Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 25
·5817-5829
·
IF 7
Shaohu Huo,Qianhui Xie,Min Zhang,Zitong Jiang,Ling Fu,Wenhong Li,Chenrong Bian,Kaile Wu,Yulin Zhu,Xuan Nie,Shenggang Ding
Antibiotic tolerance is implicated in difficult-to-treat infections and the development and spread of antibiotic resistance. The high storage capacities and excellent biocompatibilities of UiO-66-based metal–organic frameworks (MOFs) have made them emerging candidates as drug-delivery vectors. In view of hydrogen sulfide (H2S) having been associated with the development of intrinsic resistance to antibacterial agents, we designed a strategy to potentiate existing antibiotics by eliminating bacterial endogenous H2S. We efficiently fabricated an antibiotic enhancer Gm@UiO-66-MA to remove bacterial H2S and sensitize an antibacterial by modifying UiO-66-NH2 with maleic anhydride (MA) and then loading it with gentamicin (Gm). UiO-66-MA achieved the removal of bacterial endogenous H2S and the destruction of bacterial biofilm by selectively undergoing Michael addition with H2S. Moreover, Gm@UiO-66-MA further enhanced the susceptibility of tolerant E. coli to Gm after reducing bacterial intracellular H2S levels. An in vivo skin wound healing experiment confirmed that Gm@UiO-66-MA could greatly reduce the risk of bacterial reinfection and accelerate wound healing. Overall, Gm@UiO-66-MA offers a promising antibiotic sensitizer for minimizing bacterial resistance and a therapeutic strategy for tolerant bacteria-related refractory infections.
研究领域:
材料科学
·
微生物学
·
药物递送
·
感染与免疫
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Huanggen Yang,Pei Zhang,Qi Zheng,Muhammad Usman Hameed,Saleem Raza
The presence of pollutants in drinking water has become a significant concern recently. Various substances, including activated carbon, membranes, biochar, etc., are used to remove these pollutants. In the present study, a new composite comprising cotton fabric and a mixture of Metal-Organic Frameworks (MOFs) was synthesized and used as an adsorbent for eliminating pollutants from wastewater. At first, the UiO-66 MOFs were prepared by a simple method of reacting Zirconium (IV) chloride (ZrCl 4 ) and p-Phthalic acid (PTA) after successful preparation of UiO-66 then modified its surface with amino functional groups by reacting with APTES to obtain UiO-66-NH 2 . Moreover, the cellulose cotton fabric (CF) surface was modified with Polydopamine (PDA) and obtained CF@PDA. Further, with the help of EDC-HCl and NHS, the UiO-66-NH 2 grafted on the surface of the CF@PDA and finally obtained CF@PDA/UiO-66-NH 2 . In addition, the adsorption study was performed toward RhB dye and Pb(II) metal ion pollutants. The maximum adsorption toward RhB dye was 68.5 mg/g, while toward Pb(II) metal ions was 65 mg/g. In addition, the kinetic study was also conducted and the result favoured the Pseudo-second order kinetic study. The adsorption isotherm was also studied and the Langmuir model was more fitted as compared with the Freundlich model. Moreover, the material has excellent regeneration and recycling ability after ten cycles. The significant adsorption ability, the novel combination of cotton and MOFs, and the recycling feature make our material CF@PDA/UiO-66-NH 2 a promising potential absorbent material for wastewater treatment and even in other important areas of water research.
