Yupeng Gao,Libo Wang,Aiguo Zhou,Zhengyang Li,Jingkuo Chen,Hari Bala,Qianku Hu,Xinxin Cao
TiO 2 /Ti 3 C 2 nanocomposites with high photocatalytic activity were successfully fabricated via a hydrothermal process. The microstructure and phase composition of these composites were characterized by field emission scanning electron microscope (FESEM) and X-ray diffraction (XRD). The photocatalytic performance of pure TiO 2 and TiO 2 /Ti 3 C 2 nanocomposites were evaluated by photodegradation of methyl orange (MO) under ultraviolet light irradiation. Photodegradation tests results revealed that TiO 2 /Ti 3 C 2 have much better photocatalytic activity than pure TiO 2 nanomaterials . And it was suggested that the TiO 2 /Ti 3 C 2 exhibited more effective electron–hole separation than pure TiO 2 and Ti 3 C 2 under UV light irradiation.
Zhenlei Wang,Zengci Run,Huamin Wang,Xiaojun He,Jian Li
Purpose The search for effective and low-risk treatment methods for colorectal cancer (CRC) is a pressing concern, given the inherent risks and adverse reactions associated with traditional therapies. Photothermal therapy (PTT) has emerged as a promising approach for cancer treatment, offering advantages such as non-radiation, non-invasiveness, and targeted treatment. Consequently, the development of nanoparticles with high stability, biocompatibility, and photothermal effects has become a significant research focus within the field of PTT.Methods In this study, TiO2-Ti3C2 nanocomposites were synthesized and characterized, and their photothermal conversion efficiency in the near-infrared region II (NIR-II) was determined. Then studied the in vivo and in vitro photothermal activity and anti-tumor effect of TiO2-Ti3C2 in human colorectal cancer cell lines and nude mice subcutaneous tumor model.Results The results showed that TiO2-Ti3C2 nanocomposites have strong absorption ability in the NIR-II, and have high photothermal conversion efficiency under 1064 nm (0.5 W/cm2, 6 min) laser stimulation. In addition, in vitro experiments showed that TiO2-Ti3C2 nanocomposites significantly inhibited the invasion, migration, and proliferation of colorectal cancer cells, and induced cell apoptosis; in vivo, experiments showed that TiO2-Ti3C2 nanocomposites-mediated PTT had good biocompatibility and efficient targeted inhibition of tumor growth.Conclusion In conclusion, TiO2-Ti3C2 nanocomposites can be used as NIR-II absorption materials in PTT to suppress the invasion, migration, and proliferation of colorectal cancer cells, induce colorectal cancer cell apoptosis, and thus inhibit the development of CRC. Therefore, TiO2-Ti3C2 nanocomposites can be used as potential anti-tumor drugs for photothermal ablation of colorectal cancer cells.
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