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Phosphine-catalyzed synthesis of (Z)-N-alkenyl-2-pyridones: A dual Z-diastereoselective and N-selective approach under mild conditions

Nan Wang,Yuanyuan Huang,Mengke Wang,Weichun Huang,You Zi

Herein, a new approach for the synthesis of ( Z )- N -alkenyl-2-pyridones from 2-pyridones and propiolates using phosphine catalysis under mild conditions is reported. This dual Z -diastereoselective and N -selective reaction demonstrates excellent selectivity, yielding sole ( Z )- N -alkenyl-2-pyridones. Furthermore, scale-up studies confirm its practical applicability, with consistent efficiencies observed.