CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Zuizhi Lu,Hua Fan,Yingjun Ou,Mianhong Chen,Ye Yang,Linawa Shen,Liya Zhou,Xiaotong He,Jiansheng Zhao,Peican Chen
Recently, near-infrared (NIR) light-emitting diodes (LED) have attracted much research attention globally. To advance this technology, NIR phosphors with high efficiency, thermal stability, and broad bands are required. In this work, we modified ZnGa 2 O4:Cr 3+ phosphor with Mg 2+ ions. Results show that this method improves the luminescence intensity of ZnGa 2 O4:Cr 3+ phosphor, and the emission wavelength of the sample can be changed by doping different Mg 2+ concentrations. This method also improved the thermal stability of the samples. The quantum yield of Mg-modified ZnGa 2 O 4 :Cr 3+ phosphors reached 87.12%, and the white LED fabricated with Zn 0.4 Mg 0.6 Ga 2 O 4 :0.01Cr 3+ phosphor and commercial Y 3 Al 5 O 12 :Ce 3+ phosphor demonstrated good performance. The NIR-LED fabricated with Zn 0.4 Mg 0.6 Ga 2 O 4 :0.01Cr 3+ phosphor achieved a photoelectric conversion efficiency of 7.17%. The lines on the surface of an orange taken by a NIR camera reveal that phosphor can be used in night vision lighting. Meanwhile, the distribution of blood vessels in the human palm highlights the promising biological applications of the Zn 0.4 Mg 0.6 Ga 2 O 4 :0.01Cr 3+ phosphor.
研究领域:
材料科学
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光学工程
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生物医学工程
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产品关联
DOI
高影响因子
ACS Applied Electronic Materials
·
2021
·
IF 3.314
Junqing Xiahou,Qi Zhu,Lin Zhu,Siyuan Li,Ji-Guang Li
Modern engineering fields put forward requirements for optical temperature sensors, which need natural-light excitation/storage and near-infrared (NIR) afterglow emission for some special conditions. Here, NIR persistent luminescent phosphors of ZnGa2–x(Mg/Ge)xO4:Cr3+ (x = 0–1.25) have been synthesized. The incorporation of Mg2+/Ge4+ ions in ZnGa2O4:Cr3+ resulted in more defect clusters of “MgGa′–GeGa•” and “ZnGa′–GeGa•” and interstitial oxygens (OInt). Increasing the calcination temperature and Mg2+/Ge4+ doping both contributed to the generation of OInt. Higher efficiency of visible light excitation was observed, mainly due to the defect clusters and OInt. The samples exhibited a bright NIR emission at 695 nm by exposure to UV or visible light, and the NIR signal can last longer than 1 h after the stoppage of excitation. Incorporation of Mg2+/Ge4+ and increasing the calcination temperature both resulted in a deeper trap depth. However, the density of trapped charge carriers takes the dominant role in the persistent luminescence. Therefore, the x = 0.25 sample, having the most trapped charge carriers, exhibits the best afterglow performance. The prepared phosphor exhibited a temperature-dependent persistent luminescence behavior, which can charge natural light and release NIR light repeatedly many times, indicating that they are the potential natural-light rechargeable materials for temperature sensing.
研究领域:
材料科学
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光学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2017
·Vol. 9
·期 20
·6846-6853
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IF 7.367
Zhihao Zhou,Wei Zheng,Jintao Kong,Yan Liu,Ping Huang,Shanyong Zhou,Zhuo Chen,Jianlin Shi,Xueyuan Chen
Persistent luminescence nanoparticles (PLNPs) have shown great promise in the field of biomedicine, but are currently limited by the challenge in the synthesis of high-quality PLNPs with bright persistent luminescence and a long afterglow time. Herein, we report a facile strategy for the synthesis of monodisperse, rechargeable and LED-activated ZnGa2O4 : Cr3+ near-infrared (NIR) PLNPs based on a modified solvothermal liquid–solid-solution method. The as-synthesized PLNPs are not only flexible for bioconjugation, but could also circumvent the limitation of the weak persistent luminescence and short afterglow time that most PLNPs confronted owing to their rechargeable capability. It was unraveled that both thermal activation and quantum tunneling mechanisms contributed to the afterglow decay of the PLNPs, and the quantum tunneling was found to dictate the LED-activated afterglow intensity and lasting time. Furthermore, by utilizing the superior excitation-free persistent luminescence, we demonstrated for the first time the application of biotinylated ZnGa2O4 : Cr3+ PLNPs as background-free luminescent nano-bioprobes for sensitive and specific detection of avidin in a heterogeneous assay with a limit of detection down to ∼150 pM, thus revealing the great potential of these NIR PLNPs in ultrasensitive biodetection and bioimaging.
