ADVANCED FUNCTIONAL MATERIALS
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2023
·Vol. 33
·期 51
·2307402
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IF 19
Jia Yu Hu,Dejin Jiao,Xing Peng Hao,Xiangren Kong,Xin Ning Zhang,Miao Du,Qiang Zheng,Zi Liang Wu
Coordination bonds with a dynamic nature and wide-spectrum bond energy have gained great popularity in use for fabricating tough soft materials. However, most existing coordination-based elastomers are prepared through complicated procedures, usually involving elaborate synthesis of ligand-containing monomers or polymers, ion diffusion to form coordination complexes, and removal of organic solvent during the synthesis, which are neither easy operation nor environmentally friendly. Here, a facile and effective strategy is demonstrated to fabricate tough metallosupramolecular elastomers by one-pot polymerization of aqueous precursor solutions containing commercial agents, 2-acrylamido-2-methyl-1-propanesulfonic acid, 2-[2-(2-methoxyethoxy)ethoxy]ethyl acrylate, and Zr 4+ ions. After solvent (i.e. water) evaporation, the obtained elastomers are transparent and extremely tough owing to the presence of sulfonate-Zr 4+ coordination complexes as physical crosslinks. Their mechanical properties are tunable over a wide spectrum by adjusting the composition of copolymers and the density of coordination bonds. This eco-friendly strategy is further extended to various commercial monomers, manifesting good universality to toughen elastomers. Furthermore, the abundant functional groups of copolymers make the elastomers adhesive to various substrates including themselves, favoring applications such as interfacial adhesion and encapsulations. The easy fabrication, tunable mechanical properties, and adhesion ability endow the elastomers with great potential as the substrate of wearable soft electronics.
研究领域:
材料科学
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高分子化学
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软物质物理
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粘附科学
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产品关联
DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2025
·
IF 6.1
Xiaona Ren,Zhipei Chen,Peng Wang,Wenchang Wang,Yao Wang,Changchun Ge
Rare earth oxide (CeO₂/Y₂O₃) reinforced AlCrFeNiCu high-entropy alloy coatings with a Mo interlayer (designated as Mo/CeO₂-AlCrFeNiCu and Mo/Y₂O₃-AlCrFeNiCu) were successfully deposited onto a Zr-4 substrate via high-speed laser cladding. The microstructural characteristics and properties of the composite coatings were comprehensively investigated. The results demonstrate that the Mo interlayer alleviates the thermal mismatch between the substrate and the HEA coatings and, to a certain degree, counteracts the grain refinement effect induced by the rare earth oxides. Overall, it plays a critical role in enhancing interfacial structural stability, mitigating thermal stress, and improving overall coating performance. It effectively optimizes the coating-substrate bonding integrity, reduces susceptibility to high-temperature fretting fatigue and plastic deformation, and significantly lowers the specific wear rate. Furthermore, the Mo interlayer enhances the compactness and continuity of the interface, suppresses the formation of corrosive pathways, and promotes the formation of a thicker, more stable passive film on the coating surface.
研究领域:
材料科学
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表面工程
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金属学与热处理
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腐蚀与防护
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先进制造技术
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Bolong Fang,Xin Liu,Juan Peng,Yuzhi Li,Zhiyong Gong,Weihua Lai
In this study, a type of luminescent porous coordination network-224 (PCN-224) in alkaline conditions was synthesized with the dramatic fluorescence enhancement by 20.4 times, which was explained by the fact that the decrease of Zr 4+ content in alkaline conditions resulted in the partial recovery of the electron cloud density of 4,4′,4′′,4′′′-(Porphine-5,10,15,20-tetrayl) tetrakis(benzoic acid) (TCPP). Given the large overlap between the excitation spectrum of PCN-224 and the absorption band of Ag nanoparticles (Ag NPs), the coating of the Ag layer on PCN-224 triggered the fluorescence quenching effect, which was applied to “turn off” fluorescence immunoassay for sensitive detection of Escherichia coli O157:H7 ( E. coli O157:H7) in milk. The proposed immunoassay reached a low limit of detection (LOD) of 3.3 × 10 2 CFU mL −1 , 29.7 times more sensitive than the conventional ELISA. It will provide a novel alternative strategy for sensitively detecting pathogenic bacteria in the field of food safety.
研究领域:
材料科学
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分析化学
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食品安全
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生物传感器
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产品关联
DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Mingyi Ma,Li He,Xiaoxue Shi,Yanchao Wang,Hong Hai,Xiaoping Wei
This paper presents a novel strategy for ultrasensitive detection of human immunodeficiency virus (HIV) DNA by an electrochemical biosensor. By the shearing cycle of the target DNA (T-DNA), a large amount of complimentary sequence probes (CS probe DNA) are obtained. Then, the Zr 4+ functional probe DNA containing many branched DNAs is captured. Next, the initiator α-bromophenylacetic acid is connected to the branched chains of probe DNA by esterification reaction. Numerous electroactive monomers, namely, ferrocenylmethyl methacrylate (FMMA), are produced at the end of the branched chains by electrochemically mediated atomic transfer radical polymerization reaction. The signal of FMMA is greatly enhanced due to a large number of branched chain-loaded probe clusters containing numerous FMMA. T-DNA can be detected with a linear range of 0.1 fM–10 nM with a detection limit of 0.037 fM. The sensor is highly sensitive and selective. It has been applied to the detection of HIV DNA in human serum samples, and it has potential application prospects in the early clinical diagnosis of AIDS.
