CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Leyang Li,Ruiyang Sun,Rui Yuan,Manpeng Lin,Linlin Wang,Qi Wang,Jiguo Tu,Handong Jiao,Shuqiang Jiao
Molten-salt electrorefining (MSE) is currently the primary method for purifying many elements, offering promise for the sustainable upcycling of spent metals in the future. However, the conventional constant-current electrolysis protocol inevitably leads to deterioration of the microenvironment near the electrode, leading to reaction runaway and process inefficiency. In this work, we comprehensively studied for the first time the effect of constant- and pulse-electrolysis protocols on environmental evolution in electrode–electrolyte interfaces during the MSE of Ti, using a computer model. The results showed that compared to constant electrolysis, pulse-electrolysis protocols could effectively regulate the interfacial microenvironment and improve the electrorefining efficiency. Furthermore, a correlation between interfacial reconstruction and pulse parameters was established, indicating that the duty ratio was the key factor in inhibiting the deterioration of the interfacial microenvironment. To further verify the simulation results, the real-time morphological evolution of the electrodes during electrolysis was monitored by a novel in situ X-ray computed tomography (CT) technology under pulse-electrolysis protocols. The experimental results indicated that the pulse-electrolysis protocols enhanced the interfacial microenvironment and promoted electrolysis efficiency. Collectively, this work demonstrated that MSE could be effectively advanced by rationally designing the pulse-electrolysis protocols, facilitating its large-scale application in industry.
研究领域:
材料科学
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冶金工程
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2015
·Vol. 44
·期 25
·11314-11320
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IF 4.197
Ji-Tao Song,Xiao-Quan Yang,Xiao-Shuai Zhang,Dong-Mei Yan,Ming-Hao Yao,Meng-Yao Qin,Yuan-Di Zhao
In this study, silica coated Au nanospheres (Au@SiO2) were prepared by a reverse microemulsion method; subsequently, a layer of fluorescent quantum dots (QDs) were adsorbed onto it and then it was coated with silica again. After modifying with PVP, the composite silica coated gold nanosphere and quantum dots nanoparticle (Au@SiO2-QDs/SiO2-PVP) was obtained. This composite structure contained Au and QDs, and it could be used for contrast-enhanced X-ray CT imaging and fluorescence imaging. Characterization showed that the composite nanoparticle had good dispersity, a high fluorescence intensity and a good effect of X-ray absorption, and it was suitable for using as a bimodal imaging probe.
研究领域:
医学影像学
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纳米生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Hui Zhang,Jing-Chun Feng,Bin Wang,Yongming Shen,Yue Zhang,Si Zhang
Understanding the interfacial formation characteristics of methane hydrates in deep-sea environments is fundamental to isolate leaking methane (a potent greenhouse gas). We observed the three-dimensional (3-D) characteristics of methane hydrate film (HF) growth at the gas–liquid interface (GLI) under different pressures using micro-nano industrial X-ray computed tomography (X-CT). The results indicate that the primary growth mode of the HFs at the GLI after initial formation was growth through the continuous formation of cracks. This crack-induced growth enhanced the hydrate conversion rate. We compared the thickness distribution characteristics of the hydrate growth under varying pressures. While the early HF exhibited thickening, the average thickness in the later stage of hydrate growth remained relatively stable and homogeneity. This study on the growth characteristics of HFs at the GLI provides a foundation for further development of efficient and stable methods for hydrate utilization and sequestration.
研究领域:
环境科学
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材料科学
✓ 已验证
DOI
高影响因子
Theranostics
·
2013
·
IF 7.806
Yun Sun,Juanjuan Peng,Wei Feng,Fuyou Li
Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF 4 -based UCNP (NaLuF 4 :Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF 4 :Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and in vivo imaging resolution.
研究领域:
生物医学工程
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纳米医学
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医学影像学
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2014
·Vol. 39
·期 1
·589-594
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IF 3.159
Zhaogui Ba,Yumin Zhang,Junpei Wei,Jiwu Han,Zhenqiang Wang,Guangrui Shao
Nanoparticulate contrast agents have drawn considerable attention and interest because of their potential application in medical diagnosis and prognosis. In the present study, we designed and constructed high-performance nanoparticulate contrast agents based on PEGylated lutetium hydroxycarbonate nanoparticles (PEG-LuNPs) for X-ray computed tomography imaging, which were synthesized via a green and large-scale route. Under the daily clinical voltage, our PEG-LuNPs provided much more enhanced contrast than the routinely used iodine-based molecules. More importantly, PEG-LuNPs could act as liver-targeted contrast agents for the further detection of hepatic metastases. Both in vitro and in vivo toxicity studies indicated that these nanoparticles possess extremely high biocompatibility, revealing their overall safety. Based on these results, PEG-LuNPs with intrinsic physicochemical properties and excellent imaging capability demonstrated a useful nanoplatform for biomedical applications.
