Electrochemical degradation of antiviral drug abacavir was investigated by using a penetration flux porous Ti/SnO 2 –Sb anode prepared by sol-gel method. The effects of applied current density, initial pH, and inorganic anions on the degradation kinetics were systematically studied. Degradation efficiency more than 97% was performed in only 10 min at a current density of 0.2 mA cm −2 . The corresponding degradation rate constant and the lowest electrical energy per order were calculated to be 0.36 min −1 and 6.5 mWh L −1 , respectively. Extending the reaction duration to 5 h, 53.3% of TOC removal was observed. The results indicated that effective degradation of abacavir appeared in the penetration flux porous Ti/SnO 2 –Sb anode with a very low energy consumption. Furthermore, the electrochemical intermediate products and the reaction site during abacavir degradation were detected and recognized. The quantitative structure-activity relationship model revealed that the potential risks of abacavir to the aquatic organism, such as fish, greatly decreased after flowing through the penetration flux porous Ti/SnO 2 –Sb anode.
Electrochemical degradation of trace antiretroviral drug stavudine was investigated by using a reactive electrochemical membrane (REM) with Ti/SnO 2 -Sb anode. From the results it was evident that the stavudine degradation followed pseudo-first-order kinetics, with the values of the degradation rate constant and half-life being 0.24 min −1 and 2.9 min, respectively, at a current density of 8 mA cm −2 . The degradation rate was obviously decreased under alkaline condition (pH = 11.0) and the degradation was also inhibited in the presence of NO 3 − and Cl − . Five intermediates were identified in the electrochemical degradation of stavudine, and the degradation pathways were proposed. Density functional theory calculation revealed that the double bond carbon atom nearby hydroxymethyl group was the site attacked by OH and the cleavage of C N bond was the rate-determining step in the electrochemical degradation of stavudine. The nitrogen in stavudine was mainly converted to nitrate and ammonium. Quantitative structure-activity relationship model indicated that the toxicity of some intermediates was higher than the parent compound stavudine. The electric energy consumption for 90% stavudine degradation ranged from 0.87 to 2.29 Wh L −1 at the experimental conditions, indicating that stavudine can be degraded efficiently by the REM with Ti/SnO 2 -Sb anode.
危险品化学品经营许可证（带存储）