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FITOTERAPIA · 2021 · IF 2.882

Stigmastane-type steroid saponins from the leaves of Vernonia amygdalina Del

Meng-Ling Zhao,Shu-Jun Shan,Rong Tao,Le-Tian Cui,Qiu-Rong Li,Jun Luo,Yi Li

Vernoramyosides A-F ( 1 – 6 ), six new Δ 7,9(11) stigmastane-type steroid saponins , along with four known analogues ( 7 – 10 ) were isolated from the leaves of Vernonia amygdalina Delile (Compositae). Their structures were determined by the combination of NMR, ECD and HR-ESI-MS data. These compounds all possessed highly oxidized side chain and a γ-lactam or α , β -unsaturated five-membered lactone ring. All isolates were screened for their activities in reversing resistance in MCF/DOX cells.

研究领域: 植物化学 · 药物化学 · 天然产物研究

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Chinese Journal of Natural Medicines · 2022 · IF 3.887

Rapid identification of stigmastane-type steroid saponins from Vernonia amygdalina leaf based on α-glucosidase inhibiting activity and molecular networking

Juanjuan GAO,Mengling ZHAO,Shujun SHAN,Yongyi LI,Jun LUO,Yi LI

Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines, especially Vernonia amygdalina , a famous nature medicine for the treatment of tonsillitis, diabetes, pneumonia. The current study was designed to combine molecular networking (MN) with diagnostic ions for rapid identification of Δ 7,9(11) stigmastane-type saponins which were the α -glucosidase inhibitory active substances in V. amygdalina . First, the α -glucosidase inhibitory activities of five Δ 7,9(11) stigmastane-type steroid saponins that were previously isolated were screened, which indicated that the Δ 7,9(11) stigmastane-type steroid saponin was one of the active constituents responsible for ameliorating diabetes. Furthermore, a strategy was proposed to identify stigmastane-type steroid saponins and verify the plausibility of derived fragmentation pathways by applying MN, MolNetEnhancer and unsupervised substructure annotation (MS2LDA). Based on this strategy, other seven Δ 7,9(11) stigmastane-type steroid saponins were identified from this plant. Our research provide scientific evidence for the antidiabetic potential of the steroid saponin-rich extract of V. amygdalina leaf.

CAS / MDL: 2492-87-7

研究领域: 药用植物学 · 药物化学 · 植物科学

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Stigmastane-type steroid saponins from the leaves of Vernonia amygdalina Del

Rapid identification of stigmastane-type steroid saponins from Vernonia amygdalina leaf based on α-glucosidase inhibiting activity and molecular networking