RSC Advances
·
2023
·Vol. 13
·期 38
·26690-26699
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IF 3.9
Zhigang Li,Yinglin Fang,Jiawei Yang,Huayong Chen,Bo Yang,Yonghua Wang
A novel two-step enzymatic esterification-hydrolysis method that generates high-purity conjugated linoleic acid (CLA) isomers was developed. CLA was first partially purified by enzymatic esterification and then further purified by efficient, selective enzymatic hydrolysis in a three-liquid-phase system (TLPS). Compared with traditional two-step selective enzymatic esterification, this novel method produced highly pure cis-9, trans-11 (c9,t11)-CLA (96%) with high conversion (approx. 36%) and avoided complicated rehydrolysis and reesterification steps. The catalytic efficiency and selectivity of CLA ester enzymatic hydrolysis was greatly improved with TLPSs, as high-speed stirring provided a larger interface area for the reaction and product inhibition was effectively reduced by extraction of the product into other phases. Furthermore, the enzyme-enriched phase (liquid immobilization support) was effectively and economically reused more than 8 times because it contained more than 90% of the concentrated enzyme. Therefore, this novel enzymatic esterification-hydrolysis method can be considered ideal to produce high-purity fatty acid monomers.
研究领域:
食品科学
·
生物化学
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DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2019
·
IF 5.589
Xia Wang,Jianbo Zhu,Baida Kong,Bingnan He,Lai Wei,Yuanxiang Jin,Yudong Shan,Weitao Wang,Chunqiang Pan,Zhengwei Fu
Short-chain chlorinated paraffins (SCCPs, C 10–13 ) were listed as persistent organic pollutants (POPs) by the Stockholm Convention in 2017 and pose extensive exposure risks to humans. To our knowledge, there have been no studies reporting the immmunomodulatory effects of SCCPs until now. C 9 -CPs have also been shown to be present in the environment. In this study, adult male C57BL/6 mice were exposed to 1, 10, or 100 mg/kg/d C 9–13 -CPs by gavage for 28 d. The results showed that compared to those of the controls, exposure to C 9–13 -CPs led to increased spleen weight, delimited germinal centers, enhanced energy metabolism, and elevated glutathione content, but no variation in the malonaldehyde level in the spleen was observed. Exposure to C 9–13 -CPs also increased the populations of splenic lymphocytes, T lymphocytes, NK cells, and the ratio of the CD3 + /CD19 + subsets and CD4 + /CD8 + subsets compared to those of the controls. RNA-seq revealed 424 differentially expressed genes (DEGs) (fold change ≥ 1.5, FDR < 0.05) in the spleen between the control group and the 100 mg/kg/d C 9–13 -CPs-treated group. KEGG analysis demonstrated that folate biosynthesis, pathways in cancer and thyroid hormone signaling were the three most significantly enriched pathways, and despite not reaching statistical significance, some immune-related pathways were also enriched in the KEGG functional enrichment analysis, including the chemokine signaling pathway (FDR < 0.0584), the NF-κB signaling pathway (FDR < 0.0663), Th17 cell differentiation (FDR < 0.0839), and the Jak-STAT signaling pathway. Moreover, compared to those of the controls, exposure to C 9–13 -CPs enhanced the Concanavalin A (Con A)-stimulated cultured splenocyte proliferation, while the exposure showed no effect on the splenocyte proliferation that was stimulated by lipopolysaccharides (LPS). Taken together, these results demonstrated that subacute exposure to C 9–13 -CPs could have immunomodulatory effects in mice. The present study helps to provide an understanding of the comprehensive health risks posed by C 9–13 -CPs.
研究领域:
毒理学
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免疫学
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分子生物学
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环境科学
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PubMed
高影响因子
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
·
2021
·
IF 1.571
Zhi-Ping Che,Jin-Ming Yang,Song Zhang,Di Sun,Yue-E Tian,Sheng-Ming Liu,Xiao-Min Lin,Jia Jiang,Gen-Qiang Chen
Endeavor to discover biorational natural products-based insecticides, two series (27) of novel 9R/S-acyloxy derivatives of cinchonidine and cinchonine were prepared and assessed for their insecticidal activity against Mythimna separata in vivo by the leaf-dipping method at 1 mg/mL. Among all the compounds, especially derivatives 6l and 6o exhibited the best insecticidal activity with final mortality rates of 75.0% and 71.4%, respectively. Overall, a free 9-hydroxyl group is not a prerequisite for insecticidal activity and C9-substitution is well tolerated; the configuration of C8/9 position is important for insecticidal activity, and 9S-configuration is optimal; 6’-OCH3 moiety is not necessary, removal of it is also acceptable.
