Tao Li,Zhikun Gao,Ningwei Wang,Zhiping Zhou,Wanzhen Xu,Jianfeng Zheng,Wenming Yang
In this study, molecularly imprinted polymers with Mn-doped ZnS quantum dots (ZnS:Mn QDs) were prepared using dibutyl phthalate (DBP) as the template molecule, 3-aminopropyltriethoxysilane (APTES) as the functional monomer and the tetraethoxysilane (TEOS) as the cross-linker. ZnS:Mn QDs offer a readout signal to monitor the amount of DBP bound to the imprinted matrix and to evaluate the efficiency of imprinting. The products MIPs-ZnS:Mn QDs were characterized by transmission electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction and fluorescence spectroscopy. In addition, optical stability and the effect of pH on fluorescence intensity were evaluated. The obtained polymers can sensitively and selectively recognize template molecules in real samples via fluorescence intensity. The fluorescence intensity decreases linearly with increasing concentration in the range of 5.0–50 μmol L−1. It reaches a detection limit of 0.27 μmol L−1. The average recovery rate of DBP at three spiking levels is more than 98.1%.
Yingying Li,Peisen Zhang,Wen Tang,Kevin J. McHugh,Stephen V. Kershaw,Mingxia Jiao,Xiaodan Huang,Sergii Kalytchuk,Collin F. Perkinson,Saisai Yue,Yuanyuan Qiao,Lichong Zhu,Lihong Jing,Mingyuan Gao,Buxing Han
Improving the effectiveness of cancer therapy will require tools that enable more specific cancer targeting and improved tumor visualization. Theranostics have the potential for improving cancer care because of their ability to serve as both diagnostics and therapeutics; however, their diagnostic potential is often limited by tissue-associated light absorption and scattering. Herein, we develop CuInSe2@ZnS:Mn quantum dots (QDs) with intrinsic multifunctionality that both enable the accurate localization of small metastases and act as potent tumor ablation agents. By leveraging the growth kinetics of a ZnS shell on a biocompatible CuInSe2 core, Mn doping, and folic acid functionalization, we produce biocompatible QDs with high near-infrared (NIR)-II fluorescence efficiency up to 31.2%, high contrast on magnetic resonance imaging (MRI), and preferential distribution in 4T1 breast cancer tumors. MRI-enabled contrast of these nanoprobes is sufficient to timely identify small metastases in the lungs, which is critically important for preventing cancer spreading and recurrence. Further, exciting tumor-resident QDs with NIR light produces both fluorescence for tumor visualization through radiative recombination pathways as well as heat and radicals through nonradiative recombination pathways that kill cancer cells and initiate an anticancer immune response, which eliminates tumor and prevents tumor regrowth in 80% of mice.
A novel nanocomposite fluorescent probe consisting of quantum dots and a silica molecularly imprinted polymer (MIPs-capped ZnS:Mn QDs) was synthesized and applied for the rapid detection of teflubenzuron (TBZ) based on the fluorescence quenching of a composite probe via TBZ. The fluorescence quenching efficiency of MIP@SiO2@ZnS:Mn QDs displayed a linear relationship over the concentration range of 0–26.24 μmol/L with a correlation coefficient of 0.9857 and the limit of detection was 2.4 μg/L. The selectivity test showed that the nanocomposite had good selectively rebind TBZ with higher imprinting factor of 3.06 compared with four structurally similar compounds. In addition, the probe was successfully applied to the detection of TBZ in vegetable samples with a recovery of 90.3~97.1% and with a relative standard deviation below 3.2%. This developed method has the advantages of simple preparation, fast response and low toxicity for trace TBZ detection.
危险品化学品经营许可证（带存储）