Science of Advanced Materials
·
2015
·Vol. 7
·期 5
·855-860
·
IF 2.598
Yu Huijuan,Xi Chenbin,Hu Jianhua,Du Ming,Yang Dong
An amphiphilic copolymer, PEG-b-PLA-b-(PAA-co-PNIPAM), was synthesized via atom transfer radical polymerization of tert-butyl acrylate and N-isopropyl acryamide using PEG-b-PLA-Br as a macroinitiator and CuBr/Me6 TREN as a catalytic
system, followed by selectively hydrolyzing tert-butyl groups to carboxyl groups. Then, doxorubicin (DOX) was loaded to the hydrophobic core, and the PAA segments were cross-linked by cystamine to get disulfide cross-linked and DOX loaded micelles. The transmission electron microscopy
images showed that the cross-linked DOX loaded micelles were spherical nanoparticles, with a mean diameter of 100 nm. The drug release behavior of the cross-linked DOX loaded micelles was redox responsive. The cumulative release amount of DOX was 33.1% with the presence of 10 mM of glutathione
(GSH) at 37 °C, much higher than that without the presence of GSH, which was only 4.3%. Furthermore, the cumulative release amount of DOX was 50.9% at 25 °C, higher than that at 37 °C, indicating that the cross-linked DOX loaded micelles were also thermo-sensitive.
研究领域:
药剂学
·
生物材料
·
肿瘤学
✓ 已验证
DOI
高影响因子
Sustainable Chemistry and Pharmacy
·
2026
·
IF 6.7
Lizhi Niu,Yongsheng Niu,Hongchun Li
The stimuli-responsive pesticide delivery system provides a powerful strategy for enhancing the effective utilization of pesticides and reducing environmental pollution. A new copolymer containing disulfide bond, poly (propylene oxide-co-carbon dioxide-co-allyl glycidyl ether)-SS-poly (N-isopropylacrylamide) (PPAG-SS-PNIPAM) was prepared by the RAFT polymerization. PPAG-SS-PNIPAM could self-assemble into nano-sized micelle for pesticide delivery in aqueous solution. The pesticide, avermectin (AVE), was selected as a model drug to show its potential as a controlled-release pesticide system. The loading rate and encapsulation rate of PPAG-SS-PNIPAM @ AVE were 35.81% and 95.49% respectively. The temperature sensitiveness of the nanomaterials was confirmed by DLS. The results show that temperature and glutathione have a certain effect on the AVE release rate of PPAG-SS-PNIPAM @AVE in vitro. The prepared PPAG-SS-PNIPAM @ AVE exhibited excellent glutathione and temperature dual responsive release properties, which could efficiently prevent AVE from photolysis to prolong the effective duration. Therefore, this work provides a promising approach to improve the utilization of pesticide.
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 20
·13298-13313
·
IF 3.442
Zhang Liuwei,Qian Ming,Wang Jingyun,Xia Jing,Cui Hongyan,Chen Qixian
Photo-responsive nitrophenyl moieties were proposed to conjugate as pendants of the pullulan backbone through labile carbamate linkage to yield amphiphilic pullulan derivatives. Note that the hydrophobicity of the conjugated nitrophenyl components in the amphiphiles enable facile their self-assembly with the hydrophobic chemotherapeutic drug (doxorubicin) as the internal drug reservoirs, whereas the hydrophilic pullulan segments existed as the biocompatible surroundings. Upon photo-illumination, the carbamate linkage was susceptible to cleavage for departure of the nitrophenyl components from the pullulan backbone owing to the photo-responsive nitrophenyl moieties. Simultaneously, the nitrophenyl components transformed into water-soluble aldehyde-terminalized nitrosophenyl derivatives, leadingly accounting for structural disassembly and liberation of the cytotoxic doxorubicin payloads. Therefore, our proposed photo-responsive strategy could address the reluctant intracellular drug release drawbacks of the conventional amphiphile-based drug delivery systems. Notably, markedly lower IC 50 (half maximal inhibitory concentration) index of our constructed doxorubicin delivery systems was determined to be approximately 1.0 μg/mL upon photo-illumination, in contrast to IC 50 index of 5.6 μg/mL in the absence of photo-illumination (approximate fivefold), thereby representing as a facile spatiotemporal artifice to execute on-demand drug release to the photo-imposed cells.
