DYES AND PIGMENTS
·
2022
·
IF 5.122
Heng Wu,Jie Zhao,Xi Nan Yang,Dan Yang,Li Xia Chen,Carl Redshaw,Li Guo Yang,Zhu Tao,Xin Xiao
A system comprising cucurbit[8]uril (Q[8]) and a fluorescent molecule (E)-1-(2-hydroxyethyl)-4-(4-hydroxystyryl)pyridin-1-ium bromide (HPy) has been utilized to construct a fluorescent probe that is capable of detecting the pesticide tricyclazole (TC). A variety of techniques including 1 H NMR spectroscopy together with fluorescence experiments have been employed to investigate the host-guest properties of the Q[8]/HPy system in aqueous solution. Results indicate that the system forms the stable2:1 inclusion complex HPy 2 @Q[8], and that this inclusion complex imparts fluorescent quenching on HPy. The addition of a number of pesticides was found to have no obvious effect on the fluorescence, however on addition of tricycazole (TC), the fluorescence intensity underwent a dramatic enhancement. The linear relationship between the fluorescence intensity and the concentration of TC allowed for the facile detection of TC concentration in aqueous target solutions as well as in agricultural products. The detection limit was found to be 3.70 × 10 −8 mol L −1 .
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2022
·Vol. 102
·期 7
·619-628
·
IF 1.925
Yu Zhi-chao,Lu Yun,Shan Pei-hui,Fan Ying,Tao Zhu,Xiao Xin,Wei Gang,Prior Timothy J.,Redshaw Carl
The complexation between cucurbit[8]uril, Q[8], and isonicotinic acid has been studied using 1 H NMR spectroscopy, UV–Vis absorption spectroscopy, Raman spectroscopy and single crystal X-ray diffraction. The results revealed that the 2:1 inclusion complex (4-PA) 2 @Q[8]·25H 2 O is formed, with two guests simultaneously encapsulated in the hydrophobic cavity; the mean planes of the guests are 3.535 Å apart. Graphical abstract
研究领域:
化学
·
药物科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2023
·Vol. 39
·期 6
·1058-1063
·
IF 3.1
Wang Chenghui,Yu Zhichao,Bai Qinghong,Pan Dingwu,Prior Timothy J.,Tao Zhu,Redshaw Carl,Xiao Xin
T he binding behavior of cucurbit[8]uril(Q[8]) and p -hydroxybenzoic acid(p-HBA) has been investigated using 1 H NMR titration experiments, UV-Vis absorption, isothermal titration calorimetry(ITC), and X-ray crystallography. Results revealed that the Q[8] can accommodate two p -HBA molecules to form a 1:2 host-guest inclusion complex in solution, namely ( p -HBA) 2 @Q[8]. From a poorly scattering crystal, we were able to identify two symmetry unique Q[8] rings, but with different p -HBA fillings. The structure can be represented as Q[8]+1.5 p -HBA, which gives Q[8]@(p-HBA) 2 ·Q[8]@ p -HBA as the structural formula. This supramolecular structure was screened for its ability to capture iodine. The experimental results showed that the adsorption efficiency of the supramolecular organic framework material for iodine capture was 43.8%, with an equilibrium adsorption capacity of 223.3 mg/g.
研究领域:
超分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 5
·1-10
·
IF 5.7
Teng Yuanjie,Li Xin,Chen Yingxin,Xu Pei,Pan Zaifa,Shao Kang,Sun Nan
The SERS intensity of analytes is primarily influenced by the density and distribution of hotspots, which are often difficult to manipulate or regulate. In this study, cucurbit[8]uril (CB[8]), a kind of rigid macrocyclic molecule, was introduced to achieve ~ 1-nm nanogap between gold nanoparticles to increase the density of SERS hotspots. Three kinds of estrogens (estrone (E1), bisphenol A (BPA), and hexestrol (DES)) which are molecules with weak SERS signals were targeted in the hotspots by CB[8] to further improve the sensitivity and selectivity of SERS. It was demonstrated that CB[8] can link gold nanoparticles together through carbonyl groups. In addition, the host–guest interaction of CB[8] and estrogens was proved from the nuclear magnetic resonance hydrogen and infrared spectra. In the presence of CB[8], the SERS intensities of E1, BPA, and DES were increased to 19-fold, 74-fold, and 4-fold, respectively, and the LOD is 3.75 µM, 1.19 µM, and 8.26 µM, respectively. Furthermore, the proposed SERS method was applied to actual milk sample analysis with recoveries of E1 (85.0 ~ 112.8%), BPA (83.0 ~ 103.7%), and DES (62.6 ~ 132.0%). It is expected that the proposed signal enlarging strategy can be applied to other analytes after further development. Graphical Abstract
研究领域:
分析化学
·
环境科学
·
生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Jie Yin,Sizhe Li,Hao Zhang,Yao Lu,Yan Zhao,Kai A. I. Zhang
Conjugated polymers (CPs) have garnered attention for their tailorable structure properties, particularly in the context of efficient photosynthetic hydrogen peroxide (H2O2) production. However, the challenge lies in the precise molecular engineering of CPs to facilitate differing reaction pathways, thereby enhancing H2O2 photogeneration efficiency. In this study, we developed dual-chain CPs (DC-CPs) with a distinctive architecture, employing the supramolecular host cucurbit[8]uril as a "molecular lock" to conjoin two polymer chains. The dual-chain configuration is designed to harbour a central reaction centre conducive to oxygen reduction, providing dual conduction pathways for reactant molecules. The existence of this central reaction center was confirmed through the in-situ diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy measurements and density functional theory (DFT) calculations. In addition, femtosecond transient absorption (fs-TAS), variable temperature fluorescence spectroscopy and time-resolved photoluminescence (TRPL) measurements reveal double-stranded structures favourable for carrier transport and reactive site activation between dual polymer chains. Ultimately, DC-CPs demonstrate up to a threefold increase in H₂O₂ production compared to their respective single-chain CPs (SC-CPs). This work adds significantly to the application of CPs for efficient H2O2 photogeneration through molecular engineering strategy.
