Journal of Materials Chemistry A
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2026
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IF 9.2
Xin Li,Zhongya Jia,Yi Wang,Kuo Liu,Xi Li,Tao Qi
The development of electrocatalysts that simultaneously exhibit high activity and robust stability for the oxygen evolution reaction (OER) is critical to advancing proton exchange membrane water electrolysis (PEMWE). In this work, Mn-doped RuO2 is composited with acid-resistant and highly conductive Ti4O7 via a simple molten salt method, yielding a Mn-RuO2/Ti4O7 hybrid electrocatalyst. Electrochemical measurements reveal that Mn-RuO2/Ti4O7 achieves a low overpotential of 194 mV at 10 mA cm⁻² and maintains stable operation for over 220 h at this current density. In situ spectroscopic analysis and computational studies further indicate that Mn doping modulates the electronic interplay between RuO2 and Ti4O7, which not only suppresses over-oxidation of Ru at high potentials but also promotes the deprotonation kinetics of reaction intermediates, thereby significantly enhancing the overall catalytic performance. This work offers an effective strategy for balancing activity and stability in acidic OER electrocatalys.
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MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Luyan Meng,Bing Wang,Sijia Zhang,Shun Zhang,Ting Cai,Chuan-Fan Ding,Yinghua Yan
A Ti 4+ -functionalized ionic liquid polymer microsphere was proposed and prepared through free radical precipitation polymerization. The polymer microsphere demonstrates excellent performance on phosphopeptide enrichment, with a low detection limit (0.5 fmol) and good selectivity (1:2500). Through the analysis of HepG2 cell lysate using nano LC-MS/MS after material enrichment, a total of 1100 phosphopeptides and 733 phosphoproteins were identified. Additionally, in the serum of liver cancer patients, 69 phosphopeptides, 47 phosphoproteins, and 52 phosphorylation sites were identified, while healthy controls exhibited 55 phosphopeptides, 31 phosphoproteins, and 40 phosphorylation sites. Label-free quantification revealed 10 differentially expressed proteins (DEPs), with five proteins (FN1, SERPIND1, SERPINF2, IGFBP3, and MENT) being up-regulated and five proteins (SELENOP, PLG, SPP2, SERPINC1, and GP1BB) being down-regulated. These findings highlight the potential of the MBA-VImDOPA-Ti 4+ polymer microsphere in specifically enriching phosphopeptides from clinical biological samples.
研究领域:
分析化学
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生物化学
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蛋白质组学
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癌症研究
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JOURNAL OF SOLID STATE CHEMISTRY
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2022
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IF 3.656
Lei Chen,Youqun Wang,Xiaohong Cao,Zhibing Zhang,Yunhai Liu
Hydroxyapatite samples doped with different metal ions (HAP-M, M = Cu, Sr, Al, Ce, and Ti) were successfully prepared by a simple co-precipitation method for effective U(VI) uptake. The applications of HAP-M in capturing U(VI) were investigated. Besides, numerous characterizations were taken to study the chemical and physical properties of HAP-M. The critical factors affecting U(VI) adsorption were examined, such as pH, contact time, initial concentration of U(VI) and solution temperature. The present study revealed that the adsorption effect of HAP for U(VI) can be affected by doping metal cations with different ionic radii, and HAP doping with Ti 4+ ions increased its adsorption selectivity to U(VI). With the increase of the molar ratio of doped Ti 4+ ions (5%–20%), the adsorption selection of U(VI) on HAP-Ti is also gradually increasing. HAP-Ti is a potentially efficient adsorbent in removing U(VI) from radioactive solutions.
研究领域:
材料科学
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环境化学
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核废料管理
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高影响因子
FOOD CHEMISTRY
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2022
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IF 9.231
Wenrui Wu,Ruizhi Tang,Zhouxian Li,Yehua Shen,Shujuan Ma,Junjie Ou
It is prerequisite to efficient extraction of phosphopeptides in bottom-up strategy for protein phosphorylation research. A kind of Ti 4+ -immobilized polydispersed phosphate-rich microsphere was fabricated via inverse suspension polymerization by employing vinylphosphonic acid (VPA) and N,N -methylenebisacrylamide (MBA) as functional monomer and crosslinker, respectively. The resulting microsphere demonstrated excellent sensitivity (as low as 10 fmol), selectivity (the mass ratio of β-casein to BSA digests is 1/500), and adsorption capacity (up to 200 mg g −1 ). What's more, 113 unique phosphopeptides assigned to 25 unique phosphoproteins were indiscriminately identified from 5 μL of pasteurized milk digest, exhibiting great performance in capturing phosphopeptides. In this approach, only two steps were required to synthesize Ti 4+ -IMAC (Ti 4+ -Immobilized metal affinity chromatography). Compared with other methods required multistep modifying process, this strategy is simple and time-saving, offering a prospect of pilot production and commercialization. It is expected that the application of IMAC in milk and other food samples will still make it possible to unravel the huge complexity of the Foodome in the near future.
