JOURNAL OF NUCLEAR MATERIALS
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2017
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IF 2.048
Yi Ding,Xinggui Long,Shuming Peng,Dong Zhang,Zhaoyi Tan,Xirui Lu
Zr 1− x − y Ce x Nd y O 2− y/ 2 ceramics, which were designed as waste form materials, were obtained by simultaneous substitution of Ce 4+ and Nd 3+ for Zr 4+ in ZrO 2 . The influences of the simultaneous substitution of Ce and Nd on phase transformation of ZrO 2 were investigated systematically. Also, the aqueous durability of the ceramics was evaluated. The results show that the phase transformation caused by the simultaneous substitution mainly relates to the total content of Ce and Nd. The ZrO 2 ceramics containing Ce + Nd < 30 mol% exhibit both monoclinic and cubic phases, while the ceramics containing Ce + Nd ≥ 30 mol% are cubic phase. And the cubic phase can be stabilized by incorporating 30 mol% Ce + Nd. Moreover, LR i are modified by the incorporation of Ce and Nd, because of the presence of oxygen vacancies . The Nd and Ce co-doped zirconia waste form exhibit excellent aqueous durability (∼10 −5 g m −2 d −1 ).
研究领域:
材料科学
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核废料管理
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陶瓷工程
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产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
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2021
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IF 4.432
Yao Hua,Limei Zhou,Weidong Yang,Wenji An,Xiaolin Kou,Jian Ren,Hailang Su,Rong Chen,Zhengping Zhang,Jianjun Zou,Zhihong Zhao
Intracerebral hemorrhage (ICH) is a devastating disease, and there is currently no specific pharmacological treatment that can improve clinical outcomes. Y-2 sublingual tablets, each containing 30 mg edaravone and 6 mg (+) - borneol , is undergoing a phase III clinical trial for treatment of ischemic stroke in China. The purpose of the present study is to investigate the efficacy and potential mechanism of Y-2 in a rat model of collagenase IV injection induced ICH. Sublingual administration of Y-2 at the dose of 1, 3 and 6 mg/kg improved ICH-induced sensorimotor dysfunction, alleviated cell death and histopathological change, restored the hippocampal long-term potentiation (LTP), reduced brain edema and maintained blood-brain barrier (BBB) integrality in ICH rats. Further study demonstrated that Y-2 could reduce inflammatory response and oxidative stress by decreasing the levels of myeloperoxidase (MPO), ionized calcium-binding adaptor protein-1 (Iba-1), inflammatory cytokines and oxidative products, inhibit transcription factor nuclear factor-κB (NF-κB) activation, cyclooxygenase-2 (COX-2) and matrix metallopeptidase 9 (MMP-9) expression in brain tissue around in the core regions of hematoma . Importantly, the protective efficacy of Y-2 from ICH-induced injury was superior to edaravone. In conclusion, Y-2 sublingual tablets might be a promising therapeutic agent for the treatment of ICH.
研究领域:
神经病学
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药理学
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实验性卒中研究
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2015
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IF 2.353
Renping Cao,Tao Liang,Wensheng Li,Chunyan Cao,Yufeng Wen,Qianglin Hu
Sr [1−3( x + y )/2] Al 2 B 2 O 7 : x Eu 3+ , y Bi 3+ ( x = 0–5 mol% and y = 0–5 mol%) phosphors are synthesized by a solid-state reaction method in air, and their crystal structure, fluorescence lifetime, and luminescence properties are investigated. The optimal composition is determined to be (Sr 0.94 Eu 0.03 Bi 0.01 )Al 2 B 2 O 7 . The PLE band peaks within the range 200–550 nm are due to O 2− → Eu 3+ charge transfer band, 7 F 0 → 5 H 3 , 5 D 4 , 5 L 7 , 5 L 6 , 5 D 3 , 5 D 2 , and 5 D 1 transitions, respectively. The strongest PL band peak under excitation 394 nm light is at ∼615 nm owing to 5 D 0 → 7 F 2 transition of Eu 3+ ion. The PL intensity of Eu 3+ , Bi 3+ co-doped SrAl 2 B 2 O 7 phosphor is 1.3 times that of Eu 3+ doped SrAl 2 B 2 O 7 phosphor due to the energy transfer between Eu 3+ and Bi 3+ ions, which is explained by the energy level diagrams of Bi 3+ and Eu 3+ ions. The CIE chromaticity coordinates of Sr 0.955 Al 2 B 2 O 7 :0.03Eu 3+ and Sr 0.94 Al 2 B 2 O 7 :0.03Eu 3+ , 0.01Bi 3+ phosphors under excitation 394 nm light are ( x = 0.6292, y = 0.3702) and ( x = 0.6284, y = 0.3711), respectively. These phosphors will be used as reddish orange emitting phosphor candidate for white LED with ∼394 nm near ultraviolet LED chip.
