COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 298
·期 8
·1119-1128
·
IF 1.536
Wang Qiang,Gao Feng,Zhou Xianyong
Compared with conventional drug nanocarriers, multifunctional drug delivery systems exhibited characteristic advantages. In this study, we developed a multifunctional drug delivery system possessing stimuli-responsive drug release and cellular imaging. Amphiphilic polymers, methoxypolyethylene glycol-cystamine-tetraphenylethene (mPEG 1k -SS-TPE), were synthesized by combining methoxypolyethylene glycol (mPEG 1k ) and tetraphenylethene (TPE) using reduction-sensitive disulfide bonds that can be disconnected by high level of inherent glutathione (GSH). Size distribution and morphology of mPEG 1k -SS-TPE micelles were evaluated. Meanwhile, the reduction-sensitivity of mPEG 1k -SS-TPE micelles was surveyed compared with that of mPEG 1k -TPE micelles. Nile Red was encapsulated into mPEG 1k -SS-TPE micelles to visually observe intracellular drug delivery against SW480 cells. Paclitaxel (PTX) was chosen to be loaded into micelles to evaluate the cytotoxicity against HCT116, HT-29, and SW480.
Graphical Abstract
研究领域:
生物材料
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药物化学
·
肿瘤学
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DOI
高影响因子
Journal of Physical Chemistry C
·
2019
·
IF 4.309
Benfeng Zhu,Jingjing Yang,Jiao Liu,Yanbin Meng,Xiaoqing Du,Chao Cai,Zhao Zhang
To obtain amphiphilic polymers, fluorinated groups were successfully embedded in polyacrylates. The amphiphilic polymers were synthesized by free radical-initiated copolymerization using hydrophilic acrylate monomers and hydrophobic 2-perfluorooctylethyl methacrylate (FMA). 1H NMR spectroscopy and Fourier transform infrared results indicated that the fluorinated monomer FMA was successfully embedded in the polymers. The surfaces of the amphiphilic polymers were subsequently characterized by contact angle measurement, atomic force microscopy, and X-ray photoelectron spectroscopy, showing that a well-designed amphiphilic structure with fluorinated groups in the polymers was fabricated with the increase in the number of FMA units (n). Protein adsorption experiments indicated that, in addition to the surface chemical composition and roughness of the polymer, the fluorinated degree of the bulk/internal polymer layer (k) also plays a significant role in its bioadhesion behavior via adjusting the charge state of the polymer surface. With the decrease in k, the critical factor determining the protein adsorption gradually turns from the polymer’s surface to its internal area, and the minimum adsorption for both bovine serum albumin and human plasma fibrinogen on the synthesized polymer surface occurs when k is approximately 12.
研究领域:
材料科学
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聚合物化学
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生物医学工程
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表面科学
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DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 11
·1570
·
IF 4.7
Chuanying Wei,Yan Zhang,Zhen Tang,Changan Zhang,Jianhua Wu,Bo Wu
Poly(dimethylsiloxane) (PDMS) coatings are considered to be environmentally friendly antifouling coatings. However, the presence of hydrophobic surfaces can enhance the adhesion rate of proteins, bacteria and microalgae, posing a challenge for biofouling removal. In this study, hydrophilic polymer chains were synthesised from methyl methacrylate (MMA), Poly(ethylene glycol) methyl ether methacrylate (PEG-MA) and 3-(trimethoxysilyl) propyl methacrylate (TPMA). The crosslinking reaction between TPMA and PDMS results in the formation of a silicone-based amphiphilic co-network with surface reconstruction properties. The hydrophilic and hydrophobic domains are covalently bonded by condensation reactions, while the hydrophilic polymers migrate under water to induce surface reconstruction and form hydrogen bonds with water molecules to form a dense hydrated layer. This design effectively mitigates the adhesion of proteins, bacteria, algae and other marine organisms to the coating. The antifouling performance of the coatings was evaluated by assessing their adhesion rates to proteins (BSA-FITC), bacteria (B. subtilisandP. ruthenica) and algae (P. tricornutum). The results show that the amphiphilic co-network coating (e.g., P-AM-15) exhibits excellent antifouling properties against protein, bacterial and microalgal fouling. Furthermore, an overall assessment of its antifouling performance and stability was conducted in the East China Sea from 16 May to 12 September 2023, which showed that this silicon-based amphiphilic co-network coating remained intact with almost no marine organisms adhering to it. This study provides a novel approach for the development of high-performance silicone-based antifouling coatings.