研究领域:
材料科学
·
光催化
·
超分子化学
✓ 已验证
产品关联
DOI
高影响因子
AUSTRALIAN JOURNAL OF CHEMISTRY
·
2020
·Vol. 74
·期 4
·221-229
·
IF 1.073
Xiao-Xia Li,Wei-Tao Xu,Xin-Yu Deng,Li-Fei Tian,Ying Huang,Zhu Tao
The interactions of two host–guest inclusion complexes comprised of cucurbit[7]uril (Q[7]) and cucurbit[8]uril (Q[8]) with a derivative of toluidine blue O (TB) have been investigated using 1H NMR and fluorescence spectroscopy. The experimental results revealed that the Q[7] host interacts with a TB molecule to form a 1 : 1 inclusion complex and the Q[8] host interacts with two TB guest molecules to form a 1 : 2 inclusion complex. The inclusion of the TB guest molecule within the Q[7] host gave rise to significant fluorescence enhancement, whereas the inclusion of the TB guest molecule within the Q[8] host resulted in significant fluorescence quenching. Further recognition experiments involving a series of l-α-amino acids revealed that the TB@Q[7] inclusion fluorescence probe exhibits high selectivity for the recognition of phenylalanine via significant fluorescence quenching in an aqueous solution, whereas the TB@Q[8] inclusion fluorescence probe also exhibited high selectivity for phenylalanine recognition via fluorescence enhancement in an aqueous solution.
研究领域:
生物化学
·
分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.9
Jinlong Yao,Shangwei Yuan,Li Zeng,Jihong Lu,Baoqiu Yu,Zhichao Yu,Xin Xiao
Three nitrophenol@Q[8] host-guest single crystals are obtained and fully resolved for the first time. • A laboratory-scale recyclable Q[8] adsorption-ethanol desorption procedure is developed for mixed nitrophenol removal. • Q[8]@Nitrophenol host-guest recognition is cross-validated by multiple techniques. Cucurbit[8]uril (Q[8]) was employed as an adsorbent to systematically investigate its adsorption performance, interaction mechanism, and recycling potential toward o-nitrophenol (2-NP), m-nitrophenol (3-NP), and p-nitrophenol (4-NP) in aqueous solutions. Single-crystal X-ray diffraction analysis of the Q[8]-nitrophenol assemblies revealed that π-π stacking and hydrogen-bonding interactions governed the crystalline framework. Furthermore, a cyclic adsorption–desorption process was developed, leveraging the reversible nature of the host–guest interactions, which allowed for the effective regeneration and reuse of Q[8]. After treatment with Q[8], the residual concentrations of all three nitrophenol isomers in the aqueous phase fell below the first-level discharge limit of 2.0 mg·L⁻¹.
✓ 已验证
DOI
高影响因子
ACS Sensors
·
2025
·
IF 9.1
Lian Xu,Yan Xiao,Kun Yu,Hongshuo Pan,Jiayi Xu,Yiyun Guan,Mengke Wang,Xiangyu Xu,Hao Wang
The improper application of nonsteroidal anti-inflammatory drugs (NSAIDs) presents significant health hazards via vector food contamination. A critical limitation of these traditional existing approaches is their inability to concurrently discern and distinguish among diverse NSAIDs, presenting a notable gap in the analytical capabilities within this domain. Herein, a creative dual-channel fluorescence sensor array was developed for the rapid discrimination and determination of NSAIDs, utilizing complexes of cucurbit[8]uril (CB[8]) with three distinct modified poly(ethylenimines) (PEIs) to address this challenge. The array successfully differentiated and identified 19 NSAIDs with 97% accuracy at a concentration of 1 mM. In addition, it also achieved analyses of individual NSAIDs across a range of concentrations, NSAID mixtures, and impurities of aspirin using statistical analysis methods. More importantly, the approach effectively detected NSAIDs in complex matrices, such as milk and urine, demonstrating its potential for real-world applications.
