E-POLYMERS
·
2017
·Vol. 17
·期 6
·463-470
·
IF 0.949
Yongqian Nie,Xuanxi Leng,Yixue Jiang,Shigan Chai,Jinzhi Zhang,Qichao Zou
Unsaturated polyester resins (UPR) were prepared by the melt condensation method based on adipic acid, o-phthalic anhydride, maleic anhydride and ethylene glycol in the presence of PSS-(2,3-propanediol)propoxy-heptaisobutyl substituted (PSS-POSS) or/and 9 wt% [(6-oxide-6H-dibenz(c,e)(1,2)oxaphosphorin-6-yl)methyl]butanedioic (DDP). We synthesized UPR containing DDP (DDP-UPR) and UPR containing both DDP and PSS-POSS (DDP-PSS-POSS-UPR series). The chemical structures of the modified polyesters were characterized and confirmed by Fourier transform infrared (FTIR) and 31 P nuclear magnetic resonance ( 31 P NMR). The thermal stability and flammability behaviors of UPR were evaluated by thermogravimetric analysis (TGA) and limited oxygen index (LOI) and the vertical burning test. The morphology of residual char of UPR was shown by scanning electron microscopy (SEM). The results indicate that the incorporation of PSS-POSS has little influence on the thermal stability of DDP-UPR, but enhances the flame retardance of DDP-UPR, and when the PSS-POSS content reaches 10 wt%, the DDP-PSS-POSS-UPR has better flame retardance.
研究领域:
材料科学
·
聚合物化学
·
消防安全工程
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DOI
高影响因子
Advanced Science
·
2025
·
IF 14.1
Shuoting Zhou,Xi Xiong,Jialong Hou,Qi Duan,Yi Zheng,Tao Jiang,Jiani Huang,Haijun He,Jiaxue Xu,Keke Chen,Wenwen Wang,Jinlai Cai,Jingjing Qian,Huijun Chen,Weihong Song,XinShi Wang,Chenglong Xie
Serving as a pivotal hub for cellular metabolism and intracellular signaling, the mitochondrion has emerged as a crucial organelle whose dysfunction is linked to many human diseases, including neurodegenerative disorders, particularly Parkinson's disease (PD). However, whether mitochondrial quality control (MQC) can be targeted for therapeutic interventions remains uncertain. This study uses clinical samples, molecular biology techniques, pharmacological interventions, and genetic approaches to investigate the significance of NAD+ levels in cross-species models of PD. These results reveal that treatment of rotenone-incubated cells with NAD+ boosters (such as NMN, siCD38, and NAT) increases UPR mt /mitophagy-related MQC, reduces pro-inflammatory cytokine expression, inhibits apoptosis, and strengthen redox reactions. In vivo, NMN supplementation inhibits motor deficit and forestalls the neuropathological phenotypes of MPTP-induced PD mice, which are required for the atf4-related mitochondrial UPR pathway. Notably, bulk omics signatures and metabolomic profiling analyses of the striatum reveal NMN-induced transcriptional changes in genes and proteins involved in mitochondrial homeostasis. Thus, these findings demonstrate that the accelerated pathology in PD models is probably mediated by impaired MQC and that bolstering cellular NAD+ levels alleviates mitochondrial proteotoxic stress and mitigate PD phenotypes.
研究领域:
神经科学
·
细胞生物学
·
药理学
·
分子生物学
·
生物化学
·
基因组学
·
代谢组学
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产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Jing Ren,Qi Wang,Xiaxia Zhang,Yongheng Cao,JingXia Wu,Juan Tian,Yanjun Yu,Qingqiu Gong,Zhaosheng Kong
Legumes establish symbiosis with rhizobia by forming a symbiotic interface that enables cross-kingdom exchanges of signaling molecules and nutrients. However, how host organelles interact with symbiosomes at the symbiotic interface remains elusive during rhizobia endosymbiosis. Here, symbiotic cells are reconstructed using 3D scanning electron microscopy (SEM) and uncover that the host endoplasmic reticulum (ER) undergoes dynamic expansion to gradually enwrap symbiosomes, facilitating their compartmentalization and endosymbiosis. Consistently, altering ER lamellar expansion by overexpressing MtRTNLBs , the reticulons responsible for ER tubulation, impairs rhizobia accommodation and symbiosome development. Intriguingly, unfolded protein response (UPR)-marker genes, bZIP60 and IRE1A/B , show continuously activated expression during nodule development, and the two UPR-deficient mutants, ire1b , and bzip60 , exhibit compromised ER biogenesis and defective symbiosome development. Collectively, the findings underpin ER expansion and UPR activation as two key events in rhizobia accommodation and reveal an intrinsic coupling of ER morphology with proper UPR during root nodule symbiosis.
