NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 15
·7292-7301
·
IF 3.269
Yuhua Chen,Ruihan Tong,Na An,Huiming Lin,Fengyu Qu
Currently, incorporating multiple therapeutic functions into one nanostructure has attracted more and more attention for the development of efficient anticancer agents. In this study, a uniform core–shell UCNPs@mSiO2 nanocomposite was prepared as the carrier to develop the NIR light-controlled chemotherapy associated with photodynamic therapy (PDT). In view of the novel UV emission, the semiconductor photosensitizer TiO2 was exploited due to its high efficiency and chemical stability. The host modification method was used to integrate TiO2 doping and mesoporous structure, which can store anticancer drug molecules (doxorubicin, DOX). To improve the utilization of emission, a photolabile o-nitrobenzyl derivative was incorporated to form a sensitive linker (NB linker) as a “gate” to make sure the few leak. Upon NIR irradiation, the UV emission can not only excite TiO2 to produce reactive oxygen species (ROS), but also induce the breaking of NB linker as well as drug release. The NIR-triggered performances were further demonstrated by the cell experiment using HeLa cells as the model cancer cell. The synergistic effect of chemotherapy and PDT induces enhanced cytotoxicity, which is more powerful than their simple effects added together. Therefore, the novel NIR light-controlled double-therapeutic nanocomposite should be a potential candidate for anticancer agents.
研究领域:
生物医学工程
·
肿瘤治疗学
·
纳米医学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Shuang Zhao,Rongrong Tian,Baiqi Shao,Yang Feng,Senwen Yuan,Langping Dong,Liang Zhang,Kai Liu,Zhenxin Wang,Hongpeng You
Herein, a novel multifunctional nanoplatform was designed toward multimodality imaging and photothermal therapy (PTT). It was found that Bi nanoparticles could grow in situ on the surface of NaYF4:20%Yb,2%Er@NaYF4:40%Yb@NaGdF4 core–shell nanoparticles (labeled as UCNPs). In this structure, UCNPs were mainly employed as an upconversion luminescence (UCL) imaging agent, whereas the Bi nanoparticles worked as an effective CT imaging and photothermal agent. Importantly, a dense SiO2 shell was employed to protect the Bi nanoparticles from oxidation, and it also endowed the nanoplatform with excellent hydrophilic ability. The effective UCL/CT imaging and PTT performances were emphasized by a series of in vivo experiments, which suggest that the integrated nanoplatform with imaging and therapy functions shows great promise in the biomedical field.
研究领域:
纳米技术
·
生物医学工程
·
诊疗学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Yuting Gu,Xiaoyue Zheng,Zikang Chen,Ruomei Teng,Yuhan Zhang,Hang Li,Caiping Ding,Youju Huang
There is a significant need for sensitive and selective hypochlorite (ClO - ) detection in rheumatoid arthritis, especially at the site of inflammation. However, the traditional single signal strategy based on visible emission cannot meet sensitive and accurate analysis requirements in practical applications. In this work, a novel fluorescent-colorimetric dual-signal ratio luminescent nanoprobe (superstructure AuNRs@UCNPs) was developed based on Förster resonance energy transfer (FRET) between the ClO - responsive gold nanorods (AuNRs) and lanthanide doped up-conversion nanoparticles (UCNPs). ClO - gradually etched AuNRs to produce corresponding color changes and plasmon resonance absorption peak shifts. The luminescence at 650 nm of UCNPs gradually recovered, while the luminescence at 540 nm gradually weakened. It allows for the sensitive and accurate detection of ClO - with excellent limits of detection (0.156 μM for the fluorescent ratio method and 0.231 μM for the colorimetric method). It provides a powerful dual guarantee for ClO - detection. The detection in serum of actual samples shows that the probe has reasonable accuracy and precision.
