Journal of Materials Chemistry B
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2021
·Vol. 9
·期 48
·9961-9970
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IF 6.331
Shuhan Hui,Qiqi Liu,Yandong Han,Lijuan Zhang,Jun Yang,Shan Jiang,Haisheng Qian,Wensheng Yang
Bacterial infection has increasingly affected people's lives, therefore it is significant to explore novel antibacterial agents and strategies for efficient disinfection. Herein, we designed ZIF-8 based composites ICG@ZIF-8/PDA/Ag, which encapsulate photothermal agent indocyanine green (ICG) and grow polydopamine (PDA) on their surface for in situ reduction to generate Ag nanoparticles. With 20 min of 808 nm laser irradiation at 1.5 W cm−2, 100 μg mL−1 ICG@ZIF-8/PDA/Ag exhibited 100% bactericidal effects toward E. coli and S. aureus bacteria resulting from both hyperthermia of ICG and PDA and chemical toxicity of the released Ag and Zn ions. When the bacterial incubation period was extended to 12 h, the minimum bactericidal concentration (MBC) of ICG@ZIF-8/PDA/Ag was reduced to 6.25 μg mL−1, and this extremely low MBC was due to the long-term chemo-photothermal combinational effect induced by NIR irradiation. Additionally, the composites successfully promote the healing of S. aureus infected wounds on mice. This work constructed photo-responsive antibacterial composites that realize chemo-photothermal synergistic therapy.
研究领域:
医学
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材料科学
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生物工程
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DOI
PubMed
高影响因子
Journal of Magnesium and Alloys
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2025
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IF 13.8
Xiaomeng Yu,Yuejun Ouyang,Jilan Long,Dan Xu,Guangming Liang,Zhiyuan Feng,Dongmei Pu,Qiwen Yong,Zhi-Hui Xie
Conventional nanoparticles incorporated into epoxy coatings suffer from poor compatibility and insufficient corrosion improvement, hindering their practical applications. A dual-strategy approach integrating in-situ host–guest nanoconfinement and surface self-assembly was devised to fabricate 8HQ@ZIF-8/PDA smart nanocontainers. The guest 8-hydroxyquinoline (8HQ) was encapsulated within the zeolitic imidazolate framework-8 (ZIF-8) host, leveraging nanoconfinement effects. A bioinspired polydopamine (PDA) layer was then self-assembled on the 8HQ@ZIF-8 surface through dopamine oxidative self-polymerization, resulting in a robust nanocontainer architecture. Density functional theory (DFT) calculations verify that the molecular interactions between the PDA and the ZIF-8 surface was the chemical adsorption. The resultant 8HQ@ZIF-8/PDA retained the rhombic dodecahedral morphology and crystallinity of ZIF-8, demonstrating controlled pH-responsive release behavior. When incorporated into an epoxy (EP) resin matrix on magnesium alloy, the 8HQ@ZIF-8/PDA/EP smart composite coatings exhibited outstanding interfacial compatibility and long-term stability, achieving a low-frequency impedance (| Z |₀.₀₁ Hz ) of 2.49 × 10⁷ Ω cm², a maximum phase angle of 82.8°, and a breakpoint frequency ( f b ) of 63.34 Hz after 50 days of immersion in a 3.5 wt% NaCl solution. These findings highlight the exceptional self-healing and corrosion-resistant properties of the 8HQ@ZIF-8/PDA/EP smart composite coatings, underscoring its potential for protecting magnesium alloys in aggressive environments.
研究领域:
材料科学
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防腐蚀工程
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表面化学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Yue Wang,Yaning Li,Meiwen Cao,Zeyu Yan,Fenggang Wei,Tianhao Ma,Ruochen Xie,Hongchao Ma
Tumor hypoxia, limited H 2 O 2 levels, and abundant glutathione (GSH) in the tumor microenvironment (TME) pose challenges for high-efficiency reactive oxygen species (ROS)-mediated therapies. To address these limitations, an intelligent ROS-mediated nanoplatform, Ce6@ZIF-8/PDA/CuO 2 /HA (CZPCH), with photodynamic activity, self-supplied H 2 O 2 , Fenton-like reaction, GSH-depletion and photothermal activity was designed for efficient tumor treatment. In the acidic TME, CuO 2 in CZPCH deposits into Cu 2+ and H 2 O 2 , consuming GSH and triggering Fenton-like reactions to generate hydroxyl radical (•OH), enabling efficient chemodynamic therapy (CDT). Moreover, the presence of Ce6 and PDA enables CZPCH to exhibit excellent singlet oxygen ( 1 O 2 ) and temperature increase performance 660 nm and 808 nm laser irradiation, respectively, resulting in efficient photodynamic therapy (PDT) and photothermal therapy (PTT) efficacy. Interestingly, the temperature increase from PTT significantly enhances •OH and 1 O 2 generation, achieving high-efficiency ROS-based therapeutic efficacy. This synergistic CDT/PDT/PTT treatment demonstrates excellent anti-tumor efficacy and illuminates novel ROS-based therapeutic strategy design.