研究领域:
环境科学
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材料科学
·
化学工程
·
水处理
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产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Zhihua Wang,Mingda Han,Yiqiao Wang,Ning Wang,Yilin Yang,Bingru Shao,Qiannan Miao,Zhan Shi,Fei Yan,Shouhua Feng
B-cell lymphoma (BCL) is a hematological malignancy with high heterogeneity and represents an aggressive proliferation of mature B-cells. Despite the initial success of traditional treatments for BCL in clinical trials, a majority of patients eventually develop resistance to therapy and have poor clinical outcomes. Epigenetic dysregulation is a major contributor to the pathogenesis of BCL, and therapies targeting epigenetic pathways is a promising alternative strategy for treating BCL. Herein, we developed a metal–organic framework (MOF)-based nano-sonosensitizer for ultrasound-driven cascade immunotherapy against BCL. The nano-sonosensitizer was synthesized by encapsulating copper complex of the m6A-mRNA demethylase inhibitor into UiO-66-NH2, which possesses a Z-scheme heterostructure and allows efficient electron–hole pair separation for generating reactive oxygen species (ROS) under ultrasound activation. These CuR@UiO66 sonosensitizers were functionalized with mPEG-PO3 and anti-CD19 antibody, and the resulting CRUPPA19 particles could specifically accumulate in the BCL tissue and also target lymphoma cells that infiltrated into the bone marrow. Once internalized, CRUPPA19 could induce intracellular ROS production and apoptosis under ultrasound irradiation. Subsequently, ultrasonic stimulation triggered autophagy-mediated release of Cu and Rhein from CRUPPA19, thereby increasing protein lipoylation and global mRNA methylation, which led to cuproptosis and the transcriptional repression PDL1, respectively. These cascades synergistically induced immunogenic cell death in the tumors and promoted activation of CD8+ T cells, eventually leading to an antilymphoma immune response. CRUPPA19-mediated sono-immunotherapy not only eliminated the primary and metastatic lymphomas but also cleared lymphoma cells from the bone marrow. This study provided an insight into a MOF-based nanoepigenetic therapy platform with ultrasound-triggered cascade amplification for enhanced antihematological tumor immunity.
研究领域:
肿瘤学
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生物医学工程
·
免疫学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Siqi Qi,Min Lin,Pengfei Qi,Junjie Shi,Ge Song,Wenxin Fan,Kunyan Sui,Congjie Gao
With the aggravation of pollutants damage to the environment, it is crucial yet rather challenging to design powerful matrixes for nanomaterials with high ions permeability and migration, as well as multiple exposed active sites. However, most of the current nanomaterial matrixes just act as carrier supporters with introduced invalid mass. Here, a gradient natural polycation electrolyte (chitosan) hydrogel was engineered as nanomaterials matrix to boost anionic heavy metals removal such as antimonate (Sb(V)) and arsenate (As(V)) for the first time, based on the generated interfacial and build-in electric potentials due to the diffusion of counterions. The resulting dual electric potentials allow for rapid diffusion and removal efficiency of heavy metal ions. Exemplified by Sb(V) removal, the chitosan gradient hydrogel matrixes with embedded UiO-66 MOFs exhibited a 3-fold higher removal velocity than the homogeneous hydrogel matrix, and their removal efficiencies were also promoted by gathering on the high charge density side of hydrogels. In contrast to the other reported matrix materials without driving force, the gradient polyelectrolyte hydrogel can greatly boost the removal efficiency and shorten the treatment times. This study offers inspirations on eliminating heavy metal contaminations based on self-driving forces stemming from the heterogeneous structure of materials.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 12
·931
·
IF 4.3
Chao Wang,Junchao Ding,Haoyu Wu,Jiaxuan Zhang,Jing Xu,Ying Zhang,Mindan Ma,Ming Zhang,Hongping Li
The effective and deep removal of unreactive sulfides to achieve ultra-low-sulfur or sulfur-free oils has recently attracted extensive attention. In this work, a series of UiO-66 based catalysts have been prepared facilely for the effective removal of unreactive sulfides. Here, the incorporation of nitro functional groups into UiO-66, along with the construction of defects, results in remarkable sulfur removal for dibenzothiophene (DBT), achieving oil with sulfur content of less than 1 ppm. The successful construction of the designed catalysts was verified through a series of characterization studies. The exposed unsaturated metal sites help provide significantly more active reaction sites. In addition, the incorporated nitro group, with its electron-withdrawing property, would help increase the Lewis acidity of the catalytic metal sites. Thus, the catalytic oxidative capability of the designed UiO-66-based catalysts would be significantly increased. The enhanced catalytic oxidative performance helps ensure acceptable sulfur removal for oils with much higher sulfur concentrations. Additionally, the catalyst developed in this work can also be used to remove the derivatives of DBT with even lower reactivity. The relatively mild reaction conditions, combined with the exceptional sulfur removal, demonstrate the practicality of this reaction system.
