Molecular Medicine Reports
·
2019
·Vol. 19
·期 6
·4579-4588
·
IF 1.851
Shiqi Wang,Fuwei He,Zhenwei Li,Yewen Hu,Ning Huangfu,Xiaomin Chen
Oxidative stress serves important roles in cardiac injury during the process of ischemia/reperfusion (I/R). Y‑box protein 1 (YB1), a member of the highly conserved Y‑box protein family, is closely associated with inflammation and stress responses by regulating gene transcription, RNA splicing and mRNA translation. However, the roles of YB1 in oxidative stress‑induced myocardial‑I/R (M‑I/R) injury are unknown. The aim of the present study was to examine the effects of YB1 on H2O2‑induced cardiomyocyte injury and its underlying mechanism. The results demonstrated that YB1 expression was upregulated during H2O2‑induced myocardial injury. YB1 knockdown through transfection of small interfering RNA significantly aggravated cardiac cell apoptosis. Furthermore, YB1 knockdown significantly reversed the H2O2‑mediated increase in phosphorylated signal transducer and activator of transcription (STAT)3, but did not affect the phosphorylation of P38, extracellular signal‑regulated kinases 1/2, c‑Jun N‑terminal kinases, P65, Janus kinase 1 and 2 or STAT1. Moreover, protein co‑immunoprecipitation and RNA‑binding protein immunoprecipitation assays revealed that YB1 interacted with protein inhibitor of activated STAT 3 (PIAS3) mRNA but not its translated protein. YB1 overexpression may have promoted PIAS3 mRNA decay, decreasing PIAS3 protein levels, and therefore increased the levels of phosphorylated STAT3. Finally, YB1 knockdown, mediated by a lentivirus carrying YB1 targeted short hairpin RNA, significantly decreased left ventricle percentage fractional shortening and ejection fraction values, while increasing the infarct sizes in a rat model of M‑I/R injury. These results demonstrated for the first time (to the best of our knowledge) that YB1 may protect cardiac myocytes against H2O2 or M‑I/R‑induced injury by binding to PIAS3 mRNA and resulting in the phosphorylation of STAT3.
研究领域:
心脏病学
·
分子生物学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
Coatings
·
2024
·Vol. 14
·期 9
·1097
·
IF 2.9
Jiaxin Liao,Lin Chen,Luyang Zhang,Xunlei Chen,Cheng Xu,Tianyu Li,Jing Feng
Environmental barrier coatings (EBCs) are widely used to protect ceramic matrix composites (CMCs, SiCf/SiC, and Al2O3f/Al2O3), and they should have low thermal expansion coefficients (TECs) matching the CMCs and excellent mechanical properties to prolong their lifetime. Current EBC materials have disadvantages of phase transitions and insufficient mechanical properties, which affect their working temperatures and lifetime. It is necessary to develop new oxide EBCs. Ytterbium tantalate (YbTaO4) is a stable and novel EBC material, and we have improved the mechanical properties and TECs of Yb1−xAlxTaO4(x = 0.05, 0.1, 0.2, 0.3, 0.4, 0.5) ceramics by replacing Yb with Al. XRD, SEM, and EDS are used to verify the crystal and microstructures, and nano-indentation is used to measure the modulus and hardness when changes in TECs are measured within a thermal expansion device. The results show that the phase structure of Yb1−xAlxTaO4(x = 0.05, 0.1, 0.2, 0.3, 0.4, 0.5) is stable at 25–1400 °C within air atmosphere, and their high-temperature TECs (6.4–8.9 × 10−6K−1, 1400 °C) are effectively regulated by introductions of different contents of Al, which enlarge their engineering applications for SiCf/SiC and Al2O3f/Al2O3CMCs. The evolutions of TECs are analyzed from structural characteristics and phase compositions, and the increased TECs make Yb1−xAlxTaO4potential EBCs for Al2O3matrixes. Due to the high bonding strength of Al–O bonds, hardness, as well as Young’s modulus, are enhanced with the increasing Al content, with Yb1−xAlxTaO4(x = 0.05, 0.1, 0.2, 0.3, 0.4, 0.5) having a nano-hardness of 3.7–12.8 GPa and a Young’s modulus of 100.9–236.6 GPa. The TECs of YbTaO4are successfully regulated to expand their applications, and they match those of Al2O3and SiC matrixes, as well as displaying improved mechanical properties. This work promotes applications of YbTaO4as potential EBCs and provides a new way to regulate the TECs of tantalates.