研究领域:
纳米技术
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癌症治疗
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生物医学工程
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材料科学
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DOI
高影响因子
CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Ting Su,Hongxia Shang,Xinru Su,Zhixian Sun,Yuehan Li,Linwen Li,Zhen Zhang,Renyong Geng,Shuisheng Chen
In this investigation, a hydrogel adsorbent featuring remarkable efficiency in dye adsorption was successfully synthesized by the integration of natural polysaccharide (pullulan) and nanoparticles (ZIF-8@PDA). The prepared natural polysaccharide nanocomposite hydrogels not only exhibit superior mechanical strength and biocompatibility, but also demonstrate adeptness in the removal of dye pollutants. The dye removal capacities were 615.4 mg/g for malachite green (MG) and 525.8 mg/g for Congo red (CR), respectively. Notably, the adsorption process exhibits minimal susceptibility to variations in water quality and the presence of co-existing ions. The pH-responsive surface charge conversion capability of the adsorbent renders it recyclable, maintaining a dye adsorption performance exceeding 88 % even after 5 cycles of repeated usage. Overall, these environmentally friendly natural polysaccharide nanocomposite hydrogels hold potential for addressing complex wastewater treatment challenges and long-term use.
研究领域:
材料科学
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环境科学
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生物材料
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DOI
PubMed
高影响因子
CHEMOSPHERE
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2020
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IF 5.778
Gehong Zhang,Jie Zhang,Pinghai Lv,Jian Sun,Pingge Zhao,Leilei Yang
Biofouling and organic fouling are major obstacles for polymeric membranes during application. In this work, zeolitic imidazolate framework-8@polydopamine (ZIF-8@PDA) nanoparticles were prepared by an aqueous synthesis strategy and incorporated into the polyamide (PA) selective layer to synthesize thin film nanocomposite membrane (TFN) during interfacial polymerization. The permeability and selectivity of the composite membrane were simultaneously improved with the introduction of ZIF-8@PDA. The water permeability of the TFN membrane increased to 3.74 ± 0.19 L/(m2·h·bar), which is 43.8% higher than that of the control membrane. Besides, the rejection of TFN membrane to sodium chloride is 98.68 ± 0.13%, which shows 0.99% increment than the unmodified membrane. Moreover, organic fouling and biofouling of the TFN membrane were also alleviated thanks to the introduction of the hydrophilic ZIF-8@PDA. The short-term filtration results indicate the performance of the TFN membrane is stable during operation.
研究领域:
材料科学
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环境工程
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膜技术
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DOI
PubMed
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
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2023
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IF 8.7
Jianjian Luo,Congling Shi,Lian Yin,Kaili Gong,Xiaodong Qian,Keqing Zhou
Flammable and highly toxic smokes are roadblocks for thermoplastic polyurethanes (TPU) in high-tech applications. Herein, we reported polydopamine (PDA) as a functional adjuvant for the synthesis of ZIF-8@PDA@Cu nanohybrids with a “Killing three birds with one stone” strategy, modulating the morphology and dispersion of ZIF-8, providing excellent adhesion capability to enhance the complexation of copper (Cu) particles, and playing a flame retardant function. The ZIF-8@PDA@Cu nanohybrids presented a homogeneous dispersion and built up robust interfacial interactions with TPU substrate. Further, TPU/ZIF-8@PDA@Cu composites exhibited excellent thermal stability, flame resistance and toxic smoke inhibition performance, as evidenced by high char residuals, low peak heat release rate (59.2% reduction), low peak smoke production rate (54.3% reduction) and low peak CO production (40.7% reduction). Because of the physical barrier effect of stable char layer, dilution effect of non-combustible gas and free radical scavenging effect of catechol groups, TPU composites were endowed with an excellent fire safety. Notably, metal compounds formed by thermal degradation of ZIF-8@PDA@Cu nanohybrids were able to undergo cyclic redox reaction with carbon monoxide, significantly decreased the release of toxic gas.