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Minghu Zhao,Zhen Huang,Shixing Wang,Libo Zhang,Yang Zhou
Mercury ions can cause a series of hazards to humans and the environment, even in trace amounts. Here, we designed a novel adsorbent (Cys-UiO-66) by functionalizing NH2-UiO-66 with l-cysteine for selective removal of Hg(II) from solution. The Cys-UiO-66 was characterized by different instruments. The adsorption property of Cys-UiO-66 was evaluated by batch methods. The maximum adsorption capacity was 350.14 mg/g at pH 5.0. Furthermore, the adsorption isotherm and kinetics models were in accord with the Langmuir and pseudo-second-order models, respectively, evidencing that the adsorption behavior was dominated by monolayer chemisorption. The Cys-UiO-66 had better affinity for Hg(II) than other coexisting ions in wastewater and could be regenerated for at least five cycles. The results prove that Cys-UiO-66 is a talented and efficient sorbent for mercury ions.
研究领域:
环境化学
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材料科学
·
吸附技术
·
重金属去除
·
水处理
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DOI
高影响因子
ELECTROCHEMISTRY COMMUNICATIONS
·
2025
·
IF 4.2
Jie Zhang,Yuanying Shi,Liming Liu,Bin Qiu,Yue Tian,Guodong Guo
In this work, a novel homogeneous electrochemical (HEC) sensing strategy was developed for carcinoembryonic antigen (CEA) detection, addressing limitations of traditional electrochemical platforms that necessitate complex electrode modifications and receptor immobilization protocols. This approach integrates platinum nanoparticle-loaded UiO-66 metal-organic frameworks (Pt/UiO) as an oxidase-like nanozyme with CEA-specific aptamer (Apt) as recognition element, establishing a target-responsive catalytic mechanism. In solution-phase operation, the Pt/UiO nanozyme facilitates the oxidation of 1,2-diaminobenzene into electroactive diaminophenazine (DAP), generating measurable reduction current at unmodified electrode. Apt adsorption onto Pt/UiO surfaces effectively inhibits this enzymatic activity through steric hindrance, resulting in current suppression proportional to Apt coverage. The presence of CEA induces specific Apt-CEA binding, resulting Apt away from the nanozyme surface and restoring catalytic activity in a concentration-dependent manner. Optimization of experimental parameters (e.g., nanozyme concentration, incubation time) enabled the sensor to achieve a detection limit of 3 pg mL −1 with a linear range spanning 0.01–11 ng mL −1 , demonstrating potential for point-of-care applications in tumor biomarker analysis.
研究领域:
分析化学
·
生物电化学
·
纳米技术
·
生物传感器
·
癌症标志物
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产品关联
DOI
高影响因子
Journal of Environmental Sciences
·
2022
·
IF 6.796
Wan-Yi Zeng,Minzhong Huang,Minglai Fu
Compared with the traditional liquid–liquid extraction method, solid-phase extraction agents are of great significance for the recovery of indium metal due to their convenience, free of organic solvents, and fully exposed activity. In this study, P 2 O 4 (di-2-ethylhexyl phosphoric acid) was chemically modified by using UiO-66 to form the solid-phase extraction agent P 2 O 4 -UiO-66-MOFs (di-2-ethylhexyl phosphoric acid-UiO-66-metal-organic frameworks) to adsorb In(III). The results show that the Zr of UiO-66 bonds with the P-OH of P 2 O 4 to form a composite P 2 O 4 -UiO-66-MOF, which was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR). The adsorption process of indium on P 2 O 4 -UiO-66-MOFs followed pseudo first-order kinetics, and the adsorption isotherms fit the Langmuir adsorption isotherm model. The adsorption capabilities can reach 192.8 mg/g. After five consecutive cycles of adsorption-desorption-regeneration, the indium adsorption capacity by P 2 O 4 -UiO-66-MOFs remained above 99%. The adsorption mechanism analysis showed that the P=O and P-OH of P 2 O 4 molecules coated on the surface of P 2 O 4 -UiO-66-MOFs participated in the adsorption reaction of indium. In this paper, the extractant P 2 O 4 was modified into solid P 2 O 4 -UiO-66-MOFs for the first time. This work provides a new idea for the development of solid-phase extractants for the recovery of indium.