研究领域:
材料科学
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海洋生物学
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化学工程
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环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 20
·
IF 1.86
Zhou Zhu,Wanli Kang,Bauyrzhan Sarsenbekuly,Hongbin Yang,Caili Dai,Runmei Yang,Haiming Fan
An amphiphilic polymer with twin-tailed hydrophobic groups was prepared by micellar polymerization of acrylamide as hydrophilic monomers, 2-acryloylamino-2-methyl-1-propanesulfonic acid as functional monomers and N , N -dodecyl acrylamide as hydrophobic monomers. Using the same method, containing single-tailed hydrophobic group of the amphiphilic polymer and not containing the hydrophobic group of ordinary polymer were prepared. The molecular structure of the product was characterized by infrared spectrum and 1 H nuclear magnetism resonance spectrum. By inclusion complexation of β-cyclodextrin (β-CD), the hydrophobic association on the apparent viscosity contribution rate was studied. Relationship between hydrophobic group structure and its performance was investigated by the rotational viscometer, scanning electron microscopy (SEM), fluorescence spectroscopy, and rheometer. The results showed that amphiphilic polymers containing twin-tailed hydrophobic groups had a lower critical aggregation concentration (CAC). When the amphiphilic polymer concentration was higher than CAC, hydrophobic association was stronger, which led to a higher apparent viscosity contribution rate. At the same polymer solution concentration, amphiphilic polymer containing twin-tailed hydrophobic group had better performance on temperature resistance, salt tolerance, and mechanical shear resistance compared with the other two polymers. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44744.
研究领域:
高分子化学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Wanbing Li,Haibo Zhang,Zhaolan Zhai,Xujuan Huang,Shibin Shang,Zhanqian Song
Designing stimulus-responsive amphiphilic polymers with a fast photoresponsive self-assembly behavior remains a challenge. Two series of rosin-terminated and azobenzene-terminated amphiphilic polymers (PAMn and PMAn) with fast and reversible photoresponsive properties were prepared using rosin-based azobenzene groups and polyethylene glycol, respectively. Under 5–10 s of UV irradiation, the polymers showed trans-to-cis isomerization and reached a photosteady state. For the PAMn polymer, the absorbance of the absorption peak at 325 nm recovered to more than 95% of the initial value under visible light for 5–10 s, whereas that of the PMAn polymer recovered completely. Notably, the PAMn and PMAn polymers initially self-assembled to vesicles or spherical micelles, and various morphological changes were achieved by manipulating UV irradiation time, with the initial morphology again recovered under dark conditions or visible-light irradiation. Remarkably, vesicles of the PAM34 and PMA34 polymers presented an intermediate open-vesicle state before being completely deformed under UV irradiation because of the existence of a π–π interaction. Finally, the ability of PAM34 and PMA34 polymer vesicles to perform the controlled release and reversible loading of a fluorescent probe was evaluated.
研究领域:
材料科学
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聚合物化学
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光化学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2023
·Vol. 15
·期 23
·4606
·
IF 5
Dongtao Fei,Jixiang Guo,Ruiying Xiong,Xiaojun Zhang,Chuanhong Kang,Wyclif Kiyingi
The continuous growth in global energy and chemical raw material demand has drawn significant attention to the development of heavy oil resources. A primary challenge in heavy oil extraction lies in reducing crude oil viscosity. Alkali–surfactant–polymer (ASP) flooding technology has emerged as an effective method for enhancing heavy oil recovery. However, the chromatographic separation of chemical agents presents a formidable obstacle in heavy oil extraction. To address this challenge, we utilized a free radical polymerization method, employing acrylamide, 2-acrylamido-2-methylpropane sulfonic acid, lauryl acrylate, and benzyl acrylate as raw materials. This approach led to the synthesis of a multifunctional amphiphilic polymer known as PAALB, which we applied to the extraction of heavy oil. The structure of PAALB was meticulously characterized using techniques such as infrared spectroscopy and Nuclear Magnetic Resonance Spectroscopy. To assess the effectiveness of PAALB in reducing heavy oil viscosity and enhancing oil recovery, we conducted a series of tests, including contact angle measurements, interfacial tension assessments, self-emulsification experiments, critical association concentration tests, and sand-packed tube flooding experiments. The research findings indicate that PAALB can reduce oil–water displacement, reduce heavy oil viscosity, and improve swept volume upon injection into the formation. A solution of 5000 mg/L PAALB reduced the contact angle of water droplets on the core surface from 106.55° to 34.95°, shifting the core surface from oil-wet to water-wet, thereby enabling oil–water displacement. Moreover, A solution of 10,000 mg/L PAALB reduced the oil–water interfacial tension to 3.32 × 10−4mN/m, reaching an ultra-low interfacial tension level, thereby