研究领域:
生物技术
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分析化学
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病毒学
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电化学
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产品关联
DOI
高影响因子
TALANTA
·
2021
·
IF 6.057
Xin Zhu,Zenghui Liu,Jinge Li,Zutian Li,Fuchun Si,Huaixia Yang,Jinming Kong
Exosomes, as a biomarker with enhancing tumor invasion and spread, play an essential role for lung cancer diagnosis, therapy, and prognosis. In this work, a novel electrochemical sensor was fabricated for detecting exosomes secreted by lung cancer cells based on polysaccharide-initiated ring-opening polymerization (ROP) and click polymerization. First, MPA formed a self-assembled monolayer on the gold electrode surface, and then anti-EGFR was immobilized on the electrode surface by amide bond. Subsequently, a lot of phosphate groups were introduced by the specific recognition between anti-EGFR and exosomes, then sodium alginate grafted Glycidyl propargyl ether (SA- g -GPE) prepared via ROP was attached to the exosomes through PO 4 3- Zr 4+ -COOH coordination bond. After that, click polymerization was initiated by alkyne groups on the SA- g -GPE polymerization chain to realize highly sensitive detection of A549 exosomes. Under the optimum conditions, the fabricated sensor showed a good linear relationship between the logarithm of exosomes concentration and peak current in the range of 5 × 10 3 - 5 × 10 9 particles/mL, and the limit of detection (LOD) was as low as 1.49 × 10 2 particles/mL. In addition, this method had the advantages of high specificity, anti-interference, high sensitivity, simplicity, rapidity and green economy, which proposed a novel avenue for the detection of exosomes, and also had potential applications in early cancer diagnosis and biomedicine.
研究领域:
生物标志物研究
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癌症诊断
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电化学
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聚合物科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2020
·
IF 5.339
Xiaofei Li,Yawen Zhang,Lulu Hao,Yanju Liu,Xia Wang,Huaixia Yang,Jinming Kong
Cytokeratin fragment antigen 21-1 (CYFRA 21-1) DNA is perceived as sensitive tumor marker for the diagnosis of non-small cell lung cancer and other tumor. Herein, linear chain poly(ε-caprolactone) (PCL) synthesized by ring-opening polymerization is applied to ultrasensitive label-free electrochemical impedance detection system for CYFRA 21-1 DNA. First, thiolated peptide nucleic acid (PNA) is self-assembled into the Au electrode surface through the formation of Au–S bonds, allowing the PNA to act as biomolecular probe and form PNA/DNA heteroduplex with the target DNA via specific hybridization. Then, PCL is conjugated to the immobilized DNA on the electrode via “carboxylate–Zr 4+ –phosphate” bridges. Finally, the electrochemical response of modified PNA/DNA/Zr 4+ /PCL electrode is determined by electrochemical impedance method to quantify of CYFRA 21-1 DNA. Under optimal conditions, this method exhibits highly sensitivity with a broad linear range (0.1 fM – 1 nM) ( R 2 = 0.995) and the limit of detection (LOD) is as low as 10.73 aM, which is equivalent to just 64 molecules in a 10 μL sample. What's more, the high selectivity , good anti-interference, label-free operation, and real-time monitoring in complex samples of the proposed strategy demonstrate its broad application for the early diagnosis and clinical monitoring.
研究领域:
生物医学工程
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分析化学
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分子生物学
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癌症诊断
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL SCIENCES
·
2019
·Vol. 36
·期 6
·681-685
·
IF 1.618
Liu Wenwen,Ma Ligang,Guo Zhuangzhuang,Liu Tao,Liu Yanju,Wang Dazhong,Kong Jinming
We propose a novel, ultrasensitive and low-cost sensor using reversible addition-fragmentation chain transfer (RAFT) polymerization as a signal amplification strategy for the detection of CYFRA 21-1 DNA fragment, a tumor marker of non-small cell lung carcinoma. The peptide nucleic acid (PNA) probes were firstly immobilized on magnetic beads (MBs) to capture the CYFRA 21-1 DNA specifically. After hybridization, CPAD was tethered to the hetero duplexes through carboxylate-Zr 4+ -phosphate chemistry. Subsequently, a number of fluorescent tags were introduced to the heteroduplexes through RAFT polymerization, leading to an amplification of the fluorescence signal. The sensor demonstrates a low limit of detection (LOD) of 0.02 fM. It has great selectivity with respect to base mismatch DNA, and high anti-interference ability in normal human serum. Overall findings of the study suggest that proposed sensor holds enormous potential to be used as a tool for the early-stage diagnosis of lung cancers.
研究领域:
生物技术
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癌症诊断
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纳米技术
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）