研究领域:
分析化学
·
生物传感器
·
纳米技术
·
医学诊断
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2021
·Vol. 13
·期 19
·2209-2214
·
IF 2.896
Yuan Yao,Guoming Xie,Xin Zhang,Jinshan Yuan,Yulei Hou,Hui Chen
Biosensors based on nanomaterials are becoming a research hotspot for the rapid detection of pathogenic bacteria. Herein, a “turn-on” fluorescent biosensor based on a FRET system was constructed for the fast detection of a representative pathogenic microorganism, namely, E. coli, which causes most urinary tract infections. This biosensor was constructed by utilizing synthesized UCNPs as fluorescent donors with stable luminescence performance in complex biological samples and GO@Fe3O4 as a receptor with both excellent adsorption ability and fluorescence quenching ability. A specific ssDNA selected as an aptamer which could recognize E. coli was immobilized on the UCNPs to form UCNP-Apt nanoprobes. The nanoprobes were adsorbed on the surface of GO@Fe3O4 through the π-stacking interactions between aptamers and GO. In the presence of E. coli, UCNP-Apt nanoprobes detached from GO@Fe3O4 due to the specific recognition of aptamers and bacteria, resulting in obvious fluorescence recovery, and the concentration of bacteria was positively correlated with the intensity of the fluorescence signal; such a “turn-on” signal output mode ensures excellent precision. In addition, the easy magnetic separation of GO@Fe3O4 simplifies the operation process, helping the sensor detect bacteria in 30 minutes with a linear range from 103 to 107 CFU mL−1 and a limit of detection of 467 CFU mL−1. Moreover, recovery test results also showed that the sensor has clinical application potential for the rapid detection of pathogenic microorganisms in complex biological samples.
研究领域:
生物传感器
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纳米技术
·
微生物学
·
分析化学
·
医学诊断
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 38
·期 6
·1453-1460
·
IF 2.726
Yi Jiaqi,Li Xiaoshuang,Cui Di,Han Lixia,Jiang Wei,Zhang Renguo,Niu Na,Chen Ligang
A novel fluorescent probe has been constructed based on fluorescence resonance energy transfer(FRET) between upconversion nanomaterials(UCNPs) NaYF 4 :Yb,Er and gold nanoparticles(AuNPs). The fluorescent “off-on” switching was formed for the detection of thiamphenicol(TAP) in egg samples. The fluorescence of UCNPs can be quenched to a certain degree by AuNPs. After adding TAP, the AuNPs generated aggregation and the fluorescence of UCNPs was recovered. The synthesized amination UCNPs and AuNPs were characterized by Fourier transform infrared spectroscopy(FTIR), UV-Vis, X-ray diffraction(XRD), energy dispersive spectrometer(EDS), and transmission electron microscope(TEM) techniques for observation and confirmation. As a model target, the detection of TAP has two linear ranges in the buffer solution within 0.01–0.1 µmol/L and 0.1–1 µmol/L using this fluorescent probe. The detection limit was obtained to be 0.003 µmol/L( S/N =3), which is favorable for trace analysis. The recovery of TAP from 98.2% to 105.3% was obtained, and the relative standard deviation(RSD) was from 2.5% to 4.3%. Furthermore, the method established in this study based on the UCNPs auto-low background fluorescence has high selectivity and strong ability to eliminate interference, which is beneficial to analyzing complex samples.
研究领域:
分析化学
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纳米技术
·
材料科学
·
光谱学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 48
·8148-8162
·
IF 4.776
Qi Cai,Jiating Xu,Dan Yang,Yunlu Dai,Guixin Yang,Chongna Zhong,Shili Gai,Fei He,Piaoping Yang
Designing multifunctional nanoplatforms for the purpose of simultaneous theranostic modalities is critical to address the challenges of cancer therapy. Also, single modalities of phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), cannot meet the requirements of highly efficient treatment. Here, a core–shell–shell nanostructure consisting of a core of upconversion nanoparticles (UCNPs), a layer of mesoporous silica with anchored ZnO nanodots, and an outer layer of polypyrrole (PPy) was developed. In the proposed construct, the emitted ultraviolet (UV) light from the UCNPs core upon 980 nm near-infrared light irradiation can trigger the ZnO nanodots to activate ambient O2 molecules around cancerous tissues to produce toxic reactive oxygen species (ROS), realizing the PDT function. On the other hand, the coated PPy layer can concurrently give rise to an obvious heat effect upon NIR light illumination, thus achieving synergistic PDT and PTT effects; this results in excellent anti-tumor efficiency in vitro and in vivo. Furthermore, in hand with the upconversion luminescence (UCL) and computed tomography (CT) imaging derived from the UCNPs core, dual-mode imaging directed cancer therapy has been realized.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
高影响因子
Biomaterials Advances
·
2025
·
IF 6
Meng Wang,Xirao Sun,Jingxin Yang,Yanfu Wang,Siyu Song,Zheng Shi,Danfang Sun,Dan Li,Jianduo Chen,Chengyue Wang
