RUSSIAN JOURNAL OF GENERAL CHEMISTRY
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2024
·Vol. 94
·期 1
·170-183
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IF 0.9
Li T.,Fu X.,Wang Y.,Ouyang F.,Liu L.,Wen M.,Zha G.,Zhu L.
Abstract Celecoxib (CXB) is a nonsteroidal anti-inflammatory drug (NSAID). However, the application of CXB has been compromised by its poor aqueous solubility and low oral bioavailability. We developed a series of ternary solid dispersions (SDs) of CXB to increase its solubility. In this study, the polymers were screened to determine that they have the potential to increase the solubility of CXB in the solution. A hydrophilic polymer-hydroxypropyl methylcellulose (HPMC) and a surfactant Tween80 were employed as matrix respectively in the optimized formulations. Experimental data revealed that CXB was molecularly distributed within all dispersions in amorphous form by using Differential Scanning Calorimetry (DSC), Polarizing Light Microscopy (PLM), and X-ray powder diffraction (XRD). Fourier Transform Infrared Spectroscopy (FTIR) results showed that the characteristic peaks of CXB have shifted. Compared with pure CXB, the addition of excipients can reduce the contact angle, and improve the solubility of CXB. Ternary SDs were dissolved in PBS (pH 6.8) and formed drug-carrying nanoparticles. In vitro dissolution results indicated that the dissolution amount of HPMC-CXB 5 : 1 SD (32.08±1.56% for 120 min) was higher than pure CXB (3.09±0.29%). In particular, the greatest dissolution enhancement was obtained from the test of which the result was HPMC/Tween80-CXB 3 : 2 : 1 SD (44.12±2.01% for 120 min). This study showed that ternary SDs could be a promising strategy for improving CXB dissolution.
研究领域:
药剂学
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药物化学
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产品关联
DOI
高影响因子
Biomass Conversion and Biorefinery
·
2024
·
IF 3.5
Wang Xuchong,Wei Yuhe,Sun Xiaoping,Yuan Juan,Chen Haoqiu,Sun Yanfen,Luo Lianxin
Pretreatment is the key step in enzymatic hydrolysis of bamboo wood. Green liquor pretreatment is a promising method to improve enzymatic hydrolysis and saccharification efficiency by changing the physical and chemical properties of lignocellulose surface. At present, there is little work to quantitatively analyze the enzymatic saccharification rate of bamboo lignocellulose by two-stage pretreatment. In this study, a two-stage pretreatment method combining hot water and green liquid phase was mainly used, and the bamboo was treated with Bovine serum albumin (BSA) and Tween80 (TW) chemical additives. After that, the treated samples were hydrolyzed by cellulase, and the effects of pretreatment on the chemical composition and physical properties of bamboo and the influencing factors of chemical additives on the enzymatic hydrolysis efficiency of bamboo were explored. The results showed the two pretreatment stages of hot water and green liquid to have an evident effect on the enzymatic hydrolysis of bamboo. The two-stage pretreatment with hot water and green liquid (14% total alkali) resulted in an 85.51% yield of total sugar hydrolyzed by the enzyme. The addition of BSA and Tween80 improved the efficiency of the enzymatic hydrolysis of bamboo, and the synergistic effect of them could make the total sugar yield of enzymatic hydrolysis reach 99.67%. Through calculation, 65.88 g of fermentable sugar can be obtained per 100 g of bamboo fiber through enzymatic hydrolysis with cellulase. Graphical Abstract
研究领域:
生物化学
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可再生资源与环境
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
·
IF 4.9
Hairong Wu,Wenhao Shao,Genglin Li,Jiawei Chang,Xiaoxuan Bai,Huaizhu Liu,Jiqing Guo,Xiaoliang Zhao,Jirui Hou
The use of nanofluids in formations with high temperatures and high salinity is currently encountering significant obstacles. Therefore, a Janus SiO 2 -surfactant dispersion consisting of Janus nanoparticles and surfactants was constructed in the current study. The Janus SiO 2 -surfactant dispersion is resistant to both high temperatures and high salinity. The Janus SiO 2 -surfactant dispersion, consisting of Janus SiO 2 nanoparticles and the non-ionic surfactant Tween80, is abbreviated as JASN-T80 hereafter. The system can be dispersed and kept stable for one week at a salinity of 30,000 mg/L and a temperature of 85 ℃. The concentration of f nanoparticles and surfactant in the system was optimized at 0.02 wt% Janus SiO 2 nanoparticles + 0.04 wt% Tween80 based on the particle size. An assessment was conducted to measure the system's capacity to decrease interfacial tension and alternate wettability. The interfacial tension between oil and water was reduced to 1.21 mN/m. The JASN-T80 system demonstrates a notable capacity to change wettability by decreasing the contact angle of water on an oil-wet rock surface from 100.6° to 70.5°. The combination of nanoparticle and surfactant leads to a synergistic effect, resulting in an imbibition recovery of 44.28 % for ultra-low permeability core. This work provides a novel concept for the advancement and utilization of nanofluid imbibition system for unconventional reservoir.
