the γ-TaC y grains, thus grew large ζ-Ta 4 C 3-x lamellae with a uniform thickness in the microstructure of the TaC 0.6 -Cu composites. The TaC 0.6 -Cu composites with large ζ-Ta 4 C 3-x lamellae in the microstructures showed increase in fracture toughness.
研究领域:
材料科学
·
显微结构分析
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2024
·
IF 13
Yapeng Wang,Jing Yang,Yunhong Ma,Jun Liu,Peng Wang,Junhao Luo,Yongjun Rui,Yongwei Wu
The accumulation of excessive reactive oxygen species (ROS) and recurrent infections with drug-resistant bacteria pose significant challenges in diabetic wound infections, often leading to impediments in wound healing. Addressing this, there is a critical demand for novel strategies dedicated to treating and preventing diabetic wounds infected with drug-resistant bacteria. Herein, 2D tantalum carbide nanosheets (Ta 4 C 3 NSs) have been synthesized through an efficient and straightforward approach, leading to the development of a new, effective nanoplatform endowed with notable photothermal properties, biosafety, and diverse ROS scavenging capabilities, alongside immunogenic attributes for diabetic wound treatment and prevention of recurrent drug-resistant bacterial infections. The Ta 4 C 3 NSs exhibit remarkable photothermal performance, effectively eliminating methicillin-resistant Staphylococcus aureus ( MRSA ) and excessive ROS, thus promoting diabetic wound healing. Furthermore, Ta 4 C 3 NSs enhance dendritic cell activation, further triggering T helper 1 (T H 1)/T H 2 immune responses, leading to pathogen-specific immune memory against recurrent MRSA infections. This nanoplatform, with its significant photothermal and immunomodulatory effects, holds vast potential in the treatment and prevention of drug-resistant bacterial infections in diabetic wounds.
研究领域:
纳米技术
·
生物医学工程
·
传染病学
·
免疫学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Tianran Wang,Chushu Zhu,Peitao Dong
Surface-enhanced Raman scattering (SERS) is a novel spectroscopic technique that enables the identification of analytes through analysis of their unique chemical signatures. Its high sensitivity, specificity, and rapid response make it a valuable tool in a range of fields, including biological detection, food safety, and environmental monitoring. However, traditional SERS nanoparticle substrates are susceptible to instability and agglomeration. In this study, Ta4C3 MXene/gold nanostar (AuNSs) hybrids were prepared as SERS substrates. By optimizing the experimental conditions of AuNSs, the optimal preparation method for the Ta4C3 MXene/AuNSs composite structure was identified. The addition of MXene to the Ta4C3 MXene/AuNSs hybrid substrates was found to enhance the sensitivity of the composite for Raman detection, as evaluated using 4-aminothiophenol (PATP) as a Raman molecule. This improvement in sensitivity is attributed to the enhanced electromagnetic properties of the hybrid substrates, which facilitate more efficient charge transfer and enhance the Raman scattering process. The limit of detection (LOD) of Ta4C3 MXene/AuNSs is 10–9 M for PATP and 10–7 M for thiram solutions. In addition, good reproducibility and spatial uniformity were obtained for the Raman signals of Ta4C3 MXene/AuNSs. Furthermore, Ta4C3 MXene/AuNSs were combined with filter paper to create paper-based SERS substrates that could be used for detection. By directly wiping the apple peel and subsequently detecting the thiram residues using Ta4C3 MXene/AuNSs, the level of detection of thiram residues on the peel surface was down to 7.8 ng/cm2.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2025
·Vol. 21
·期 15
·2412815
·
IF 12.1
Junchang Qin,Chang Wang,Min Di,Ruizhi Hu,Hui Huang,Xinran Song,Wei Feng,Chen Dai,Yu Chen,Ruifang Zhang
Atherosclerosis (AS), marked by lipid buildup and chronic inflammation in arteries, leads to major cardiovascular events. Macrophages contribute to AS by engulfing low-density lipoproteins, forming foam cells, and driving inflammation that promotes plaque growth and instability. The emerging piezocatalytic therapy uses piezoelectric materials to generate radicals that target inflammation-related macrophages for AS treatment, but the conventional materials suffer from low radical yield, substantially limiting clinical use. In this study, the construction of piezoelectric BaTiO 3 /Ta 4 C 3 MXene heterostructured nanosheets (BTOMX NSs) is reported for achieving enhanced piezoelectric AS treatment by blocking early atherosclerotic plaque progression. The composite BTOMX NSs feature high electron-hole separation efficiency due to their narrowed bandgap and high surface potential under ultrasound irradiation, enabling more effective radical generation by piezocatalytic effects. Especially, these biocompatible piezoelectric nanosheets accumulate in plaques and are efficiently internalized by macrophages, where they generate radicals under ultrasound stimulation, ultimately triggering macrophage apoptosis and interrupting plaque progression. In ApoE −/− mice, the BTOMX NSs remove lesional macrophages, reduce lipid accumulation, and mitigate inflammation, decreasing plaque burden from 21.42% to 9.04%. Taken together, this work provides a paradigm for enhancing BaTiO 3 -based piezocatalytic performance by heterostructure construction, demonstrating an efficient, noninvasive, and safe therapeutic approach for treating early-stage AS.