研究领域:
医学影像学
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生物材料学
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Jie Zhou,Qiaolei Wang,Shizhen Geng,Rui Lou,Qianwen Yin,Weiran Ye
To tackle the barrier of the insufficient intra-cellular delivery of reactive oxygen species (ROS) and heat, we designed a multifunctional nanoplatform to release ROS and heat directly in the cell nucleus for enhancing combined photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors. As a photothermal agent, WS 2 nanoparticles were adsorbed photosensitive Au 25 (Captopril) 18 − (Au 25 ) nanoclusters via electrostatic interaction. And Dexamethasone (Dex), a glucocorticoid with nucleus targeting capability, played a key role in the intra-nuclear process of heat and ROS. PTT can increase intra-tumoral blood flow to promote Au 25 produce more ROS for PDT. Under near infrared (NIR) laser irradiation at a single 808 nm, these nucleus targeting WS 2 nanoplatforms showed a significant decreased cell viability of 18.2 ± 1.7% and a high DNA damage degree of 59.6 ± 8.3%. Furthermore, the WS 2 nanoplatform could be further used for X-ray computed tomography (CT) images. Taken together, our study provided a new prospect for effectively diagnostic and enhancing PTT/PDT efficacy.
研究领域:
肿瘤学
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纳米医学
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生物医学工程
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影像医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 94
·51950-51959
·
IF 3.708
Jie Feng,Di Chang,Zhifei Wang,Bin Shen,Jinjin Yang,Yanyun Jiang,Shenghong Ju,Nongyue He
Dual-modal imaging contrast agents with unique X-ray computed tomography (CT) and optical imaging capabilities have attracted much attention in recent years. Herein, the new silica hybrid nanocomposites containing Au nanoparticles and FITC dyes (FITC–Au@SiO2) were investigated as this kind of contrast agent. TEM characterization showed that the as-synthesized FITC–Au@SiO2 nanoprobes were uniform in morphology with the average size of 90 nm. After the PEGylation, the obtained FITC–Au@SiO2@PEG exhibited good dispersion stability under different conditions. The MTT assay suggested that FITC–Au@SiO2@PEG didn't show appreciable toxicity toward KB cells even at high concentration of up to 1000 μg mL−1. In addition, it was found that FITC–Au@SiO2@PEG could cross the cell membrane and enter into the cytoplasm during the incubation with cells. In vivo dual modal optical/CT imaging of C57BL/6J mice uncovered that within 2 h post-injection FITC–Au@SiO2@PEG nanoprobes preferred to accumulate in the liver and were gradually cleared through the enterohepatic circulation system, which could bring novel opportunities to the next generation of dual-modality contrast agents.
研究领域:
纳米技术
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生物医学工程
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医学成像
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2021
·
IF 1.134
Ting-Hua LI,Su-Qing SHI,Xue-Song LU,Lu-Lu SHI,Shan-Shan WEI,Hui GUO,Xin-Yu ZHANG,Hong-Yuan ZHANG,Guo-Ying SUN
Versatile nano-theranostic agents are highly desirable for the precision nanomedicine of tumors in recent years. In this work, a multifunctional diagnostic and therapeutic agent Bi 2 S 3 -MnO 2 @BSA-Ce6 (BMBC) was successfully prepared by a combination strategy of facile chemical coupling and biomineralization under mild conditions. These BMBC nanoparticles with an average diameter of 17.6 ± 4.6 nm exhibited favorable physiological stability and negligible toxicity. This agent expressed outstanding performance of photothermal conversion (η = 45.8%) under 808 nm laser radiation and generation of 1 O 2 under 650 nm laser irradiation. Due to the strong X-ray attenuation performance of element Bi and the highly effective magnetic moment of Mn 2+ , this agent exhibited favorable performance of X-ray computed tomography (CT) imaging (35.60 HU•mL•mg −1 ) and magnetic resonance (MR) imaging (r 1 = 5.22 mM −1 •s −1 ) in vitro. Furthermore, most of the HeLa cells treated with BMBC NPs were dead in the MTT and Calcein-AM/PI staining experiments, demonstrating the excellent effect of intracellular synergistic therapy. Overall, this theranostic agent could serve as a promising nano-platform for photothermal/photodynamic synergistic therapy of tumors under the guidance of infrared thermal (IRT)/MR/CT imaging.
研究领域:
纳米医学
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癌症治疗
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医学影像
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）