研究领域:
材料科学
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光学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2021
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IF 5.302
Yongchang Guo,Ying Zhang,Mathieu Allix,Shaowei Feng,Hong Sun,Cécile Genevois,Emmanuel Véron,Jianqiang Li
Pyrochlore-based glass-ceramics are attracting attention as a promising host material for immobilizing minor actinide in high-level wastes. However, the loading capacity of pyrochlore-based materials for actinide elements is to be improved, and only conventional synthetic approaches of powder sintering and glassy bulk crystallization were reported. Here, new (La,Y) 2 (Zr,Ti) 2 O 7 pyrochlore-based glass-ceramics were subtly designed and successfully prepared through a rapid melting and solidification process. The solidification behavior of samples with different cooling rates was investigated, the dense and crack-free (La,Y) 2 (Zr,Ti) 2 O 7 pyrochlore-based glass-ceramics were prepared at the cooling rate of 500 °C/s (within 1.5 s). The present amorphous La 2 O 3 -TiO 2 -Al 2 O 3 phase demonstrates the outstanding thermal stability compared with the currently used borosilicate glass for high-level waste immobilization due to the lack of conventional glass-forming components. The results show the great feasibility of this novel synthesis route for glass-ceramics by direct solidification and its good potential for immobilizing high-level wastes.
研究领域:
材料科学
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核废料处理
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无机化学
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产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
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2024
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IF 4.5
Wenliang Sun,Chao Han,Ruirui Ge,Xiaotong Jiang,Yu Wang,Yingchao Han,Ning Wang,Yanzhi Song,Mingshi Yang,Guoliang Chen,Yihui Deng
Cationic lipids play a pivotal role in developing novel drug delivery systems for diverse biomedical applications, owing to the success of mRNA vaccines against COVID-19 and the Phase III antitumor agent EndoTAG-1. However, the therapeutic potential of these positively charged liposomes is limited by dose-dependent toxicity. While an increased content of cationic lipids in the formulation can enhance the uptake and cytotoxicity toward tumor-associated cells, it is crucial to balance these advantages with the associated toxic side effects. In this work, we synthesized the cationic lipid HC-Y-2 and incorporated it into sialic acid (SA)-modified cationic liposomes loaded with paclitaxel to target tumor-associated immune cells efficiently. The SA-modified cationic liposomes exhibited enhanced binding affinity toward both RAW264.7 cells and 4T1 tumor cells in vitro due to the increased ratios of cationic HC-Y-2 content while effectively inhibiting 4T1 cell lung metastasis in vivo. By leveraging electrostatic forces and ligand–receptor interactions, the SA-modified cationic liposomes specifically target malignant tumor-associated immune cells such as tumor-associated macrophages (TAMs), reduce the proportion of cationic lipids in the formulation, and achieve dual objectives: high cellular uptake and potent antitumor efficacy. These findings highlight the potential advantages of this innovative approach utilizing cationic liposomes.
研究领域:
药学
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肿瘤学
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药物递送系统
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）