Summary A luminescent all-inorganic manganese-bismuth heterometallic Cs 4 MnBi 2 Cl 12 perovskite single crystal has been synthesized with a [BiCl 6 ] 3− -[MnCl 6 ] 4− -[BiCl 6 ] 3− triple-layered two-dimensional structure. Benefit from the effective energy transfer from [BiCl 6 ] 3 − octahedron donor to luminescent [MnCl 6 ] 4− acceptor, Cs 4 MnBi 2 Cl 12 shows a photoluminescence quantum yield (PLQY) of up to 25.7% (~610 nm), 51-fold higher than the Bi unalloyed CsMnCl 3 ·2H 2 O counterpart. Suggested by the theoretical calculations, Bi and Mn exhibit hybridization in conduction and valence band, which further results in a favorable low activation energy for exciton transfer (~23 meV). By virtue of all-inorganic chemical composition, Cs 4 MnBi 2 Cl 12 exhibits impressive stability toward moisture, light, and heat. Furthermore, Cs 4 MnBi 2 Cl 12 features strong soft X-ray attenuation and bright radiative luminescence under X-ray excitation, which pave a way for its application in medical flat-panel X-ray digital radiography. This work presents a new avenue toward fabrication of function-directed material with tailored photoelectric properties.
Lanfang Ren,Xijian Liu,Tao Ji,Guoying Deng,Fengjiao Liu,Haikuan Yuan,Jing Yu,Junqing Hu,Jie Lu
Most of the existing single-component nanostructures cannot provide comprehensive diagnostic information, and their treatment strategies always have to combine other therapeutics as a complementary for effective biomedical application. Here, we adopted a facile approach to design a theranostic nanoflower (NF) with robust efficacy for comprehensive tumor diagnosis and quadruple synergistic cancer therapy. The NF is equipped with a metallic hybrid of several functional elements and flower-like superstructures and thus shows excellent in vitro and in vivo theranostic performance. It shows high X-ray attenuation coefficiency for the Bi element, strong near-infrared (NIR) plasmon absorbance and singlet oxygen (1O2) generation ability for the Mo element, and great photothermal conversion efficiency (54.7%) because of enhanced photoabsorption of the petal structure. Moreover, the NF realizes a very high doxorubicin-loading efficiency (90.0%) and bimodal pH/NIR-responsive drug release, posing a promise as a controlled drug carrier. The NF also shows excellent performance at trimodal magnetic resonance/X-ray computed tomography/photoacoustic imaging for comprehensive tumor diagnosis. To our best knowledge, it is the first time that integrating at least seven functions into one biomedical nanomaterial for well-rounded tumor theranostics has been reported. This “all-in-one” NF opens a new perspective in developing novel and efficient multifunctional nanotheranostics.
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