Magnesium alloys have attracted significant interest in bone tissue engineering because of their beneficial characteristics. However, their widespread application is still hindered by rapid degradation rates and the challenges associated with real-time monitoring. Given that up-conversion nanoparticles (UCNPs) possess imaging capabilities and that nanofillers can enhance the degradation behavior of these materials, we have utilized UCNPs to develop metal matrix composites. Specifically, we employed powder metallurgy technology to prepare up-conversion nanoparticles/magnesium/zinc composites (UCNPs/Mg/Zn). We systematically studied the mechanical properties, degradation behavior, biocompatibility, osteogenic activity, and degradation monitoring of the composite. In vivo and in vitro degradation studies demonstrated that the composite containing 10 % UCNPs, 86 % Mg, and 4 % Zn (10U-Mg-4Zn) gradually degrades over time, with luminous intensity initially increasing from weak to strong before subsequently diminishing. Furthermore, compared to complexes containing 96 % Mg and 4 % Zn (Mg 4Zn), the degradation rate of the 10U-Mg-4Zn complex was significantly reduced, while cytocompatibility improved and osteogenic differentiation of mouse embryonic osteoblasts (MC3T3-E1) was markedly enhanced. Therefore, the 10U-Mg-4Zn composite not only demonstrates good degradation performance and supports bone tissue regeneration but also facilitates the monitoring of material degradation, thereby providing a novel method for material evaluation and a fresh perspective for developing new magnesium matrix composites.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Optical Materials
·
2023
·
IF 0
Dan Li,Hongbo Xia,Wen Xu,Jianshan He,Xiumei Yin,Rongjie Liu,Bin Dong
Lanthanide-doped upconversion nanoparticles (UCNPs) exhibit abundant emission wavelengths under near infrared (NIR) excitation. This property enables UCNPs to have potential for multicolor output. However, the realization of multicolor-tunable emission output in UCNPs at a fixed composition has remained challenging. Here, a luminescent color controller that can dynamically control the upconversion luminescence (UCL) colors from UCNPs is reported. By constructing bilayer photonic crystals (PCs) in which the UCNPs are distributed between the two-layer PCs, the propagation of green and red emission can be modulated by the top and bottom PCs, respectively. Moreover, the photonic bandgap (PBG) could be varied by changing the reflected angles, according to Bragg diffraction. Thus, the variation in the viewing angles also results in the yellow to blue and red to cyan structural color changes on the top and bottom bilayer PC-UCNPs-PC films. Correspondingly, the emission color outputs are changed from red to yellow-green and green to yellow-green, respectively. These findings provide a general method to achieve multicolor-tunable UCL by a bilayer PC-UCNPs-PC film. Moreover, the UCNPs with multicolor emissions in this work enrich the upconversion system and should have potential applications in display and anticounterfeiting.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
DOI
MACROMOLECULES
·
2020
·
IF 5.918
Wenna Wu,Ling Wang,Jin Yuan,Zhuo Zhang,Xiaolai Zhang,Shuli Dong,Jingcheng Hao
The constant and noninvasive tracking of the distribution and degradation of engineered hydrogel scaffolds using fluorescent probes is considered to be one of the important research studies. Conventional fluorophores were simply mixed into hydrogels by physical doping, and they suffered from photoinstability or UV–vis light excitation, which usually led to the potential leak of the fluorescent tag and imprecise tracking results. In this article, upconversion nanoparticles, NaGdF4:Yb3+,Er3+@NaGdF4 (UCNPs) with near-infrared light (NIR) excitation, were synthesized and were coated with polydopamine (PDA). A biodegradable composite hydrogel OSA-I-CMCS-I-UCNPs@PDA (“I” means “linked-by”) was constructed by the UCNPs@PDA, serving as both the construction unit and NIR-excited fluorescent probe, where carboxymethyl chitosan (CMCS) was used as the cross-linker to chemically cross-link UCNPs@PDA and oxidized sodium alginate (OSA) based on dynamic covalent Schiff-base linkages. It is demonstrated that the composite hydrogels possess enhanced mechanical strength, excellent self-healing capacity, injectable performance, and good biocompatibility with the tissue. In addition, the composite hydrogels possess a deep penetrating ability from UCNPs@PDA in vitro through about 10 mm thick chicken strips. A mimetic lysozyme biodegradation test was performed for 108 h in vitro for evaluating the feasibility and accuracy of UCNPs@PDA in tracking the hydrogel degradation. The degradation signals were obtained by the decrease in fluorescence intensity, which were well consistent with the weight changes in composite hydrogels, suggesting the accuracy of the UCNPs@PDA in consecutively monitoring the hydrogel degradation in vitro. With these superior properties, the composite hydrogels are expected to be promising candidates for various biomedical fields, for example, as tissue engineering or delivery carriers in vivo.