研究领域:
药学
·
材料科学
·
纳米技术
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
Gels
·
2025
·Vol. 12
·期 1
·27
·
IF 5.3
Yuyao Wang,Dou Jin,Zichen Huang,Fan Chen,Kun Liu,Xiacong Zhang
Dynamic covalent hydrogels exhibiting multi-responsive and antibacterial properties offer significant potential for biomedical applications, including smart wound dressings and controlled drug delivery. Herein, a series of amphiphilic quaternized copolymers (Q-C8PEG-n) with tunable quaternization degrees was synthesized from C8PEG via iodomethane addition and characterized by1H NMR, COSY, FTIR, UV-vis spectroscopy, DLS, TEM, and zeta potential analyses, confirming successful quaternization and micelle formation. These copolymers displayed thermosensitive behavior, with cloud point temperatures increasing due to enhanced hydrophilicity. Q-C8PEG-3 micelles, incorporating diethanolamine units, were crosslinked with phenylboronic acid-grafted hyaluronic acid (HA-PBA) to yield dynamic covalent hydrogels (Gel) through reversible boronic ester bonds stabilized by B-N coordination. The Gel exhibited multi-responsiveness, undergoing degradation in acidic or alkaline conditions and exposure to glucose or H2O2. SEM confirmed a porous microstructure, enabling efficient drug encapsulation, as demonstrated by the release of Nile red (NR). In vitro antibacterial tests revealed enhanced post-quaternization efficacy, with the Gel showing strong activity againstS. aureus. This micelle-crosslinked platform synergistically combines tunable stimuli-responsiveness with inherent antibacterial properties, holding promise for applications in wound healing and tissue engineering.
研究领域:
生物医学工程
·
高分子科学
·
药物递送
·
组织工程
·
抗菌材料
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产品关联
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2019
·Vol. 3
·期 6
·1097-1104
·
IF 0
Xiaojie Yuan,Zhe Wang,Lishan Li,Jiawei Yu,Yuqing Wang,Hongkun Li,Jiandong Zhang,Zhengbiao Zhang,Nianchen Zhou,Xiulin Zhu
Enzyme-sensitive amphiphilic polymers play an important role as smart materials in drug delivery and biological detection. Azobenzene, an azoreductase active site, has received significant attention in recent years. Herein, we synthesized a novel aggregation-induced emission (AIE) fluorescent probe of amphiphilic block copolymer PCL-TPE-Azo-PEG based on an azoreductase response, in which tetraphenylethylene (TPE) conjugated to an azo group provides the junction between the hydrophilic and hydrophobic (PEG and PCL) chain segments. In phosphate buffer solution, the resulting amphiphilic polymers self-assembled into rod-like micelles that are non-fluorescent owing to the quenching effect of the azo moieties on the AIE activity of TPE. In the presence of a reducing agent (such as azoreductase or Na2S2O4), the azo bond was broken and the assemblies fragmented into PEG and PCL chain segments. Following disassembly of the micelles, the AIE effect of TPE was activated because the TPE moiety is encapsulated in the resulting PCL aggregation. Furthermore, the amphiphilic polymer could encapsulate drugs, such as DOX, to form drug-loaded micelles in PB solution. And the micelles indicated an increasing fluorescence with drug release under the action of reducing agent. This amphiphilic block copolymer could potentially be applied in biosensing and controlled drug delivery for colonic conditions.
