LANGMUIR
·
2021
·
IF 3.882
Ximing Lu,Lei Fan,Chao Song,Zhilong Xu,Yimin Hu,Rong Guo
Lamellar liquid crystals have amazing lubricating and drug-solubilizing properties. Hence, the combination of drug molecules with lamellar liquid crystals is expected to be used in joint lubrication and treatment. In this study, the partial phase diagram of the Tween 85/Tween 80/H2O three-component system was determined. The phase structure of the system changed from a hexagonal liquid crystal to a lamellar liquid crystal with the increase of Tween 85 content. The lamellar liquid crystals showed superior lubricating properties due to their unique lamellar structure. Furthermore, the model of drug release during friction was established for the first time. It was found that the order of the lamellar liquid crystals increased with the increase of the mass ratio of Tween 85/Tween 80, leading to the decrease of the ibuprofen release rate. In addition, the release rate of ibuprofen increased progressively with the increase of the friction frequency, but the load had little effect on it. Therefore, the lamellar liquid crystals consisting of nonionic surfactants with good biocompatibility have potential application prospects for joint lubrication and treatment of arthritis.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED TOXICOLOGY
·
2014
·Vol. 35
·期 3
·295-301
·
IF 3.174
Rui Yang,Qiao-Cong Lao,Hang-Ping Yu,Yong Zhang,Hong-Cui Liu,Lin Luan,Hui-Min Sun,Chun-Qi Li
A number of recent reports suspected that Tween-80 in injectable medicines, including traditional Chinese medicine injections could cause life-threatening anaphylactoid reaction, but no sound conclusion was drawn. A drug-induced anaphylactoid reaction is hard to be assayed in vitro and in conventional animal models. In this study, we developed a microplate-based quantitative in vivo zebrafish assay for assessing anaphylactoid reaction and live whole zebrafish mast cell tryptase activity was quantitatively measured at a wavelength of 405 nm using N -benzoyl- dl -arginine p-nitroanilide as a substrate. We assessed 10 batches of Tween-80 solutions from various national and international suppliers and three Tween-80 impurities (ethylene glycol, 2-chloroethanol and hydrogen peroxide) in this model and found that three batches of Tween-80 (nos 2, 20080709 and 20080616) and one Tween-80 impurity, hydrogen peroxide (H 2 O 2 ), induced anaphylactoid reactions in zebrafish. Furthermore, we found that H 2 O 2 residue and peroxide value were much higher in Tween-80 samples 2, 20080709 and 20080616. These findings suggest that H 2 O 2 residue in combination with oxidized fatty acid residues (measured as peroxide value) or more likely the oxidized fatty acid residues in Tween-80 samples, but not Tween-80 itself, may induce anaphylactoid reaction. High-throughput zebrafish tryptase assay developed in this report could be used for assessing safety of Tween-80-containing injectable medicines and potentially for screening novel mast cell-modulating drugs. Copyright © 2014 John Wiley & Sons, Ltd.