研究领域:
材料科学
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生物医学工程
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分析化学
✓ 已验证
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2017
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IF 4.164
Hongbin Chen,Bin Zheng,Chao Liang,Li Zhao,Ying Zhang,Huizhuo Pan,Wanying Ji,Xiaoqun Gong,Hanjie Wang,Jin Chang
The photothermal therapy agents induced by 808 nm near infrared light laser have good potential for photothermal therapy (PTT) in vivo, with the advantages of harmless treatment, minimally invasion, high efficiency and deep tissue penetration. For the traditional photothermal therapy agents, however, it was impossible to track them in vivo because of the low signal-to-noise ratio, so we cannot conduct the extra near infrared light laser to radiate tumors sites accurately. Herein, we introduce a new complex: indocyanine green (ICG), near-infrared persistent luminescence (PL) phosphors ZnGa 2 O 4 :Cr 3 + (ZGC) and mesoporous silica nanoparticles (MSNs) (ICG@mZGC nanoparticles) were assembled for long-lasting optical imaging to guide PTT. The results revealed that the novel nanoparticle, ICG@mZGC, could lower signal-to-noise ratio, enable highly sensitive optical detection during optical imaging-guided PTT and perform a good effect of photothermal therapy in vivo, and thus providing possibilities for mZGC to improve the localization precision of tumor sites in photothermal therapy in the body.
研究领域:
生物医学工程
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纳米医学
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光学成像
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Yi-Fan Gao,Rui Zou,Guang-Feng Chen,Bo-Mei Liu,Yong Zhang,Ju Jiao,Ka-Leung Wong,Jing Wang
Featured with excellent biocompatibility and background-free biomedical imaging, near infrared persistent luminescence (NIR-PersL) nanomaterials synthesized by mesoporous silica nanoparticles (MSNs) template have captured increasing attentions to be as a tumor theranostic nanoplatform. Unfortunately, many researches in the past decades have mainly focused on bioimaging performance of NIR-PersL nanomaterials themselves but not synergistically on tailoring the pore volume of the MSNs to optimize the drug loading/releasing performance, which greatly limits their potential application in tumor theranostics. In this work, we propose a tailorable large-pore mesoporous-silica-assisted synthesis strategy to synthesize a series of ZnGa 2 O 4 :Cr 3+ /Sn 4+ @MSNs (ZGOCS@MSNs) NIR-PersL nanospheres as nanoplatform. The ZGOCS@MSNs possess average diameters of ~ 80 nm. More interestingly, the mass ratio of ZGOCS to MSNs (MRZM) increases with the increasing of pore sizes of MSNs and the NIR-PersL performances of ZGOCS@MSNs enhance with the increase of MRZM, suggesting that MRZM plays an important role in optimizing NIR-PersL performance of the nanospheres. In vitro and in vivo NIR-PersL imaging further confirm the MRZM-dependent performance enhancement in NIR-PersL nanospheres. More importantly, the employment of large pore MSNs maintains the mesoporous structure of NIR-PersL nanospheres and the residual pore volume of ZnGa 2 O 4 :Cr 3+ /Sn 4+ @MSNs is high enough and available for efficient drug loading/releasing. Benefited from excellent rechargeable tumor NIR-PersL imaging ability and large residual cavities, ZGOCS@MSNs show high dose (~53%) of loading DOX and exhibit outstanding cancer cell killing efficiency, implying the MRZM also plays an important role in optimizing the drug loading/releasing performance of the nanospheres. In summary, the as-synthesized high performance ZnGa 2 O 4 :Cr 3+ /Sn 4+ @MSNs bi-functional nanoplatform showcases its great potential for imaging-guided cancer chemotherapy. We expect our work could take the development of NIR-PersL-based theranostic nanoplatforms a step forward.