研究领域:
材料科学
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消防安全
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高分子化学
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DOI
高影响因子
Particuology
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2022
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IF 3.251
Yukui Gou,Yuanye Hao,Weilong Cai,Jianying Huang,Yuekun Lai
Particulate matter (PM) is a significant danger to both environment and human health. Despite the development of a series of air filters, they do not work well in harsh environment such as high temperature, high humidity or long-time filtration. To make a three-dimensional (3D) particle capture device, a sacrificial template approach was used to manufacture polydimethylsiloxane (PDMS) sponge, and then zeolite imidazole framework-8 (ZIF-8) was grown in situ on the 3D network of PDMS sponge. The removal efficiency of PM 2.5 or PM 10 is greater than 99.8% because of the high specific surface area and porous network structure of PDMS sponge, as well as the large number of metal sites of ZIF-8. In addition, the sponge filter has long-term filtration stability and still achieves excellent performance after 65 h of filtration. The composite sponge can adapt to harsh environments such as high temperature (250 °C) and high humidity (90% RH). Composite sponge filter has a regular shape, and it may be customized to any shape as required. This study provides a new idea for designing 3D high-efficiency air filters that can adapt to harsh environments.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
Materials Today Chemistry
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2025
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IF 6.7
Henigul osman,Xiaohui Tang,Dong Zhang,Bo Liu,Jie Gao,Xin Chen,Tao Jiang,Haobo Pan,Yingbo Wang
To address the dual challenges of controlled drug delivery and microenvironment modulation in repairing osteoporotic bone defects, we developed a multifunctional poly(l-lactic acid) (PLLA)-based composite fibrous scaffold (PLLA/PDA/ZIF-8@Qu). The scaffold was fabricated via electrospinning, followed by in situ polydopamine (PDA) polymerization to robustly immobilize ZIF-8 nanocarriers loaded with quercetin (Qu) on the fiber surface. The mussel-inspired PDA coating served as an adhesive interlayer between ZIF-8 and PLLA. Additionally, it provided near-infrared (NIR) responsiveness and surface functionalization capability. Under osteoporotic acidic conditions (pH 5.0–6.0), the scaffold exhibited pH-triggered release behavior, ZIF-8 degradation accelerated Zn 2+ release, and cumulative Qu release reached 90 %. Zn 2+ contributed to antibacterial activity, while the PDA coating enabled NIR-driven photothermal/photodynamic synergy, achieving 100 % inhibition against both E. coliand S. aureus. Quercetin (Qu) exerted antioxidant effects via the Nrf2/ARE pathway and promoted macrophage polarization toward the M2 phenotype, thereby ameliorating the local inflammatory microenvironment. In vitro , the scaffold enhanced osteogenic differentiation of bone marrow mesenchymal stem cells, as indicated by a 2.3-fold increase in alkaline phosphatase activity, a 1.85-fold increase in mineralized nodule formation, and upregulated Runx2 expression. In a rat femoral defect model, the scaffold group at 8 weeks post-implantation showed increased bone mineral density (BMD) from 0.454 to 0.935 g/cm 3 and trabecular number (Tb.N) from 0.694 to 0.923 mm −1 , with the defect largely filled by newly formed bone. Collectively, these results demonstrate that the PDA-enabled, ZIF-8/Qu-integrated PLLA scaffold couples pH-responsive release with antibacterial, anti-inflammatory, and pro-osteogenic functions, supporting its potential as a bone repair material responsive to pathological microenvironments.
研究领域:
生物医学工程
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组织工程
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药物递送系统
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骨再生医学
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纳米材料
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生物材料
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产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
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2021
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IF 8.198
Cijun Shuai,Jun Zan,Fang Deng,Youwen Yang,Shuping Peng,Zhenyu Zhao
Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles are able to act as effective reinforcements to enhance the overall performance of a poly-l-lactic acid (PLLA) scaffold due to its interface compatibility and natural degradability. Nevertheless, the fast degradation of ZIF-8 would release excessive zinc ions, which produces adverse effects on natural cell growth. In this study, a core–shell-structured nanoparticle, in which ZIF served as a core and hydroxyapatite (HA) served as a shell, was constructed by polydopamine (PDA)-induced in situ growth of HA on ZIF-8 nanoparticles, aiming to control the zinc ion release. Then, the core–shell-structured nanoparticle (ZIF-8@PDA-HA) was introduced into the PLLA scaffold using selective laser sintering. Results showed that the zinc ion concentration for the PLLA/ZIF-8@PDA-HA scaffold decreased by 65.3% after 28 days of immersion, as compared with the PLLA/ZIF-8 scaffold. Moreover, the in situ-synthesized HA possessed superior bioactivity, which effectively enhanced the mineralization ability of scaffolds and promoted cell adhesion, proliferation, and differentiation.