研究领域:
生物材料学
·
组织工程学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 9
·6563-6575
·
IF 2.779
Li Jie,Xu Sai,Yu Yang,Liu Kaiying,Gao Yuefeng,Chen Baojiu
Multifunctional nanoparticles with marvelous temperature sensing and photothermal conversion are preferable in photothermal therapeutic applications. Herein, nanocomposites of NaYF 4 :Er 3+ /Yb 3+ @NaYF 4 :Nd 3+ /Yb 3+ core–shell upconversion nanoparticles (UCNPs) modified by polydopamine (PDA) were designed to achieve temperature sensing and efficiency of photothermal conversion. It has been found that under the irradiation of 808 nm laser, temperature sensing can be realized on the basis of the fluorescence intensity ratio of Er 3+ green light emission. In addition, the photothermal conversion ability of the UCNPs modified by PDA is greatly improved. Moreover, Nd 3+ as activator endows UNCPs excited by 808 nm, which can avoid overheating due to the absorption of the excitation band (980 nm) in water. Therefore, the multifunctional nanoparticles are expected to become an effective drug for cancer therapy in the future and this research will stimulate interest in designing multifunctional nanoparticles that are biocompatible, especially for in vivo tumor diagnosis.
研究领域:
生物医学工程
·
材料科学
·
纳米医学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-8
·
IF 5.3
Guo Keyu,Liu Tong,Li Shun,Zhu Daobin,Fan Yuanyuan,Fan Rangrang,Ding Changchun,Jin Wei,Hu Junshan
An upconversion luminescence (UCL) nanoprobe is reported for the rapid detection of hypochlorite ions (ClO − ) in complex environments. The probe is fabricated by sensitizing rhodamine B (RhB) on the surface of core@shell upconversion nanoparticles (C/S UCNPs) with the bridging of polyethylene glycol (PEG) molecules. Under 980 nm excitation, the UCL of C/S UCNPs is quenched by RhB through fluorescence resonance energy transfer (FRET), which can be restored by the oxidative cleavage of RhB induced by ClO − . It is observed that the green emission intensity of RhB-modified C/S UCNPs increases linearly with the concentration of ClO − , enabling quantitative detection of ClO − . Moreover, the excitation of C/S UCNPs requires only a low power density (0.09 W/cm 2 ), which minimizes the photodegradation of RhB and stabilizes the FRET process. Under optimized conditions, the detection limit for ClO − ions in tap water was 5 µg mL⁻ 1 . Graphical abstract
研究领域:
分析化学
·
纳米材料
·
生物传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2017
·
IF 3.887
Yuhua Chen,Huiming Lin,Ruihan Tong,Na An,Fengyu Qu
Recently, incorporating multiple components into one nanoplatform for anticancer theranostics has attracted most attention. Herein, a rattle-structured nanocomposite by using UCNPs (NaYF 4 :Yb,Tm@NaYF 4 ) as core coated with hollow mesoporous TiO 2 (UCNPs@mHTiO 2 ) was constructed as the nanocarrier. First, UCNPs@SiO 2 @TiO 2 was prepared, by a selective etching method to remove SiO 2 shell, to make sure the hollow mesoporous structure and high surface area (347 m 2 g −1 ) of UCNPs@mHTiO 2 . Under near-infrared (NIR) light irradiation, the UV emission can excite TiO 2 to produce ROS and to realize photodynamic therapy (PDT). In addition, the hollow structure offers space to store antitumor drug molecules (doxorubicin, DOX) and this nanocomposite also exhibits the improved DOX release in mildly acidic environment, which could greatly promote chemotherapy efficiency. Moreover, the luminescence resonance energy transfer (LRET) from UCNPs to DOX, owing to the effective distance restricted by the cavity, can be used to monitor the intercellular drug release kinetics. HeLa cells were used as the model cancer cells and the detailed cell experiments show the enhanced cytotoxicity, ascribing to the synergistic effect of chemotherapy and PDT. Therefore, the novel multifunctional nanocomposite, combining with chemotherapy, PDT, and imaging, should be a potential candidate in anticancer field.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）