Yi Shao,Hao Suo,Shuting Wang,Yaou Peng,Xiaoying Chu,Ziyue Long,Kanghui Du,Lili Su,Xinyue Sun,Xinyi Wang,Qingying Wang,Renlong Li,Bailiang Wang
Eye trauma, ophthalmic surgery and contact lens (CL) wearing cause corneal infection and bacterial biofilms formation, which further lead to corneal ulcer and perforation. In view of the low bioavailability of antibiotic eye drops and the clinical problems that cause bacterial resistance, we used pH sensitive zeolitic imidazolate framework-8 metal–organic frameworks (ZIF-8 MOFs) to load broad-spectrum antibacterial drugs levofloxacin (LEVO). After the surface modification by hyaluronic acid (HA), the nanomaterial surface was negatively charged. A simple amination treatment was used to endow CL surface with amino groups to combine the negatively charged nano drug loading system through electrostatic forces. The bacteriostatic ring of ZIF-8@LEVO@HA-PEI modified CL (ZLHP-CL) was 34 mm, which could be owing to the high drug loading capacity of ZIF-8 (0.65 mg/cm 2 ). The bactericidal function was further confirmed by shake flask method and live/dead bacterial staining assay against S. aureus , S. epidermidis and E. coli . It is worth mentioning that ZLHP-CL showed significant pH sensitivity to the bacterial infection, which released drug rapidly at pH 5.5 and hardly released drug at pH 7.4. In the bacterial biofilm’s formation experiment, it was found that ZLHP-CL obviously inhibited bacterial adhesion and biofilms formation. Furthermore, it was proved in infectious keratitis animal that ZLHP-CL could kill the bacteria and reduce the inflammation reaction, which showed advantages in corneal tissue repair and light transmittance maintenance. In this work, based on nanotechnology, a facile CL drug loading technology is developed, which can be used to sustained release of various drugs for ophthalmic diseases treatment.
Mengfan Hu,Zhining Huang,Peihua Zhang,Nanliang Chen,Jinhua Jiang,Shaoju Fu
Magnetoelectrical textiles, as self-power device to generate energy from motions, are promising building blocks for wearable electronic fields, but these traditional strategies towards magnetoelectrical textiles still suffer from insufficient stability and reliability, and the large-scale fabrication of magnetoelectrical textiles still remains challenging. Herein, soft magnetic fiber and its knitted fabric based NdFeB@ZIF-8 composite particles were proposed, and their electro-magnetic response performances were comprehensively characterized. NdFeB@ZIF-8 composite particles were synthesized, and they exhibited excellent magnetic property with the remnant magnetization (Mr) and coercivity (Hc) at 80 emg/g and 8604 Oe, respectively, the Ms. of NdFeB@ZIF-8 particles was 113.5 emu/g. The magnetoelectrical fibers prepared by micro-controlled flow spinning technology exhibited a breaking elongation of 575%. Driven by an external magnetic field, the magnetoelectrical fibers could bend up to 43°, and moved easily in tiny tube and lift a weight of 20 g. Similarly, the magnetoelectrical fabrics can undergo various deformations. Moreover, the magnetoelectric power generation system delivered a continuous and stable output voltage, allowing the generation of a stable electrical signal of 15 mV under various external forces. The maximum output peak power density was 551.25 mW/m2 when the resistance of the external load was 1 Ω. The presence of a magnetic field endowed magnetic fabrics with a certain degree of electromagnetic shielding effectiveness. In sum, this study employed an efficient and environmentally friendly fabricating strategy for magnetoelectrical textiles with self-power ability, showing great potential for the wearable electronics application.
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