Yi Xia,Han Gui,Xinyi Li,Yuanhao Wu,Jinjian Liu,Jianfeng Liu
Radiotherapy (RT) is widely applied in tumor therapy, but inevitable side effects, especially for skin radiation injury, are still a fatal problem and life-threatening challenge for tumor patients. The main components of topical radiation protection preparations currently available on the market are antioxidants, such as SOD, which are limited by their unstable activity and short duration of action, making it difficult to achieve the effects of radiation protection and skin radiation damage treatment. Therefore, we designed a drug-free antioxidant hydrogel patch with encapsulated bioactive epidermal growth factor (EGF) for the treatment of radiation skin injury. The X-ray responsive hydrogel formed by copolymerization of the disulfide-containing hyperbranched poly(β-hydrazide ester) macromer polymer (PBAE), methacryloylated hyaluronic acid, and acrylamide exhibits continuous antioxidant activity through the oxidation of disulfide bonds in PBAE as well as the triggered release of EGF after X-ray responsive breakage of the polymer network to finally promote radioactive wound healing. Upon radiotherapy, the antioxidant hydrogel is able to alleviate local oxidative stress by continuously eliminating excessive ROS and can prevent deterioration of radiation skin injury. Moreover, the drug-free hydrogel with its excellent antioxidant property can overcome the disadvantages of traditional medicine (such as poor solubility, random diffusion, rapid drug clearance, and interference with tumor efficacy). Notably, the drug-free hydrogel exhibits a negligible effect for tumor therapy because the antioxidant hydrogel acts only on the epidermis and displays no shielding effect for ionization radiation. Ultimately, in vivo animal studies affirm the efficacy of our methodology, wherein the administration of the antioxidant hydrogel on acute irradiated skin attenuates the progression of radiation skin injury and promotes radioactive wound healing. This innovative strategy points out a new inspiration for the precise treatment of skin radiation damage with X-ray responsive antioxidant drug-free hydrogels.
Lead-free double perovskite has become a candidate material for green optoelectronic applications due to its low toxicity and human-friendly characteristics. Double perovskite has a huge application prospect in the field of optical detectors, especially X-ray detection in recent years. By introducing propylammonium (PA), we have grown a larger size 2D double perovskite (PA) 4 AgBiBr 8 single crystal . While inheriting the high stability of the 2D material , it also exhibits good X-ray response. The constructed planar Au/(PA) 4 AgBiBr 8 /Au X-ray detector displays a sensitivity of 6.89 μC Gy −1 cm −2 under 40 V bias voltage and 40 keV X-ray radiation.
Cs3Cu2I5 nanocrystals (NCs) are considered to be promising materials due to their high photoluminescence efficiency, lack of lead toxicity, and X-ray responsiveness. However, during the crystallization process, NCs are prone to agglomeration and exhibit uneven size distribution, resulting in several light scattering that severely affect their imaging resolution. Herein, we successfully developed a high-resolution scintillator film by growing copper-based perovskite NCs within a hybrid polymer matrix. By leveraging the ingenious integration of polyvinylidene fluoride (PVDF) and polymethyl methacrylate (PMMA), the size and distribution uniformity of Cs3Cu2I5 NCs can be effectively controlled. Consequently, a high spatial resolution of 14.3 lp mm–1 and a low detection limit of 105 nGy s–1 are achieved, and the scintillator film has excellent flexibility and stability. These results highlight the promising application of Cs3Cu2I5 scintillator films in low-cost, flexible, and high-performance medical imaging.
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