inducing spontaneous emulsification of heavy oil within the formation. Under the condition of an oil–water ratio of 7:3, a solution of 10,000 mg/L PAALB can reduce the viscosity of heavy oil from 14,315 mPa·s to 201 mPa·s via the glass bottle inversion method, with a viscosity reduction rate of 98.60%. In sand-packed tube flooding experiments, under the injection volume of 1.5 PV, PAALB increased the recovery rate by 25.63% compared to traditional hydrolyzed polyacrylamide (HPAM) polymer. The insights derived from this research on amphiphilic polymers hold significant reference value for the development and optimization of chemical flooding strategies aimed at enhancing heavy oil recovery.Keywords:amphiphilic polymer;hydrophobic association;self-emulsification;heavy oil viscosity reduction;enhanced oil recovery
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Zhongqiang Yu,Wen Sun,Lida Wang,Zhengqing Yang,Yine Ren,Yanke Li,Guichang Liu,Qian Zhang
The development of nontoxic antifouling coatings in static marine environments is urgent. Herein, the successful synthesis of sulfobetaine borneol fluorinated polymers (PEASBF) by a free radical polymerization method is reported. The PEASBF coatings exhibit outstanding antifouling activity, which effectively resists the adhesion of Bovine serum albumin (FITC-BSA adhesion rate: 0.5%), Pseudomonas sp. (Biofilm: 1.3 absorbance) and Navicula sp. (Diatom attachment rate: 33%). More importantly, the PEASBF coatings display outstanding fouling release properties, achieving a release rate of 98% for Navicula sp., and the absorbance of the Pseudomonas sp. biofilm is only 0.2 under 10 Pa shear stress. XPS and MD studies showed that the fluorinated/isobornyl groups induce more sulfobetaine groups to migrate toward polymer surfaces for intensify antifouling. Additionally, the chiral stereochemical structure of borneol enhances antifouling and fouling release ability of amphiphilic polymers. Therefore, the PEASBF has the potential for static marine antifouling applications.
研究领域:
材料科学
·
海洋生物学
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Zi Long,Meiying Liu,Ke Wang,Fengjie Deng,Dazhuang Xu,Liangji Liu,Yiqun Wan,Xiaoyong Zhang,Yen Wei
In this work, we reported a rather facile method for fabrication of ultrabright, well dispersible and biocompatible fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) properties through combination of esterification and ring-opening reaction. The hydroxyl groups of Pluronic F127 was first reacted with the chloride of trimellitic anhydride chloride (TMAC), and its anhydride groups were further reacted with the amino groups of amino-terminated AIE dye (PhNH 2 ) through ring-opening reaction. The optical properties , biocompatibility as well as cell uptake behavior of these obtained AIE-active nanoparticles (F127-TMAC-PhNH 2 FONs) were examined by a series of characterization techniques and assays. We demonstrated that uniform organic nanoparticles with high water dispersibility, strong luminescence and desirable biocompatibility can be facilely obtained, which are promising for biological imaging applications. More importantly, a number of carboxyl groups were introduced into these AIE-active nanoparticles, which can be further utilized for further conjugation reaction and carrying anticancer drugs such as cisplatin. Therefore, the strategy of described in this work should be a simple and useful route for fabrication of multifunctional AIE-active luminescent nanotheranostic systems.
研究领域:
材料科学
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生物学
·
医学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Haoran Ma,Fengzhi Guo,Xinmeng Ma,Jinzhi Jiang,Guorui Li,Shupei Wang,Yang Liu,Zhihong Li,Keyi Li,Tengfei Dong,Xiao Zhang,Lu Gong
Amphiphilic polymers are widely used to regulate oil–water interfaces and improve oil displacement, yet the role of hydrophilic–hydrophobic balance in coupling interfacial behavior, self-aggregation, and residual-oil mobilization remains unclear. Here, lignin-based graft copolymers (ALGCs) with systematically varied HLB values were synthesized and investigated using interfacial measurements, atomic force microscopy (AFM), sand-pack flooding, and molecular dynamics (MD) simulations. Increasing hydrophobicity accelerated the apparent interfacial response and reduced oil–water interfacial tension (IFT), but oil recovery did not vary monotonically with IFT. The ALGC with an intermediate HLB achieved the highest incremental oil recovery of 31.1%, showing that IFT reduction alone cannot predict displacement performance. AFM measurements showed that ALGC adsorption reduced the pull-off adhesion between model asphaltene-coated surfaces. MD simulations indicated competing effects of hydrophobicity: stronger hydrophobic interactions enhanced ALGC–asphaltene association, whereas excessive hydrophobicity promoted polymer self-aggregation and potentially decreased the availability of freely dispersed chains for effective interfacial interactions. These results indicate that oil-displacement performance is governed by the coupled effects of interfacial adsorption, self-aggregation, and asphaltene-associated adhesion. These findings provide mechanistic insights for the rational design of sustainable amphiphilic polymers for EOR and other interfacially controlled transport processes.