研究领域:
分析化学
·
食品安全
·
药物检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.7
Xutao Ding,Li Zeng,Peijian Ma,Rui Wang,Jinlong Yao,Zhichao Yu,Yu Xia,Xin Xiao
Nitrotoluene isomers are vital chemical intermediates, but their separation is challenging due to similar properties. This work introduces a supramolecular strategy using cucurbit[8]uril (Q[8]) to selectively isolate ortho-nitrotoluene (ONT). Through methods including single-crystal XRD, ITC, GC, and theoretical calculations, host–guest interactions in formic acid were characterized. Gradient solvent volatilization of Q[8] with isomer mixtures enabled controlled crystallization. Results show Q[8] strongly prefers ONT, with binding constants of 3.628×10⁶ M⁻¹ (ortho) vs. 8.712×10⁵ M⁻¹ (meta) and 2.173×10⁵ M⁻¹ (para), giving selectivity ratios of 4.16 and 13.37, respectively. Crystal structures reveal stabilization via π–π stacking and hydrogen-bonding networks. These interactions drive multidimensional assembly into ordered architectures through synergistic surface interactions, hydrogen bonding, and aromatic stacking. This work extends cucurbituril applications in adsorption and separation.
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2013
·
IF 4.187
Dan-dan Li,Ke-feng Ren,Hao Chang,Hai-bo Wang,Jin-lei Wang,Chao-jian Chen,Jian Ji
The design of positively charged ultrathin films for surface modification is of crucial importance for biomedical applications. Herein, we report the layer-by-layer assembly of pure positively charged ultrathin films based on the host–guest interaction of cucurbit[8]uril (CB[8]). Two positively charged poly(ethylenimine)s (PEI) functionalized with guest moieties methyl viologen (MV) and indole (ID) were alternately assembled with the formation of CB[8] ternary complex under basic conditions. The growth of the (PEI-MV@CB[8]/PEI-ID) films was monitored by spectroscopic ellipsometry and quartz crystal microbalance. The morphology and structure of the films were characterized by scanning electron microscopy and UV–vis spectroscopy, respectively. These positively charged (PEI-MV@CB[8]/PEI-ID) films were very stable in the pH range from 4 to 9 but disassembled immediately when subjected to a competitive guest adamantylamine. Finally, the films were successfully employed as nanocontainers for DNA loading and subsequent directing the transfection of the adhered cells.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Soft Matter
·
2019
·Vol. 15
·期 47
·9797-9804
·
IF 3.399
Jin Zhang,Shengzhen Hou,Yanru Chen,Jing Zhou,Hao Chen,Yebang Tan
The strategy of dual cross-linking was investigated by enhancing the performance of dynamic hydrogels. To this end, phenylalanine modified ε-polylysine was synthesized and employed as the polymer backbone of hydrogels. The phenylalanine moieties and amine groups of the polymer could be cross-linked with cucurbit[8]uril (CB[8]) and the dialdehyde cross-linker, respectively. Single CB[8] linkage with fast dynamics led to an increase in the viscosity of the polymer solution, and single imine linkage with slow dynamics led to the formation of weak and brittle hydrogels. However, the two linkages were combined together to form a dual-cross-linked hydrogel and the performance of the hydrogel could be well enhanced. Compared with the single imine cross-linked hydrogel, the dual-cross-linked hydrogel demonstrated a higher mechanical strength, better extensibility and faster self-healing rate. It is anticipated that this line of research could provide a useful method to enhance the performance of dynamic hydrogels.
研究领域:
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SUPRAMOLECULAR CHEMISTRY
·
2017
·
IF 1.264
Yun-Yun Xi,Qing Tang,Ying Huang,Zhu Tao,Sai-Feng Xue,Qingdi Zhou,Gang Wei
Fluorescent indicator displacement assays have become popular for converting synthetic receptors into optical sensors. We have now shown that a 1:2 host–guest complex between cucurbit[8]uril (Q[8]) and proflavine (PF) can be used as a fluorescent indicator for sensing the anticancer drug gefitinib. The 2PF@Q[8] complex can be used to detect gefitinib with high selectivity using fluorescence spectrometry with a detection limit of 6.63 × 10−8 mol−L. The proposed sensing mechanism was investigated using 1H nuclear magnetic resonance spectroscopy (1H NMR), isothermal titration calorimetry and electrospray ionisation mass spectrometry. The 2PF@Q[8] complex was shown to be suitable for imaging gefitinib in prostate cancer (PC3) cells, which may help to elucidate relevant biological processes at the molecular level. We have developed a novel F-IDA to detect the anticancer drug GEF with high selectivity. The new indicator has excellent selectivity and a low detection limit for GEF. We have also demonstrated that the F-IDA can be used for the practical determination of drugs in living cells.
研究领域:
生物化学
·
药物分析
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）