研究领域:
材料科学
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生物医学工程
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纳米医学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Zi-Jin Wei,Chang Yin,Mengjie Sun,Kai Long,Zhouyu Zhang,Zichao Yan,Wei Wang,Zhi Yuan
Due to their unique afterglow ability, long-wavelength-light rechargeable persistent luminescence (PersL) nanoparticles (PLNPs) have been emerging as an important category of imaging probes. Among them, ZnGa2O4:0.6% Cr3+ (ZGC) PLNPs have gained widespread recognition due to the ease of synthesis and uniform morphology. Unfortunately, the limited absorption arising from the low molar extinction coefficient of Cr3+ results in relatively low afterglow intensity and rapid decay after long-wavelength LED light irradiation. Herein, we discovered a strategy that boosting dye-sensitization performance was able to effectively amplify the PersL signal under white LED light. Specifically, Dil served as a highly efficient sensitizer for Cr3+, promoting the absorption of the excitation light. By adjusting the Pr dopant concentrations, ZGCP0.5 PLNPs with optimal trap densities were obtained, which showed the highest PersL intensity and dye-sensitized performance. Strikingly, ZGCP0.5-Dil PLNPs exhibited a 24.3-fold enhancement in intensity and a 2-fold prolongation of decay time over bare ZGC PLNPs through the synergy effect of optimal electron traps and dye sensitization. Photostable ZGCP0.5-Dil PLNPs enabled imaging of the HepG2 tumor and effectively guided tumor surgical resection verified by the H&E staining analysis. This strategy could be a significant reference in other dye-sensitization PLNPs to enhance longer-wavelength rechargeable PersL.
研究领域:
材料科学
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生物医学工程
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光学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 15
·5829-5839
·
IF 8.067
Cheng Zhou,Lu Peng,Zihui Kong,Meihan Wu,Maxim S. Molokeev,Zhi Zhou,Jing Wang,Mao Xia
Cationic substitution is a common material modification strategy. Generally, it follows the principles of radius matching, valency equilibrium and stoichiometric substitution. However, radius-mismatched, nonstoichiometric-ratio ion substitution can achieve unexpected experimental results. Such unexpected results are very important for expanding the research of materials, but the modification mechanism is still unclear. In this work, the optical performance of ZnGa2O4:0.02Cr3+ (ZGO:0.02Cr3+) is effectively regulated by chemical unit cosubstitution (Ge4+–Li+/Na+ for Ga3+–Zn2+) and excess cation substitution synergetic strategies, and the thermal stability is retained at 97.7% at room temperature and 150 °C. Ge4+–Li+ and Ge4+–Na+ replace the lattice position of Ga3+–Zn2+ to enhance the photoluminescence (PL) intensity and quantum efficiency (QE) of ZGO:0.02Cr3+. The optimal doping contents of Ge4+–Li+ and Ge4+–Na+ are all 0.3 mol (PL intensity is 130.3% and 153.4% and QE = 77.4% and 85.1%). With further addition of Li+ ions, the emission intensity and QE continued to increase to 176.4% and 83.8%, respectively. The synergistic effect of the mechanism on optical properties is explained via Rietveld refinement, optical band gap energy and thermoluminescence. Finally, LED devices were fabricated by using the ZGO:0.02Cr3+,0.03Ge4+,0.11Li+ phosphor to investigate the effect on plant growth. The growth period was reduced and the fruit quality was improved in dwarf potted tomato, which shows the application prospect in plant growth of the ZGO:0.02Cr3+ phosphor.
研究领域:
材料科学
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植物学
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光学工程
✓ 已验证
产品关联
DOI
高影响因子
Advanced Optical Materials
·
2024
·Vol. 12
·期 15
·2303018
·
IF 8
Xueqing Liu,Lu Chen,Xiaowen Huo,Feng Liu,Chuan Liao,Liangliang Zhang,Jiahua Zhang,Shaoan Zhang,Yang Li,Xiao-jun Wang,Yichun Liu
The ZnGa 2 O 4 :Cr 3+ phosphor has emerged as a significant luminescent material due to its long-lasting afterglow and near-infrared emission, making it suitable for applications in bioimaging and night-vision detection. However, the limited availability of excitation light sources poses a challenge for charging the phosphor. In this study, the charging capabilities of ZnGa 2 O 4 :Cr 3+ using visible lasers and a white flashlight as excitation sources are explored. By absorbing two excitation photons, the high-lying delocalized state of Cr 3+ can be excited through a two-step process, resulting in the filling of persistent luminescence traps and producing a long-lasting emission peaking at 696 nm. The application of the white flashlight revealed a nonlinear excitation threshold for charging at 1.5 mW cm −2 . The findings also uncovered that the excitation mechanism involves excited-state absorption and energy-transfer upconversion. Moreover, taking advantage of the unique excitability of the near-infrared persistent phosphor, the potential for charging persistent luminescent probes in vivo using chicken breast tissue as a representative model is showcased. The present upconversion charging approach may offer promising possibilities and introduce a novel excitation technique for ZnGa 2 O 4 :Cr 3+ persistent phosphor.