研究领域:
药理学
·
毒理学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2014
·
IF 3.552
Lingling Ge,Shuhui Lu,Rong Guo
Janus emulsions of a polymerizable monomer tripropyleneglycol diacrylate (TP) combined with silicone oil (SO) as inner oil phases and Tween 80 aqueous solution as continuous phase are prepared in a one-step high energy mixing process. The dependence of droplet topology on the concentration of surfactant, TP/SO ratio, and the stirring speed during emulsification is investigated. The result shows that the volume ratio of two oils within an individual droplet changes correspondingly to the total composition of emulsion. Increasing the speed of stirring results in a significant reduction in the droplet size, i.e. a five times increase in the stirring speed produces a droplet size reduction from hundreds to a few microns. What is more important, the topology of Janus drops remains similar for the different preparations. These fundamental investigations illustrate the potential for future Janus particle synthesis in batch scale with a controllable particle topology.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Binglu Deng,Xingqiu Zhou,Xingjian Yang,Zhi Dang,Guining Lu
ABSTRACT This study reports on the adsorption of polychlorinated biphenyls (PCBs) by powder activated carbon (PAC) in soil washing eluents containing tween-80 surfactant micelles. Factors influencing of adsorption were studied (i.e., time, adsorbents doses, molecular structure of different PCBs congeners, dynamic and thermodynamic models). The adsorption of PCBs on nano bamboo charcoal (NBC) was compared with those on PAC. Finally, the prospect for recycling soil eluents was explored. We found that the PAC and NBC were both effective in removal of 12 mg/L PCBs in soil washing eluents. The results of the adsorption kinetics showed that both materials have different adsorption rate controlling step, the particles diffusion became adsorption rate controlling step of NBC while particle diffusion and adsorption reaction like chemical bonding reactions co-control the adsorption rate of PAC. The adsorption of PCBs on PAC was probably chemisorption through interaction between aromatic rings and oxygen-containing functional groups while the adsorption on NBC was mainly physisorption by micropore filling. After the PAC treatment, the residual tween-80 in the eluents was 27.78% (total mass ratio). The addition of acetone to break micelles before adsorption could increase the recovery of tween-80 to 73.30% while PCBs removal rate could still reach 78.06%. Therefore, the surfactant solutions can be reused after adsorption. The studies provide valuable information on the adsorption of PCBs by PAC in soil washing eluents, which may improve the utilization and selection of PAC in the recovery of soil washing eluents.
研究领域:
环境科学
·
污染治理
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2014
·Vol. 22
·期 1
·555-564
·
IF 2.757
Wu Yingxin,Wu Zihao,Huang Xiongfei,Simonnot Marie-Odile,Zhang Tao,Qiu Rongliang
Effective dehalogenation by nanoscale zerovalent iron (nZVI) has been reported. In this study, the effects of Ni 2+ , Cu 2+ ions, and the nonionic surfactant Tween-80 on dechlorination of 2,2’,5,5’-tetrachlorinated biphenyl (PCB-52) by nZVI were investigated in aqueous solution. The rate of dechlorination was significantly enhanced by Ni 2+ , while Cu 2+ had a less significant catalytic effect. Ni 2+ and Tween-80 used in combination synergistically enhanced dechlorination of PCB-52 by nZVI, although the enhancement by Tween-80 was inhibitory in the presence of Cu 2+ and insignificant in the absence of both metal ions. Congener specificity in the dechlorination pathway resulted from the preferential retention of ortho-chlorine, which restricted the formation of environmentally toxic coplanar PCB congeners. The application of nZVI dehalogenation enhanced by Ni 2+ and Tween-80 is a promising technique for posttreatment of PCB-contaminated soil washing solutions.
研究领域:
环境科学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
BIORESOURCE TECHNOLOGY
·
2017
·
IF 5.651
Dan Sun,Aftab Alam,Yuanyuan Tu,Shiguang Zhou,Yanting Wang,Tao Xia,Jiangfeng Huang,Ying Li,Zahoor,Xiaoyang Wei,Bo Hao,Liangcai Peng
In this study, total ten Miscanthus accessions exhibited diverse cell wall compositions, leading to largely varied hexoses yields at 17%–40% (% cellulose) released from direct enzymatic hydrolysis of steam-exploded (SE) residues. Further supplied with 2% Tween-80 into the enzymatic digestion, the Mis7 accession showed the higher hexose yield by 14.8-fold than that of raw material, whereas the Mis10 had the highest hexoses yield at 77% among ten Miscanthus accessions. Significantly, this study identified four wall polymer features that negatively affect biomass saccharification as p < 0.05 or 0.01 in the SE residues, including cellulose DP, Xyl and Ara of hemicellulose, and S-monomer of lignin. Based on Simons’ stain, the SE porosity (defined by DY/DB) was examined to be the unique positive factor on biomass enzymatic digestion. Hence, this study provides the potential strategy to enhance biomass saccharification using optimal biomass process technology and related genetic breeding in Miscanthus and beyond.