研究领域:
植物学
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分子生物学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2025
·
IF 6.1
Jiajun Tan,Zhengjun Su,Huiqi Gao,Jinjin Cui,Shaoxia Zhao,Yingming Li,Ran Chang,Jianzhong Xu
Reasonably controlling the structure of a polymer-based composite film is crucial for optimizing flame retardant and electromagnetic interference (EMI) shielding performance. Herein, an adjustable serrated structure was designed into a heterogeneous unsaturated polyester resin (UPR) composite film to enhance interfacial adhesion between organic and inorganic components, thereby boosting the overall performance of the composite film. First, halloysite nanotubes (HNTs) serve as fillers, incorporated into the UPR matrix to enhance flame retardancy and thermal stability. Meanwhile, HNTs could endow the film (UPR/HNTs) with an adjustable serrated structure, which provides conditions for MXene deposition. Subsequently, due to the dual action of physical interlocking and chemical bonding, MXene was deposited onto the serrated interface of the UPR/HNTs film for EMI shielding, flame retardant, Joule-heating, and infrared stealth performance. Consequently, the optimized composite film (UPR/10 %HNTs-MXene) exhibits significantly improved flame retardant performance. The peak heat release rate (PHRR), total heat release rate (THR), peak smoke production rate (PSPR), and total smoke production (TSR) of the composite film were reduced by 53.87 %, 45.45 %, 53.03 %, and 57.06 %, respectively, compared to pure UPR. Moreover, due to the high conductivity and low reflectivity of MXene, UPR/10 %HNTs-MXene has good Joule heating and infrared stealth performance. Benefiting from the serrated interface structure, which induces synergistic multiple reflections, interfacial polarization, and heat-dissipation losses, the optimized film exhibits a superior EMI shielding performance of 40.17 dB. These findings not only provided a scalable approach to designing other advanced films but also promoted the application of multifunctional films in electronic devices.
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DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2024
·
IF 6.3
Ying-Ming Li,Dan-Ping Zhu,Shuang-Lin Hu,Yun-Hong Jiao,Jian-Zhong Xu,De-Yi Wang
In order to design UPR composites with high mechanical property and improved flame retardancy, an organic-inorganic hybrid flame retardant (DA-Si-HNT) was fabricated by grafting silane coupling agent (KH560) and the phosphorus-nitrogen containing structure (DOPA-A, the production of 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide and adenine) on the surface of halloysite nanotube (HNTs). The UPR/DA-Si-HNT 15 composites exhibited significant improvements in tensile strength , tensile modulus , and flexural strength , with respective increases of 65.6 %, 140.6 %, and 80.2 % compared to neat UPR . These enhancements can be attributed to the enhanced compatibility and interfacial force between the flame retardants and the polymer matrix . Meanwhile, it passed the UL-94 V-0 rating at a limiting oxygen index (LOI) value of 34.5 %. The peak of heat release rate (PHRR) and total heat release (THR) decreased by 49.5 % and 43.5 % comparing to that of UPR, indicating a sharp decline in the heat hazard. Moreover, an obvious catalytic carbonization effect in the condensed phase accompanied with moderate gas-phase effect jointly improved flame retardancy of the UPR/DA-Si-HNT 15 composites.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2018
·Vol. 59
·期 2
·411-417
·
IF 1.551
Xuelin Zheng,Wei Cheng,Shuning Chen,Jiawen Chen,Qinhui Chen