研究领域:
有机化学
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植物保护学
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DOI
PubMed
高影响因子
AICHE JOURNAL
·
2024
·
IF 3.5
Yanru Zhu,Zhen Zhang,Yunfei Zou,Jian Zhang,Zhe An,Xin Shu,Hongyan Song,Jing He
Catalytic conversion of biomass-derived 5-(hydroxymethyl)furfural (5-HMF) into carbon-increased hydrocarbons as drop-in energy-rich biofuels has received a great deal of concern for the development of sustainable chemical industry. Here, we demonstrate a one-pot conversion of 5-HMF into C 9 -alkanes on one single catalyst, acidic–basic layered double oxides (Mg(Al)(Zr)O) supported CuCo alloy. The well-defined multifunctional catalytic sites with harmonious combination carry out cascade catalysis, affording C 9 -alkanes (including 30% of more value-added branched-cycloalkanes) in 83% yield. The basic–acidic sites on Mg(Al)(Zr)O show high activity for aldol condensation of 5-HMF and acetone, producing 4-[5-(hydroxymethyl)-2-furanyl]-3-buten-2-one (HAc) in a yield of >99%. The engineered Co–Cu–Co linkages on supported CuCo perform efficient hydrodeoxygenation, affording C 9 -alkanes in a selectivity of 96% from HAc. C 9 -cycloalkanes are generated from the cyclization of the corresponding monohydric alcohol intermediates by the synergy of acidic and CuCo sites in the hydrodeoxygenation reaction.
研究领域:
化学工程
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催化
·
可再生能源
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生物质转化
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高影响因子
Food Analytical Methods
·
2016
·Vol. 10
·期 5
·1293-1300
·
IF 2.167
Zhang Jie,Li Tiezhu,Zhang Tiehua,Xue Peiyu,Guan Tianzhu,Yuan Yuan,Yu Hansong
This work developed a fluorescence polarization (FP) assay for detection of phthalate esters (PAEs) in Chinese spirits. A mouse-derived recombinant peroxisome proliferator-activated receptor α ligand binding domain (mPPARα-LBD*) and a fluorescent-labeled fatty acid (C4-BODIPY-C9) were employed as recognition element and fluorescent tracer, respectively, providing the limits of detection (LODs) below 11.2 μM for the 10 PAEs tested in buffer. Chinese spirits spiked with DEHP and DBP could be positively detected in combination with simple pretreatment, with recoveries ranging from 76.9 to 87.0 % and with coefficients of variation below 10 %. Additionally, the mechanisms of mPPARα-LBD* binding to PAEs were investigated by using molecular simulation approach. The results suggested that the proposed method was reliable for monitoring PAEs in Chinese spirits.