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
DOI
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Hao Xu,Zhongwei Li,Chengyu Wang,Zhengfu Wang,Rongjian Yu,Yebang Tan
A series of amphiphilic copolymers (PIDs) were synthesized through free radical copolymerization of isobutyl acrylate (IBA) with N,N-dimethylacrylamide (DMAA). The structure, composition , and average molecular weights of these copolymers were characterized by 1 H NMR spectra, infrared spectra , elemental analyse, and gel permeation chromatography . The solubility and aggregation behavior of these copolymers in different solvents were studied. In addition, thermo-responsive behavior of water-soluble copolymers in water was investigated by means of transmittance tests and DLS tests. The demulsification experiment showed that PID demulsifiers had excellent demulsification efficiency toward super heavy oil emulsions. The dehydration ratio reached 92.69 % at a concentration of 400 mg·L −1 for 210 min at 80 °C. Combined with the morphological changes of water droplets and active substances during demulsification, the characteristics of viscosity and interfacial activity proved that the higher content of lipophilic segments in PID copolymer could facilitate the diffusion of demulsifiers at the oil-water interface and accelerate the condensation of water droplets. Therefore, it is envisioned that this heavy oil demulsifiers with excellent demulsification performance and clean water phase will have promising prospects.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Mochou Liu,Huixia Xu,Limei Liu,Xia Han,Honglai Liu
The persistent challenge of treating oily wastewater from industrial effluents and environmental spills demands advanced separation materials with sustainable antifouling capabilities. While superwetting interfaces show promise in oil/water separation, the long-term stability and fabrication complexity of functional coatings remain critical limitations. This study presents a systematic comparison of two surface engineering approaches for stainless-steel meshes (SSMs): (1) terminal anchoring of dopamine-end-functionalized amphiphilic copolymers versus (2) self-assembly mediated codeposition of polymer–dopamine complexes. Through controlled integration of zwitterionic moieties and hydrophobic segments, both strategies create hierarchically structured surfaces combining strong hydrophilicity with oil-repellent characteristics. The results reveal that the codeposited PDA–PMB30 coating achieves superior hydration capacity through three-dimensional polymer networking, while the terminally anchored PMBD70 system demonstrates enhanced hydration stability via covalent grafting density optimization. In practical testing, both modified SSMs maintain exceptional separation efficiencies (96% for PDA–PMB30, 93% for PMBD70) through 20 operational cycles, outperforming all other coating systems in durability metrics. The synergistic combination of bioinspired adhesion mechanisms and amphiphilic balance endows these meshes with unique antifouling resilience, showing >96% separation efficiencies and stable performance in high salinity (1 M NaCl), strong acidity (pH = 1), and strong alkalinity (pH = 14) environments. This work establishes fundamental structure–property relationships between surface grafting architectures and separation performance, providing actionable insights for designing robust oil/water separation systems for petrochemical wastewater treatment and marine spill remediation.
研究领域:
材料科学
·
环境科学
·
高分子化学
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产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2017
·Vol. 295
·期 2
·371-378
·
IF 1.723
Wang Youpeng,Li Guo,Cheng Ruidong,Zhang Xuan,Jiang Jinqiang
Amphiphilic random copolymer micelle of P(NVP- co -NHPM) that responds to both UV and NIR light was designed and investigated. N -hydroxyphthalimide methacrylate — bearing a photoacid generator functional group was synthesized and used to construct the hydrophobic segment of P(NVP- co -NHPM); the N–O bond can be photocleaved when exposing the polymer aqueous solution to 310 nm UV light irradiation, inducing the micellar dissociation and delivery of loaded substances. Dynamic light scattering (DLS), atomic force microscope (AFM), and transmission electron microscopy (TEM) were used to characterize the micellar dissociation and controlled release processes. Moreover, the upconverting nanoparticles (NaLuF 4 :Gd/Yb/Tm) that can effectively absorb NIR light and convert it into visible and UV light were coloaded into polymer micelles to activate the micellar dissociation and the delivery of loaded cargoes via 980 nm NIR light.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2022
·
IF 6.206
Peng Wang,Baoluo He,Biwen Wang,Li Wang,Hong Yu,Shujuan Liu,Qian Ye,Feng Zhou
Marine biofouling is detrimental to ships and has been a significant issue in the marine industry for several decades. The development of effective, long-term, and environment-friendly antifouling coating is important but remains a challenge in oceanographic engineering. A series of novel amphiphilic block copolymers (PVP- co -PTFEMA), containing hydrophilic segments (N-vinylpyrrolidone, or NVP) and hydrophobic segments (trifluoromethyl methacrylate, or TFEMA), are grafted on the nanosilica surface via surface-initiated atom transfer radical polymerization (SI-ATRP). The as-prepared amphiphilic copolymers-functionalized silica , SiO 2 - g -(PVP- co -PTFEMA), can be blended well with self-polishing resin, which could obtain a new type of self-polishing nanocomposite coating. The SiO 2 - g -(PVP- co -PTFEMA) based composite coating exhibits satisfactory antibacterial and antifouling properties due to the synergistic effect of a strong hydration layer of hydrophilic NVP fragments and low adhesion of hydrophobic TFEMA unit. The slow hydrolysis of the as-prepared self-polishing nanocomposite coating results in the formation of micro/nano structures due to the exposure of SiO 2 - g -(PVP- co -PTFEMA) in seawater. Moreover, the SiO 2 - g -(PVP- co -PTFEMA) based nanocomposite coating exhibits high mechanical durability. The as-prepared self-polishing nanocomposite coating combines outstanding antifouling performance and high mechanical durability, which could be an ideal choice in marine antifouling applications.