Urushiol praseodymium-polystyrene (UPr-PS) Janus composite particles were synthesized by emulsion swelling assisted protruding from UPr/PS core-shell composite microspheres. The effects of sulfonated time and the outer electronic configuration of metal on the shell of urushiol metal/PS composite microspheres, together with the effects of monomer type, monomer dosage and swelling time on the swelling behaviour, were studied. The morphology, chemical composition and thermal performance of UPr/PS core-shell composite microspheres and UPr-PS Janus composite particles were studied by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray analyzer (EDX), Thermogravimetric analysis (TG) and infrared spectrometer (IR). Results showed that the morphology could be controlled by the metal kind, the sulfonated time, the monomer type, the monomer dosage and the swelling time. Attributing to the novel anisotropic structure, the UPr-PS Janus composite particles will be expected to be applied in oriented catalyst. POLYM. ENG. SCI., 59:411–417, 2019. © 2018 Society of Plastics Engineers
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
CELL
·
2018
·
IF 31.398
Qian Zhang,Xueying Wu,Peng Chen,Limeng Liu,Nan Xin,Ye Tian,Andrew Dillin
Summary The mitochondrial unfolded protein response (UPR mt ) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organism from local mitochondrial challenges. We find that animals use retromer-dependent Wnt signaling to propagate mitochondrial stress signals from the nervous system to peripheral tissues. Specifically, the polyQ40-triggered activation of mitochondrial stress or reduction of cco-1 (complex IV subunit) in neurons of C. elegans results in the Wnt-dependent induction of cell-non-autonomous UPR mt in peripheral cells. Loss-of-function mutations of retromer complex components that are responsible for recycling the Wnt secretion-factor/MIG-14 prevent Wnt secretion and thereby suppress cell-non-autonomous UPR mt . Neuronal expression of the Wnt ligand/EGL-20 is sufficient to induce cell-non-autonomous UPR mt in a retromer complex-, Wnt signaling-, and serotonin-dependent manner, clearly implicating Wnt signaling as a strong candidate for the “mitokine” signal.
研究领域:
分子生物学
·
细胞生物学
·
遗传学
·
神经科学
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产品关联
DOI
PubMed
高影响因子
AGING CELL
·
2021
·Vol. 20
·期 3
·e13319
·
IF 9.304
Gang Du,Zhiming Liu,Zihua Yu,Zhangpeng Zhuo,Yuedan Zhu,Juanyu Zhou,Yang Li,Haiyang Chen
As they age, adult stem cells become more prone to functional decline, which is responsible for aging-associated tissue degeneration and diseases. One goal of aging research is to identify drugs that can repair age-associated tissue degeneration. Multiple organ development-related signaling pathways have recently been demonstrated to have functions in tissue homeostasis and aging process. Therefore, in this study, we tested several chemicals that are essential for organ development to assess their ability to delay intestinal stem cell (ISC) aging and promote gut function in adult Drosophila . We found that taurine, a free amino acid that supports neurological development and tissue metabolism in humans, represses ISC hyperproliferation and restrains the intestinal functional decline seen in aged animals. We found that taurine represses age-associated ISC hyperproliferation through a mechanism that eliminated endoplasmic reticulum (ER) stress by upregulation of the target genes of unfolded protein response in the ER (UPR ER ) and inhibiting the c-Jun N-terminal kinase (JNK) signaling. Our findings show that taurine plays a critical role in delaying the aging process in stem cells and suggest that it may be used as a natural compound for the treatment of age-associated, or damage-induced intestinal dysfunction in humans.
