Fan Wu,Xiangxiao Meng,Zongxing Liu,Tiantian Lv,Long Yu,Jiarong Zhang,Ya’nan Zhao,Chang Zhao,Guangjian Xing
Flexible and long-term stable piezoresistive sensors still have room for improvement, in terms of sensitivity and cost reduction. Therefore, future research will focus on developing pressure-sensitive materials with improved performance and reduced cost. This study presents a stable suspension of Ta4C3 nanosheet using an etching and intercalation method. Subsequently, a Ta4C3 nanosheet/melamine sponge was created through a dipping-drying method and utilized as a flexible framework for wearable piezoresistive sensors. The sensors demonstrate exceptional pressure-sensing performance, including a high sensitivity (4.01 kPa–1) over a wide linear range of 0.018–12.06 kPa, a low hysteresis, a low detection limit (18.5 Pa), a short response time (35.4 ms), and a quick recovery time (27.88 ms), as well as long-term stability and durability. These sensors can be utilized for real-time monitoring of various physiological activities in the human body. Moreover, they hold potential applications in wirelessly detecting human movement and robot motion.
The accumulation of excessive reactive oxygen species (ROS) and recurrent infections with drug-resistant bacteria pose significant challenges in diabetic wound infections, often leading to impediments in wound healing. Addressing this, there is a critical demand for novel strategies dedicated to treating and preventing diabetic wounds infected with drug-resistant bacteria. Herein, 2D tantalum carbide nanosheets (Ta 4 C 3 NSs) have been synthesized through an efficient and straightforward approach, leading to the development of a new, effective nanoplatform endowed with notable photothermal properties, biosafety, and diverse ROS scavenging capabilities, alongside immunogenic attributes for diabetic wound treatment and prevention of recurrent drug-resistant bacterial infections. The Ta 4 C 3 NSs exhibit remarkable photothermal performance, effectively eliminating methicillin-resistant Staphylococcus aureus ( MRSA ) and excessive ROS, thus promoting diabetic wound healing. Furthermore, Ta 4 C 3 NSs enhance dendritic cell activation, further triggering T helper 1 (T H 1)/T H 2 immune responses, leading to pathogen-specific immune memory against recurrent MRSA infections. This nanoplatform, with its significant photothermal and immunomodulatory effects, holds vast potential in the treatment and prevention of drug-resistant bacterial infections in diabetic wounds.
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