研究领域:
材料科学
·
陶瓷工程
✓ 已验证
产品关联
DOI
高影响因子
Crystals
·
2024
·Vol. 14
·期 1
·91
·
IF 2.4
Fan Zhang,Hua Hao,Minghe Cao,Zhonghua Yao,Shuai Fu,Hanxing Liu
Piezoelectric ceramics with excellent piezoelectric properties and a high Curie temperature are important for numerous electromechanical devices in a broad range of temperature environments. In this work, the relaxor ferroelectric Pb(Yb1/2Nb1/2)O3end member was selected to be introduced into a BiScO3-PbTiO3high-temperature piezoelectric ceramic to reduce the dielectric loss and improve the piezoelectric properties while slightly reducing the Curie temperature. The phase structure and dielectric, ferroelectric and piezoelectric properties of 0.025Pb(Yb1/2Nb1/2)O3-(0.975−x)BiScO3-xPbTiO3(0.60 ≤x≤ 0.63) ceramics were systematically analyzed, and the best electrical properties were observed in the morphotropic phase boundary regionx= 0.61 withd33= 370 pC/N,kp= 44%,Pr= 33.9 μC/cm2. Importantly, no significant depolarization was observed in thex= 0.61 ceramic from room temperature to 290 °C, demonstrating its good thermal stability and potential applications in a wide range of temperature environments.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
Journal of Materiomics
·
2025
·
IF 9.6
Qing Li,Wei Deng,Tian-Ci Ma,Changhao Zhao,Mupeng Zheng,Lei Zhao,Qiong Wu,Chaofeng Wu,Fang-Zhou Yao,Wen Gong,Dragan Damjanovic,Mao-Hua Zhang
Complex lead-based perovskites with the general formula Pb(B x ’B 1- x ’’)O 3 , represent an important class of antiferroelectrics beyond the prototypical PbZrO 3 and NaNbO 3 . Depending on the combination of B-site species and the degree of cationic ordering, these materials exhibit a wide range of ferroic behaviors, spanning from antiferroelectric to (relaxor) ferroelectric responses. In this study, we investigate (Pb 1- x Ba x )(Yb 1/2 Nb 1/2 )O 3 polycrystals synthesized via a two-step processing route. Despite displaying antiferroelectric, ferroelectric, or nearly linear dielectric behavior at room temperature, all compositions exhibit double polarization hysteresis loops in proximity to a lower-temperature dielectric anomaly. This dielectric anomaly originates from the competition between antipolar and nanoscale polar regions, and shifts towards lower temperature with increasing Ba content, reflecting the suppression of long-range antiferroelectric ordering. Notably, a composition-invariant temperature scale, T *, is identified and associated with the onset of static correlations among nanoscale polar entities, consistent with behavior reported in other complex Pb-based relaxor ferroelectrics. Superlattice reflections arising from antiparallel Pb 2+ displacements persist above T *, suggesting an intricate cation-ordering landscape requiring further investigation. These findings underscore the coexistence and competition of polar and antipolar instabilities in complex lead-based perovskites, and their pronounced sensitivity to chemical substitution, thermal fluctuations, and external electric fields.
研究领域:
凝聚态物理
·
材料科学
·
铁性材料
·
介电与绝缘体
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2017
·
IF 3.454
Teng Zheng,Laihui Luo,Peng Du,Anmeng Deng,Weiping Li
The (0.98- x )(0.6Pb(Mg 1/3 Nb 1/3 )O 3 -0.4PbTiO 3 )- x Pb(Yb 1/3 Nb 1/3 )O 3 -0.02Pb(Er 1/2 Nb 1/2 )O 3 ((0.98- x )(PMN-PT)- x PYN:Er 3+ ) ceramics were prepared through a solid-state reaction method. The phase structure, piezoelectric response, ferroelectric performance and upconversion emission of the ceramics were systematically investigated. The phase structure, the electrical and optical properties are strongly related to the content of PYN. The optimized piezoelectric response and upconversion emissions of the ceramics were achieved near x = 0.12, which locates in the morphotropic phase boundary (MPB) composition. Furthermore, the temperature sensing behaviors of the resultant compounds based on the thermally coupled levels of 2 H 11/2 and 4 S 3/2 of Er 3+ ions in the temperature range of 133–573 K were studied by utilizing the fluorescence intensity ratio technique. Additionally, the thermal effect, which is induced by the laser pump power, of the studied ceramics is also investigated and the produced temperature is enhanced from 268 to 348 K with the pump power rising from 109 to 607 mW.
研究领域:
材料科学
·
光学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）