研究领域:
植物学
·
生物能源
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2018
·
IF 4.513
Rui Li,Yunkang Chang,Yuran Zhang,Xiang'e Chen,Youshuang Zhu
The foam-induced enzyme denaturation , which often results in a large activity loss, is a common phenomenon in foam fractionation of enzymes. To reduce it effectively, we used a Tween 20-containing antifoaming agent to assist the renaturation of the enzyme molecules adsorbed at the gas-liquid interface during defoaming with pepsin as a model enzyme. We studied the roles of the antifoaming agent and its ingredients in renaturation of the adsorbed pepsin molecules. The results show that during defoaming, Tween 20 in the antifoaming agent was able to assist the adsorbed pepsin molecules to restore their native structures as soon as they were desorbed from the gas-liquid interface. The other ingredients, including polydimethylsiloxane, polyether L61 and aluminum silicate, did not affect the pepsin structure during defoaming. However, they enhanced the Tween 20-assisted renaturation of the adsorbed pepsin molecules by increasing the defoaming efficiency. Furthermore, the separation of the antifoaming agent from pepsin in the foamate had no significant effect on its specific activity. When the addition amount of the antifoaming agent in the foamate was 15.0‰ ( v / v ), almost all the adsorbed pepsin molecules were reactivated. Therefore, the foam-induced pepsin denaturation was reduced effectively without any changes of the foam fractionation process itself. The results are important to improve the performances of foam fractionation of enzymes.
研究领域:
生物化学
·
酶工程
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Xiaojing Liu,Yangcheng Lu
Tween 80 coated magnetic polymer nanocomposite particles (NCPs), as functional materials with good biological application prospects, still confront a challenge in high-yield preparation inhibiting either plain polymer particles or aggregates. In this study, we are devoted to make a breakthrough by using emulsion polymerization solely stabilized by nonionic surfactant Tween 80 and initiated by an oil-soluble initiator, 2,2′-azobis(isobutyronitrile). After carefully investigating the effects of Fe3O4, monomer, initiator, and emulsifier dosages on the monomer conversion, encapsulation efficiency, and particle characteristics, we confirm that a low but sufficient Tween 80 dosage relative to the Fe3O4 dosage enables the high-yield synthesis of NCPs. Using a micromixing method to prepare colloidal Fe3O4 clusters at the reduced Tween 80 concentration allows for the production of monodispersed NCPs with considerable monomer conversion and total encapsulation. The mechanism to achieve controlled NCPs synthesis is also revealed by monitoring and analyzing the time profiles of monomer conversion and products morphology.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Nanomaterials
·
2021
·
IF 2.986
Nguyen Tuan Anh,Ngo Xuan Dinh,Hoang Van Tuan,Tran Hung Thuan,Le Minh Tung,Van Phan Le,Doan Quang Tri,Anh-Tuan Le
Thiram plays a critical role in protecting fruits and vegetables from damage by various crop diseases, but its residues significantly affect the environment, such as soil and water pollution, and becoming a serious threat to human health. Herein, Tween 80-capped copper nanoparticles (Tween 80-CuNPs) were developed as a convenient and low-cost colorimetric probe for selective detection of thiram pesticide. In the presence of thiram, the color of Tween 80-capped CuNPs changed from dark brown to olive green and colorless at high thiram concentrations. The Tween 80-capped CuNPs-based colorimetric probe exhibited good selectivity and high sensitivity (LOD about 0.17 μM) with a high linearity level in the calibration range of 0.5–25 μM of thiram concentrations. The thiram limit of detection (LOD) of proposed sensor is lower than the maximum residue limit (MRL) regulated by the governments of EU and Vietnam. Moreover, the proposed sensor was successfully applied to determine thiram in tap water with percentage recovery of 98-107% and high repeatability (). The obtained results indicated that Tween 80-capped CuNPs would become a cost-effective sensing platform for ultrahigh-sensitive thiram determination in the environmental water samples.