研究领域:
材料科学
·
海洋工程
·
高分子化学
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产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 24
·18233-18241
·
IF 3.84
Xiaoma Fei,Jing Luo,Ren Liu,Jingcheng Liu,Xiaoya Liu,Mingqing Chen
We have synthesized an electro-active amphiphilic copolymer with carbazole side chains via free radical polymerization using 7-(4-vinylbenzyloxy)-4-methyl coumarin and 9-(4-vinylbenzyl)-9H-carbazole as the monomers. The copolymer can self-assemble to form micelles (termed EACMs) in aqueous solution and can adsorb onto the surfaces of MWCNTs via π–π interactions and thereby cause the efficient dispersion of the MWCNTs in aqueous solution. The coumarin groups in the copolymer undergo UV-induced photo-crosslinking, which further improves the stability of the suspension. Moreover, the electro-active carbazole moieties in the EACMs can undergo electropolymerization to form a conducting network on the MWCNTs that significantly accelerates electron transfer. The EACM/MWCNTs hybrid was applied to the amperometric sensing of dopamine (DA) as a model analyte. After electropolymerization, the electrode exhibited good sensitivity and selectivity toward the determination of dopamine with a 0.2 μM detection limit and a wide linear range. The method described here provides a viable route to water-dispersible and stable carbon nanotubes while preserving their outstanding electrical properties. We presume that the composite described here represents a valuable tool for the construction of electrochemical sensors and electronics.
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DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2019
·Vol. 220
·期 5
·1800528
·
IF 2.622
Du Beibei,Fan Tiantang,Li Jiafeng,Gong Li,Zhang Qin,Ye Wuyou,Tai Hongyun,Wang Wenxin,Fan Zhongyong
A series of poly( l -lactide)-grafted gelatin (Gel-g-PLLA) copolymers are synthesized by coupling the amino groups of gelatin with different molar masses and the carboxyl endgroup of poly( l -lactide) in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N -hydroxysuccinimide. Fourier transform infrared and nuclear magnetic resonance ( 1 H NMR) data confirm the successful bonding between gelatin and PLLA. Self-assembled micelles of copolymers are prepared by using the direct dissolution method. The size and micellar morphology are determined from dynamic light scattering as well as transmission electron microscopy measurements. Meanwhile, in vitro drug release reveals that Gel-g-PLLA micelles show excellent sustained-release properties when used as the carrier of the anticancer drug paclitaxel. A burst release of about 70% is observed in the first 24 h. All these features, together with the outstanding biocompatibility, make Gel-g-PLLA micelles a promising drug carrier for cancer therapy.
研究领域:
高分子化学
·
纳米技术
·
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
POLYMER
·
2011
·
IF 3.829
Zhuan Yi,Liping Zhu,Liang Cheng,Baoku Zhu,Youyi Xu
An amino-substituted polyethersulfone (PES) was synthesized by the polycondensation of a functional monomer bis(3-amino-4-hydroxyphenyl) sulfone with bis(4-fluorophenyl) sulfone. The amine groups incorporated into PES were employed as anchors to immobilize the chain transfer agents of reversible addition-fragmentation polymerization (RAFT). The resultant macro chain transfer agent was used to initiate the polymerization of the hydrophilic monomers N -isopropyl acrylamino (NIPAAm) and N, N -dimethylamino-2-ethyl methacrylate (DMAEMA), respectively. The gel permeation chromatography (GPC) results confirmed the successful synthesis of the amphiphilic copolymers PES- g -PNIPAAm and PES- g -PDMAEMA, and these two copolymers were perhaps the few examples of amphiphilic copolymer synthesized via a radical polymerization from PES main chains. The amino-substituted PES seemed a versatile precursor that showed a potential of functionalization via various strategies including click chemistry, atom transfer radical polymerization and RAFT polymerization. The synthesized amphiphilic copolymers were finally used as additives to improve the hydrophilicity and the filtration performances of PES membranes.
研究领域:
高分子化学
·
材料科学
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）