DALTON TRANSACTIONS
·
2015
·Vol. 44
·期 25
·11314-11320
·
IF 4.197
Ji-Tao Song,Xiao-Quan Yang,Xiao-Shuai Zhang,Dong-Mei Yan,Ming-Hao Yao,Meng-Yao Qin,Yuan-Di Zhao
In this study, silica coated Au nanospheres (Au@SiO2) were prepared by a reverse microemulsion method; subsequently, a layer of fluorescent quantum dots (QDs) were adsorbed onto it and then it was coated with silica again. After modifying with PVP, the composite silica coated gold nanosphere and quantum dots nanoparticle (Au@SiO2-QDs/SiO2-PVP) was obtained. This composite structure contained Au and QDs, and it could be used for contrast-enhanced X-ray CT imaging and fluorescence imaging. Characterization showed that the composite nanoparticle had good dispersity, a high fluorescence intensity and a good effect of X-ray absorption, and it was suitable for using as a bimodal imaging probe.
研究领域:
医学影像学
·
纳米生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Theranostics
·
2013
·
IF 7.806
Yun Sun,Juanjuan Peng,Wei Feng,Fuyou Li
Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF 4 -based UCNP (NaLuF 4 :Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF 4 :Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and in vivo imaging resolution.
研究领域:
生物医学工程
·
纳米医学
·
医学影像学
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2014
·Vol. 39
·期 1
·589-594
·
IF 3.159
Zhaogui Ba,Yumin Zhang,Junpei Wei,Jiwu Han,Zhenqiang Wang,Guangrui Shao
Nanoparticulate contrast agents have drawn considerable attention and interest because of their potential application in medical diagnosis and prognosis. In the present study, we designed and constructed high-performance nanoparticulate contrast agents based on PEGylated lutetium hydroxycarbonate nanoparticles (PEG-LuNPs) for X-ray computed tomography imaging, which were synthesized via a green and large-scale route. Under the daily clinical voltage, our PEG-LuNPs provided much more enhanced contrast than the routinely used iodine-based molecules. More importantly, PEG-LuNPs could act as liver-targeted contrast agents for the further detection of hepatic metastases. Both in vitro and in vivo toxicity studies indicated that these nanoparticles possess extremely high biocompatibility, revealing their overall safety. Based on these results, PEG-LuNPs with intrinsic physicochemical properties and excellent imaging capability demonstrated a useful nanoplatform for biomedical applications.
研究领域:
医学影像学
·
生物材料学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Jie Zhou,Qiaolei Wang,Shizhen Geng,Rui Lou,Qianwen Yin,Weiran Ye
To tackle the barrier of the insufficient intra-cellular delivery of reactive oxygen species (ROS) and heat, we designed a multifunctional nanoplatform to release ROS and heat directly in the cell nucleus for enhancing combined photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors. As a photothermal agent, WS 2 nanoparticles were adsorbed photosensitive Au 25 (Captopril) 18 − (Au 25 ) nanoclusters via electrostatic interaction. And Dexamethasone (Dex), a glucocorticoid with nucleus targeting capability, played a key role in the intra-nuclear process of heat and ROS. PTT can increase intra-tumoral blood flow to promote Au 25 produce more ROS for PDT. Under near infrared (NIR) laser irradiation at a single 808 nm, these nucleus targeting WS 2 nanoplatforms showed a significant decreased cell viability of 18.2 ± 1.7% and a high DNA damage degree of 59.6 ± 8.3%. Furthermore, the WS 2 nanoplatform could be further used for X-ray computed tomography (CT) images. Taken together, our study provided a new prospect for effectively diagnostic and enhancing PTT/PDT efficacy.
研究领域:
肿瘤学
·
纳米医学
·
生物医学工程
·
影像医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2021
·
IF 1.134
Ting-Hua LI,Su-Qing SHI,Xue-Song LU,Lu-Lu SHI,Shan-Shan WEI,Hui GUO,Xin-Yu ZHANG,Hong-Yuan ZHANG,Guo-Ying SUN
Versatile nano-theranostic agents are highly desirable for the precision nanomedicine of tumors in recent years. In this work, a multifunctional diagnostic and therapeutic agent Bi 2 S 3 -MnO 2 @BSA-Ce6 (BMBC) was successfully prepared by a combination strategy of facile chemical coupling and biomineralization under mild conditions. These BMBC nanoparticles with an average diameter of 17.6 ± 4.6 nm exhibited favorable physiological stability and negligible toxicity. This agent expressed outstanding performance of photothermal conversion (η = 45.8%) under 808 nm laser radiation and generation of 1 O 2 under 650 nm laser irradiation. Due to the strong X-ray attenuation performance of element Bi and the highly effective magnetic moment of Mn 2+ , this agent exhibited favorable performance of X-ray computed tomography (CT) imaging (35.60 HU•mL•mg −1 ) and magnetic resonance (MR) imaging (r 1 = 5.22 mM −1 •s −1 ) in vitro. Furthermore, most of the HeLa cells treated with BMBC NPs were dead in the MTT and Calcein-AM/PI staining experiments, demonstrating the excellent effect of intracellular synergistic therapy. Overall, this theranostic agent could serve as a promising nano-platform for photothermal/photodynamic synergistic therapy of tumors under the guidance of infrared thermal (IRT)/MR/CT imaging.
研究领域:
纳米医学
·
癌症治疗
·
医学影像
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）