Crystalline structures, as the basics of materials, are tightly associated with transport properties. Designing a structure through doping, alloying, and phase engineering to optimize thermoelectric transport properties has always been a crucial strategy in thermoelectrics. In this work, hybrid architectures containing an inherently long-range, nearly cubic framework as well as localized short-range noncubic lattice distortions, are designed in the pristine CuInTe2 chalcopyrites by a unique high-pressure technology. As a result, the long-range order structures motivate degeneracy in electronic bands, markedly improving the electrical transport properties. Meanwhile, suppressed lattice thermal conductivity due to strong phonon scattering is achieved by the short-range disorder structures composed of dense dislocations introduced by pressure. The above incorporation effects lead to a distinguished thermoelectric performance of zT = 1.13 at 773 K for pristine CuInTe2 prepared under 3 GPa. This study demonstrates the bright potential of high pressure as a significant approach in designing bespoke crystalline structures for tuning thermoelectric transport properties.
The formation of amyloid- β (A β ) plaques in the brain is one of the main pathological features of Alzheimer's disease (AD). The imaging probes, capable of detecting A β deposition, are important tools for early diagnosis of AD. In this article, we designed, synthesized and evaluated a cyanine-based near-infrared fluorescence (NIRF) probe ZT-1 for the detection of A β deposits in the brain. The probe had excellent fluorescent properties with an emission maximum above 720 nm upon binding to A β aggregates with affinity of 445.0 nM ( K d ). Furthermore, ZT-1 exhibited good biostability, photostability, and binding selectivity toward A β 1-42 aggregates by in vitro fluorescence staining experiments. In vivo NIRF imaging result also revealed that our probe could efficiently differentiate transgenic and wild-type mice. All these studies indicated that ZT-1 is a promising fluorescent probe for A β plaques in the AD brains.
危险品化学品经营许可证（带存储）