研究领域:
医学
·
生物材料学
·
心血管疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2019
·
IF 2.781
Faqiang Shi,Limeng Liu,Zhaoping Hou,Guihong Geng,Yujin Wang
Tantalum carbide ceramics with an overall composition of TaC 0.6 were prepared by hot pressing at 1700 °C for 1 h under 30 MPa pressure with fcc TaC and bcc Ta powder as starting materials. Effects of adding 0–30 mol% Cu on densification, phase formation, microstructural evolution , mechanical properties and electrical conductivity of the obtained composite ceramics were investigated. Full density could be reached at 20 mol% Cu addition and above. Reactions between TaC and Ta resulted in the final phases of hexagonal Ta 2 C and rhombohedral ζ-Ta 4 C 3-x . Plate-shaped ζ laminate grew in both TaC and Ta 2 C and consequently had their sizes confined by the parental grains. Addition of 20–30 mol% Cu could significantly grow the intermediate Ta 2 C grains, hence controlling length of the ζ laminates precipitated in them to form bimodal microstructures consisting of large grains. The 20 mol% Cu composition had a better flexural strength (706 ± 46 MPa) and fracture toughness (9.2 ± 1.7 MPa m 1/2 ). Electrical resistivity at room temperature of the composites decreased with Cu content from 1.03 μΩ m at 0 mol% addition to 0.12 μΩ m at 30 mol% Cu.
研究领域:
材料科学
·
陶瓷学
·
复合材料
·
粉末冶金
·
结构陶瓷
·
物理化学
·
固态化学
✓ 已验证
DOI
高影响因子
Communications Chemistry
·
2026
·
IF 6.9
Yuan Yuan,Liu Yongze,He Lei,Ma Xiaofeng,Wang Heyan,Li Yuanchao,Zhang Zhaoxiang,Zhang Jun,Wu Yongjun,Gao Xia
Acute sinusitis, common across populations, worsens seasonally due to pollution and improper medication, increasing the risk of chronic disease and impairing quality of life. To improve treatment and limit antimicrobial resistance in acute sinusitis, we developed a natural injectable QACS/SA@Py@Ta 4 C 3 hydrogel. It integrates the traditional Chinese medicine phillyrin with Ta 4 C 3 quantum dots and natural polymers—quaternary chitosan and sodium alginate. The hydrogel is designed for NIR II–mediated treatment of acute sinusitis via combined photothermal and photodynamic therapy. It exhibited a photothermal conversion efficiency of 22.6% and generated transient ROS, as demonstrated in vitro. Bacteriostatic experiments revealed that the hydrogel inhibited S. aureus with an efficiency of 99.7%. Furthermore, cell studies showed that the hydrogel was minimally cytotoxic, modulated macrophage cytokine expression, and displayed anti-inflammatory and antioxidant activities. Finally, in a rabbit sinusitis model, hydrogel implantation at the treatment site significantly reduced bacterial burden and decreased inflammation after NIR II laser treatment, demonstrating promising therapeutic potential.
✓ 已验证
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Faqiang Shi,Zhonghua Li,Limeng Liu,Jiandong Wu,Jinfu Ma,Yujin Wang
In previous works, it was found hard to synthesize “phase pure” ζ-Ta 4 C 3-z at relatively low temperatures even by prolonged heating, though ζ-Ta 4 C 3-z was believed stable till decomposition at ~2130°C. When the samples were subjected to TEM , vast richness of locally disordered structures in close relation with stacking of the close-pacted Ta-atom planes was observed. Although kinetic factors including diffusion of C atoms/vacancies and re-stacking of the Ta-atom planes explain the densely disordered structures, the richness of local disorders is a scenario that shows cohabitant of the cubic, rhombohedral, and hexagonal structures in a single grain, i.e. formation of a “hybrid grain” consisted of the three symmetries, indicating a transitional or intermediate stage before complete formation of the final phase of rhombohedral ζ-Ta 4 C 3-z . This time tantalum carbide ceramics TaC x with C:Ta atomic ratios x = 0.66 and 0.7 were prepared by reaction hot pressing of TaC and Ta powder mixtures. 5–30 mol% Cu/Ag additives and heat treatments were used to reproduce “hybrid grains” to facilitate further TEM and HRTEM observations on the disordered hybrid grains to argue for the transitional/intermediate stage. The cohabitant cubic, rhombohedral, and hexagonal structures in single grains may also help explain the difficulty in identification of the various phases by XRD in the transitional/intermediate stage of ζ-Ta 4 C 3-z reaction. Microstructural evolution and fracture toughness of the composites were also investigated.
研究领域:
材料科学
·
陶瓷
·
纳米材料
·
固体化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）