研究领域:
环境科学
·
分析化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2023
·
IF 4.1
Bo Peng,Yifan Hao,Chao Si,Bo Wang,Chengfeng Luo,Menghao Chen,Cheng Luo,Baijuan Gong,Zhimin Li
Oral cancer is the most common malignant tumor in the oral and maxillofacial region, which seriously threatens the health of patients. At present, radiotherapy is one of the commonly used methods for oral cancer treatment. However, the resistance of cancerous tissues to ionizing radiation, as well as the side effects of X-rays on healthy tissues, still limit the application of radiotherapy. Therefore, how to effectively solve the above problems is still a challenge at present. Generally speaking, elements with high atomic numbers, such as bismuth, tungsten, and iodine, have a high X-ray attenuation capacity. Using nanomaterials containing these elements as radiosensitizers can greatly improve the radiotherapy effect. At the same time, the modification of nanomaterials based on the above elements with the biocompatible polymer can effectively reduce the side effects of radiosensitizers, providing a new method for the realization of efficient and safe radiotherapy for oral cancer. In this work, we prepared Tween-20-modified BiVO4 nanorods (Tw20-BiVO4 NRs) and further used them in the radiotherapy of human tongue squamous cell carcinoma. Tw20-BiVO4 NRs are promising radiosensitizers, which can generate a large number of free radicals under X-rays, leading to the damage of cancer cells and thus playing a role in tumor therapy. In cell experiments, radiotherapy sensitization of Tw20-BiVO4 NRs significantly enhanced the production of free radicals in oral cancer cells, aggravated the destruction of chromosomes, and improved the therapeutic effect of radiotherapy. In animal experiments, the strong X-ray absorption ability of Tw20-BiVO4 NRs makes them effective contrast agents in computed tomography (CT) imaging. After the tumors are located by CT imaging, it helps to apply precise radiotherapy; the growth of subcutaneous tumors in nude mice was significantly inhibited, confirming the remarkable effect of CT imaging-guided radiotherapy.
研究领域:
肿瘤学
·
放射学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2022
·
IF 8.634
Yanting Lv,Zhengyu Chen,Huan Wang,Yongcang Xiao,Rongxin Ling,Murong Gong,Weiqi Wei
In this work, an HCl-catalyzed ethylene glycol (EG) pretreatment was exploited for promoting sugar release from sugarcane bagasse (SCB). The results showed that the combination of HCl and EG could remove the xylan (∼100.0%) and lignin (∼61.3%) in SCB together, which finally resulted in the pretreated substrate having a good efficacy for follow-up enzymatic hydrolysis . The maximum glucose yield of this work was 93.9% and obtained after pretreatment at 130 °C for 60 min with 0.5% HCl and 72 h enzymatic digestion. The analysis of various pretreated or un-pretreated SCB indicated that the changes of surface morphology and internal compositions of SCB were the mainly reasons for its hydrolysis efficiency enhancement. The addition of Tween 80 into hydrolysis process could remarkably shorten hydrolysis time and cellulase dosage from 72 h to 36 h and 20 FPU/g substrate to 10 FPU/g substrate, respectively, meanwhile maintaining a relatively high glucose yield (91.4%).
研究领域:
生物技术
·
可再生资源工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2015
·
IF 2.752
Xiaokun Wang,Yingqin Wei,Shasha Wang,Lingxin Chen
In this work, a simple “red-to-blue” colorimetric method for highly sensitive and selective determination of Cr (III) and Cr (VI) was presented, which was based on the aggregation of Tween 20-stabilized gold nanoparticles (Tween 20-Au NPs). This strategy relied upon the distance-dependent optical properties of gold nanoparticles (Au NPs), strong chelating between Cr (III) and citrate, and the reduction of Cr (VI) to Cr (III) by ascorbic acid (AA). Cr (III) could chelate with citrate to form a stable Cr (III)-citrate complex and thereby induce the aggregation of Tween 20-Au NPs. Thus, the sensing of Cr (III) and Cr (VI) based on aggregation of Au NPs was developed with the color of the Au NPs changing from red to blue, which was readily seen by the naked eye. The color change and surface plasmon resonance (SPR) absorption were used to monitor Cr (III) and Cr (VI) levels. Under the optimal assay conditions, good linear relationship was obtained, and the detection limit of Cr (III) and Cr (VI) were 0.016 μM and 0.009 μM in standard aqueous solution, respectively. Furthermore, the colorimetric method exhibited a good selectivity over other metal ions and was successfully applied to detect Cr (III) and Cr (VI) in real water samples.
研究领域:
分析化学
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）