研究领域:
分析化学
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环境科学
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分子生物学
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高影响因子
Carbon Resources Conversion
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2026
·
IF 10.9
Zhixing Li,Fei Wang,Yanchao Liu,Jinghong Ma,Kai Bian,Xinwei Zhang,Yanze Du,Ruifeng Li
The efficient conversion of C 9 heavy aromatics into high-value benzene, toluene, and xylenes (BTX) products is essential for optimizing petroleum refining. This process often depends on both diffusion and the unresolved relationship among structure, acidity, and reactivity of zeolite catalysts. This study focuses on the intracrystalline micro-/ meso -pores in ZSM-5 and decouples the interdependent effects of crystalline morphology and Al distribution of Brønsted acid sites (BAS) in ZSM-5 on C 9 aromatic conversion pathways. The hierarchical ZSM-5 catalysts have the identical SiO 2 /Al 2 O 3 ratios (SAR) and the different distribution of framework Al-species. This dominates the acid distribution of the zeolites and catalytic performances of the catalysts in C 9 aromatic reaction. In toluene/trimethylbenzene (TMB) transalkylation, the hierarchical porosity coupled with reduced crystallite size of the ZSM-5 enhances 1,2,4-TMB conversion by 24.4% and xylene selectivity by 17.9% versus conventional microporous ZSM-5. The product distribution is positively correlated to the concentration of Al atoms localized at channel intersections of the ZSM-5. Diffusion-decoupled experiments demonstrated acid site spatial configuration in the ZSM-5 governs the reaction pathway selection, with aluminum enrichment at channel intersections favoring transalkylation over disproportionation. The hierarchical ZSM-5 in submicron with intracrystalline mesopores and enriched intersection-channel aluminum favors transalkylation of C 9 aromatics to BTX. The hierarchical ZSM-5, with submicron crystallites, intracrystalline mesopores, and enriched intersection-channel aluminum, enhances transalkylation of C 9 aromatics to BTX.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Siyi Chen,Tianming Li,Wentao Pan,Tianbin Bai,Pengxi Li,Yian Zheng
Per- and polyfluoroalkyl substances (PFAS) pose serious environmental risks due to their persistence and bioaccumulation potential. In this study, unmodified coal gasification fine slag (CGFS), an industrial solid residue, was directly used as an adsorbent for the efficient removal of C7-C9 perfluorocarboxylic acids (PFCAs) from aqueous solution, namely perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA). Comprehensive characterization revealed that CGFS is a mesoporous adsorbent rich in carbon-based functional groups. Batch adsorption experiments demonstrated that the adsorption process was pH-dependent and exothermic, with optimal performance achieved at pH 3. The adsorption kinetics were well described by the pseudo-second-order model, whereas the equilibrium data were satisfactorily fitted by the Langmuir isotherm. The maximum adsorption capacities reached 181.5, 240.0 and 297.3 mg/g for PFHpA, PFOA and PFNA, comparable to those of widely reported carbon-based and amine-functionalized adsorbents. The adsorption process exhibited a clear chain-length dependence, favoring longer-chain PFCAs, and was governed by electrostatic attraction and hydrophobic interactions, as corroborated by density functional theory calculations. After four regeneration cycles involving desorption with 1 M NaOH solution for 3 h, CGFS retained over 80% of its initial adsorption capacity, indicating good stability and reusability. Moreover, CGFS showed promising performance in real water matrices, effectively removing organic substances and enhancing biodegradability. This work shows that low-cost CGFS can achieve high-efficiency removal of PFCAs, providing a promising strategy for the remediation of emerging PFCAs and the resource utilization of industrial solid waste.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Jinqian Pang,Wenli Zhao,Yu Wang,Yan Li,Hong Wang,Weimin Zhang,Wenjuan Liang
Nephelium lappaceum L. is a tropical fruit with a characteristic hairy appearance, whose peel is used to reduce fever and diarrhea, while its leaves are employed to mitigate headaches. These advantages are mostly attributed to the accumulation of phenolic-related compounds in N. lappaceum . To investigate phenols accumulation and transformation in N. lappaceum peel, leaves and branches, this study investigated the major metabolites and their antioxidant and xanthine oxidase (XO) inhibitory activities. The results showed that the characteristic metabolites in peel, leaves and branches reflected a conversion process from simple phenols (C 6 ) to phenylpropanoids (C 9 ), and then to flavonoids (C 12 ). The peel extract exhibited the highest antioxidant activity, driven by its predominant simple phenols, gallic acid ( Ph7 ). The branch extracts displayed the strongest XO inhibitory activity, primarily attributed to the flavonoids: kaempferol 7- O - α - L -rhamnopyranoside ( Fl9 ), miquelianin ( Fl34 ) and procyanidin B2 ( Fl8 ). This study provides new directions for precisely utilization of N. lappaceum by-products.