研究领域:
分析化学
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生物化学
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蛋白质组学
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食品科学
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PubMed
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ANALYTICA CHIMICA ACTA
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2021
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IF 6.558
Chenhui Zhang,Yini Pan,Yameng Zhao,Peiyao Wang,Lingyi Zhang,Weibing Zhang
Functional materials with good biocompatibility have been widely used in the study of genomics, proteomics and disease diagnosis, which has improved the progress of life science. In this paper, the material not only exhibited a strong affinity to the phosphate groups on the exosomal membrane due to the coexistence of Zr–O clusters and Ti 4+ , but also owned great hydrophilicity to reduce non-specific adsorption of contaminated proteins, achieving the separation and purification of exosomes from complex biosamples. The model exosomes extracted by ultracentrifugation (UC) were used to evaluate the feasibility of Fe 3 O 4 @UiO-66-NH 2 @PA-Ti 4+ capturing exosomes. The process of Fe 3 O 4 @UiO-66-NH 2 @PA-Ti 4+ capturing exosomes was simple to operate with a high recovery rate (97.3%) within a short time (5 min). Then Fe 3 O 4 @UiO-66-NH 2 @PA-Ti 4+ was further applied to capture exosomes in media and urine followed by the downstream proteomics analysis. 348 and 284 exosomal proteins were identified for cell medium and urine, respectively. This work shows great potential of the material for subsequent function research of disease-related exosomes by separating exosomes rapidly and efficiently.
研究领域:
材料科学
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生物技术
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生物化学
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纳米技术
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诊断学
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PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2024
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IF 3.8
Luyan Meng,Bing Wang,Sijia Zhang,Shun Zhang,Ting Cai,Chuan-Fan Ding,Yinghua Yan
A dipeptide-based bifunctional material immobilized with Ti 4+ (denoted as APE-MBA-VPA-Ti 4+ ) was developed using precipitation polymerization. This polymer combines hydrophilic interaction liquid chromatography (HILIC) and immobilized metal affinity chromatography (IMAC) enrichment strategies, allowing for the individual and simultaneous enrichment of glycopeptides and phosphopeptides . It demonstrated high sensitivity (0.1 fmol μL −1 for glycopeptides , 0.005 fmol μL −1 for phosphopeptides), strong selectivity (molar ratio HRP: BSA = 1:1000, β-casein: BSA = 1:2500), consistent reusability (10 cycles) and satisfactory recovery rate (93.5 ± 1.8 % for glycopeptides, 91.6 ± 0.6 % for phosphopeptides) in the individual enrichment. Utilizing nano LC-MS/MS technology, the serum of liver cancer patients was analyzed after enrichment individually, resulting in the successful capture of 333 glycopeptides covering 262 glycosylation sites, corresponding to 131 glycoproteins, as well as 67 phosphopeptides covering 57 phosphorylation sites, related to 48 phosphoproteins. In comparison, the serum of normal healthy individuals yielded a total of 283 glycopeptides covering 244 glycosylation sites corresponding to 126 glycoproteins, as well as 66 phosphopeptides covering 56 phosphorylation sites related to 37 phosphoproteins. Label-free quantification identified 10 differentially expressed glycoproteins and 8 differentially expressed phosphoproteins in the serum of liver cancer patients. Among them, glycoproteins (HP, BCHE, AGT, C3, and PROC) and phosphoproteins (ZYX, GOLM1, GP1BB, CLU, and TNXB) showed upregulation and displayed potential as biomarkers for liver cancer.
研究领域:
分析化学
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生物化学
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癌症生物学
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蛋白质组学
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DOI
PubMed
高影响因子
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