研究领域:
衰老研究
·
干细胞生物学
·
分子遗传学
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DOI
PubMed
高影响因子
Open Life Sciences
·
2025
·Vol. 20
·期 1
·
IF 1.7
Chengrong Huang,Hao Zhang,Jing Wang,Jianfei Li,Qian Liu,Qiyin Zong,Yunyun Zhang,Qin Wang,Qiang Zhou
A growing body of evidence has shown that hepatitis B surface antigen (HBsAg) mutations can influence the occurrence of occult hepatitis B infection (OBI), particularly amino acid substitutions in small hepatitis B surface proteins (SHBs). The mechanistic basis for these results, however, remains unclear. This study was designed to explore the potential impact and mechanisms of OBI-related SHBs mutations on serum HBsAg. Huh7 and HepG2 cells were transfected with plasmids encoding wild-type (WT) or OBI-related SHB mutation-containing sequences, after which a chemiluminescence approach was used to detect HBsAg levels in cell culture supernatants. Western blotting was further used to assess HBsAg and endoplasmic reticulum stress (ERS)-related protein levels in lysates prepared from these cells, while the localization of HBsAg within cells was assessed via immunofluorescent staining. Cells transfected with OBI-related SHB mutation-encoding plasmids exhibited lower supernatant HBsAg levels than cells transfected with WT plasmids. Intracellular and extracellular HBsAg levels in these mutant plasmid-transfected cells were lower relative to those for WT plasmid-transfected cells, and HBsAg accumulation within the ER was detected via immunofluorescent staining in cells transfected with OBI-related SHB mutation-encoding plasmids, ERS-related protein content was also significantly increased in mutant plasmid-transfected cells as compared to those in the WT group. These results suggest that proteins harboring OBI-related mutations may tend to accumulate in the ER, thereby triggering an ERS response and impairing the transcription and translation of HBsAg via the activation of the unfolded protein response and ER-associated protein degradation pathway. These effects ultimately reduce the overall assembly of HBV virions in the ER and their associated secretion.
研究领域:
病毒学
·
分子生物学
·
医学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2018
·
IF 4.358
Yi Zhao,Zheng-Hai Du,Milton Talukder,Jia Lin,Xue-Nan Li,Cong Zhang,Jin-Long Li
The widely used Di-(2-ethylhexyl) phthalate (DEHP) has been reported to exhibit ubiquitous environmental and global health hazards. The bioaccumulation and environmental persistence of DEHP can cause serious health hazards in wildlife animals and human. However, DEHP-induced nephrotoxicity in bird is remained unknown. Thus, this study explored the related mechanism of DEHP nephrotoxicity in quail. For this purpose, quail were exposed with DEHP at doses of 0, 250, 500, and 1000 mg/kg body weight daily by gavage administration for 45 days. The results showed that DEHP exposure induced renal injury, oxidative stress , and endoplasmic reticulum (ER) degeneration. Low level DEHP (250 mg/kg) exposure inhibited Nrf2 signaling pathway and induced renal injury via oxidative stress and suppressed the unfolded protein response (UPR) signaling pathway and induced ER stress in the kidney. But surprisingly, high level DEHP (500 mg/kg and 1000 mg/kg) exposure activated Nrf2 and UPR signaling pathways and protected kidney, but they still couldn't resist the toxicity of DEHP. Our study demonstrated that DEHP-induced nephrotoxicity in quail was associated with activating Nrf2-mediated antioxidant defense response and UPR signaling pathway.
研究领域:
毒理学
·
环境科学
·
分子生物学
·
动物生理学
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Jia-Gen Cui,Hao Zhang,Ming-Shan Chen,Jia-Xin Wang,Yi Zhao,Jin-Long Li
Phthalates (PAEs), especially di (2-ethylhexyl) phthalate (DEHP), are generally considered to have adverse impact on nervous system. The residue of DEHP in the environment has gradually become a widely concerned environmental problem due to its widespread use in plastic items. Lycopene (LYC) as the readily available natural antioxidant is considered to have the potential to alleviate exogenous poisons-induced nerve damage. However, there is currently a lack of strategies to alleviate the neurotoxicity caused by DEHP, and it is also unknown whether LYC can alleviate the neurotoxicity caused by DEHP. The experiment demonstrated that LYC had the potential to mitigate DEHP-induced mitochondrial damage in cerebellum. DEHP induced the disorder of Ca 2+ transport in cerebellum, thereby resulting in the imbalance of protein homeostasis. Such disruption in protein homeostasis further results in the overactivation of mitochondrial unfolded protein response (UPR mt ) and mitochondrial injury. Mechanistically, LYC could alleviate the imbalance of calcium homeostasis and protein homeostasis induced by DEHP via regulating inositol 1, 4, 5-trisphosphate receptor type1 (IP3R1) and sarco/endoplasmic reticulum Ca (2+)-ATPase 2 (SERCA2), further alleviating mitochondrial damage in cerebellum. Subsequently, the present study suggested the mechanism of cerebellar injury induced by DEHP, and provided a novel approach to treating DEHP-induced neurotoxicity.
研究领域:
神经科学
·
毒理学
·
药理学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）