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DOI
高影响因子
POLYMER
·
2024
·
IF 4.1
Yudan Yi,Qijun Li,Qingyong Sun,Ya-nan Wang,Bi Shi
The manufacture of metal-free leather is considered to be favorable for environment compared to conventional technology of chrome tanning. However, metal-free leather crust presents some disadvantages for further processing, like low isoelectric point (pI) and high hydrophilicity . Applying cationic amphiphilic polymer retanning agent is expected to overcome the disadvantages. The aggregation behavior of this polymer, which is influenced by its charged nature, will greatly affect the leather properties. However, the structure-function relationship has not been clarified yet. Here we synthesized a series of cationic amphiphilic acrylic polymers , Poly(SMA- co -DMA)s (PSDs), with increasing protonation degrees (PSD-40 %, PSD-60 %, PSD-80 %, PSD-100 %) and applied them to metal-free leather retanning. Experiments and molecular dynamics simulations show that PSD with higher protonation degree exhibits smaller aggregate size and better dispersion in water. PSD retanning significantly promotes the uptake of anionic fatliquors by leather (>90 %) because PSD enhances the pI of leather. PSD-40 % cannot be uniformly dispersed in water. PSD-60 %, PSD-80 % and PSD-100 % possess suitable particle size (45–90 nm) to penetrate into leather fibrils and form hydrophobic films, thereby greatly improving the hydrophobicity of leather. The hydrophobicity of leather increases with decreased protonation degree of PSD. Moreover, the fiber dispersion and organoleptic properties of leather are positively correlated with leather hydrophobicity because of the separating and lubricating effects of the amphiphilic PSD.
研究领域:
材料科学
·
化学工程
·
皮革加工
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2018
·
IF 4.513
Wanli Kang,Changxiao Cao,Shujun Guo,Xuechen Tang,Zeeshan Ali Lashari,Yongbo Gao,Xiangfeng Zhang,Muhammad Waseem Iqbal,Hongbin Yang
Recently, the composite materials developed by the combination of polymer and inorganic nanomaterial have gained various attraction for researchers. In this paper, the negative charged silica nanoparticles (silica NPs) with hydroxyl groups on the surface were mixed with the amphiphilic polymer having positive charged hydrophobic groups to form a NP-polymer composite at the high temperature and high salinity condition. The thickening mechanism of silica NPs on amphiphilic polymers in high salinity condition was analyzed by measuring the viscosity and viscoelasticity of solution compared with HPAM. In order to clarify the function of the spatial network structure, the β-cyclodextrin (β-CD) was used to destroy the associated structure, and the microstructure was analyzed by scanning electron microscopy (SEM). Results revealed that the apparent viscosity and viscoelasticity of the polymer solution significantly increased only by involved silica NPs, and a viscous system also turned into an elastic one increasing. This study concludes that silica NPs collaborate with the hydrophobic association structure formed by the amphiphilic polymer due to electrical interaction and hydrogen bond . Thus, silica NPs can strengthen the spatial network structure. This kind of composite material provides a new way to increase the viscosity of the polymer at elevated temperature, and enhances its application in high salinity reservoirs.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2023
·
IF 6.2
Yu Rao,Xiuyang Zou,Xiran Shen,Hengyuan Zhang,Shuna Gao,Jiangna Guo,Hong Chen
Antimicrobial peptide mimics have been used to kill bacteria and construct antibacterial materials. Precise design and construction of chemical structure are essential for easy access to highly effective antimicrobial peptide mimics. Herein, cationic guanidinium-based polymers (PGXs) with varying hydrophobic structures were synthesized to explore the structure and antibacterial activity relationship of antimicrobial peptide mimics and to construct antibacterial implants. The effect of the hydrophobic chemical structure, including carbon chain length and configuration, on the antimicrobial activities against both Escherichia coli and Staphylococcus aureus was investigated. The antibacterial activities of PGXs improved with increasing alkyl chain length, and PGXs with a straight-chain hydrophobic structure exhibited better bactericidal activities than those with cyclic alkane and aromatic hydrocarbon. Furthermore, PGXs grafted with poly(dimethylsiloxane) (PDMS-PGXs) showed a similar bactericidal change tendency of PGXs in solution. Additionally, the PDMS-PGXs showed potent antibiofilm performance in vitro, which can inhibit bacterial infection in vivo as subcutaneous implants. This study may propose a basis for the precise design and construction of antibacterial materials and provide a promising way of designing biomedical devices and implants with bacterial infection-combating activities.
研究领域:
材料科学
·
微生物学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）