研究领域:
材料科学
·
环境科学
·
冶金工程
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Yiyang Liu,Hengyuan Zhang,Dechang Xie,Huiyu Lai,Qiufeng Qiu,Xiaoguo Ma
Macrolide antibiotics (MALs) are widely used in various fields and are resistant to degrade in the water environment, thus constituting potential hazards to human health. In this work, a new composite, molecularly imprinted polymers coated magnetic metal-organic frameworks with carboxyl modification ( [email protected] ) was selected and characterized, for the simultaneous specific adsorption and determination of five MALs from aqueous solution. It was found that UIO-66-COOH with ligand defects showed better pre-polymerization effect than other matrix materials . The synthesis conditions for the imprinting polymer were optimized via response surface methodology . The characteristics of related materials were studied, and a series of adsorption experiments were carried out. The results showed that the adsorption equilibriums of [email protected] were reached within 1 h, with the total adsorption capacity for the five MALs was 99.05 mg g −1 . The pseudo-second-order kinetic model and Freundlich isotherm model could best fit the adsorption process , and the adsorption thermodynamics was controlled by the change of entropy. Adsorption mechanisms were deduced as hydrogen bonding interaction and electrostatic interaction. In addition, [email protected] has good selectivity and reusability. Furthermore, a new detection method for the five MALs was developed, using the prepared material as the adsorbent for magnetic solid-phase extraction, coupled with high-performance liquid chromatography . Under the optimal extraction condition, the limits of detection for five MALs were 3.1–44.6 μg L −1 , and the recoveries were 92.9–108.7 % in the determination of real water samples. Therefore, the [email protected] could be the efficient adsorbent for simultaneous selective removal and sensitive determination of multi-residual MALs.
研究领域:
环境科学
·
分析化学
·
材料科学
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DOI
高影响因子
ANALYST
·
2023
·
IF 4.2
Wei Li,Huili Wang,Xinxin Ying,Zhen Liang,Jianna Li,Xiangjuan Chen,Lei Su,Xueji Zhang
Zr-metal–organic frameworks (Zr-MOFs) have received increasing interest for their use as the signal marker in the development of sandwich-structured aptasensors for the detection of exosomes. However, Zr4+ ions of the Zr-MOFs can interact with not only the exosomes, but also the aptamers, leading to possible false positives and a large background response. In the present study, we report for the first time aptasensors with Pd nanoparticle (NP)-decorated and hemin-embedded UiO-66 MOFs serving as the signal amplification marker to eliminate false positives and decrease the background response of aptasensors. To construct aptasensors for detection of exosomes, CD63-specific aptamers were tethered onto magnetic Fe3O4 particles coated with polydopamine (PDA) and UiO-66-NH2 using glutaraldehyde crosslinking for capturing the exosomes. To prepare highly catalytic Zr-MOF-based signal markers, UiO-66 MOFs were modified with hemin followed by Pd NPs. The as-prepared Pd-decorated hemin-embedded MOFs showed high catalytic activity towards the chromogenic oxidation reaction of TMB by H2O2. Moreover, the decoration with Pd NPs led to the change of the surface charge state of the catalytic hemin-embedded UiO-66 MOFs from positive to negative, weakening the interaction between the signal marker and the negatively charged aptamers. Therefore, the as-prepared aptasensors showed an improved sensing performance towards exosomes with a linear concentration range from 4.28 × 102 to 4.28 × 105 and a limit of detection (LOD) of 86.2 particles per μL. The as-prepared aptasensors also showed high sensitivity and selectivity to the exosomes from different origins including the HeLa cell line and MCF-7 cell line.
研究领域:
生物传感器
·
纳米技术
·
分析化学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）