研究领域:
材料科学
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生物医学工程
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组织工程
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DOI
高影响因子
International Journal of Nanomedicine
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2026
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IF 8.7
Zidong Wu,Kai Ma,Zixuan Wu,Xiaoyu Guo,Yuning Qu,Zheyue Zhu,Weidong Zhu,Chengxin Li,Yi Liu,Rui Ma,Pei Yang
Background Polyetheretherketone (PEEK) is a promising orthopedic implant material due to its bone-matched elastic modulus and radiolucency. However, its clinical application is limited by biological inertness and lack of antibacterial activity, which predispose to implant-associated infection (IAI) and poor osseointegration. This study developed a multifunctional coating on sulfonated PEEK (SPEEK) via polydopamine (PDA)-mediated co-delivery of simvastatin-loaded ZIF-8 nanoparticles (SIM@ZIF-8) and moxifloxacin (MOX) to address these limitations.Methods A time-programmed release coating was fabricated on SPEEK by embedding SIM@ZIF-8 within a PDA layer and surface-loading MOX onto the surface. The coating’s physicochemical properties, drug release profiles, biocompatibility, antibacterial activity, and osteogenic capacity were evaluated in vitro. Antibacterial efficacy and osseointegration were further assessed in vivo using rat subcutaneous infection and rabbit femoral defect models.Results Release profiles revealed that MOX exhibited burst release within 24 h, whereas SIM quickly reached therapeutic concentrations during the initial phase and was slowly released over five weeks, while Zn2+ from ZIF-8 was released synchronously with SIM. In vitro antimicrobial assays showed that the synergistic release of MOX and SIM exhibited potent antibacterial activity against Staphylococcus aureus and Escherichia coli, providing sustained inhibition of Staphylococcus aureus biofilms. The coating also promoted MC3T3-E1 cell adhesion, spreading, and osteogenic differentiation, as indicated by upregulated osteogenic markers (Runx2, OCN, OPN, COL1A1), enhanced matrix mineralization, and increased BMP-2 expression. In rat models, bacterial colonization on the coated surface and residual bacteria in tissues were significantly reduced. In rabbit femoral defects, sustained co-release of SIM and Zn2+ accelerated new bone formation and improved osseointegration, confirmed by micro-CT, double fluorescence labeling, and histological analysis.Conclusion This study presents a novel bioactive PEEK implant coating integrating antibacterial and osteogenic functions through a MOX/SIM@ZIF-8/PDA system. The strategy effectively combats IAI and enhances osseointegration, offering potential for clinical orthopedic applications.
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
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2025
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IF 6.9
Junxian Yang,Yunqing He,Fangfei Sun,Peiyuan Zhu,Yuzhou Wu,Lincai Peng,Hui Li
Paper emerges as an ideal substrate for flexible piezoresistive pressure sensors (PRSs) due to its inherent flexibility, cost-effectiveness, renewability, and lightweight properties. However, the intrinsic hydrophilicity of original paper poses substantial challenges for practical sensor applications. Herein, we coated Ti 3 C 2 T x @ZIF-8@PDA@AgNPs (TZPA) and PDMS/CaCO 3 on the surface of paper by facile spray-coating technique to prepare paper-based superhydrophobic flexible PRSs. By employing a bioinspired micro-cracked architecture derived from crustacean sensory systems, the sensor exhibited exceptional sensing properties: three linear sensitivity regions (S 1 = 1.36 kPa −1 , 0–3 kPa; S 2 = 8.71 kPa −1 , 3–10 kPa; S 3 = 0.81 kPa −1 , 10–30 kPa), rapid response/recovery times (98.1/97.9 ms), and stable operation over 500 cycles. The superhydrophobic PDMS/CaCO 3 layer, with its micro-nano structure and low surface energy, imparted the paper-based sensor with excellent waterproofing (water contact angle ∼151.1° and water sliding angle ∼9°), self-cleaning, and synergistic antibacterial properties when combined with the TZPA layer. Finally, the fabricated paper-based PRS demonstrated real-time detection capabilities for human bodily motions (including large/small movements) even under high-moisture conditions and underwater. Presented here is an environmentally friendly and simple method for fabricating superhydrophobic paper-based PRSs which have significant potential in the fields of wearable electronics, healthcare surveillance and human–computer interaction, even in aqueous environments.
研究领域:
材料科学
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传感器
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纳米技术
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生物医学工程
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柔性电子学
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表面工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）