研究领域:
石油工程
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材料科学
·
化学工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Aihua Qiao,Yanyi Duan,Xue Gao,Ning Ren,Renliang Huang,Jiangjiexing Wu,Wei Qi,Anastasia Penkova,Rongxin Su
Oil from offshore oil spills may be stranded on beaches and exist for decades, requiring appropriate cleaning agents to adequately remove it. Herein, a phosphorylated cellulose nanocrystals (PCNCs) −Tween80 composite cleaning agent was developed by adding trace amounts of nonionic surfactant Tween80. Through the synergistic interaction of various components, the cleaning agent exhibited high oil removal efficiencies for the oiled sand at 25 ℃ and sea salt concentration of 3.5 wt%. The difference among the oil removal efficiencies of cleaning agents containing different components was mainly attributed to variations in the interfacial tension and the zeta potential. The oil removal efficiencies of the cleaning agent for contaminated sand containing engine oil were 81.2 % and 91.4 % at the cleaning speeds of 150 rpm and 300 rpm, respectively. Surprisingly, the composite cleaning agent reached an oil removal efficiency of 89.9 % at just 150 rpm for the real-world polluted system of the sand contaminated with crude oil. At a relatively mild cleaning speed of 150 rpm, the cleaning effect exceeded those reported in most previous studies at 300 rpm. Furthermore, the washing wastewater achieved rapid and efficient oil/water separation under flocculation of using polyaluminum chloride, which was expected to significantly reduce the discharge of wastewater and avoid secondary pollution. This work has developed a PCNCs-based cleaning agent with advantages of high efficiency, environment-friendliness, convenient preparation, low cost, and low discharge of wastewater, which can efficiently remove oil from oiled sand.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
INTERNATIONAL MICROBIOLOGY
·
2024
·
IF 2.3
Zhang Mingle,He Zhimin,Xu Xiaoyi,Ji Fan,Wang Bin
This study investigates the advantages of combined microbial degradation of polycyclic aromatic hydrocarbons (PAHs) in reducing the inhibitory effects of high-concentration eluents commonly used in soil washing. A microbial synergistic strategy was proposed using Arthrobacter sp. SZ-3 and Pseudomonas putida B6-2 as the key bacteria in the presence of Tween 80. The results show that in systems with Tween 80, the SZ-3 strain exhibits a strong capacity to degrade three types of PAH compounds, while the B6-2 strain follows multiple degradation pathways. Mixed bacteria achieved degradation rates 60.70% higher than single bacteria at varying concentrations of Tween 80. Additionally, the average growth rates of mixed bacteria increased by 1.17–1.37 times, aligning with the changes in the functional group. Protein activity detection within each degradation system corresponded with growth quantity and the cyclic variation characteristics of ETS enzyme activity. Notably, the ETS activity of mixed bacteria was 150% higher than that of single bacteria. At a Tween 80 concentration of 500 mg/L, the degradation rates of PAHs (Phe, Flu, Pyr) by mixed bacteria were significantly higher than those by single bacteria. The catechol 1,2-dioxygenase activity of mixed bacteria was 2.30 times higher than that of single bacteria. While Tween 80 did not alter the PAH degradation pathways, it significantly influenced the accumulation amount and duration of the characteristic intermediate product. This provides a reference for the remediation of recalcitrant pollutants under conditions involving high-concentration surfactants.
研究领域:
环境微生物学
·
污染修复
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）