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PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Wenfei Yang,Shuzheng Wu,Cejun Hu,Hongwei Zhang,Qingyan Cui,Xiaojun Bao,Pei Yuan
The hydrogenation of unsaturated bonds and elimination of sulfur impurities in C 9 petroleum resin (C 9 PR) are crucial for improving its quality and performance. In this study, we prepared a nanoflower-like Ni 2 P/Al 2 O 3 catalyst using an in-situ synthesis combined with liquid-phase phosphidation strategy and applied for the production of value-added hydrogenated C 9 PR. In-situ synthesis of Ni-Al hydrotalcite anchors and disperses Ni nanoparticles, while liquid-phase phosphidation introduces high-content Ni δ+ and P δ− active sites and prevents the formation of inactive AlPO 4 , synergistically enhancing both hydrogenation and desulfurization activities. The synthesized Ni 2 P/Al 2 O 3 catalyst achieves a 99.6 % hydrogenation degree and reduces sulfur content from 137 ppm to 0 ppm, much better than the catalysts prepared by conventional impregnation and metal phosphate reduction methods. These results give valuable insights for designing efficient catalysts and advancing single-step hydrorefining processes to generate high-quality, value-added hydrogenated petroleum resins.
研究领域:
催化化学
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能源化工
·
材料科学
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高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2026
·
IF 6.7
Zhaoyu Chen,Jialin Zhang,Zihui Xiong,Song Hu,Nan Li,Sheng Su,Yi Wang,Long Jiang,Jun Xu,Kai Xu,Jun Xiang
Selective recovery of phenolics from waste wind-turbine blade epoxy is limited by uncontrolled secondary reactions during pyrolysis. Here, choline chloride–ethylene glycol deep eutectic solvent (DES) swelling was coupled with iron(III) citrate-assisted Fe introduction. Final temperature (400–600 °C) and Fe level were varied to resolve changes in thermal behavior, phase yields, and normalized gas chromatography–mass spectrometry peak areas. Pretreatment retained 81.16–88.81% of the resin, and inductively coupled plasma optical emission spectrometry measured 0.629–1.406 wt% Fe in Fe-containing composites. The main decomposition region shifted to lower temperature, while the full width at half maximum of the main DTG peak narrowed from 42.51 to 35.48 °C. At 500 °C, Fe0.45 (0.45 mol L −1 Fe 3+ in the treatment solution; 0.750 wt% Fe in the composite) gave a C 9 -substituted-phenol normalized peak area of 57.70%, 35.26% higher than that of Raw. These products represented 63.65% of total phenolics. Higher Fe levels or a final temperature of 600 °C increased gas formation and reduced oil recovery, consistent with stronger secondary conversion. Product-distribution, Raman, and textural trends indicate that Fe0.45 at 500 °C provided the most favorable observed balance between precursor conversion and downstream dealkylation and condensation. Coupling DES swelling with controlled Fe introduction therefore offers a tunable route for the relative enrichment of C 9 -substituted phenols during the thermochemical valorization of waste wind-turbine blade epoxy.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Zunrui Zhong,Ziliang Rui,Zide Wu,Xinyu Zhai,Sisheng Yang,Hao Peng
In view of the present scarcity in the study of very low temperature (<−100 °C) phase change materials (PCMs) and the typical high volatility issue of these low temperature PCMs, the present work aims to develop the potential PCMs and select an appropriate anti-volatile method for cryogenic applications. In this work, cryogenic C 7 ∼C 9 n-alkanes were selected to prepare C 7 -C 8 and C 7 -C 9 binary systems, and their phase equilibrium behavior and thermophysical properties were investigated. For volatility problem, anti-volatility emulsion templates were successfully synthesized by high-energy emulsification method. The volatilization rate of the emulsion templates was characterized by combining DSC and mass transfer model, and the preparation parameters of the emulsion template with the finest anti-volatility were obtained. The results show that the eutectic compositions of C 7 -C 8 and C 7 -C 9 binary systems are 12 wt%C 8 and 10 wt%C 9 , respectively. Both eutectic systems have eutectic temperatures suitable (−99.4 °C for C 7 -C 8 , −103.1 °C for C 7 -C 9 ), satisfactory melting enthalpy (127.6 J/g for C 7 -C 8 , 129.7J/g for C 7 -C 9 ), and good phase transformation reversibility for cryogenic energy storage. Under the optimized preparation parameters (WOR=2:1, EOR=18%, HLB=11.44), the volatilization coefficient of emulsion template is reduced from the maximum of 0.01408/min to 0.00236/min, which implies that the anti-volatility of emulsion is enhanced by nearly 6 times.
研究领域:
材料科学
·
能源工程
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高影响因子
危险品化学品经营许可证（带存储）