研究领域:
材料科学
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光子学
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发光材料
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生物成像
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光学传感
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2024
·Vol. 14
·期 19
·1613
·
IF 4.4
Xiaomeng Wang,Hengli Zhu,Yan Liu,Jingyuan Li,Lejia Cao,Jiaren Du,Hengwei Lin
Near-infrared (NIR) persistent luminescence (PersL) materials have attracted extensive attention due to their great promise in medical diagnostics, bio-imaging, night vision surveillance, multi-level anticounterfeiting, and information encryption. To achieve NIR PersL (micro/nano-) materials with the desired properties, a variety of synthesis methods have been employed, including solid-phase reaction and liquid-phase synthesis. Different synthesis methods have different but important effects on the micro/nano-structure, luminescence, and PersL properties of the materials. Moreover, the influence of various synthesis methods on the properties of NIR PersL materials determines the selection of preparation approaches for other new material systems. Taking the representative NIR PersL ZnGa 2 O 4 :Cr 3+ material as an example, four synthesis procedures are applied, namely, high-temperature solid-state reaction (SSR), high-temperature molten salt method (MSM), hydrothermal method (HM), and microwave-assisted solid-state (MASS) method. The structural and luminescent properties of samples made by SSR, MSM, HM, and MASS are compared. Notably, it is revealed that the MASS method can create additional trapping energy levels, which is of great significance for emerging applications. This work demonstrates the different effects of synthesis methods on PersL performance and provides a good guideline for the rapid and reasonable selection of preparation methods for diverse applications.
研究领域:
材料科学
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纳米技术
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生物医学工程
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光学材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Honghong Feng,Yangjing Zhao,Yeping Li,Xueyong Qi,Song Shen,Shengwang Zhou
Nanotechnology provides the platform to develop functional nanocomposites with outstanding features, such as persistent luminescence (PL), photothermal conversion, magnetic resonance (MR), and so on, that has been incorporated in nanomedicine for diagnosis and therapy. Herein, the nanocomposites of ZnGa2O4:Cr3+ embedded in mesoporous silica coating surrounding gold nanorods (cGNR@MSNs) were developed for the codelivery of chemotherapeutic drugs and anti-CD40 antibodies. The nanocomposites were functionalized with tetrazaheterocycle linking divinylpyrimidine derivatives (DOTVs), which covalently capture anti-CD40 by disulfide re-bridging on the surface of cGNR@MSNs. The anti-CD40-mediated dual drug delivery system simultaneously realized the combination of chemo-, immuno-, and photothermal therapies, enhancing the synergistic effect of combination therapy for multiple tumor cells. Moreover, the nanodrug delivery system achieved multimodality imaging with fluorescence, PL, and MR modes for precise diagnosis. This study provides fascinating insights into the development of nanocomposite-based multimodality imaging strategies and imaging-guided combination therapies.
研究领域:
纳米技术
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纳米医学
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癌症治疗
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成像技术
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 21
·2200813
·
IF 15.153
Zhanlin Zhang,Hui Yan,Bo Qiu,Pan Ran,Wenxiong Cao,Xinwei Jia,Kun Huang,Xiaohong Li
External light irradiation is usually required in bacterial infection theranostics; however, it is always accompanied by limited light penetration, imaging interference, and incomplete bacterial destruction. Herein, a feasible “image-launching therapy” strategy is developed to integrate real-time optical imaging and simultaneous photodynamic therapy (PDT) of bacterial infections into persistent luminescence (PL) nanoparticles (NPs). Mesoporous silica NPs are used as a substrate for in situ deposition of PL nanodots of ZnGa 2 O 4 :Cr 3+ to obtain mPL NPs, followed by surface grafting with silicon phthalocyanine (Si-Pc) and electrostatic assembly of cyanine 7 (Cy7) to fabricate mPL@Pc-Cy NPs. The PL emission of light-activated mPL@Pc-Cy NPs is quenched by Cy7 assembly at physiological conditions through the fluorescence resonance energy transfer effect, but is rapidly restored after disassembly of Cy7 in response to bacterial infections. The self-illuminating capabilities of NPs avoid tissue autofluorescence under external light irradiation and achieve real-time colorimetric imaging of bacterial infections. In addition, the afterglow of mPL NPs can persistently excite Si-Pc photosensitizers to promote PDT efficacy for bacterial elimination and accelerate wound full recovery with normal histologic features. Thus, this study expands the theranostic strategy for precise imaging and simultaneous non-antibiotic treatment of bacterial infections without causing side effects to normal tissues.
研究领域:
纳米技术
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生物医学工程
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药学
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传染病学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）